Detailed information for compound 1010691

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 205.339 | Formula: C14H23N
  • H donors: 0 H acceptors: 0 LogP: 3.06 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CCN(CC1)C12CC3CC2CC(C1)C3
  • InChi: 1S/C14H23N/c1-2-4-15(5-3-1)14-9-11-6-12(10-14)8-13(14)7-11/h11-13H,1-10H2
  • InChiKey: MPCPLRFLUHEXCX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Hsp90 protein 0.0014 0.0098 0.0098
Onchocerca volvulus 0.0046 0.1303 0.5898
Loa Loa (eye worm) hypothetical protein 0.007 0.2266 0.2266
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.1184 0.535
Loa Loa (eye worm) CHromoDomain protein family member 0.0012 0.0017 0.0017
Echinococcus multilocularis GPCR, family 2 0.0033 0.0799 0.0784
Echinococcus granulosus geminin 0.0184 0.6689 0.6683
Onchocerca volvulus 0.0033 0.0828 0.3718
Loa Loa (eye worm) hypothetical protein 0.0046 0.1303 0.1303
Echinococcus multilocularis peroxidasin 0.0069 0.2198 0.2185
Trypanosoma brucei transcription factor BTF3, putative 0.011 0.3813 1
Entamoeba histolytica hypothetical protein 0.0037 0.096 0.2485
Leishmania major heat shock protein, putative 0.0014 0.0098 0.0256
Loa Loa (eye worm) animal heme peroxidase 0.0069 0.2198 0.2198
Onchocerca volvulus 0.0069 0.2198 1
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0014 0.0098 0.0081
Echinococcus granulosus para nitrobenzyl esterase 0.0046 0.1303 0.1289
Plasmodium vivax endoplasmin, putative 0.0035 0.0907 0.2347
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0017
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.1347 0.1347
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Loa Loa (eye worm) carboxylesterase 0.0046 0.1303 0.1303
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0907 0.238
Schistosoma mansoni hypothetical protein 0.0033 0.0799 0.0784
Echinococcus granulosus peroxidasin 0.0069 0.2198 0.2185
Trichomonas vaginalis chromobox protein, putative 0.0076 0.2477 0.648
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0017
Echinococcus granulosus endoplasmin 0.0028 0.0628 0.0612
Brugia malayi Blistered cuticle protein 3 0.0069 0.2198 0.2198
Trypanosoma brucei heat shock protein, putative 0.0035 0.0907 0.238
Loa Loa (eye worm) hypothetical protein 0.027 1 1
Brugia malayi hypothetical protein 0.0037 0.096 0.096
Onchocerca volvulus Peroxidase homolog 0.0069 0.2198 1
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Onchocerca volvulus Peroxidasin homolog 0.0069 0.2198 1
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Trichomonas vaginalis conserved hypothetical protein 0.011 0.3813 1
Trichomonas vaginalis conserved hypothetical protein 0.011 0.3813 1
Echinococcus granulosus transcription factor btf3 0.011 0.3813 0.3802
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0799 0.0799
Loa Loa (eye worm) acetylcholinesterase 1 0.027 1 1
Onchocerca volvulus Peroxidase homolog 0.0069 0.2198 1
Echinococcus granulosus heat shock protein 90 0.0028 0.0628 0.0612
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0046 0.1303 1
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0628 0.161
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Trypanosoma brucei heat shock protein, putative 0.0035 0.0907 0.238
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Loa Loa (eye worm) animal heme peroxidase 0.0069 0.2198 0.2198
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0017
Trypanosoma cruzi heat shock protein 90, putative 0.0021 0.0345 0.0905
Schistosoma mansoni hypothetical protein 0.0184 0.6689 0.6683
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.3529 0.3529
Loa Loa (eye worm) hypothetical protein 0.0046 0.1303 0.1303
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1347 0.1332
Trichomonas vaginalis chromobox protein, putative 0.0076 0.2477 0.648
Loa Loa (eye worm) heterochromatin protein 1 0.0076 0.2477 0.2477
Brugia malayi Carboxylesterase family protein 0.0046 0.1303 0.1303
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Echinococcus multilocularis acetylcholinesterase 0.027 1 1
Schistosoma mansoni heat shock protein 0.0014 0.0098 0.0081
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.0907 0.238
Loa Loa (eye worm) hypothetical protein 0.0046 0.1303 0.1303
Trichomonas vaginalis heat shock protein, putative 0.0014 0.0098 0.0213
Loa Loa (eye worm) heat shock protein 75 0.0014 0.0098 0.0098
Brugia malayi hypothetical protein 0.0012 0.0017 0.0017
Trichomonas vaginalis endoplasmin, putative 0.0022 0.0377 0.0949
Giardia lamblia Heat shock protein HSP 90-alpha 0.0035 0.0907 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.3529 0.3529
Brugia malayi Animal haem peroxidase family protein 0.0069 0.2198 0.2198
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.1303 0.1289
Schistosoma mansoni heat shock protein 0.0035 0.0907 0.0892
Onchocerca volvulus Chorion peroxidase homolog 0.0069 0.2198 1
Toxoplasma gondii heat shock protein HSP90 0.0035 0.0907 0.2347
Mycobacterium ulcerans heat shock protein 90 0.0028 0.0628 0.4818
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0028 0.0628 0.0612
Echinococcus multilocularis heat shock protein 90 0.0028 0.0628 0.0612
Toxoplasma gondii heat shock protein 75, putative 0.0014 0.0098 0.0213
Schistosoma mansoni hypothetical protein 0.0184 0.6689 0.6683
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Schistosoma mansoni hypothetical protein 0.0033 0.0799 0.0784
Echinococcus multilocularis neuroligin 0.0046 0.1303 0.1289
Echinococcus granulosus BC026374 protein S09 family 0.0046 0.1303 0.1289
Plasmodium falciparum basic transcription factor 3b, putative 0.011 0.3813 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1347 0.1332
Loa Loa (eye worm) animal heme peroxidase 0.0069 0.2198 0.2198
Schistosoma mansoni peroxidasin 0.0069 0.2198 0.2185
Echinococcus granulosus chromobox protein 1 0.0076 0.2477 0.2464
Plasmodium vivax heat shock protein, putative 0.0014 0.0098 0.0213
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0017 0.0017
Onchocerca volvulus 0.0069 0.2198 1
Entamoeba histolytica hypothetical protein 0.011 0.3813 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0035 0.0907 0.238
Schistosoma mansoni BC026374 protein (S09 family) 0.0046 0.1303 0.1289
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0017 0.0017
Brugia malayi Animal haem peroxidase family protein 0.0069 0.2198 0.2198
Onchocerca volvulus 0.0069 0.2198 1
Plasmodium falciparum endoplasmin, putative 0.0022 0.0377 0.0949
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Entamoeba histolytica heat shock protein 90, putative 0.0035 0.0907 0.2347
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.1184 0.3075
Brugia malayi Peroxidasin 0.0069 0.2198 0.2198
Brugia malayi Protein cec-1. 0.0012 0.0017 0.0017
Mycobacterium tuberculosis Carboxylesterase LipT 0.0046 0.1303 1
Trypanosoma cruzi transcription factor btf3, putative 0.011 0.3813 1
Trypanosoma cruzi heat shock protein 90, putative 0.0028 0.0628 0.1647
Echinococcus multilocularis heat shock protein 90 0.0035 0.0907 0.0892
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0799 0.0784
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0703 0.1807
Echinococcus granulosus heat shock protein 90 0.0035 0.0907 0.0892
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.1309 0.5924
Entamoeba histolytica hypothetical protein 0.0037 0.096 0.2485
Echinococcus multilocularis chromobox protein 1 0.0076 0.2477 0.2464
Plasmodium vivax heat shock protein 86, putative 0.0035 0.0907 0.2347
Loa Loa (eye worm) ICD-1 protein 0.011 0.3813 0.3813
Loa Loa (eye worm) helicase 0.0012 0.0017 0.0017
Schistosoma mansoni chromobox protein 0.0076 0.2477 0.2464
Echinococcus multilocularis heat shock protein 0.0035 0.0907 0.0892
Onchocerca volvulus Dual oxidase homolog 0.0069 0.2198 1
Echinococcus granulosus heat shock protein 0.0035 0.0907 0.0892
Schistosoma mansoni hypothetical protein 0.0033 0.0799 0.0784
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.1184 0.3075
Treponema pallidum heat shock protein 90 0.0028 0.0628 0.5
Brugia malayi hypothetical protein 0.0046 0.1303 0.1303
Brugia malayi heat shock protein 90 0.0035 0.0907 0.0907
Trypanosoma brucei heat shock protein, putative 0.0035 0.0907 0.238
Plasmodium vivax basic transcription factor 3b, putative 0.011 0.3813 1
Onchocerca volvulus 0.0046 0.1303 0.5898
Echinococcus multilocularis endoplasmin 0.0028 0.0628 0.0612
Toxoplasma gondii Hsp90 domain-containing protein 0.0014 0.0098 0.0213
Brugia malayi CHD4 protein 0.0012 0.0017 0.0017
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.027 1 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.1303 0.1289
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0703 0.1807
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0017
Schistosoma mansoni acetylcholinesterase 0.0046 0.1303 0.1289
Trypanosoma brucei Heat shock protein 83, putative 0.0035 0.0907 0.238
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0014 0.0098 0.0081
Trichomonas vaginalis heat shock protein, putative 0.0022 0.0377 0.0949
Brugia malayi SET domain containing protein 0.0012 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Echinococcus multilocularis para nitrobenzyl esterase 0.0046 0.1303 0.1289
Echinococcus multilocularis chromobox protein 1 0.0076 0.2477 0.2464
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.2266 0.2266
Mycobacterium ulcerans carboxylesterase, LipT 0.0046 0.1303 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1303 0.1303
Entamoeba histolytica transcription factor BTF3, putative 0.011 0.3813 1
Loa Loa (eye worm) animal heme peroxidase 0.0069 0.2198 0.2198
Brugia malayi Carboxylesterase family protein 0.0046 0.1303 0.1303
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.3529 0.3529
Echinococcus granulosus acetylcholinesterase 0.027 1 1
Entamoeba histolytica hypothetical protein 0.0037 0.096 0.2485
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Loa Loa (eye worm) hypothetical protein 0.0042 0.1184 0.1184
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Schistosoma mansoni hypothetical protein 0.007 0.2266 0.2253
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.0907 0.238
Trypanosoma cruzi heat shock protein 90, putative 0.0035 0.0907 0.238
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Echinococcus multilocularis carboxylesterase 5A 0.027 1 1
Brugia malayi Animal haem peroxidase family protein 0.0069 0.2198 0.2198
Loa Loa (eye worm) heat shock protein 90 0.0035 0.0907 0.0907
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0907 0.238
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Trypanosoma cruzi heat shock protein 85, putative 0.0028 0.0628 0.1647
Schistosoma mansoni hypothetical protein 0.0037 0.096 0.0945
Loa Loa (eye worm) hypothetical protein 0.0103 0.3529 0.3529
Loa Loa (eye worm) carboxylesterase 0.0046 0.1303 0.1303
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Schistosoma mansoni endoplasmin 0.0035 0.0907 0.0892
Loa Loa (eye worm) hypothetical protein 0.0046 0.1303 0.1303
Leishmania major basic transcription factor 3a, putative 0.011 0.3813 1
Schistosoma mansoni peroxidasin 0.0069 0.2198 0.2185
Schistosoma mansoni chromobox protein 0.0076 0.2477 0.2464
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.1303 0.1289
Plasmodium falciparum heat shock protein 90, putative 0.0014 0.0098 0.0213
Schistosoma mansoni transcription factor btf3 0.011 0.3813 0.3802
Plasmodium vivax heat shock protein 90, putative 0.0014 0.0098 0.0213
Brugia malayi beta-NAC-like protein 0.011 0.3813 0.3813
Onchocerca volvulus 0.0046 0.1303 0.5898
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0046 0.1303 0.1289
Brugia malayi hypothetical protein 0.0069 0.2198 0.2198
Plasmodium falciparum heat shock protein 90 0.0035 0.0907 0.2347
Trichomonas vaginalis spcc417.12 protein, putative 0.0046 0.1303 0.339
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0907 0.238
Brugia malayi chromobox protein homolog 3 0.0042 0.1184 0.1184
Trypanosoma brucei heat shock protein 84, putative 0.0014 0.0098 0.0256
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0046 0.1303 1
Brugia malayi Carboxylesterase family protein 0.0046 0.1303 0.1303
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0046 0.1303 0.1289
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Schistosoma mansoni heat shock protein 0.0035 0.0907 0.0892
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0628 0.161
Brugia malayi Heterochromatin protein 1 0.0076 0.2477 0.2477
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1347 0.1332
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0799 0.0784
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0799 0.0799
Echinococcus granulosus GPCR family 2 0.0033 0.0799 0.0784
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0799 0.0784
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.096 0.0945
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0014 0.0098 0.0213
Toxoplasma gondii heat shock protein 90, putative 0.0035 0.0907 0.2347
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0028 0.0628 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.1347 0.1347
Trichomonas vaginalis conserved hypothetical protein 0.011 0.3813 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.096 0.0945
Brugia malayi Endoplasmin precursor 0.0035 0.0907 0.0907
Trypanosoma cruzi heat shock protein, putative 0.0014 0.0098 0.0256
Loa Loa (eye worm) carboxylesterase 0.027 1 1
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Trichomonas vaginalis chromobox protein, putative 0.0046 0.1309 0.3405
Schistosoma mansoni endoplasmin 0.0035 0.0907 0.0892
Trypanosoma brucei heat shock protein, putative 0.0035 0.0907 0.238
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0028 0.0628 0.5
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0028 0.0628 0.1647
Onchocerca volvulus Peroxidasin homolog 0.0069 0.2198 1
Echinococcus granulosus chromobox protein 1 0.0076 0.2477 0.2464
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0017 0.0017
Onchocerca volvulus 0.0046 0.1303 0.5898
Schistosoma mansoni gliotactin 0.0046 0.1303 0.1289
Trypanosoma brucei heat shock protein, putative 0.0035 0.0907 0.238
Loa Loa (eye worm) endoplasmin 0.0035 0.0907 0.0907
Echinococcus granulosus acetylcholinesterase 0.027 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0828 0.0828
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0014 0.0098 0.0371
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0799 0.0784
Trypanosoma brucei heat shock protein, putative 0.0035 0.0907 0.238
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Brugia malayi Animal haem peroxidase family protein 0.0069 0.2198 0.2198
Echinococcus multilocularis transcription factor btf3 0.011 0.3813 0.3802
Loa Loa (eye worm) blistered cuticle protein 3 0.0069 0.2198 0.2198
Trichomonas vaginalis heat shock protein, putative 0.0035 0.0907 0.2347
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0017
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.096 0.0945
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0628 0.161
Trichomonas vaginalis chromobox protein, putative 0.0046 0.1309 0.3405
Onchocerca volvulus 0.0046 0.1303 0.5898
Loa Loa (eye worm) hypothetical protein 0.027 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1347 0.1332
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0046 0.1303 0.339
Trypanosoma cruzi transcription factor btf3, putative 0.011 0.3813 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0017
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Echinococcus multilocularis BC026374 protein (S09 family) 0.0046 0.1303 0.1289
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0799 0.0799
Schistosoma mansoni hypothetical protein 0.0033 0.0799 0.0784
Loa Loa (eye worm) hypothetical protein 0.0046 0.1303 0.1303
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1347 0.1332
Entamoeba histolytica hypothetical protein 0.0037 0.096 0.2485
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Loa Loa (eye worm) hypothetical protein 0.0033 0.0799 0.0799
Trypanosoma brucei heat shock protein, putative 0.0035 0.0907 0.238
Brugia malayi Carboxylesterase family protein 0.027 1 1
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Toxoplasma gondii NAC domain-containing protein 0.011 0.3813 1
Echinococcus granulosus carboxylesterase 5A 0.027 1 1
Echinococcus multilocularis geminin 0.0184 0.6689 0.6683
Plasmodium falciparum heat shock protein 90, putative 0.0014 0.0098 0.0213
Brugia malayi Animal haem peroxidase family protein 0.0069 0.2198 0.2198
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Schistosoma mansoni neuroligin 3 (S09 family) 0.0046 0.1303 0.1289
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Echinococcus granulosus neuroligin 0.0046 0.1303 0.1289
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1347 0.1332
Trypanosoma brucei heat shock protein, putative 0.0035 0.0907 0.238
Brugia malayi Carboxylesterase family protein 0.0046 0.1303 0.1303
Entamoeba histolytica heat shock protein 90, putative 0.0035 0.0907 0.2347
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1347 0.1332
Echinococcus multilocularis acetylcholinesterase 0.027 1 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1303 0.1303

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 45 uM Antagonist activity at NMDA receptor in cerebellar granule neurons assessed as inhibition of NMDA-induced increase in intracellular calcium concentration by fluorometric assay ChEMBL. 18954995
IC50 (functional) > 500 uM Antagonist activity at NMDA receptor in cerebellar granule neurons assessed as inhibition of glutamate-induced increase in intracellular calcium concentration by fluorometric assay ChEMBL. 18954995

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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