Detailed information for compound 1009692

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 306.362 | Formula: C18H18N4O
  • H donors: 2 H acceptors: 0 LogP: 2.74 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=N)N/N=C/C1=C(Oc2ccccc2)c2c(CC1)cccc2
  • InChi: 1S/C18H18N4O/c19-18(20)22-21-12-14-11-10-13-6-4-5-9-16(13)17(14)23-15-7-2-1-3-8-15/h1-9,12H,10-11H2,(H4,19,20,22)/b21-12+
  • InChiKey: QBFQCTGYUBNAND-CIAFOILYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mouse mammary tumor virus (strain GR) (MMTV) Envelope glycoprotein gp70 Starlite/ChEMBL References
Avian erythroblastosis virus (strain ES4) Gag polyprotein Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Nuclear hormone receptor-like 1 Get druggable targets OG5_156853 All targets in OG5_156853
Brugia malayi Nuclear hormone receptor-like 1 Get druggable targets OG5_156853 All targets in OG5_156853
Brugia malayi Nuclear hormone receptor-like 1 Get druggable targets OG5_156853 All targets in OG5_156853
Plasmodium yoelii integrase-related Get druggable targets OG5_139608 All targets in OG5_139608
Loa Loa (eye worm) nuclear hormone receptor-like 1 Get druggable targets OG5_156853 All targets in OG5_156853
Schistosoma mansoni hypothetical protein Get druggable targets OG5_139608 All targets in OG5_139608
Trypanosoma brucei RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
Trypanosoma congolense RNA helicase, putative Get druggable targets OG5_139608 All targets in OG5_139608
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_156853 All targets in OG5_156853
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0048 0.0246
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0048 0.0075
Plasmodium vivax hypothetical protein, conserved 0.001 0.0003 0.0025
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0048 0.0054
Brugia malayi AF-10 protein 0.001 0.0003 0.0003
Brugia malayi nuclear hormone receptor 0.0012 0.0048 0.0054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0048 0.0246
Onchocerca volvulus 0.0035 0.0532 0.0487
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0048 0.0246
Loa Loa (eye worm) hypothetical protein 0.0035 0.0532 0.0595
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.4538 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0048 0.0054
Trichomonas vaginalis DNA helicase recq, putative 0.0027 0.0363 0.027
Onchocerca volvulus 0.0035 0.0532 0.0487
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0048 0.0053
Loa Loa (eye worm) hypothetical protein 0.0294 0.6019 0.6733
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.6785 0.6753
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0532 0.0441
Schistosoma mansoni hypothetical protein 0.001 0.0003 0.0004
Schistosoma mansoni DNA helicase recq5 0.0011 0.0026 0.0041
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0048 0.0075
Brugia malayi jmjC domain containing protein 0.0037 0.0581 0.0664
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0294 0.6033 0.6749
Loa Loa (eye worm) hypothetical protein 0.0431 0.8939 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.6785 0.6753
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.001 0.0003 0.006
Loa Loa (eye worm) hypothetical protein 0.0093 0.1768 0.1978
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0532 0.0441
Brugia malayi Bromodomain containing protein 0.0031 0.0444 0.0506
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0532 0.0607
Giardia lamblia PHD finger protein 15 0.0031 0.0444 0.0618
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0532 0.0441
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0048 0.0053
Schistosoma mansoni hypothetical protein 0.0031 0.0444 0.07
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0048 0.0054
Loa Loa (eye worm) hypothetical protein 0.0136 0.2681 0.2999
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0003 0.0005
Loa Loa (eye worm) RecQ helicase 0.0027 0.0363 0.0406
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.1075 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0048 0.0053
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0048 0.0075
Brugia malayi ecdysteroid receptor 0.0012 0.0048 0.0054
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0444 0.07
Onchocerca volvulus Alhambra homolog 0.0031 0.0444 0.0398
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0031 0.0444 0.0496
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0177 0.1647
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0733 0.082
Onchocerca volvulus 0.0061 0.1075 0.1033
Brugia malayi beta-lactamase family protein 0.0035 0.0532 0.0607
Loa Loa (eye worm) hypothetical protein 0.0035 0.0532 0.0595
Trichomonas vaginalis esterase, putative 0.0035 0.0532 0.0441
Toxoplasma gondii PHD-finger domain-containing protein 0.001 0.0003 0.0025
Loa Loa (eye worm) hypothetical protein 0.0035 0.0532 0.0595
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0048 0.0075
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0048 0.0246
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0581 0.3006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.6785 0.6753
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0532 0.2751
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0444 0.4124
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.1075 0.1699
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0532 1
Trypanosoma brucei RNA helicase, putative 0.025 0.5092 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0048 0.0246
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0581 0.3006
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0048 0.0246
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0026 0.0029
Brugia malayi hypothetical protein 0.0093 0.1768 0.2018
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0173 0.1604
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0048 0.0054
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0293 0.6616
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0048 0.0246
Brugia malayi jmjC domain containing protein 0.0101 0.1934 0.2207
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0444 0.2294
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0048 0.0246
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.6785 0.6753
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.005 0.0057
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0581 0.065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.1075 0.1699
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0048 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0048 0.0053
Brugia malayi Bloom's syndrome protein homolog 0.0027 0.0363 0.0415
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0048 0.0054
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0048 0.0075
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0733 0.1158
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0048 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0048 0.0054
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0048 0.0075
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0532 1
Brugia malayi glutaminase DH11.1 0.0308 0.6332 0.7228
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0048 0.0054
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0161 0.3206 0.6676
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0532 0.084
Loa Loa (eye worm) hypothetical protein 0.0093 0.1768 0.1978
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0532 0.0595
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0026 0.024
Loa Loa (eye worm) beta-lactamase 0.0035 0.0532 0.0595
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0444 0.0496
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.0026 0.0029
Loa Loa (eye worm) hypothetical protein 0.0053 0.0911 0.102
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0532 0.2751
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.0026 0.0134
Leishmania major hypothetical protein, conserved 0.0035 0.0532 1
Schistosoma mansoni hypothetical protein 0.025 0.5092 0.8041
Schistosoma mansoni coup transcription factor 0.0012 0.0048 0.0075
Echinococcus granulosus bloom syndrome protein 0.0027 0.0363 0.1879
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0048 0.0246
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0048 0.0246
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0053
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0048 0.0075
Loa Loa (eye worm) glutaminase 2 0.0308 0.6332 0.7084
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.1028 0.5317
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0532 0.1045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0053
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.6785 0.6753
Schistosoma mansoni jumonji domain containing protein 0.008 0.1493 0.2357
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0733 0.3791
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0048 0.0053
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0048 0.0246
Brugia malayi nuclear receptor NHR-88 0.0012 0.0048 0.0054
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.0026 0.0134
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0026 0.0029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0733 0.1158
Brugia malayi beta-lactamase family protein 0.0035 0.0532 0.0607
Schistosoma mansoni DNA helicase recq1 0.0011 0.0026 0.0041
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0733 0.1158
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0003 0.0005
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0048 0.0075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0048 0.0053
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0026 0.024
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0423 0.876 0.98
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0733 0.3791
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0161 0.3206 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0053
Onchocerca volvulus 0.0035 0.0532 0.0487
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0444 0.4124
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0053
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.0242 0.0383
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.0026 0.0134
Loa Loa (eye worm) hypothetical protein 0.0061 0.1075 0.1203
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.1141 0.1276
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.033 0.6785 1
Brugia malayi Pre-SET motif family protein 0.0061 0.1075 0.1228
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0048 0.0246
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0532 0.4946
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0048 0.0246
Echinococcus granulosus jumonji domain containing protein 0.0043 0.07 0.362
Brugia malayi Nuclear hormone receptor-like 1 0.0294 0.6033 0.6887
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0048 0.0075
Brugia malayi PHD-finger family protein 0.001 0.0003 0.0003
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.1934 1
Brugia malayi Pre-SET motif family protein 0.0423 0.876 1
Echinococcus multilocularis peregrin 0.0031 0.0444 0.2294
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.005 0.0079
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0048 0.0054
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.0026 0.0134
Trichomonas vaginalis set domain proteins, putative 0.0481 1 1
Giardia lamblia Fructose-bisphosphate aldolase 0.033 0.6785 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.1075 0.5562
Toxoplasma gondii ABC1 family protein 0.0035 0.0532 0.4946
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0048 0.0246
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.1934 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0048 0.0246
Mycobacterium ulcerans glutaminase 0.0308 0.6332 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0096 0.0188
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.1075 0.5562
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0048 0.0075
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0053
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0733 0.0837
Loa Loa (eye worm) hypothetical protein 0.0035 0.0532 0.0595
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0048 0.0246
Brugia malayi steroid hormone receptor 0.0012 0.0048 0.0054
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.6785 0.6753
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0048 0.0246
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0444 0.4124
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0048 0.0246
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0096 0.1797
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0733 0.3791
Brugia malayi beta-lactamase 0.0035 0.0532 0.0607
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.1075 0.1699
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0161 0.3206 0.4611
Loa Loa (eye worm) hypothetical protein 0.0011 0.0026 0.0029
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0048 0.0054
Loa Loa (eye worm) hypothetical protein 0.0431 0.8939 1
Loa Loa (eye worm) glutaminase 0.0308 0.6332 0.7084
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0048 0.0054
Brugia malayi Nuclear hormone receptor-like 1 0.0294 0.6033 0.6887
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0048 0.0054
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.6785 0.6753
Schistosoma mansoni glutaminase 0.0308 0.6332 1
Brugia malayi PHD-finger family protein 0.0031 0.0444 0.0506
Plasmodium vivax SET domain protein, putative 0.0061 0.1075 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0027 0.0363 0.027
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0733 0.3791
Echinococcus multilocularis bloom syndrome protein 0.0027 0.0363 0.1879
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.1075 0.1699
Treponema pallidum fructose-bisphosphate aldolase 0.033 0.6785 0.5
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.1075 0.5562
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0532 0.0441
Schistosoma mansoni eyes absent homolog 0.0093 0.1768 0.2792
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0532 0.084
Plasmodium falciparum phd finger protein, putative 0.0031 0.0444 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0444 0.2294
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0048 0.0054
Brugia malayi Nuclear hormone receptor-like 1 0.03 0.6155 0.7026
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0053
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0532 0.0441
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0096 0.1797
Trichomonas vaginalis glutaminase, putative 0.0308 0.6332 0.6296
Loa Loa (eye worm) hypothetical protein 0.0035 0.0532 0.0595
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0048 0.0053
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0581 0.0918
Echinococcus granulosus peregrin 0.0031 0.0444 0.2294
Loa Loa (eye worm) hypothetical protein 0.0035 0.0532 0.0595
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0048 0.0075
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.6785 0.6753
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0581 0.0918
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.07 0.362
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.0026 0.0582
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0048 0.0054
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.001 0.0003 0.0025
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.033 0.6785 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0048 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0048 0.0054

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 50 % Antagonist activity at estrogen receptor alpha expressed in human HEC1 cells assessed as inhibition of estradiol-induced transcriptional activity at 20 uM after 24 hrs by beta-galactosidase reporter gene assay ChEMBL. 18976929
IC50 (functional) = 3.5 uM Antagonist activity at estrogen receptor alpha expressed in human HEC1 cells assessed as inhibition of 1 nM estradiol-induced transcriptional activity after 24 hrs by luciferase reporter gene assay ChEMBL. 18976929
IC50 (binding) = 5.9 uM Inhibition of estradiol-induced coactivator peptide SRC1 binding to estrogen receptor alpha expressed in human HEC1 cells after 24 hrs by luciferase based mammalian two-hybrid assay ChEMBL. 18976929

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.