Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA binding protein | 0.0147 | 0.2529 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0147 | 0.2529 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0299 | 0.1184 |
Echinococcus granulosus | tar DNA binding protein | 0.0147 | 0.2529 | 0.2529 |
Schistosoma mansoni | tar DNA-binding protein | 0.0147 | 0.2529 | 1 |
Brugia malayi | TAR-binding protein | 0.0147 | 0.2529 | 1 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0538 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0147 | 0.2529 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0032 | 0.0126 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.031 | 0.1227 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.1062 | 0.5 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0538 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.031 | 0.1116 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0147 | 0.2529 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.031 | 0.031 |
Schistosoma mansoni | tar DNA-binding protein | 0.0147 | 0.2529 | 1 |
Brugia malayi | RNA binding protein | 0.0147 | 0.2529 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.031 | 0.031 |
Echinococcus multilocularis | tar DNA binding protein | 0.0147 | 0.2529 | 0.2529 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0071 | 0.1062 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0147 | 0.2529 | 1 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0538 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0147 | 0.2529 | 1 |
Echinococcus granulosus | lamin | 0.0031 | 0.031 | 0.031 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.031 | 0.1116 |
Onchocerca volvulus | 0.0031 | 0.031 | 0.5 | |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0071 | 0.1062 | 0.1062 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.031 | 0.031 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0071 | 0.1062 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.031 | 0.1227 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.1062 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0071 | 0.1062 | 0.1062 |
Echinococcus multilocularis | lamin | 0.0031 | 0.031 | 0.031 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.1062 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0071 | 0.1062 | 0.3385 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0071 | 0.1062 | 0.3385 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.031 | 0.1227 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0071 | 0.1062 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0147 | 0.2529 | 1 |
Onchocerca volvulus | 0.0031 | 0.031 | 0.5 | |
Echinococcus multilocularis | musashi | 0.0031 | 0.031 | 0.031 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.06 ug ml-1 | In vitro cytotoxic activity against HeLaS3 cells in tissue culture was determined | ChEMBL. | 2296035 |
T/C (functional) | = 180 % | In vivo antitumor activity was determined against P 388 leukemia cells implanted (ip) in BDF1 mice at a dose of 25 mg/kg | ChEMBL. | 2296035 |
T/C (functional) | = 188 % | In vivo antitumor activity was determined against P 388 leukemia cells implanted (ip) in BDF1 mice at a dose of 25 mg/kg | ChEMBL. | 2296035 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 2296035 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.