Detailed information for compound 1011210

Basic information

Technical information
  • TDR Targets ID: 1011210
  • Name: 5,7-dimethoxy-3-(4-methoxyphenyl)-1H-quinolin -4-one
  • MW: 311.332 | Formula: C18H17NO4
  • H donors: 1 H acceptors: 1 LogP: 3.11 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1c[nH]c2c(c1=O)c(OC)cc(c2)OC
  • InChi: 1S/C18H17NO4/c1-21-12-6-4-11(5-7-12)14-10-19-15-8-13(22-2)9-16(23-3)17(15)18(14)20/h4-10H,1-3H3,(H,19,20)
  • InChiKey: FNEUTVQHOSJBOC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5,7-dimethoxy-3-(4-methoxyphenyl)-4-quinolone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.012 0.012
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0348 0.0294
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0055 0.0055
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.1876 1 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0215 0.1957
Mycobacterium tuberculosis Conserved protein 0.0074 0.0348 0.0294
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0525
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0348 0.0851
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0215 0.0193
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0795 0.4209 1
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.1876 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0056
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0348 0.0326
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0348 0.0348
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.012 0.012
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0058 0.0058
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.1876 1 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0733 0.3874 1
Echinococcus multilocularis dna polymerase kappa 0.002 0.0055 0.0129
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0055 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0055 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0058 0.0058
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0058 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0055 0.0033
Loa Loa (eye worm) hypothetical protein 0.0027 0.0092 0.0836
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.012 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0055 0.0033
Echinococcus granulosus cpg binding protein 0.0061 0.0279 0.0717
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.1876 1 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0348 0.0294
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0215 0.0507
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0056
Brugia malayi Zinc finger, C2H2 type family protein 0.0733 0.3874 0.3873
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0525
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0215 0.0507
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0215 0.0554
Trichomonas vaginalis esterase, putative 0.0074 0.0348 0.0851
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0058 0.0137
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0058 0.0525
Schistosoma mansoni nuclear hormone receptor 0.001 0.0001 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0058 0.0148
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.1876 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0055 0.0033
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0033 0.0083
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0058 0.0058
Loa Loa (eye worm) beta-lactamase 0.0074 0.0348 0.3168
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0055 0.0033
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0733 0.3874 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0215 0.0507
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0215 0.051
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0058 0.0058
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0058 0.0137
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0058 0.0148
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0348 0.0294
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0058 0.0058
Entamoeba histolytica hypothetical protein 0.0074 0.0345 0.0759
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0056
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.1876 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0525
Trypanosoma brucei protein kinase, putative 0.005 0.0215 0.0193
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0058 0.0137
Brugia malayi nuclear hormone receptor 0.002 0.0058 0.0058
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0058 0.0459
Echinococcus granulosus geminin 0.052 0.2733 0.7055
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0348 0.0294
Schistosoma mansoni nuclear hormone receptor 0.002 0.0058 0.0058
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0052 0.0466
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0058 0.0137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0058 0.0525
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0056
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0058 0.0058
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0348 0.0294
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0525
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0058 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0058 0.0525
Entamoeba histolytica hypothetical protein 0.0074 0.0345 0.0759
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0348 0.0825
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0055 0.0033
Brugia malayi ecdysteroid receptor 0.002 0.0058 0.0058
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0215 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.012 0.1086
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0215 0.0161
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0055 0.0054
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0215 0.0161
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0058 0.0525
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0092 0.0037
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0013 0.003
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0733 0.3874 1
Schistosoma mansoni cpg binding protein 0.0058 0.0261 0.0261
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.012 0.0028
Onchocerca volvulus 0.0074 0.0348 0.277
Brugia malayi hypothetical protein 0.0017 0.0042 0.0041
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0033 0.0076
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0733 0.3874 0.9203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0058 0.0525
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0348 0.0851
Brugia malayi MAP kinase sur-1 0.005 0.0215 0.0215
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0733 0.3874 1
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0348 0.0851
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.012 0.0283
Brugia malayi Pre-SET motif family protein 0.0214 0.1097 0.1096
Onchocerca volvulus 0.0244 0.1254 1
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0215 0.0215
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.1876 1 1
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0348 0.0294
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0058 0.0459
Loa Loa (eye worm) hypothetical protein 0.002 0.0055 0.0497
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0058 0.0058
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0058 0.0459
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0055 0.0054
Mycobacterium ulcerans beta-lactamase 0.0074 0.0348 0.0294
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0074 0.0348 0.3168
Schistosoma mansoni zinc finger protein 0.001 0.0001 0.0001
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0058 0.0137
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.012 0.0307
Echinococcus granulosus dnaJ subfamily B 0.0401 0.2098 0.5415
Brugia malayi steroid hormone receptor 0.002 0.0058 0.0058
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.1876 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0058 0.0137
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0055 0.0091
Loa Loa (eye worm) hypothetical protein 0.0074 0.0348 0.3168
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0733 0.3874 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0348 0.0347
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.0616 0.0616
Brugia malayi hypothetical protein 0.0074 0.0345 0.0344
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0215 0.051
Mycobacterium ulcerans lipase LipD 0.0074 0.0348 0.0294
Onchocerca volvulus 0.0058 0.0261 0.2075
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0215 0.0124
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0007 0.0007
Schistosoma mansoni thyroid hormone receptor 0.002 0.0058 0.0058
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0007 0.0006
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0058 0.0058
Brugia malayi hypothetical protein 0.0027 0.0092 0.0092
Brugia malayi Pre-SET motif family protein 0.0032 0.012 0.0119
Echinococcus granulosus dna polymerase kappa 0.002 0.0055 0.0141
Entamoeba histolytica hypothetical protein 0.0074 0.0345 0.0759
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0215 0.0161
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0058 0.0058
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0033 0.0083
Brugia malayi hypothetical protein 0.0011 0.0007 0.0006
Plasmodium falciparum dihydroorotate dehydrogenase 0.1876 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0092 0.0037
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0058 0.0148
Onchocerca volvulus 0.0032 0.012 0.095
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0058 0.0058
Brugia malayi nuclear receptor NHR-88 0.002 0.0058 0.0058
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0733 0.3874 1
Schistosoma mansoni nuclear hormone receptor 0.001 0.0001 0.0001
Trichomonas vaginalis set domain proteins, putative 0.0244 0.1254 0.3203
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0058 0.0137
Brugia malayi beta-lactamase 0.0074 0.0348 0.0347
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0058 0.0058
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0058 0.0148
Schistosoma mansoni DNA polymerase eta 0.002 0.0055 0.0055
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0215 0.0507
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.0545 0.0457
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0055 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0058 0.0058
Schistosoma mansoni hypothetical protein 0.052 0.2733 0.2733
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0055 0.0033
Brugia malayi beta-lactamase family protein 0.0074 0.0348 0.0347
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0525
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0055 0.0055
Brugia malayi CXXC zinc finger family protein 0.0058 0.0261 0.026
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0733 0.3874 0.384
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0058 0.0148
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0525
Trypanosoma brucei unspecified product 0.002 0.0055 0.0033
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0058 0.0148
Loa Loa (eye worm) hypothetical protein 0.0074 0.0348 0.3168
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0058 0.0058
Leishmania major hypothetical protein, conserved 0.0074 0.0348 0.0294
Leishmania major hypothetical protein, conserved 0.0027 0.0092 0.0037
Brugia malayi nuclear receptor RXR 0.0011 0.0007 0.0006
Brugia malayi beta-lactamase family protein 0.0074 0.0348 0.0347
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0007 0.0006
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0345 0.0818
Mycobacterium ulcerans hypothetical protein 0.0074 0.0348 0.0294
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0733 0.3874 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0525
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.012 0.012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0058 0.0058
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0007 0.0056
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0052 0.0121
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0475 0.2496 0.2455
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0348 0.0258
Loa Loa (eye worm) hypothetical protein 0.0074 0.0348 0.3168
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0345 0.0345
Entamoeba histolytica hypothetical protein 0.0074 0.0345 0.0759
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.1876 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0348 0.0851
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0215 0.0554
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0058 0.0058
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0215 0.0161
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0058 0.0058
Schistosoma mansoni coup transcription factor 0.002 0.0058 0.0058
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0033 0.0033
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0058 0.0525
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0058 0.0148
Schistosoma mansoni hypothetical protein 0.0401 0.2098 0.2098
Onchocerca volvulus 0.0074 0.0348 0.277
Plasmodium vivax SET domain protein, putative 0.0032 0.012 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0058 0.0525
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0348 0.0294
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0056
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0058 0.0148
Echinococcus multilocularis dna polymerase eta 0.002 0.0055 0.0129
Schistosoma mansoni dihydroorotate dehydrogenase 0.1876 1 1
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0092 0.007
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0033 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0055 0.0033
Schistosoma mansoni hypothetical protein 0.0012 0.0013 0.0013
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0215 0.0161
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.1097 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0055 0.0033
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0107 0.0274
Mycobacterium tuberculosis Conserved protein 0.0074 0.0348 0.0294
Toxoplasma gondii ABC1 family protein 0.0074 0.0348 0.0258
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0733 0.3874 0.9203
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.2098 0.4984
Echinococcus granulosus dna polymerase eta 0.002 0.0055 0.0141
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0001 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0348 0.0294
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0058 0.0525
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0055 0.0033
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0348 0.0294
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0007 0.0015
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0052 0.0132
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0345 0.0889
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0261 0.2373
Schistosoma mansoni hypothetical protein 0.052 0.2733 0.2733
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0055 0.0033
Leishmania major dihydroorotate dehydrogenase 0.1876 1 1
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0348 0.0294
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0055 0.0141
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0348 0.0348
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0055 0.0033
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0348 0.3168
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0058 0.0137
Echinococcus multilocularis geminin 0.052 0.2733 0.6492
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0733 0.3874 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0348 0.0897
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0058 0.0058
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.1876 1 0.5
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0058 0.0137
Mycobacterium tuberculosis Conserved protein 0.0074 0.0348 0.0294
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0001 0.0001
Schistosoma mansoni thyroid hormone receptor 0.002 0.0058 0.0058
Schistosoma mansoni cpg binding protein 0.0061 0.0279 0.0279
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0055 0.0497
Schistosoma mansoni nuclear receptor 0.001 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0074 0.0345 0.0345
Echinococcus granulosus FTZ F1 alpha 0.002 0.0058 0.0148
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0013 0.0033
Echinococcus multilocularis cpg binding protein 0.0061 0.0279 0.066
Loa Loa (eye worm) hypothetical protein 0.002 0.0058 0.0525
Schistosoma mansoni nuclear receptor 0.001 0.0001 0.0001
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0055 0.0033
Schistosoma mansoni cpg binding protein 0.0061 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0074 0.0348 0.3168
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0058 0.0058
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.012 0.0283
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0348 0.0294
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0733 0.3874 1
Brugia malayi hypothetical protein 0.0011 0.0007 0.0006
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0055 0.0091
Loa Loa (eye worm) hypothetical protein 0.0074 0.0348 0.3168
Onchocerca volvulus 0.0074 0.0348 0.277
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.1876 1 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0007 0.0016
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0215 0.0161
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0348 0.0851
Onchocerca volvulus 0.002 0.0058 0.0459
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0058 0.0058
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0007 0.0007

Activities

Activity type Activity value Assay description Source Reference
%max (binding) < 10 % Displacement of [3H]-E2 from recombinant human ERalpha at 20 uM after 9 hrs by competitive binding assay relative to control ChEMBL. 25078314
%max (binding) = 10.1 % Transactivation of human ERalpha expressed in CV1 cells assessed as maximum activity at 20 uM after 24 hrs by luciferase reporter gene assay relative to 17beta-estradiol ChEMBL. 25078314
%max (binding) = 10.9 % Transactivation of human ERbeta expressed in CV1 cells assessed as maximum activity at 20 uM after 24 hrs by luciferase reporter gene assay relative to 17beta-estradiol ChEMBL. 25078314
%max (binding) = 47.2 % Displacement of [3H]-E2 from recombinant human ERbeta at 20 uM after 9 hrs by competitive binding assay relative to control ChEMBL. 25078314
IC50 (functional) = 20.5 uM Inhibition of NO production in LPS-activated mouse BV2 cells after 24 hrs by Griess method ChEMBL. 18556197
Inhibition (functional) = 23.2 % Inhibition of NO production in LPS-activated mouse BV2 cells at 10 uM after 24 hrs by Griess method relative to control ChEMBL. 18556197

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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