Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0606 | 0.3291 | 0.3291 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1472 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1472 | 1 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1472 | 1 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1472 | 1 | 0.5 |
Onchocerca volvulus | 0.0181 | 0 | 0.5 | |
Onchocerca volvulus | 0.0181 | 0 | 0.5 | |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1472 | 1 | 0.5 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0606 | 0.3291 | 0.3291 |
Onchocerca volvulus | 0.0181 | 0 | 0.5 | |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0606 | 0.3291 | 0.3291 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1472 | 1 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0691 | 0.3946 | 1 |
Onchocerca volvulus | 0.0181 | 0 | 0.5 | |
Onchocerca volvulus | 0.0181 | 0 | 0.5 | |
Onchocerca volvulus | 0.0181 | 0 | 0.5 | |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0691 | 0.3946 | 1 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0181 | 0 | 0.5 |
Onchocerca volvulus | 0.0181 | 0 | 0.5 | |
Brugia malayi | CHE-14 protein | 0.0606 | 0.3291 | 0.3291 |
Echinococcus multilocularis | protein patched | 0.0606 | 0.3291 | 0.3291 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0606 | 0.3291 | 0.3291 |
Onchocerca volvulus | 0.0181 | 0 | 0.5 | |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1472 | 1 | 1 |
Onchocerca volvulus | 0.0181 | 0 | 0.5 | |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0691 | 0.3946 | 1 |
Onchocerca volvulus | 0.0181 | 0 | 0.5 | |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0691 | 0.3946 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0606 | 0.3291 | 0.3291 |
Echinococcus multilocularis | protein dispatched 1 | 0.0606 | 0.3291 | 0.3291 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0606 | 0.3291 | 0.3291 |
Onchocerca volvulus | 0.0181 | 0 | 0.5 | |
Onchocerca volvulus | 0.0181 | 0 | 0.5 | |
Onchocerca volvulus | 0.0181 | 0 | 0.5 | |
Onchocerca volvulus | 0.0181 | 0 | 0.5 | |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1472 | 1 | 0.5 |
Onchocerca volvulus | 0.0181 | 0 | 0.5 | |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1472 | 1 | 1 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0181 | 0 | 0.5 |
Schistosoma mansoni | patched 1 | 0.0606 | 0.3291 | 0.3291 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0606 | 0.3291 | 0.3291 |
Onchocerca volvulus | 0.0181 | 0 | 0.5 | |
Onchocerca volvulus | 0.0181 | 0 | 0.5 | |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0606 | 0.3291 | 0.3291 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.