Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | D-aminoacylase, putative | 0.0077 | 0.0474 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0114 | 0.0819 | 0.2364 |
Onchocerca volvulus | 0.0114 | 0.0819 | 0.655 | |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0246 | 0.071 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0077 | 0.0474 | 0.1082 |
Loa Loa (eye worm) | beta-lactamase | 0.0077 | 0.0474 | 0.1368 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0058 | 0.0295 | 0.0071 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.0967 | 0.2792 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0055 | 0.0265 | 0.0041 |
Echinococcus multilocularis | tumor protein p63 | 0.1088 | 1 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0077 | 0.0474 | 0.1082 |
Brugia malayi | beta-lactamase family protein | 0.0077 | 0.0474 | 0.1368 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.016 | 0.1255 | 0.3624 |
Schistosoma mansoni | lamin | 0.0114 | 0.0819 | 0.1831 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0114 | 0.0825 | 0.1851 |
Echinococcus granulosus | lamin | 0.0114 | 0.0819 | 0.0606 |
Trichomonas vaginalis | esterase, putative | 0.0077 | 0.0474 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0051 | 0.0226 | 0.0652 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0226 | 0.0652 |
Echinococcus granulosus | lamin dm0 | 0.0114 | 0.0819 | 0.0606 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0077 | 0.0474 | 0.0254 |
Leishmania major | hypothetical protein, conserved | 0.0129 | 0.0967 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.016 | 0.1255 | 0.3624 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0077 | 0.0474 | 0.0766 |
Onchocerca volvulus | 0.0077 | 0.0474 | 0.3791 | |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0058 | 0.0295 | 0.0071 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0109 | 0.0779 | 0.2248 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0077 | 0.0474 | 0.1082 |
Echinococcus multilocularis | tar DNA binding protein | 0.0394 | 0.3463 | 0.3312 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0061 | 0.0322 | 0.093 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0077 | 0.0474 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0129 | 0.0967 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0114 | 0.0819 | 0.2364 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0265 | 0.0766 |
Schistosoma mansoni | hypothetical protein | 0.0109 | 0.0779 | 0.1708 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0077 | 0.0474 | 0.1368 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0799 | 0.2307 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0077 | 0.0474 | 0.1082 |
Onchocerca volvulus | 0.0077 | 0.0474 | 0.3791 | |
Brugia malayi | beta-lactamase | 0.0077 | 0.0474 | 0.1368 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0474 | 0.1368 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0077 | 0.0474 | 1 |
Onchocerca volvulus | 0.0114 | 0.0819 | 0.655 | |
Brugia malayi | beta-lactamase family protein | 0.0077 | 0.0474 | 0.1368 |
Mycobacterium leprae | Probable lipase LipE | 0.0077 | 0.0474 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0474 | 0.1368 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0129 | 0.0967 | 1 |
Brugia malayi | hypothetical protein | 0.0083 | 0.0535 | 0.1546 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.0825 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0055 | 0.0265 | 0.0041 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.0825 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0394 | 0.3463 | 1 |
Brugia malayi | TAR-binding protein | 0.0394 | 0.3463 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0077 | 0.0474 | 0.1368 |
Brugia malayi | hypothetical protein | 0.0129 | 0.0967 | 0.2792 |
Mycobacterium tuberculosis | Conserved protein | 0.0077 | 0.0474 | 0.1082 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0051 | 0.0226 | 0.0652 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.1255 | 0.3624 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0077 | 0.0474 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0114 | 0.0819 | 0.0606 |
Schistosoma mansoni | tar DNA-binding protein | 0.0394 | 0.3463 | 1 |
Brugia malayi | MH2 domain containing protein | 0.026 | 0.2199 | 0.6349 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0114 | 0.0825 | 0.0613 |
Echinococcus multilocularis | musashi | 0.0114 | 0.0819 | 0.0606 |
Schistosoma mansoni | lamin | 0.0114 | 0.0819 | 0.1831 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0077 | 0.0474 | 0.0766 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0077 | 0.0474 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0474 | 0.1368 |
Mycobacterium ulcerans | beta-lactamase | 0.0077 | 0.0474 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0394 | 0.3463 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0394 | 0.3463 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0077 | 0.0474 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0077 | 0.0474 | 0.1082 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.0825 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0394 | 0.3463 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0129 | 0.0967 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0394 | 0.3463 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0114 | 0.0819 | 0.0606 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.026 | 0.2199 | 0.6349 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0061 | 0.0322 | 0.093 |
Onchocerca volvulus | 0.0077 | 0.0474 | 0.3791 | |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0129 | 0.0967 | 1 |
Onchocerca volvulus | 0.0159 | 0.125 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0114 | 0.0825 | 0.1851 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.0825 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0077 | 0.0474 | 0.1082 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0779 | 0.2248 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0077 | 0.0474 | 0.1082 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0129 | 0.0967 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0246 | 0.071 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0114 | 0.0825 | 0.0613 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0051 | 0.0226 | 0.0652 |
Mycobacterium ulcerans | lipase LipD | 0.0077 | 0.0474 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0474 | 0.1368 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0295 | 0.0215 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0077 | 0.0474 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0114 | 0.0819 | 0.2364 |
Echinococcus granulosus | tar DNA binding protein | 0.0394 | 0.3463 | 0.3312 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0474 | 0.1368 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.026 | 0.2199 | 0.6349 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0474 | 0.1368 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0077 | 0.0474 | 0.1082 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0129 | 0.0967 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.125 | 0.3609 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0159 | 0.125 | 0.3163 |
Brugia malayi | hypothetical protein | 0.0114 | 0.0825 | 0.2382 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0394 | 0.3463 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0077 | 0.0474 | 0.1082 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0077 | 0.0474 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.016 | 0.1255 | 0.3624 |
Schistosoma mansoni | tar DNA-binding protein | 0.0394 | 0.3463 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0129 | 0.0967 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0114 | 0.0819 | 0.2364 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0491 | 0.4377 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0394 | 0.3463 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0819 | 0.2364 |
Mycobacterium leprae | conserved hypothetical protein | 0.0077 | 0.0474 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0077 | 0.0474 | 0.0254 |
Brugia malayi | RNA binding protein | 0.0394 | 0.3463 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0077 | 0.0474 | 0.49 |
Schistosoma mansoni | intermediate filament proteins | 0.0114 | 0.0819 | 0.1831 |
Echinococcus multilocularis | lamin | 0.0114 | 0.0819 | 0.0606 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Concentration (functional) | = 0.0001 M | Concentration that exerts maximum contractile response, in isolated guinea pig ileum preparations, equivalent to that elicited by the concentrations of acetylcholine. | ChEMBL. | 2066974 |
IC50 (functional) | = 200 uM | Concentration required to inhibit 50% of the transport of [3H]-choline into synaptosomes, using rat hippocampal synaptosomes. | ChEMBL. | 2066974 |
Relative potency (functional) | = 2 | Relative potency with respect to choline in isolated guinea pig ileum preparations. | ChEMBL. | 2066974 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.