Detailed information for compound 1010081

Basic information

Technical information
  • TDR Targets ID: 1010081
  • Name: 4,5-dimethyl-1,3-thiazol-2-amine hydrochlorid e
  • MW: 164.656 | Formula: C5H9ClN2S
  • H donors: 1 H acceptors: 0 LogP: 1.9 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: N=c1[nH]c(c(s1)C)C.Cl
  • InChi: 1S/C5H8N2S.ClH/c1-3-4(2)8-5(6)7-3;/h1-2H3,(H2,6,7);1H
  • InChiKey: XYTUTNQRQLAZLK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4,5-dimethylthiazol-2-amine hydrochloride
  • 4,5-dimethyl-2-thiazolamine hydrochloride
  • (4,5-dimethylthiazol-2-yl)amine hydrochloride
  • 174408_ALDRICH
  • SBB003911
  • 2-Amino-4,5-dimethylthiazole hydrochloride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0025 1
Brugia malayi MH2 domain containing protein 0.0009 0.0025 0.0025
Mycobacterium leprae Polyketide synthase Pks13 0.0042 0.279 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0028 0.1634 0.581
Brugia malayi AMP-binding enzyme family protein 0.0009 0.0015 0.0015
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0025 0.5
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0023 0.1208 0.4329
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0028 0.1634 0.1634
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0009 0.003 0.0108
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0042 0.279 1
Brugia malayi MH2 domain containing protein 0.0009 0.0025 0.0025
Mycobacterium leprae Probable polyketide synthase Pks1 0.003 0.1779 0.6337
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0028 0.1634 0.5856
Trichomonas vaginalis conserved hypothetical protein 0.0009 0 0.5
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0026 0.148 0.1459
Onchocerca volvulus Fatty acid synthase homolog 0.0051 0.3511 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0028 0.1634 0.5834
Schistosoma mansoni smad1 5 8 and 0.0009 0.0025 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0606 0.0582
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0019 0.0842 0.2981
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0023 0.1177 0.4188
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.003 0.1779 0.6337
Brugia malayi AMP-binding enzyme family protein 0.0026 0.148 0.148
Toxoplasma gondii type I fatty acid synthase, putative 0.002 0.096 0.3708
Echinococcus multilocularis Smad4 0.0009 0.0025 0.5
Mycobacterium ulcerans thioesterase TesA 0.0024 0.1244 0.443
Onchocerca volvulus 0.0049 0.3366 0.9285
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0028 0.1634 0.5856
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0028 0.1634 0.581
Mycobacterium ulcerans fatty acid synthase Fas 0.0009 0.003 0.0056
Mycobacterium tuberculosis Polyketide synthase Pks12 0.003 0.1779 0.6376
Loa Loa (eye worm) transcription factor SMAD2 0.013 1 1
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0027 0.1562 0.5599
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0026 0.148 0.5305
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0025 0.5
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0016 0.0625 0.224
Schistosoma mansoni smad1 5 8 and 0.0009 0.0025 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0023 0.1177 0.4188
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.003 0.1779 0.6357
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0028 0.1634 0.5856
Schistosoma mansoni Smad4 0.0009 0.0025 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0025 0.5
Brugia malayi MH1 domain containing protein 0.0009 0.0025 0.0025
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.001 0.0099 0.0356
Echinococcus granulosus Smad4 0.0009 0.0025 0.5
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0018 0.0813 0.2574
Mycobacterium ulcerans polyketide synthase 0.003 0.1779 0.6357
Schistosoma mansoni smad1 5 8 and 0.0009 0.0025 1
Brugia malayi Smad1 0.0009 0.0025 0.0025
Mycobacterium tuberculosis Probable thioesterase TesA 0.0024 0.1244 0.4459
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0011 0.0241 0.0864
Mycobacterium ulcerans Type I modular polyketide synthase 0.0028 0.1634 0.5834
Loa Loa (eye worm) MH2 domain-containing protein 0.013 1 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.3224 0.3207
Loa Loa (eye worm) acyl carrier protein 0.0013 0.0371 0.0347
Echinococcus multilocularis smad 0.0009 0.0025 0.5
Toxoplasma gondii type I fatty acid synthase, putative 0.003 0.1779 1
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0009 0.0015 0.0052
Echinococcus granulosus smad 0.0009 0.0025 0.5
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0024 0.1244 0.4398
Mycobacterium ulcerans polyketide synthase Pks13 0.0042 0.279 1
Schistosoma mansoni smad 0.0009 0.0025 1
Leishmania major hypothetical protein, conserved 0.0009 0 0.5
Loa Loa (eye worm) fatty acid synthase 0.0028 0.1603 0.1582
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0027 0.1562 0.5599
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0025 0.5
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0028 0.1634 0.5834
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.003 0.1779 0.6376
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0023 0.1177 0.4155
Giardia lamblia Methyltransferase like 2 0.0009 0 0.5
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.003 0.1779 0.6337
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.002 0.0975 0.3495
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0042 0.279 1
Mycobacterium ulcerans thioesterase 0.0024 0.1244 0.443
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0019 0.0842 0.2941
Brugia malayi MH1 domain containing protein 0.0009 0.0025 0.0025
Mycobacterium ulcerans polyketide synthase Pks9 0.0019 0.0842 0.2981
Mycobacterium ulcerans Type I modular polyketide synthase 0.0028 0.1634 0.5834
Mycobacterium ulcerans polyketide synthase 0.0028 0.1634 0.5834
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0054 0.3728 0.3728
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.003 0.1779 0.6357
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.003 0.1779 0.6376

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.