Detailed information for compound 1009488

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 600.913 | Formula: C41H60O3
  • H donors: 0 H acceptors: 2 LogP: 11.19 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2[C@@H](C)[C@H](C)CC1)C)C)C)CCCC(=O)c1ccccc1
  • InChi: 1S/C41H60O3/c1-27-19-22-38(5)25-26-40(7)30(36(38)28(27)2)17-18-33-39(6)23-21-34(37(3,4)32(39)20-24-41(33,40)8)44-35(43)16-12-15-31(42)29-13-10-9-11-14-29/h9-11,13-14,17,27-28,32-34,36H,12,15-16,18-26H2,1-8H3/t27-,28+,32+,33-,34+,36+,38-,39+,40-,41-/m1/s1
  • InChiKey: WLPHZRYBLGDKFO-ONBSVCAQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0075 0.0389 0.6298
Echinococcus multilocularis cysteine protease 0.0055 0.0251 0.0201
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0089 0.0325
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1126 0.6173
Schistosoma mansoni hypothetical protein 0.0117 0.0678 0.1365
Trypanosoma cruzi cruzipain precursor, putative 0.0209 0.1305 0.5879
Onchocerca volvulus 0.003 0.0082 0.0209
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0069 0.0253
Brugia malayi Cathepsin L-like precursor 0.0037 0.0127 0.0464
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0419 0.2737 1
Brugia malayi cathepsin L-like precursor 0.0037 0.0127 0.0464
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0371 0.3005
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.003 0.0082 0.027
Trichomonas vaginalis set domain proteins, putative 0.0238 0.1504 0.8381
Loa Loa (eye worm) hypothetical protein 0.0026 0.0056 0.0204
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0103 0.0577 0.4809
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0502 0.0453
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0168 0.0577
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.1305 0.5772
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0089 0.0325
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0089 0.0325
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.003 0.0082 0.1094
Loa Loa (eye worm) ctsf protein 0.0055 0.0251 0.0918
Plasmodium vivax vivapain-3 0.0028 0.0069 0.1733
Echinococcus granulosus tumor protein p63 0.1121 0.754 0.7527
Brugia malayi RNA recognition motif domain containing protein 0.0419 0.2737 1
Onchocerca volvulus 0.0238 0.1504 1
Echinococcus granulosus tar DNA binding protein 0.0419 0.2737 0.27
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0251 0.1063
Entamoeba histolytica hypothetical protein 0.0075 0.0389 0.6298
Entamoeba histolytica cysteine protease, putative 0.0055 0.0251 0.3585
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.1781 1
Onchocerca volvulus 0.003 0.0082 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0251 0.1063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0251 0.1063
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0371 0.3005
Brugia malayi hypothetical protein 0.0026 0.0051 0.0188
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0168 0.475
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0168 0.0577
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0089 0.0325
Plasmodium vivax vivapain-2 0.0055 0.0251 0.6286
Brugia malayi nuclear hormone receptor 0.0031 0.0089 0.0325
Schistosoma mansoni cellular tumor antigen P53 0.0164 0.0998 0.2009
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0082 0.027
Schistosoma mansoni cathepsin F (C01 family) 0.0055 0.0251 0.0506
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0055 0.0251 0.0918
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.1305 0.5772
Plasmodium vivax acyl-CoA synthetase, putative 0.0077 0.04 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0089 0.0038
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0089 0.0038
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0117 0.0678 0.2476
Onchocerca volvulus 0.0055 0.0251 0.1375
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0089 0.0179
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0089 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0251 0.1063
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0371 0.241 0.8806
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0028 0.0069 0.0312
Onchocerca volvulus Cathepsin L homolog 0.0055 0.0251 0.1375
Loa Loa (eye worm) AMP-binding enzyme family protein 0.003 0.0082 0.0299
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0089 0.0325
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0279 0.1781 0.6505
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0103 0.0577 0.4809
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0089 0.0038
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.003 0.0082 0.0368
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0089 0.0325
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.003 0.0082 0.1094
Mycobacterium ulcerans hypothetical protein 0.0103 0.0577 0.4809
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.1305 0.5772
Brugia malayi Papain family cysteine protease containing protein 0.0055 0.0251 0.0918
Brugia malayi AMP-binding enzyme family protein 0.0103 0.0577 0.2107
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0144 0.1468
Schistosoma mansoni coup transcription factor 0.0031 0.0089 0.0179
Leishmania major cysteine peptidase A (CPA) 0.0055 0.0251 0.0902
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0089 0.0038
Entamoeba histolytica hypothetical protein 0.0075 0.0389 0.6298
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0055 0.0251 0.0918
Schistosoma mansoni hypothetical protein 0.0253 0.1608 0.3239
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0251 0.1063
Leishmania major cathepsin L-like protease 0.0209 0.1305 0.5772
Mycobacterium ulcerans acyl-CoA synthetase 0.0103 0.0577 0.4809
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.003 0.0082 0.0368
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0188
Brugia malayi Cathepsin L-like precursor 0.0055 0.0251 0.0918
Loa Loa (eye worm) hypothetical protein 0.0103 0.0577 0.2107
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0051 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0055 0.0251 0.1063
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0103 0.0577 0.4809
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0077 0.04 0.3275
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0089 0.0038
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.003 0.0082 0.027
Trichomonas vaginalis antibiotic synthetase, putative 0.003 0.0082 0.0073
Brugia malayi Cathepsin L-like precursor 0.0055 0.0251 0.0918
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0089 0.0325
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0089 0.0038
Schistosoma mansoni peroxidasin 0.0026 0.0051 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0089 0.0325
Loa Loa (eye worm) latrophilin receptor protein 2 0.0117 0.0678 0.2476
Trypanosoma cruzi cysteine peptidase, putative 0.0055 0.0251 0.1131
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0089 0.0259
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0089 0.0325
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0089 0.0179
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1126 0.6173
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0162 0.0986 0.4438
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0089 0.0325
Leishmania major acetyl-CoA synthetase, putative 0.003 0.0082 0.0119
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0325
Brugia malayi hypothetical protein 0.0026 0.0056 0.0204
Loa Loa (eye worm) hypothetical protein 0.0253 0.1608 0.5876
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1126 0.6173
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0089 0.0179
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0055 0.0251 0.1063
Echinococcus multilocularis tar DNA binding protein 0.0419 0.2737 0.27
Trypanosoma cruzi cysteine proteinase, putative 0.0028 0.0069 0.0312
Brugia malayi AMP-binding enzyme family protein 0.0103 0.0577 0.2107
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0188
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0371 0.241 0.8806
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0089 0.0325
Brugia malayi AMP-binding enzyme family protein 0.0103 0.0577 0.2107
Schistosoma mansoni hypothetical protein 0.0117 0.0678 0.1365
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0251 0.1063
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0089 0.0179
Plasmodium falciparum acetyl-CoA synthetase, putative 0.003 0.0082 0.0752
Plasmodium falciparum cysteine proteinase falcipain 3 0.0055 0.0251 0.5682
Loa Loa (eye worm) hypothetical protein 0.0077 0.04 0.146
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0127 0.1141
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0089 0.0179
Leishmania major cathepsin L-like protease 0.0055 0.0251 0.0902
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.003 0.0082 0.027
Brugia malayi steroid hormone receptor 0.0031 0.0089 0.0325
Brugia malayi Cathepsin L-like precursor 0.0055 0.0251 0.0918
Brugia malayi Calcitonin receptor-like protein seb-1 0.0371 0.241 0.8806
Loa Loa (eye worm) AMP-binding enzyme family protein 0.003 0.0082 0.0299
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0089 0.0325
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0081 0.0163
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0325
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0089 0.0325
Echinococcus granulosus geminin 0.0177 0.1085 0.1039
Brugia malayi Cathepsin L-like precursor 0.0055 0.0251 0.0918
Schistosoma mansoni tar DNA-binding protein 0.0419 0.2737 0.5513
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.003 0.0082 0.003
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.003 0.0082 0.0119
Trypanosoma cruzi cysteine peptidase, putative 0.0209 0.1305 0.5879
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.003 0.0082 0.003
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0191 0.1184 0.4326
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0251 0.1063
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0502 0.1012
Entamoeba histolytica cysteine proteinase, putative 0.0055 0.0251 0.3585
Loa Loa (eye worm) acetyltransferase 0.0145 0.0869 0.3176
Echinococcus granulosus cathepsin L cysteine proteinase 0.0055 0.0251 0.0201
Leishmania major cathepsin L-like protease 0.0209 0.1305 0.5772
Toxoplasma gondii hypothetical protein 0.0055 0.0254 0.8394
Echinococcus multilocularis neuropeptide s receptor 0.1481 1 1
Echinococcus multilocularis cathepsin L 0.0028 0.0069 0.0018
Echinococcus granulosus cathepsin L cysteine protease 0.0028 0.0069 0.0018
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0051 0.0188
Onchocerca volvulus 0.003 0.0082 0.0209
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0188
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.003 0.0082 0.027
Onchocerca volvulus 0.003 0.0082 0.0209
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.1305 0.5772
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.1305 0.5772
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0292 0.2259
Plasmodium vivax unspecified product 0.0028 0.0069 0.1733
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0103 0.0577 0.495
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0069 0.0312
Mycobacterium ulcerans hypothetical protein 0.0181 0.1111 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0325
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0188
Brugia malayi Cathepsin L-like precursor 0.0037 0.0127 0.0464
Echinococcus granulosus cathepsin L 0.0028 0.0069 0.0018
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0162 0.0986 0.4295
Onchocerca volvulus 0.003 0.0081 0.0204
Mycobacterium ulcerans acyl-CoA synthetase 0.0103 0.0577 0.4809
Onchocerca volvulus Cathepsin F homolog 0.0055 0.0251 0.1375
Echinococcus granulosus cysteine protease 0.0028 0.0069 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0502 0.1012
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0089 0.0179
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0117 0.0678 0.063
Leishmania major cathepsin L-like protease 0.0055 0.0251 0.0902
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0103 0.0577 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0251 0.1063
Brugia malayi Latrophilin receptor protein 2 0.0117 0.0678 0.2476
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.003 0.0082 0.0246
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0502 0.1012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0127 0.0338
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0251 0.1063
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0089 0.0038
Echinococcus granulosus cathepsin l1 0.0055 0.0251 0.0201
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0188
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0069 0.0253
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0325
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0251 0.1063
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0089 0.0038
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0188
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0056 0.0252
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.0869 0.1751
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0089 0.0038
Echinococcus granulosus microtubule associated protein 2 0.0744 0.4965 0.4939
Loa Loa (eye worm) hypothetical protein 0.0077 0.04 0.146
Loa Loa (eye worm) hypothetical protein 0.0077 0.04 0.146
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0089 0.0179
Schistosoma mansoni tar DNA-binding protein 0.0419 0.2737 0.5513
Trypanosoma cruzi cysteine peptidase, putative 0.0209 0.1305 0.5879
Loa Loa (eye worm) oxidoreductase 0.003 0.0082 0.0299
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0144 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.0127 0.0464
Leishmania major cathepsin L-like protease 0.0055 0.0251 0.0902
Onchocerca volvulus 0.0055 0.0251 0.1375
Toxoplasma gondii propionate-CoA ligase 0.003 0.0082 0.1094
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0117 0.0678 0.063
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1126 0.6173
Loa Loa (eye worm) hypothetical protein 0.0191 0.1184 0.4326
Leishmania major cathepsin L-like protease 0.0055 0.0251 0.0902
Trypanosoma cruzi cysteine peptidase, putative 0.0209 0.1305 0.5879
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0081 0.003
Loa Loa (eye worm) hypothetical protein 0.003 0.0081 0.0296
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0292 0.0588
Trichomonas vaginalis conserved hypothetical protein 0.0186 0.1148 0.6305
Loa Loa (eye worm) hypothetical protein 0.003 0.0082 0.0299
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0292 0.2044
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0089 0.0179
Echinococcus granulosus neuropeptide receptor A26 0.1481 1 1
Onchocerca volvulus 0.0103 0.0577 0.3617
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0292 0.1091
Brugia malayi Peroxidasin 0.0026 0.0051 0.0188
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.003 0.0082 0.027
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.0841 0.0794
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0051 0.0188
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0292 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0389 0.0339
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0089 0.0325
Plasmodium vivax acetyl-CoA synthetase, putative 0.003 0.0082 0.2045
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0292 0.0242
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0251 0.1063
Brugia malayi nuclear receptor NHR-88 0.0031 0.0089 0.0325
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0343 0.2221 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0089 0.0259
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0103 0.0577 0.495
Mycobacterium ulcerans acyl-CoA synthetase 0.0103 0.0577 0.4809
Leishmania major 4-coumarate:coa ligase-like protein 0.0103 0.0577 0.2406
Echinococcus granulosus cathepsin l1 0.0037 0.0127 0.0076
Loa Loa (eye worm) hypothetical protein 0.0037 0.0127 0.0464
Echinococcus multilocularis geminin 0.0177 0.1085 0.1039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.1305 0.5772
Schistosoma mansoni hypothetical protein 0.0177 0.1085 0.2186
Schistosoma mansoni hypothetical protein 0.0177 0.1085 0.2186
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0089 0.0325
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0127 0.0338
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0089 0.0038
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.1781 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0279 0.1781 0.6505
Loa Loa (eye worm) hypothetical protein 0.0103 0.0577 0.2107
Loa Loa (eye worm) hypothetical protein 0.0117 0.0678 0.2476
Brugia malayi Cathepsin L-like precursor 0.0055 0.0251 0.0918
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0074 0.0022
Echinococcus multilocularis cathepsin L cysteine protease 0.0055 0.0251 0.0201
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0389 0.0783
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0051 0.0188
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0077 0.04 0.3088
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0168 0.0117
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0069 0.0062
Schistosoma mansoni peroxidasin 0.0026 0.0051 0.0104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0089 0.0325
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0069 0.0139
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.0756 0.2764
Schistosoma mansoni hypothetical protein 0.0117 0.0678 0.1365
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.0869 0.3176
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0089 0.0038
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1126 0.6173
Schistosoma mansoni microtubule-associated protein tau 0.0744 0.4965 1
Plasmodium vivax vivapain-2 0.0055 0.0251 0.6286
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0502 0.1835
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0251 0.1063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.1305 0.5772
Loa Loa (eye worm) fibroinase 0.0055 0.0251 0.0918
Loa Loa (eye worm) TAR-binding protein 0.0419 0.2737 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0089 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0251 0.1063
Trichomonas vaginalis antibiotic synthetase, putative 0.003 0.0082 0.0073
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0089 0.0038
Schistosoma mansoni hypothetical protein 0.0075 0.0389 0.0783
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0251 0.1063
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1126 0.6173
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0343 0.2221 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0188
Schistosoma mansoni tar DNA-binding protein 0.0419 0.2737 0.5513
Echinococcus multilocularis cysteine protease 0.0055 0.0251 0.0201
Loa Loa (eye worm) hypothetical protein 0.0371 0.241 0.8806
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0389 0.0339
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0069 0.0139
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.003 0.0082 0.027
Loa Loa (eye worm) RNA binding protein 0.0419 0.2737 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0089 0.0179
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0055 0.0251 0.0201
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0055 0.0251 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0089 0.0325
Echinococcus multilocularis neuropeptide receptor A26 0.1481 1 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0103 0.0577 1
Schistosoma mansoni cathepsin F (C01 family) 0.0055 0.0251 0.0506
Echinococcus granulosus cathepsin l cysteine peptidase 0.0055 0.0251 0.0201
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0081 0.0163
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0082 0.027
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0502 0.0453
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0089 0.0259
Onchocerca volvulus Cathepsin L homolog 0.0055 0.0251 0.1375
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0188
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0117 0.0678 0.063
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0089 0.0179
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0251 0.1063
Leishmania major 4-coumarate:coa ligase-like protein 0.0103 0.0577 0.2406
Brugia malayi ecdysteroid receptor 0.0031 0.0089 0.0325
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0051 0.0188
Onchocerca volvulus 0.0037 0.0127 0.0521
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0089 0.0325
Echinococcus multilocularis cathepsin L cysteine protease 0.0055 0.0251 0.0201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0251 0.1063
Schistosoma mansoni acetyl-CoA synthetase 0.003 0.0082 0.0165
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0051 0.0188
Loa Loa (eye worm) hypothetical protein 0.003 0.0082 0.0299
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0056 0.1398
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0089 0.0325
Loa Loa (eye worm) hypothetical protein 0.0055 0.0251 0.0918
Schistosoma mansoni tar DNA-binding protein 0.0419 0.2737 0.5513
Entamoeba histolytica acyl-CoA synthetase, putative 0.0103 0.0577 1
Echinococcus granulosus GPCR family 2 0.0117 0.0678 0.063
Leishmania major 4-coumarate:coa ligase-like protein 0.0103 0.0577 0.2406
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.1781 1
Plasmodium vivax vivapain-1 0.0028 0.0069 0.1733
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0325
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.1193 0.6566
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0081 0.1067
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.003 0.0082 0.0299
Onchocerca volvulus Glucosylceramidase homolog 0.0183 0.1126 0.7398
Loa Loa (eye worm) hypothetical protein 0.0103 0.0577 0.2107
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0188
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0188
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0292 0.2044
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0325
Schistosoma mansoni hypothetical protein 0.0117 0.0678 0.1365
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0055 0.0251 0.5682
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0188
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.1781 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0056 0.0252
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0292 0.0588
Entamoeba histolytica acyl-coA synthetase, putative 0.0103 0.0577 1
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0051 0.0188
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0059 0.0278 0.1251
Leishmania major mitochondrial DNA polymerase beta 0.0343 0.2221 1
Brugia malayi AMP-binding enzyme family protein 0.003 0.0082 0.0299
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0206 0.0926
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0251 0.1063
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0089 0.0179
Toxoplasma gondii cathepsin CPL 0.0055 0.0251 0.8268
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0168 0.4206
Loa Loa (eye worm) cysteine protease 0.0055 0.0251 0.0918
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1126 0.6173
Brugia malayi TAR-binding protein 0.0419 0.2737 1
Plasmodium vivax SET domain protein, putative 0.003 0.0081 0.2029
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.1306 0.4771
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0251 0.1063
Trypanosoma cruzi cysteine protease, putative 0.0028 0.0069 0.0312
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0082 0.027
Plasmodium falciparum acyl-CoA synthetase 0.0077 0.04 1
Loa Loa (eye worm) hypothetical protein 0.0164 0.0998 0.3645
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0089 0.0325
Onchocerca volvulus 0.0055 0.0251 0.1375
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0206 0.0926
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0089 0.0325
Entamoeba histolytica acyl-CoA synthetase, putative 0.0103 0.0577 1
Brugia malayi Pre-SET motif family protein 0.0209 0.1306 0.4771
Entamoeba histolytica cysteine proteinase, putative 0.0055 0.0251 0.3585
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0051 0.0188
Brugia malayi Cathepsin L-like precursor 0.0055 0.0251 0.0918
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.1305 0.5772
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.003 0.0082 0.027
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0343 0.2221 1
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.0127 0.0256
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0089 0.0325
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0089 0.0325
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0371 0.3005
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.0869 0.0822
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.003 0.0082 0.0368
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0188
Loa Loa (eye worm) hypothetical protein 0.0037 0.0127 0.0464
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0081 0.0163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0251 0.1063
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0371 0.3005
Brugia malayi RNA binding protein 0.0419 0.2737 1
Echinococcus multilocularis GPCR, family 2 0.0117 0.0678 0.063
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0251 0.1063
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0051 0.0188
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0502 0.1835
Loa Loa (eye worm) hypothetical protein 0.0077 0.04 0.146
Brugia malayi AMP-binding enzyme family protein 0.003 0.0082 0.0299
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0081 0.003
Leishmania major cathepsin L-like protease 0.0055 0.0251 0.0902
Leishmania major cathepsin L-like protease 0.0209 0.1305 0.5772
Loa Loa (eye worm) hypothetical protein 0.0077 0.04 0.146
Brugia malayi hypothetical protein 0.0075 0.0389 0.1421
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0325
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0089 0.0325
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.0251 0.1063
Schistosoma mansoni tar DNA-binding protein 0.0419 0.2737 0.5513
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0069 0.0062
Echinococcus multilocularis microtubule associated protein 2 0.0744 0.4965 0.4939
Brugia malayi AMP-binding enzyme family protein 0.003 0.0082 0.0299
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0144 0.2556
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.1305 0.5772
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0028 0.0069 0.0139
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0251 0.1063
Onchocerca volvulus 0.0055 0.0251 0.1375
Plasmodium falciparum cysteine proteinase falcipain 1 0.0028 0.0069 0.0389
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0077 0.04 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0089 0.0038
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0117 0.0678 0.063
Trypanosoma cruzi major cysteine proteinase, putative 0.0164 0.0999 0.4501
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0325
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.0756 0.2764
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.1781 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.003 0.0082 0.0119
Onchocerca volvulus 0.0055 0.0251 0.1375
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0502 0.0453
Onchocerca volvulus 0.0055 0.0251 0.1375
Brugia malayi latrophilin 2 splice variant baaae 0.0253 0.1608 0.5876
Brugia malayi AMP-binding enzyme family protein 0.003 0.0082 0.0299
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0089 0.0038
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.1193 0.6566
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0051 0.0188
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0188
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0292 0.2044
Brugia malayi Cathepsin L-like cysteine proteinase 0.0037 0.0127 0.0464
Brugia malayi Pre-SET motif family protein 0.003 0.0081 0.0296
Entamoeba histolytica hypothetical protein 0.0075 0.0389 0.6298
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0055 0.0251 0.5682
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0502 0.0453
Brugia malayi acetyl-Coenzyme A synthetase 2 0.003 0.0082 0.0299
Mycobacterium tuberculosis Conserved hypothetical protein 0.0181 0.1111 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0292 0.0242
Loa Loa (eye worm) hypothetical protein 0.0026 0.0051 0.0188
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.0206 0.0692
Onchocerca volvulus 0.0031 0.0089 0.0259
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0082 0.027
Brugia malayi Blistered cuticle protein 3 0.0026 0.0051 0.0188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.1305 0.5772
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0089 0.0038
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0081 0.003
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0089 0.0038
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0103 0.0577 0.4809
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0081 0.0163
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.1781 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.0251 0.1063
Echinococcus multilocularis tumor protein p63 0.1121 0.754 0.7527
Onchocerca volvulus 0.0055 0.0251 0.1375
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0089 0.0179
Trypanosoma brucei acetyl-CoA synthetase, putative 0.003 0.0082 0.0119
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0162 0.0986 0.4295
Trypanosoma cruzi cysteine proteinase, putative 0.0028 0.0069 0.0312
Leishmania major acetyl-CoA synthetase, putative 0.003 0.0082 0.0119
Brugia malayi MH2 domain containing protein 0.0129 0.0756 0.2764
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0168 0.475
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0209 0.1305 0.5772
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.003 0.0082 0.0368
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0191 0.1181 0.532
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0206 0.0926
Onchocerca volvulus 0.0164 0.0998 0.6517

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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