Detailed information for compound 1010707

Basic information

Technical information
  • TDR Targets ID: 1010707
  • Name: sodium [(2R,3R,4S,5R)-3-[(2S,3R,4S,5R)-4,5-di hydroxy-3-methoxyoxan-2-yl]oxy-5-hydroxy-2-[( 6R)-2-methyl-3-methylidene-6-[(3S,5S,6S,8S,9R ,10S,13R,14S,15R,17R)-3,6,8,15-tetrahydroxy-1 0,13-dimethyl-1,2,3,4,5,6,7,9,11,12,14,15,16, 17-tetradecahydrocyclopenta[a]phenanthren-17- yl]heptoxy]oxan-4-yl] sulfate
  • MW: 844.979 | Formula: C39H65NaO16S
  • H donors: 8 H acceptors: 10 LogP: 1.39 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 3
  • SMILES: CO[C@H]1[C@@H](OC[C@H]([C@@H]1O)O)O[C@H]1[C@@H](OC[C@H]([C@@H]1OS(=O)(=O)[O-])O)OCC(C(=C)CC[C@H]([C@H]1C[C@H]([C@@H]2[C@]1(C)CC[C@H]1[C@@]2(O)C[C@@H]([C@@H]2[C@]1(C)CC[C@@H](C2)O)O)O)C)C.[Na+]
  • InChi: 1S/C39H66O16S.Na/c1-19(21(3)16-51-35-33(31(28(44)18-52-35)55-56(47,48)49)54-36-32(50-6)30(45)27(43)17-53-36)7-8-20(2)23-14-25(41)34-38(23,5)12-10-29-37(4)11-9-22(40)13-24(37)26(42)15-39(29,34)46;/h20-36,40-46H,1,7-18H2,2-6H3,(H,47,48,49);/q;+1/p-1/t20-,21?,22+,23-,24-,25-,26+,27-,28-,29-,30+,31+,32-,33-,34-,35-,36+,37+,38-,39+;/m1./s1
  • InChiKey: BFELZYPVGWVVKJ-ZYUGDXNYSA-M  


Substructure search Similarity search

Network

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Synonyms

  • sodium [(2R,3R,4S,5R)-3-[(2S,3R,4S,5R)-4,5-dihydroxy-3-methoxy-tetrahydropyran-2-yl]oxy-5-hydroxy-2-[(6R)-2-methyl-3-methylene-6-[(3S,5S,6S,8S,9R,10S,13R,14S,15R,17R)-3,6,8,15-tetrahydroxy-10,13-dimethyl-1,2,3,4,5,6,7,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]heptoxy]tetrahydropyran-4-yl] sulfate
  • sodium [(2R,3R,4S,5R)-3-[[(2S,3R,4S,5R)-4,5-dihydroxy-3-methoxy-2-tetrahydropyranyl]oxy]-5-hydroxy-2-[(6R)-2-methyl-3-methylene-6-[(3S,5S,6S,8S,9R,10S,13R,14S,15R,17R)-3,6,8,15-tetrahydroxy-10,13-dimethyl-1,2,3,4,5,6,7,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]heptoxy]-4-tetrahydropyranyl] sulfate
  • sodium [(2R,3R,4S,5R)-3-[(2S,3R,4S,5R)-4,5-dihydroxy-3-methoxy-tetrahydropyran-2-yl]oxy-5-hydroxy-2-[2-methyl-3-[(3R)-3-[(3S,5S,6S,8S,9R,10S,13R,14S,15R,17R)-3,6,8,15-tetrahydroxy-10,13-dimethyl-1,2,3,4,5,6,7,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]butyl]but-3-enoxy]tetrahydropyran-4-yl] sulfate
  • sodium [(2R,3R,4S,5R)-3-[(2S,3R,4S,5R)-4,5-dihydroxy-3-methoxy-oxan-2-yl]oxy-5-hydroxy-2-[(6R)-2-methyl-3-methylidene-6-[(3S,5S,6S,8S,9R,10S,13R,14S,15R,17R)-3,6,8,15-tetrahydroxy-10,13-dimethyl-1,2,3,4,5,6,7,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]heptoxy]oxan-4-yl] sulfate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0014 0.0016
Brugia malayi transcriptional regulator, Sir2 family protein 0.0066 0.0041 0.0041
Echinococcus multilocularis integrin alpha ps 0.0893 0.1027 0.1285
Loa Loa (eye worm) sirtuin 4 0.0066 0.0041 0.0041
Brugia malayi Protein kinase domain containing protein 0.0067 0.0043 0.0043
Brugia malayi Calcitonin receptor-like protein seb-1 0.0044 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0043 0.0014 0.0014
Trichomonas vaginalis hypothetical protein 0.0188 0.0187 0.0299
Trichomonas vaginalis hypothetical protein 0.1683 0.1968 0.3221
Schistosoma mansoni memapsin-2 (A01 family) 0.0035 0.0004 0.0004
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0088 0.0067 0.0067
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0066 0.0041 0.0041
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2055 0.2412 0.3947
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0447 0.0495 0.0806
Echinococcus granulosus integrin alpha ps 0.0396 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0463 0.0514 0.0514
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0372 0.0406 0.0659
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0081 0.0059 0.0059
Echinococcus multilocularis serine:threonine protein kinase N2 0.008 0.0058 0.0073
Schistosoma mansoni hypothetical protein 0.0067 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0108 0.0091 0.0091
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0111 0.0095 0.0119
Loa Loa (eye worm) hypothetical protein 0.0067 0.0043 0.0043
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0066 0.0041 0.0081
Loa Loa (eye worm) hypothetical protein 0.0035 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0032 0.0001 0.0001
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0228 0.0235 0.0235
Mycobacterium ulcerans oxidoreductase 0.0099 0.0081 0.1467
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0014 0.0016
Echinococcus granulosus discoidin domain containing receptor 2 0.0043 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0188 0.0187 0.0187
Echinococcus multilocularis Tolloid protein 1 0.0038 0.0008 0.0011
Toxoplasma gondii F5/8 type C domain-containing protein 0.0043 0.0014 0.0246
Onchocerca volvulus Putative cubilin 0.0039 0.0009 0.0083
Echinococcus granulosus Tolloid protein 1 0.0038 0.0008 0.0008
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0043 0.0014 0.0266
Loa Loa (eye worm) hypothetical protein 0.0099 0.0081 0.0081
Brugia malayi protein kinase C II. 0.0088 0.0067 0.0067
Mycobacterium ulcerans thioesterase TesA 0.007 0.0046 0.0544
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0081 0.0059 0.1151
Trichomonas vaginalis conserved hypothetical protein 0.0372 0.0406 0.0659
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0447 0.0495 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0004 0.0004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5152 0.6103 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0031 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0014 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.1683 0.1968 0.3221
Loa Loa (eye worm) WD40 repeat protein 0.0134 0.0123 0.0123
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.5152 0.6103 0.6103
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0397 0.0436 0.876
Entamoeba histolytica hypothetical protein 0.0046 0.0018 0.012
Schistosoma mansoni growth factor receptor-bound protein 0.0122 0.0109 0.0109
Schistosoma mansoni amine oxidase 0.0099 0.0081 0.0081
Echinococcus multilocularis discoidin domain containing receptor 2 0.0043 0.0014 0.0017
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0041 0.0061
Brugia malayi EGF-like domain containing protein 0.0188 0.0187 0.0187
Brugia malayi proprotein convertase 2 0.5324 0.6308 0.6308
Giardia lamblia Neurogenic locus notch-like protein 0.0188 0.0187 0.0479
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0372 0.0406 0.0659
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.008 0.0058 0.0863
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0066 0.0041 0.0886
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0046 0.0018 0.012
Schistosoma mansoni chromatin regulatory protein sir2 0.0066 0.0041 0.0041
Echinococcus granulosus epidermal growth factor receptor 0.0603 0.0682 0.0682
Echinococcus granulosus furin 0.8421 1 1
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1683 0.1968 0.3221
Loa Loa (eye worm) hypothetical protein 0.007 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0134 0.0122 0.0122
Echinococcus granulosus nmda type glutamate receptor 0.0111 0.0095 0.0095
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0086 0.0065 0.105
Onchocerca volvulus 0.0067 0.0043 0.0655
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0372 0.0406 0.0659
Trichomonas vaginalis conserved hypothetical protein 0.1683 0.1968 0.3221
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0447 0.0495 1
Mycobacterium ulcerans monoamine oxidase 0.0099 0.0081 0.1467
Echinococcus granulosus membrane bound transcription factor site 1 0.0372 0.0406 0.0406
Schistosoma mansoni btb and poz domain-containing protein 0.0043 0.0014 0.0014
Echinococcus multilocularis protoporphyrinogen oxidase 0.0099 0.0081 0.0101
Schistosoma mansoni hypothetical protein 0.1683 0.1968 0.1968
Giardia lamblia Tenascin precursor 0.0188 0.0187 0.0479
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0156 0.0148 0.0148
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0004 0.0004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0372 0.0406 0.0659
Toxoplasma gondii subtilisin SUB10 0.0372 0.0406 1
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0035 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.053 0.0594 0.0594
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0488 0.0545 0.0545
Echinococcus granulosus integrin beta 2 0.6197 0.7349 0.7349
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5152 0.6103 1
Echinococcus granulosus chromatin regulatory protein sir2 0.0447 0.0495 0.0495
Schistosoma mansoni septate junction protein 0.0056 0.003 0.003
Giardia lamblia High cysteine protein 0.0188 0.0187 0.0479
Schistosoma mansoni protein kinase 0.0135 0.0123 0.0123
Echinococcus granulosus integrin alpha ps 0.0893 0.1027 0.1027
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0372 0.0406 1
Brugia malayi hypothetical protein 0.0099 0.0081 0.0081
Schistosoma mansoni tyrosine kinase 0.0603 0.0682 0.0682
Trichomonas vaginalis conserved hypothetical protein 0.1683 0.1968 0.3221
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0043 0.0014 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0372 0.0406 0.0659
Echinococcus multilocularis integrin alpha ps 0.0396 0.0435 0.0544
Toxoplasma gondii aldehyde dehydrogenase 0.0053 0.0026 0.0558
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0078 0.0056 0.1312
Loa Loa (eye worm) hypothetical protein 0.0141 0.013 0.013
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0372 0.0406 0.0406
Echinococcus multilocularis discoidin domain containing receptor 2 0.0043 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0095 0.0076 0.0076
Loa Loa (eye worm) proprotein convertase 2 0.2055 0.2412 0.2412
Toxoplasma gondii SWIRM domain-containing protein 0.0041 0.0012 0.0201
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0122 0.0108 0.2612
Giardia lamblia High cysteine protein 0.0188 0.0187 0.0479
Echinococcus multilocularis 0.6738 0.7994 1
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0263 0.0276 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0014 0.0016
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0141 0.0131 0.0131
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0118 0.0103 0.0103
Echinococcus granulosus fibrillin 2 0.0188 0.0187 0.0187
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0004 0.0004
Plasmodium vivax subtilisin-like protease 1 0.0372 0.0406 0.9527
Mycobacterium ulcerans aldehyde dehydrogenase 0.0053 0.0026 0.0032
Mycobacterium tuberculosis Possible oxidoreductase 0.0099 0.0081 0.1935
Loa Loa (eye worm) hypothetical protein 0.0188 0.0187 0.0187
Echinococcus granulosus MAM 0.0067 0.0043 0.0043
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0372 0.0406 0.0659
Brugia malayi hypothetical protein 0.0067 0.0043 0.0043
Echinococcus granulosus Furin 1 0.2055 0.2412 0.2412
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0044 0.0015 0.0015
Brugia malayi Probable ATP-dependent helicase DHX35 0.0032 0.0001 0.0001
Trichomonas vaginalis WD repeat domain, putative 0.0134 0.0123 0.0195
Loa Loa (eye worm) hypothetical protein 0.0108 0.0091 0.0091
Schistosoma mansoni hypothetical protein 0.0396 0.0435 0.0435
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0038 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.1683 0.1968 0.3221
Brugia malayi AMP-binding enzyme family protein 0.0078 0.0056 0.0056
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0041 0.0061
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0372 0.0406 0.0659
Brugia malayi hypothetical protein 0.0046 0.0018 0.0018
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0602 0.0681 0.0681
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.8421 1 1
Schistosoma mansoni cathepsin D (A01 family) 0.0035 0.0004 0.0004
Plasmodium vivax hypothetical protein, conserved 0.0066 0.0041 0.0886
Schistosoma mansoni chromatin regulatory protein sir2 0.0066 0.0041 0.0041
Echinococcus granulosus serine:threonine protein kinase N2 0.0072 0.0048 0.0048
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0372 0.0406 0.0406
Loa Loa (eye worm) hypothetical protein 0.0043 0.0014 0.0014
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0066 0.0041 0.0492
Echinococcus granulosus discoidin domain containing receptor 2 0.0043 0.0014 0.0014
Toxoplasma gondii subtilisin SUB2 0.0372 0.0406 1
Plasmodium falciparum LCCL domain-containing protein 0.0043 0.0014 0.0235
Echinococcus granulosus adam 17 protease 0.0095 0.0076 0.0076
Brugia malayi Integrin alpha cytoplasmic region family protein 0.1144 0.1326 0.1326
Onchocerca volvulus 0.0372 0.0406 0.6813
Loa Loa (eye worm) hypothetical protein 0.1289 0.1499 0.1499
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0035 0.0004 0.0005
Plasmodium vivax LCCL domain-containing protein 0.0043 0.0014 0.0235
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0372 0.0406 0.0659
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0057 0.0031 0.0031
Brugia malayi Protein kinase domain containing protein 0.0043 0.0014 0.0014
Echinococcus multilocularis neuroendocrine convertase 2 0.5324 0.6308 0.7891
Schistosoma mansoni site-1 peptidase (S08 family) 0.0372 0.0406 0.0406
Schistosoma mansoni discoidin domain receptor 0.0043 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0041 0.0012 0.0012
Echinococcus granulosus protein will die slowly 0.0134 0.0123 0.0123
Loa Loa (eye worm) integrin beta-2 0.8395 0.9969 0.9969
Loa Loa (eye worm) hypothetical protein 0.0497 0.0555 0.0555
Loa Loa (eye worm) angiogenesis inhibito 0.0063 0.0038 0.0038
Toxoplasma gondii F5/8 type C domain-containing protein 0.0043 0.0014 0.0246
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0019 0.0019
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0041 0.0061
Loa Loa (eye worm) hypothetical protein 0.0188 0.0187 0.0187
Loa Loa (eye worm) metalloprotease 0.0063 0.0038 0.0038
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0067 0.0043 0.0043
Schistosoma mansoni integrin alpha-ps 0.0497 0.0555 0.0555
Toxoplasma gondii subtilisin SUB8 0.0372 0.0406 1
Brugia malayi Sex muscle abnormal protein 5 0.0122 0.0109 0.0109
Leishmania major silent information regulator 2, putative 0.0447 0.0495 1
Loa Loa (eye worm) DEAH box polypeptide 35 0.0032 0.0001 0.0001
Trichomonas vaginalis hypothetical protein 0.0043 0.0014 0.0016
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0099 0.0081 0.1827
Loa Loa (eye worm) hypothetical protein 0.0372 0.0406 0.0406
Echinococcus granulosus disintegrin and metalloproteinase 0.0095 0.0076 0.0076
Plasmodium vivax plasmepsin V, putative 0.0389 0.0426 1
Echinococcus multilocularis fibrillin 2 0.0188 0.0187 0.0233
Onchocerca volvulus 0.0188 0.0187 0.3093
Toxoplasma gondii subtilisin SUB6 0.0372 0.0406 1
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0099 0.0081 0.1827
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0372 0.0406 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0008 0.0008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0372 0.0406 0.0659
Schistosoma mansoni amine oxidase 0.0099 0.0081 0.0081
Brugia malayi Will die slowly protein 0.0134 0.0123 0.0123
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0372 0.0406 0.0659
Toxoplasma gondii subtilisin SUB5 0.0372 0.0406 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0064 0.004 0.0654
Loa Loa (eye worm) hypothetical protein 0.0488 0.0545 0.0545
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0372 0.0406 0.0659
Trichomonas vaginalis conserved hypothetical protein 0.1683 0.1968 0.3221
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0488 0.0545 0.0682
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0095 0.0076 0.0076
Mycobacterium ulcerans thioesterase 0.007 0.0046 0.0544
Schistosoma mansoni glutamate receptor NMDA 0.0263 0.0276 0.0276
Trypanosoma brucei subtilisin peptidase 0.0372 0.0406 0.8127
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0099 0.0081 0.1918
Loa Loa (eye worm) TK/EGFR protein kinase 0.0603 0.0682 0.0682
Loa Loa (eye worm) integrin alpha pat-2 0.2319 0.2727 0.2727
Loa Loa (eye worm) hypothetical protein 0.0488 0.0545 0.0545
Mycobacterium ulcerans polyketide synthase Pks13 0.0122 0.0108 0.2183
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0081 0.0059 0.1151
Brugia malayi neuroendocrine convertase 1 precursor 0.5324 0.6308 0.6308
Brugia malayi Angiotensin-converting enzyme family protein 0.0602 0.0681 0.0681
Mycobacterium ulcerans Type I modular polyketide synthase 0.0081 0.0059 0.0887
Schistosoma mansoni hypothetical protein 0.0067 0.0043 0.0043
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0372 0.0406 0.0508
Echinococcus granulosus fibrillin 1 0.019 0.0189 0.0189
Echinococcus multilocularis adam 0.0487 0.0543 0.0679
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0053 0.0026 0.0578
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0066 0.0041 0.0041
Echinococcus multilocularis protein jagged 2 0.0188 0.0187 0.0233
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0372 0.0406 1
Mycobacterium ulcerans polyketide synthase 0.0086 0.0065 0.105
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0044 0.0015 0.0015
Echinococcus granulosus c-Jun N-terminal kinases 0.024 0.0248 0.0248
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0064 0.004 0.0376
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0004 0.0004
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0019 0.0024
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0068 0.0044 0.0044
Brugia malayi Integrin alpha pat-2 precursor 0.1638 0.1915 0.1915
Echinococcus multilocularis Furin 1 0.2055 0.2412 0.3017
Brugia malayi hypothetical protein 0.0035 0.0004 0.0004
Brugia malayi Reprolysin 0.0134 0.0122 0.0122
Trypanosoma brucei SIR2-like protein 4, putative 0.0066 0.0041 0.0492
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0043 0.0014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0043 0.0014 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0372 0.0406 0.0659
Brugia malayi hypothetical protein 0.0108 0.0091 0.0091
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0099 0.0081 0.1467
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2055 0.2412 0.3947
Echinococcus multilocularis epidermal growth factor receptor 0.0603 0.0682 0.0853
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.5152 0.6103 0.7634
Toxoplasma gondii PA14 domain-containing protein 0.0043 0.0014 0.0246
Echinococcus multilocularis fibrillin 1 0.0203 0.0205 0.0256
Plasmodium falciparum LCCL domain-containing protein 0.0043 0.0014 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0014 0.0016
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0004 0.0004
Leishmania major UDP-galactopyranose mutase 0.0099 0.0081 0.1215
Brugia malayi metalloprotease 0.0063 0.0038 0.0038
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0043 0.0014 0.0014
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0081 0.0059 0.1387
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.008 0.0058 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2055 0.2412 0.3947
Toxoplasma gondii subtilisin SUB11 0.0372 0.0406 1
Schistosoma mansoni cathepsin D (A01 family) 0.0035 0.0004 0.0004
Plasmodium vivax hypothetical protein, conserved 0.0099 0.0081 0.1827
Giardia lamblia High cysteine membrane protein Group 2 0.3097 0.3654 1
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0397 0.0436 0.876
Loa Loa (eye worm) hypothetical protein 0.0811 0.093 0.093
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0057 0.0031 0.0031
Mycobacterium ulcerans dehydrogenase 0.0099 0.0081 0.1467
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0447 0.0495 0.062
Echinococcus multilocularis integrin alpha 3 0.1208 0.1402 0.1754
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0043 0.0014 0.0017
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.008 0.0058 0.1364
Echinococcus multilocularis MAM 0.0067 0.0043 0.0053
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0041 0.0061
Onchocerca volvulus 0.0078 0.0056 0.0882
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0372 0.0406 0.0659
Mycobacterium leprae Probable polyketide synthase Pks1 0.0086 0.0065 0.1309
Loa Loa (eye worm) hypothetical protein 0.1242 0.1443 0.1443
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0066 0.0041 0.0492
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0014 0.0016
Giardia lamblia Furin precursor putative serine protease 0.1683 0.1968 0.5371
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0064 0.004 0.0376
Loa Loa (eye worm) hypothetical protein 0.0046 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0057 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.8421 1 1
Loa Loa (eye worm) hypothetical protein 0.0188 0.0187 0.0187
Brugia malayi aspartic protease BmAsp-1, identical 0.0035 0.0004 0.0004
Brugia malayi Integrin beta pat-3 precursor 0.8395 0.9969 0.9969
Trichomonas vaginalis conserved hypothetical protein 0.0372 0.0406 0.0659
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0041 0.0061
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0053 0.0026 0.0056
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0053 0.0026 0.0033
Toxoplasma gondii type I fatty acid synthase, putative 0.0086 0.0065 0.1523
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0052 0.0025 0.0289
Leishmania major sir2-family protein-like protein 0.0066 0.0041 0.0373
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0048 0.002 0.0406
Schistosoma mansoni chromatin regulatory protein sir2 0.0447 0.0495 0.0495
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0228 0.0235 0.0294
Echinococcus multilocularis integrin alpha ps 0.0827 0.0948 0.1186
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0086 0.0065 0.1309
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0041 0.0061
Echinococcus granulosus neuroendocrine convertase 2 0.5324 0.6308 0.6308
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0372 0.0406 1
Echinococcus multilocularis discoidin domain receptor 0.0043 0.0014 0.0017
Schistosoma mansoni discoidin domain receptor 0.0043 0.0014 0.0014
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0228 0.0235 0.0235
Loa Loa (eye worm) endoprotease bli-4 0.8421 1 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2055 0.2412 0.3947
Echinococcus multilocularis nmda type glutamate receptor 0.0111 0.0095 0.0119
Echinococcus granulosus integrin alpha 3 0.1208 0.1402 0.1402
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1683 0.1968 0.3221
Onchocerca volvulus Huntingtin homolog 0.0108 0.0091 0.1478
Trichomonas vaginalis conserved hypothetical protein 0.1683 0.1968 0.3221
Schistosoma mansoni growth factor receptor-bound protein 0.0122 0.0109 0.0109
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0099 0.0081 0.1827
Brugia malayi EGF-like domain containing protein 0.0188 0.0187 0.0187
Brugia malayi Disintegrin family protein 0.0095 0.0076 0.0076
Giardia lamblia Tenascin-like 0.0188 0.0187 0.0479
Loa Loa (eye worm) hypothetical protein 0.0081 0.006 0.006
Schistosoma mansoni chromatin regulatory protein sir2 0.0447 0.0495 0.0495
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0066 0.0041 0.0041
Toxoplasma gondii F5/8 type C domain-containing protein 0.0043 0.0014 0.0246
Schistosoma mansoni chromatin regulatory protein sir2 0.0066 0.0041 0.0041
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0447 0.0495 0.0806
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0004 0.0004
Schistosoma mansoni glutamate receptor NMDA 0.0047 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0014 0.0016
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0038 0.0008 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.0022 0.0077
Loa Loa (eye worm) hypothetical protein 0.1144 0.1326 0.1326
Toxoplasma gondii subtilisin SUB12 0.0372 0.0406 1
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0035 0.0004 0.0004
Echinococcus granulosus discoidin domain receptor 0.0043 0.0014 0.0014
Schistosoma mansoni site-1 peptidase (S08 family) 0.0372 0.0406 0.0406
Echinococcus granulosus discoidin domain containing receptor 2 0.0043 0.0014 0.0014
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0065 0.0041 0.0936
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0372 0.0406 0.0659
Echinococcus granulosus lysine specific histone demethylase 1A 0.0099 0.0081 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0014 0.0016
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0447 0.0495 1
Plasmodium falciparum plasmepsin V 0.0389 0.0426 1
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.125 0.1453 0.1453
Loa Loa (eye worm) kelch domain-containing protein family protein 0.1314 0.1529 0.1529
Toxoplasma gondii aspartyl protease ASP5 0.0354 0.0385 0.9473
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.007 0.0046 0.0817
Plasmodium vivax LCCL domain-containing protein 0.0043 0.0014 0.0235
Echinococcus multilocularis 0.0099 0.0081 0.0101
Toxoplasma gondii subtilisin SUB1 0.0372 0.0406 1
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.0067 0.0067
Brugia malayi SWIRM domain containing protein 0.0041 0.0012 0.0012
Brugia malayi celfurPC protein 0.6738 0.7994 0.7994
Mycobacterium ulcerans Type I modular polyketide synthase 0.0081 0.0059 0.0887
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0066 0.0041 0.0492
Brugia malayi Calcium binding EGF domain containing protein 0.0039 0.0009 0.0009
Toxoplasma gondii hypothetical protein 0.0188 0.0187 0.454
Loa Loa (eye worm) transcriptional regulator 0.0447 0.0495 0.0495
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0041 0.0012 0.0015
Toxoplasma gondii subtilisin SUB7 0.0372 0.0406 1
Schistosoma mansoni serine/threonine protein kinase 0.024 0.0248 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0014 0.0016
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0099 0.0081 0.1467
Brugia malayi Furin-like cysteine rich region family protein 0.0603 0.0682 0.0682
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0066 0.0041 0.0052
Loa Loa (eye worm) hypothetical protein 0.0067 0.0043 0.0043
Onchocerca volvulus 0.0067 0.0043 0.0655
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0053 0.0026 0.0026
Schistosoma mansoni furin-1 (S08 family) 0.3641 0.4303 0.4303
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0014 0.0016
Echinococcus granulosus protein kinase c epsilon type 0.0088 0.0067 0.0067
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0372 0.0406 0.0659
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0372 0.0406 1
Mycobacterium ulcerans NAD-dependent deacetylase 0.0066 0.0041 0.0424
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0066 0.0041 0.0373
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0012 0.0013
Plasmodium vivax subtilisin-like serine protease, putative 0.0372 0.0406 0.9527
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0447 0.0495 0.0495
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.024 0.0248 0.0248
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0057 0.0031 0.0038
Onchocerca volvulus 0.0043 0.0014 0.0168
Toxoplasma gondii subtilisin SUB4 0.0372 0.0406 1
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0063 0.0038 0.0038
Entamoeba histolytica PH domain containing protein kinase, putative 0.0072 0.0048 0.0745
Toxoplasma gondii subtilisin SUB9 0.0372 0.0406 1
Loa Loa (eye worm) hypothetical protein 0.3269 0.386 0.386
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0019 0.0019
Schistosoma mansoni chromatin regulatory protein sir2 0.0447 0.0495 0.0495
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0086 0.0065 0.1541
Giardia lamblia Tenascin-X 0.0188 0.0187 0.0479
Onchocerca volvulus Fatty acid synthase homolog 0.0151 0.0143 0.235
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0135 0.0123 0.0154
Loa Loa (eye worm) hypothetical protein 0.0138 0.0127 0.0127
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0713 0.0813 0.1017
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0372 0.0406 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0019 0.0024
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0019 0.0019
Echinococcus multilocularis glutamate receptor 2 0.0047 0.0019 0.0024
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0188 0.0187 0.0299
Loa Loa (eye worm) hypothetical protein 0.0044 0.0015 0.0015
Brugia malayi transcriptional regulator, Sir2 family protein 0.0066 0.0041 0.0041
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0372 0.0406 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0012 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0014 0.0016
Schistosoma mansoni dock 0.0043 0.0014 0.0014
Mycobacterium leprae Possible secreted protease 0.0372 0.0406 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0099 0.0081 0.1324
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0122 0.0108 0.2612
Schistosoma mansoni hypothetical protein 0.0057 0.0031 0.0031
Schistosoma mansoni SWI/SNF complex-related 0.0041 0.0012 0.0012
Echinococcus granulosus adam 0.0487 0.0543 0.0543
Loa Loa (eye worm) fatty acid synthase 0.0083 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.1683 0.1968 0.3221
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0447 0.0495 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0081 0.0081
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0095 0.0076 0.0095
Echinococcus granulosus glutamate NMDA receptor subunit 0.0263 0.0276 0.0276
Mycobacterium ulcerans polyketide synthase 0.0081 0.0059 0.0887
Loa Loa (eye worm) hypothetical protein 0.0044 0.0015 0.0015
Onchocerca volvulus 0.0043 0.0014 0.0168
Loa Loa (eye worm) hypothetical protein 0.0228 0.0235 0.0235
Echinococcus multilocularis protein will die slowly 0.0134 0.0123 0.0154
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0043 0.0014 0.0017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0372 0.0406 0.0659
Onchocerca volvulus 0.0146 0.0136 0.2245
Loa Loa (eye worm) hypothetical protein 0.0134 0.0122 0.0122
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0372 0.0406 0.0659
Echinococcus multilocularis discoidin domain containing receptor 2 0.0043 0.0014 0.0017
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0447 0.0495 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0004 0.0004
Giardia lamblia Tenascin-37 0.0188 0.0187 0.0479
Loa Loa (eye worm) transcriptional regulator 0.0066 0.0041 0.0041
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0042 0.0013 0.023
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0372 0.0406 0.0659
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0372 0.0406 0.0659
Brugia malayi hypothetical protein 0.0299 0.0319 0.0319
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0066 0.0041 0.0949
Brugia malayi Subtilase family protein 0.0372 0.0406 0.0406
Giardia lamblia hypothetical protein 0.0188 0.0187 0.0479
Trichomonas vaginalis conserved hypothetical protein 0.1683 0.1968 0.3221
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.2055 0.2412 0.2412
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0372 0.0406 0.0406
Mycobacterium tuberculosis Conserved hypothetical protein 0.0099 0.0081 0.1935
Loa Loa (eye worm) acyl carrier protein 0.0038 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0372 0.0406 0.0659
Toxoplasma gondii type I fatty acid synthase, putative 0.006 0.0034 0.0742
Giardia lamblia Sirtuin type 2 0.0066 0.0041 0.0081
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0086 0.0065 0.1541
Loa Loa (eye worm) transcriptional regulator 0.0066 0.0041 0.0041
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0372 0.0406 0.0406
Echinococcus multilocularis c Jun NH2 terminal kinase 0.024 0.0248 0.0311
Brugia malayi transcriptional regulator, Sir2 family protein 0.0447 0.0495 0.0495
Echinococcus multilocularis chromatin regulatory protein sir2 0.0447 0.0495 0.062
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0041 0.0061
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.008 0.0058 0.5
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0066 0.0041 0.0607
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0066 0.0041 0.0607
Echinococcus multilocularis disintegrin and metalloproteinase 0.0095 0.0076 0.0095
Giardia lamblia Transcriptional regulator, Sir2 family 0.0066 0.0041 0.0081
Plasmodium vivax hypothetical protein, conserved 0.0099 0.0081 0.1827
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0032 0.0001 0.0001
Brugia malayi amine oxidase, flavin-containing family protein 0.0141 0.013 0.013
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0227 0.0234 0.0234
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0066 0.0041 0.0886
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0086 0.0065 0.1309
Plasmodium vivax subtilisin-like protease 2, putative 0.0372 0.0406 0.9527
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0081 0.006 0.1399
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0004 0.0004
Echinococcus multilocularis growth factor receptor bound protein 2 0.0122 0.0109 0.0136
Toxoplasma gondii histone deacetylase SIR2-like 0.0066 0.0041 0.093
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0372 0.0406 0.0659
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0035 0.0004 0.0004
Loa Loa (eye worm) aspartyl protease 6 0.0035 0.0004 0.0004
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0086 0.0065 0.105
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0299 0.0319 0.0319
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0372 0.0406 0.0659
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0372 0.0406 1
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0047 0.0019 0.0024
Brugia malayi NAD-dependent deacetylase SIRT1 0.0066 0.0041 0.0041
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2055 0.2412 0.3947
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0066 0.0041 0.0052
Echinococcus granulosus glutamate receptor 2 0.0047 0.0019 0.0019
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0066 0.0041 0.0052
Loa Loa (eye worm) apoptosis regulator protein 0.0057 0.0031 0.0031
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0081 0.0059 0.1387
Schistosoma mansoni protein kinase 0.0135 0.0123 0.0123
Schistosoma mansoni aldehyde dehydrogenase 0.0053 0.0026 0.0026
Loa Loa (eye worm) subtilase 0.0372 0.0406 0.0406
Plasmodium vivax NAD-dependent deacetylase, putative 0.0066 0.0041 0.0886
Echinococcus multilocularis protein kinase c epsilon type 0.0088 0.0067 0.0084
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0372 0.0406 0.0659
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0141 0.0131 0.0164
Brugia malayi Stress-activated protein kinase jnk-1 0.024 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0066 0.0042 0.0042
Onchocerca volvulus 0.0134 0.0123 0.2015
Trypanosoma cruzi UDP-galactopyranose mutase 0.0099 0.0081 0.1324
Brugia malayi Eukaryotic aspartyl protease family protein 0.0035 0.0004 0.0004
Mycobacterium tuberculosis Probable thioesterase TesA 0.007 0.0046 0.1062
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0014 0.0016
Schistosoma mansoni integrin alpha 0.1638 0.1915 0.1915
Schistosoma mansoni dihydroceramide desaturase 0.0095 0.0076 0.0076
Mycobacterium ulcerans aldehyde dehydrogenase 0.0053 0.0026 0.0032
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0035 0.0004 0.0004
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0135 0.0123 0.0123
Onchocerca volvulus 0.0163 0.0158 0.2605
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0099 0.0081 0.1467
Chlamydia trachomatis protoporphyrinogen oxidase 0.0099 0.0081 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0488 0.0545 0.0545
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0099 0.0081 0.1714
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0047 0.0019 0.0019
Entamoeba histolytica hypothetical protein, conserved 0.0066 0.0041 0.0607
Mycobacterium ulcerans Sir2-like regulatory protein 0.0066 0.0041 0.0424
Plasmodium falciparum subtilisin-like protease 2 0.0372 0.0406 0.9527
Brugia malayi EGF-like domain containing protein 0.0188 0.0187 0.0187
Giardia lamblia Hypothetical protein 0.0447 0.0495 0.1327
Brugia malayi Pepsin A precursor 0.0035 0.0004 0.0004
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1683 0.1968 0.3221
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0372 0.0406 0.8127
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0041 0.0061
Leishmania major subtilisin-like serine peptidase 0.0372 0.0406 0.8104
Trichomonas vaginalis conserved hypothetical protein 0.1683 0.1968 0.3221
Brugia malayi Kelch motif family protein 0.1314 0.1529 0.1529
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0019 0.0024
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0118 0.0103 0.0103
Brugia malayi SWIRM domain containing protein 0.053 0.0594 0.0594
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.006 0.0034 0.0777
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0372 0.0406 0.0659
Schistosoma mansoni hypothetical protein 0.0134 0.0123 0.0123
Echinococcus granulosus growth factor receptor bound protein 2 0.0122 0.0109 0.0109
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0713 0.0813 0.0813
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0078 0.0056 0.0056
Giardia lamblia Neurogenic locus Notch protein precursor 0.0188 0.0187 0.0479
Schistosoma mansoni chromatin regulatory protein sir2 0.0066 0.0041 0.0041
Schistosoma mansoni aldehyde dehydrogenase 0.0053 0.0026 0.0026
Brugia malayi hypothetical protein 0.1289 0.1499 0.1499
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0122 0.0109 0.0109
Plasmodium falciparum subtilisin-like protease 3 0.0372 0.0406 0.9527
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0014 0.0016
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0372 0.0406 1
Plasmodium falciparum protoporphyrinogen oxidase 0.0099 0.0081 0.1827
Trichomonas vaginalis conserved hypothetical protein 0.1683 0.1968 0.3221
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0054 0.0028 0.0586
Brugia malayi aspartic protease BmAsp-2, identical 0.0035 0.0004 0.0004
Schistosoma mansoni apoptosis regulator bax 0.0057 0.0031 0.0031
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0372 0.0406 0.0659
Schistosoma mansoni integrin alpha-ps 0.0827 0.0948 0.0948
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0057 0.0031 0.0031
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2055 0.2412 0.3947
Mycobacterium leprae Polyketide synthase Pks13 0.0122 0.0108 0.2409
Schistosoma mansoni protein kinase 0.0135 0.0123 0.0123
Trypanosoma cruzi subtilisin peptidase 0.0372 0.0406 0.8127
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0014 0.0016
Brugia malayi ADAM-TS Spacer 1 family protein 0.0134 0.0122 0.0122
Onchocerca volvulus 0.053 0.0594 1
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0099 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0039 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.1683 0.1968 0.3221
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0081 0.0059 0.1387
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0099 0.0081 0.1827
Loa Loa (eye worm) hypothetical protein 0.0066 0.0041 0.0041
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0081 0.006 0.1399
Brugia malayi angiogenesis inhibito 0.0134 0.0122 0.0122
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0372 0.0406 0.0659
Plasmodium falciparum subtilisin-like protease 1 0.0372 0.0406 0.9527
Trichomonas vaginalis conserved hypothetical protein 0.0372 0.0406 0.0659
Loa Loa (eye worm) reprolysin 0.0228 0.0235 0.0235
Mycobacterium ulcerans aldehyde dehydrogenase 0.0053 0.0026 0.0032
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0228 0.0235 0.0235
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0397 0.0436 0.876
Brugia malayi hypothetical protein 0.0035 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0014 0.0016
Schistosoma mansoni integrin beta subunit 0.4908 0.5813 0.5813
Brugia malayi ADAMTS-like protease 0.0134 0.0122 0.0122
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0372 0.0406 0.0406
Onchocerca volvulus Huntingtin homolog 0.0108 0.0091 0.1478
Schistosoma mansoni hypothetical protein 0.0057 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0035 0.0004 0.0004
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0066 0.0041 0.0061
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0043 0.0014 0.0016
Brugia malayi EGF-like domain containing protein 0.0188 0.0187 0.0187
Toxoplasma gondii histone lysine-specific demethylase 0.0099 0.0081 0.1918
Loa Loa (eye worm) TK/ALK protein kinase 0.0067 0.0043 0.0043
Mycobacterium ulcerans Type I modular polyketide synthase 0.0081 0.0059 0.0887
Loa Loa (eye worm) hypothetical protein 0.0035 0.0004 0.0004
Echinococcus multilocularis membrane bound transcription factor site 1 0.0372 0.0406 0.0508
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0086 0.0065 0.1541
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0081 0.0059 0.0887
Echinococcus multilocularis integrin beta 2 0.6197 0.7349 0.9193
Loa Loa (eye worm) hypothetical protein 0.0063 0.0038 0.0038
Toxoplasma gondii histone deacetylase SIR2 0.0066 0.0041 0.093
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0041 0.0012 0.0012

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 1.4 ug ml-1 Cytotoxicity against human MT4 cells after 5 days by MTT assay ChEMBL. 12444692
CC50 (ADMET) > 100 ug ml-1 Cytotoxicity against human HeLa cells after 2 days by MTT assay ChEMBL. 12444692

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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