Detailed information for compound 1010691

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 205.339 | Formula: C14H23N
  • H donors: 0 H acceptors: 0 LogP: 3.06 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CCN(CC1)C12CC3CC2CC(C1)C3
  • InChi: 1S/C14H23N/c1-2-4-15(5-3-1)14-9-11-6-12(10-14)8-13(14)7-11/h11-13H,1-10H2
  • InChiKey: MPCPLRFLUHEXCX-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus carboxylesterase 5A 0.027 1 1
Trypanosoma brucei heat shock protein, putative 0.0035 0.0907 0.238
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0014 0.0098 0.0081
Echinococcus granulosus transcription factor btf3 0.011 0.3813 0.3802
Trichomonas vaginalis heat shock protein, putative 0.0014 0.0098 0.0213
Brugia malayi SET domain containing protein 0.0012 0.0017 0.0017
Brugia malayi heat shock protein 90 0.0035 0.0907 0.0907
Echinococcus multilocularis acetylcholinesterase 0.027 1 1
Echinococcus multilocularis GPCR, family 2 0.0033 0.0799 0.0784
Trypanosoma cruzi heat shock protein 90, putative 0.0028 0.0628 0.1647
Echinococcus granulosus peroxidasin 0.0069 0.2198 0.2185
Echinococcus granulosus acetylcholinesterase 0.027 1 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.3529 0.3529
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0017
Trichomonas vaginalis heat shock protein, putative 0.0035 0.0907 0.2347
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Trypanosoma cruzi transcription factor btf3, putative 0.011 0.3813 1
Brugia malayi hypothetical protein 0.0012 0.0017 0.0017
Echinococcus granulosus heat shock protein 90 0.0028 0.0628 0.0612
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.1347 0.1347
Schistosoma mansoni chromobox protein 0.0076 0.2477 0.2464
Loa Loa (eye worm) hypothetical protein 0.0046 0.1303 0.1303
Loa Loa (eye worm) acetylcholinesterase 1 0.027 1 1
Loa Loa (eye worm) carboxylesterase 0.0046 0.1303 0.1303
Brugia malayi Heterochromatin protein 1 0.0076 0.2477 0.2477
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.1184 0.3075
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Schistosoma mansoni transcription factor btf3 0.011 0.3813 0.3802
Echinococcus multilocularis endoplasmin 0.0028 0.0628 0.0612
Trypanosoma cruzi transcription factor btf3, putative 0.011 0.3813 1
Trypanosoma brucei heat shock protein, putative 0.0035 0.0907 0.238
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0799 0.0784
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0799 0.0799
Trichomonas vaginalis endoplasmin, putative 0.0022 0.0377 0.0949
Trichomonas vaginalis conserved hypothetical protein 0.011 0.3813 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0703 0.1807
Brugia malayi Animal haem peroxidase family protein 0.0069 0.2198 0.2198
Brugia malayi hypothetical protein 0.0069 0.2198 0.2198
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Plasmodium falciparum heat shock protein 90, putative 0.0014 0.0098 0.0213
Echinococcus multilocularis geminin 0.0184 0.6689 0.6683
Onchocerca volvulus 0.0046 0.1303 0.5898
Loa Loa (eye worm) hypothetical protein 0.0042 0.1184 0.1184
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Loa Loa (eye worm) hypothetical protein 0.0046 0.1303 0.1303
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0799 0.0799
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.027 1 1
Brugia malayi Animal haem peroxidase family protein 0.0069 0.2198 0.2198
Loa Loa (eye worm) hypothetical protein 0.0046 0.1303 0.1303
Brugia malayi Hsp90 protein 0.0014 0.0098 0.0098
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0014 0.0098 0.0081
Onchocerca volvulus Dual oxidase homolog 0.0069 0.2198 1
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0628 0.161
Leishmania major heat shock protein, putative 0.0014 0.0098 0.0256
Schistosoma mansoni hypothetical protein 0.0033 0.0799 0.0784
Plasmodium falciparum heat shock protein 90, putative 0.0014 0.0098 0.0213
Brugia malayi hypothetical protein 0.0046 0.1303 0.1303
Trypanosoma brucei heat shock protein, putative 0.0035 0.0907 0.238
Trypanosoma cruzi Heat shock protein 83, putative 0.0035 0.0907 0.238
Loa Loa (eye worm) hypothetical protein 0.0033 0.0828 0.0828
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0017 0.0017
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0014 0.0098 0.0213
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.0907 0.238
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.096 0.0945
Loa Loa (eye worm) hypothetical protein 0.0046 0.1303 0.1303
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0017
Echinococcus granulosus acetylcholinesterase 0.027 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0799 0.0799
Schistosoma mansoni heat shock protein 0.0014 0.0098 0.0081
Schistosoma mansoni peroxidasin 0.0069 0.2198 0.2185
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.096 0.0945
Loa Loa (eye worm) animal heme peroxidase 0.0069 0.2198 0.2198
Trypanosoma brucei transcription factor BTF3, putative 0.011 0.3813 1
Entamoeba histolytica heat shock protein 90, putative 0.0035 0.0907 0.2347
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Onchocerca volvulus Peroxidasin homolog 0.0069 0.2198 1
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0628 0.161
Plasmodium falciparum endoplasmin, putative 0.0022 0.0377 0.0949
Onchocerca volvulus Peroxidasin homolog 0.0069 0.2198 1
Entamoeba histolytica hypothetical protein 0.0037 0.096 0.2485
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.3529 0.3529
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1347 0.1332
Brugia malayi Carboxylesterase family protein 0.0046 0.1303 0.1303
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0017
Echinococcus granulosus BC026374 protein S09 family 0.0046 0.1303 0.1289
Toxoplasma gondii heat shock protein 75, putative 0.0014 0.0098 0.0213
Treponema pallidum heat shock protein 90 0.0028 0.0628 0.5
Echinococcus granulosus neuroligin 0.0046 0.1303 0.1289
Echinococcus multilocularis heat shock protein 90 0.0035 0.0907 0.0892
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0046 0.1303 0.1289
Loa Loa (eye worm) helicase 0.0012 0.0017 0.0017
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1347 0.1332
Trichomonas vaginalis spcc417.12 protein, putative 0.0046 0.1303 0.339
Toxoplasma gondii heat shock protein 90, putative 0.0035 0.0907 0.2347
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Trypanosoma cruzi heat shock protein 85, putative 0.0028 0.0628 0.1647
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0046 0.1303 1
Echinococcus multilocularis BC026374 protein (S09 family) 0.0046 0.1303 0.1289
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0046 0.1303 0.339
Trichomonas vaginalis chromobox protein, putative 0.0076 0.2477 0.648
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0799 0.0799
Brugia malayi Carboxylesterase family protein 0.027 1 1
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0017 0.0017
Brugia malayi Protein cec-1. 0.0012 0.0017 0.0017
Mycobacterium ulcerans carboxylesterase, LipT 0.0046 0.1303 1
Echinococcus granulosus GPCR family 2 0.0033 0.0799 0.0784
Loa Loa (eye worm) hypothetical protein 0.027 1 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Schistosoma mansoni heat shock protein 0.0035 0.0907 0.0892
Echinococcus multilocularis heat shock protein 90 0.0028 0.0628 0.0612
Echinococcus granulosus chromobox protein 1 0.0076 0.2477 0.2464
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Trypanosoma cruzi heat shock protein 90, putative 0.0035 0.0907 0.238
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0017
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.3529 0.3529
Loa Loa (eye worm) hypothetical protein 0.0046 0.1303 0.1303
Loa Loa (eye worm) endoplasmin 0.0035 0.0907 0.0907
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1347 0.1332
Plasmodium vivax basic transcription factor 3b, putative 0.011 0.3813 1
Onchocerca volvulus 0.0069 0.2198 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0046 0.1303 1
Plasmodium falciparum basic transcription factor 3b, putative 0.011 0.3813 1
Schistosoma mansoni hypothetical protein 0.0033 0.0799 0.0784
Brugia malayi Carboxylesterase family protein 0.0046 0.1303 0.1303
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.1184 0.3075
Toxoplasma gondii Hsp90 domain-containing protein 0.0014 0.0098 0.0213
Trypanosoma cruzi heat shock protein 90, putative 0.0021 0.0345 0.0905
Schistosoma mansoni acetylcholinesterase 0.0046 0.1303 0.1289
Loa Loa (eye worm) hypothetical protein 0.027 1 1
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Echinococcus granulosus geminin 0.0184 0.6689 0.6683
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.0907 0.238
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Trypanosoma brucei heat shock protein, putative 0.0035 0.0907 0.238
Onchocerca volvulus 0.0046 0.1303 0.5898
Entamoeba histolytica hypothetical protein 0.0037 0.096 0.2485
Schistosoma mansoni hypothetical protein 0.0033 0.0799 0.0784
Entamoeba histolytica hypothetical protein 0.0037 0.096 0.2485
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0017
Giardia lamblia Heat shock protein HSP 90-alpha 0.0035 0.0907 1
Onchocerca volvulus Chorion peroxidase homolog 0.0069 0.2198 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2266 0.2266
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.1347 0.1347
Loa Loa (eye worm) CHromoDomain protein family member 0.0012 0.0017 0.0017
Loa Loa (eye worm) carboxylesterase 0.0046 0.1303 0.1303
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Loa Loa (eye worm) animal heme peroxidase 0.0069 0.2198 0.2198
Brugia malayi Peroxidasin 0.0069 0.2198 0.2198
Loa Loa (eye worm) blistered cuticle protein 3 0.0069 0.2198 0.2198
Loa Loa (eye worm) heat shock protein 90 0.0035 0.0907 0.0907
Trypanosoma brucei heat shock protein, putative 0.0035 0.0907 0.238
Schistosoma mansoni neuroligin 3 (S09 family) 0.0046 0.1303 0.1289
Loa Loa (eye worm) hypothetical protein 0.0046 0.1303 0.1303
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Schistosoma mansoni hypothetical protein 0.0037 0.096 0.0945
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Schistosoma mansoni endoplasmin 0.0035 0.0907 0.0892
Schistosoma mansoni chromobox protein 0.0076 0.2477 0.2464
Loa Loa (eye worm) hypothetical protein 0.0046 0.1303 0.1303
Brugia malayi chromobox protein homolog 3 0.0042 0.1184 0.1184
Plasmodium vivax heat shock protein 86, putative 0.0035 0.0907 0.2347
Plasmodium vivax heat shock protein 90, putative 0.0014 0.0098 0.0213
Echinococcus multilocularis chromobox protein 1 0.0076 0.2477 0.2464
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1347 0.1332
Entamoeba histolytica heat shock protein 90, putative 0.0035 0.0907 0.2347
Toxoplasma gondii heat shock protein HSP90 0.0035 0.0907 0.2347
Onchocerca volvulus 0.0033 0.0828 0.3718
Echinococcus multilocularis transcription factor btf3 0.011 0.3813 0.3802
Entamoeba histolytica hypothetical protein 0.011 0.3813 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.1303 0.1289
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Schistosoma mansoni BC026374 protein (S09 family) 0.0046 0.1303 0.1289
Schistosoma mansoni hypothetical protein 0.0184 0.6689 0.6683
Brugia malayi Endoplasmin precursor 0.0035 0.0907 0.0907
Echinococcus granulosus heat shock protein 90 0.0035 0.0907 0.0892
Brugia malayi Blistered cuticle protein 3 0.0069 0.2198 0.2198
Trypanosoma brucei heat shock protein, putative 0.0035 0.0907 0.238
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Trypanosoma brucei Heat shock protein 83, putative 0.0035 0.0907 0.238
Brugia malayi Animal haem peroxidase family protein 0.0069 0.2198 0.2198
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Brugia malayi Animal haem peroxidase family protein 0.0069 0.2198 0.2198
Loa Loa (eye worm) heterochromatin protein 1 0.0076 0.2477 0.2477
Echinococcus granulosus para nitrobenzyl esterase 0.0046 0.1303 0.1289
Schistosoma mansoni hypothetical protein 0.0184 0.6689 0.6683
Schistosoma mansoni gliotactin 0.0046 0.1303 0.1289
Schistosoma mansoni heat shock protein 0.0035 0.0907 0.0892
Trypanosoma brucei heat shock protein, putative 0.0035 0.0907 0.238
Entamoeba histolytica transcription factor BTF3, putative 0.011 0.3813 1
Loa Loa (eye worm) heat shock protein 75 0.0014 0.0098 0.0098
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0907 0.238
Loa Loa (eye worm) carboxylesterase 0.027 1 1
Leishmania major basic transcription factor 3a, putative 0.011 0.3813 1
Echinococcus granulosus heat shock protein 0.0035 0.0907 0.0892
Trichomonas vaginalis conserved hypothetical protein 0.011 0.3813 1
Onchocerca volvulus Peroxidase homolog 0.0069 0.2198 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.1303 0.1289
Schistosoma mansoni hypothetical protein 0.0033 0.0799 0.0784
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.2266 0.2266
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.096 0.0945
Loa Loa (eye worm) hypothetical protein 0.0103 0.3529 0.3529
Schistosoma mansoni peroxidasin 0.0069 0.2198 0.2185
Onchocerca volvulus 0.0046 0.1303 0.5898
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Entamoeba histolytica hypothetical protein 0.0037 0.096 0.2485
Loa Loa (eye worm) ICD-1 protein 0.011 0.3813 0.3813
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1347 0.1332
Echinococcus multilocularis heat shock protein 0.0035 0.0907 0.0892
Trichomonas vaginalis chromobox protein, putative 0.0046 0.1309 0.3405
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0046 0.1303 0.1289
Trichomonas vaginalis chromobox protein, putative 0.0046 0.1309 0.3405
Plasmodium vivax heat shock protein, putative 0.0014 0.0098 0.0213
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.1184 0.535
Trichomonas vaginalis chromobox protein, putative 0.0076 0.2477 0.648
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1347 0.1332
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Mycobacterium tuberculosis Carboxylesterase LipT 0.0046 0.1303 1
Loa Loa (eye worm) animal heme peroxidase 0.0069 0.2198 0.2198
Onchocerca volvulus 0.0046 0.1303 0.5898
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Brugia malayi beta-NAC-like protein 0.011 0.3813 0.3813
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.1303 0.1289
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0799 0.0784
Mycobacterium ulcerans heat shock protein 90 0.0028 0.0628 0.4818
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0907 0.238
Onchocerca volvulus 0.0069 0.2198 1
Brugia malayi Animal haem peroxidase family protein 0.0069 0.2198 0.2198
Brugia malayi Carboxylesterase family protein 0.0046 0.1303 0.1303
Echinococcus granulosus endoplasmin 0.0028 0.0628 0.0612
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Trypanosoma brucei heat shock protein 84, putative 0.0014 0.0098 0.0256
Onchocerca volvulus 0.0046 0.1303 0.5898
Echinococcus multilocularis peroxidasin 0.0069 0.2198 0.2185
Schistosoma mansoni hypothetical protein 0.007 0.2266 0.2253
Echinococcus multilocularis neuroligin 0.0046 0.1303 0.1289
Plasmodium vivax endoplasmin, putative 0.0035 0.0907 0.2347
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0017 0.0017
Echinococcus granulosus chromobox protein 1 0.0076 0.2477 0.2464
Schistosoma mansoni endoplasmin 0.0035 0.0907 0.0892
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0703 0.1807
Plasmodium falciparum heat shock protein 90 0.0035 0.0907 0.2347
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0799 0.0784
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0028 0.0628 0.5
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0907 0.238
Echinococcus multilocularis acetylcholinesterase 0.027 1 1
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0014 0.0098 0.0371
Brugia malayi CHD4 protein 0.0012 0.0017 0.0017
Loa Loa (eye worm) animal heme peroxidase 0.0069 0.2198 0.2198
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.1309 0.5924
Toxoplasma gondii NAC domain-containing protein 0.011 0.3813 1
Leishmania major heat shock protein 83-1 0.0035 0.0907 0.238
Echinococcus multilocularis chromobox protein 1 0.0076 0.2477 0.2464
Trichomonas vaginalis conserved hypothetical protein 0.011 0.3813 1
Onchocerca volvulus 0.0069 0.2198 1
Brugia malayi hypothetical protein 0.0037 0.096 0.096
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0017
Onchocerca volvulus Peroxidase homolog 0.0069 0.2198 1
Trypanosoma cruzi heat shock protein, putative 0.0014 0.0098 0.0256
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1347 0.1332
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0028 0.0628 0.1647
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0628 0.161
Brugia malayi Carboxylesterase family protein 0.0046 0.1303 0.1303
Echinococcus multilocularis para nitrobenzyl esterase 0.0046 0.1303 0.1289
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0799 0.0784
Loa Loa (eye worm) hypothetical protein 0.0069 0.2198 0.2198
Trypanosoma brucei heat shock protein, putative 0.0035 0.0907 0.238
Echinococcus multilocularis carboxylesterase 5A 0.027 1 1
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0028 0.0628 0.0612
Trichomonas vaginalis heat shock protein, putative 0.0022 0.0377 0.0949
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0028 0.0628 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 45 uM Antagonist activity at NMDA receptor in cerebellar granule neurons assessed as inhibition of NMDA-induced increase in intracellular calcium concentration by fluorometric assay ChEMBL. 18954995
IC50 (functional) > 500 uM Antagonist activity at NMDA receptor in cerebellar granule neurons assessed as inhibition of glutamate-induced increase in intracellular calcium concentration by fluorometric assay ChEMBL. 18954995

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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