Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2957 | 0.2957 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2957 | 0.2957 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.2957 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2957 | 0.2957 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.2957 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.2957 | 0.2957 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2957 | 0.2957 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.2957 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.2957 | 0.2957 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0066 | 0.2957 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.2957 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2957 | 0.2957 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0178 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.2957 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.