TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 303.311 | Formula: C19H13NO3
H donors: 0 H acceptors: 2 LogP: 4.43 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)Oc1ccc(cc1)c1oc2c(n1)c1ccccc1cc2
InChi: 1S/C19H13NO3/c1-12(21)22-15-9-6-14(7-10-15)19-20-18-16-5-3-2-4-13(16)8-11-17(18)23-19/h2-11H,1H3
InChiKey: SHPDJRVURUILFF-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.038	0.0537
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0021	0.0129	0.0129
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0138	0.2674	0.2674
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0129	0.0129
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0035	0.0443	0.0443
Brugia malayi	nuclear receptor NHR-88	0.0021	0.0129	0.0129
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0129	0.0129
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.0129	0.0129
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0129	0.0129
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0129	0.0129
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0208	0.4193	0.4193
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0483	0.009
Schistosoma mansoni	cyclins	0.0035	0.0443	0.0965
Schistosoma mansoni	serine/threonine protein kinase	0.0171	0.3386	1
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0276	0.0451
Giardia lamblia	Kinase, CMGC CDK	0.0171	0.3386	1
Plasmodium vivax	protein kinase Crk2	0.0171	0.3386	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0102	0.189	0.189
Brugia malayi	photoreceptor-specific nuclear receptor	0.0261	0.5336	0.5336
Onchocerca volvulus		0.0027	0.0276	0.0314
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0727	0.1835
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0483	0.0483
Echinococcus multilocularis	cyclin dependent kinase 1	0.0171	0.3386	0.6962
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0328	0.0426
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0998	0.1884
Onchocerca volvulus		0.0035	0.0443	0.067
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0129	0.0129
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0483	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0129	0.0129
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0035	0.0443	0.0671
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0171	0.3386	1
Echinococcus multilocularis	cyclins	0.0035	0.0443	0.0671
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0021	0.0129	0.0129
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.038	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0483	0.0483
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0328	0.0612
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0483	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0483	0.0483
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0328	0.0612
Loa Loa (eye worm)	cyclin domain-containing protein	0.0476	1	1
Echinococcus multilocularis	cyclins	0.0035	0.0443	0.0671
Echinococcus multilocularis	cyclin B3 1	0.0035	0.0443	0.0671
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0129	0.0129
Onchocerca volvulus		0.0037	0.0483	0.0754
Onchocerca volvulus		0.0027	0.0276	0.0314
Brugia malayi	beta-lactamase family protein	0.0037	0.0483	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0261	0.5336	0.5336
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0138	0.2674	0.544
Echinococcus granulosus	survival motor neuron protein 1	0.0236	0.4807	1
Entamoeba histolytica	cell division protein kinase 2, putative	0.0171	0.3386	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0998	0.2666
Trypanosoma cruzi	cdc2-related kinase 1	0.0171	0.3386	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.038	0.038
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0102	0.189	0.189
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0998	0.2361
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0129	0.0129
Schistosoma mansoni	cyclin B	0.0035	0.0443	0.0965
Echinococcus multilocularis	lamin	0.0027	0.0276	0.0314
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0138	0.2674	0.544
Echinococcus granulosus	cyclin b3	0.0035	0.0443	0.0671
Echinococcus granulosus	cyclins	0.0035	0.0443	0.0671
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0276	0.0276
Brugia malayi	nuclear hormone receptor	0.0021	0.0129	0.0129
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0171	0.3386	0.3386
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0483	0.009
Onchocerca volvulus		0.0237	0.4816	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0328	0.0426
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0483	0.1085
Schistosoma mansoni	hypothetical protein	0.0032	0.038	0.0771
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.0129	0.0129
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.0129	0.0129
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0129	0.0129
Plasmodium falciparum	protein kinase 5	0.0171	0.3386	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0138	0.2674	0.7814
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0998	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.0129	0.0129
Toxoplasma gondii	ABC1 family protein	0.0037	0.0483	0.0714
Loa Loa (eye worm)	hypothetical protein	0.0169	0.3346	0.3346
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0129	0.0129
Brugia malayi	beta-lactamase	0.0037	0.0483	0.0483
Schistosoma mansoni	cyclin B3	0.0035	0.0443	0.0965
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0328	0.0221
Trypanosoma brucei	cdc2-related kinase 3	0.0171	0.3386	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.189	0.189
Echinococcus granulosus	cyclins	0.0035	0.0443	0.0671
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.1079	0.1079
Schistosoma mansoni	hypothetical protein	0.0032	0.038	0.0771
Onchocerca volvulus		0.0037	0.0483	0.0754
Echinococcus multilocularis	cyclins	0.0035	0.0443	0.0671
Trypanosoma cruzi	cdc2-related kinase 3	0.0171	0.3386	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0328	0.0612
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.0129	0.0129
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.0129	0.0129
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0138	0.2674	0.544
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1079	0.2915
Loa Loa (eye worm)	hypothetical protein	0.0032	0.038	0.038
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0328	0.0612
Schistosoma mansoni	serine/threonine protein kinase	0.0171	0.3386	1
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0035	0.0443	0.0443
Echinococcus multilocularis	cyclins	0.0035	0.0443	0.0671
Echinococcus granulosus	lamin dm0	0.0027	0.0276	0.0314
Brugia malayi	TAR-binding protein	0.0064	0.1079	0.1079
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0483	0.0483
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0483	0.0133
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0998	0.1856
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0171	0.3386	1
Onchocerca volvulus		0.0037	0.0483	0.0754
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0483	0.0133
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.1079	0.1079
Brugia malayi	RNA binding protein	0.0064	0.1079	0.1079
Schistosoma mansoni	hypothetical protein	0.0166	0.3292	0.9712
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0483	0.0133
Brugia malayi	intermediate filament protein	0.0027	0.0276	0.0276
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.038	0.038
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0236	0.48	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0129	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0129	0.0129
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.0129	0.0129
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1079	0.2915
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0276	0.0276
Echinococcus multilocularis	cyclin dependent kinase 5	0.0171	0.3386	0.6962
Brugia malayi	Protein kinase domain containing protein	0.0171	0.3386	0.3386
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0483	0.009
Loa Loa (eye worm)	hypothetical protein	0.003	0.0328	0.0328
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0035	0.0443	0.0443
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0998	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0138	0.2674	0.7814
Brugia malayi	Pre-SET motif family protein	0.003	0.0328	0.0328
Loa Loa (eye worm)	RNA binding protein	0.0064	0.1079	0.1079
Schistosoma mansoni	lamin	0.0027	0.0276	0.0451
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0483	0.0755
Echinococcus multilocularis	cyclin dependent kinase	0.0171	0.3386	0.6962
Schistosoma mansoni	hypothetical protein	0.0032	0.038	0.0771
Echinococcus granulosus	cyclin dependent kinase 5	0.0171	0.3386	0.6962
Echinococcus granulosus	cyclin B3 1	0.0035	0.0443	0.0671
Trypanosoma cruzi	cdc2-related kinase 3	0.0171	0.3386	1
Brugia malayi	steroid hormone receptor	0.0021	0.0129	0.0129
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1079	0.2915
Echinococcus granulosus	GPCR family 2	0.0032	0.038	0.0537
Leishmania major	hypothetical protein, conserved	0.0037	0.0483	0.0133
Trichomonas vaginalis	CMGC family protein kinase	0.0171	0.3386	0.673
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0138	0.2674	0.7814
Echinococcus granulosus	cyclin dependent kinase 1	0.0171	0.3386	0.6962
Loa Loa (eye worm)	hypothetical protein	0.0236	0.4807	0.4807
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0998	0.1193
Loa Loa (eye worm)	cyclin domain-containing protein	0.0035	0.0443	0.0443
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0171	0.3386	0.3386
Schistosoma mansoni	hypothetical protein	0.007	0.1191	0.3261
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0483	0.0483
Loa Loa (eye worm)	steroid hormone receptor	0.0021	0.0129	0.0129
Echinococcus multilocularis	survival motor neuron protein 1	0.0236	0.4807	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0021	0.0129	0.0129
Echinococcus granulosus	cyclin B	0.0035	0.0443	0.0671
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0129	0.0129
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.038	0.038
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0998	0.2666
Onchocerca volvulus		0.0048	0.0727	0.1275
Echinococcus multilocularis	cyclins	0.0035	0.0443	0.0671
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0483	0.009
Entamoeba histolytica	cell division protein kinase 2, putative	0.0171	0.3386	1
Echinococcus multilocularis	cyclin b3	0.0035	0.0443	0.0671
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0483	0.0755
Echinococcus granulosus	intermediate filament protein	0.0027	0.0276	0.0314
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0171	0.3386	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0483	0.1085
Schistosoma mansoni	hypothetical protein	0.0032	0.038	0.0771
Echinococcus multilocularis	cyclin dependent kinase 1	0.0171	0.3386	0.6962
Brugia malayi	ecdysteroid receptor	0.0021	0.0129	0.0129
Schistosoma mansoni	hypothetical protein	0.0048	0.0727	0.1835
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0021	0.0129	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0129	0.0129
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0483	0.5
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0171	0.3386	0.6962
Echinococcus multilocularis	geminin	0.0166	0.3292	0.6761
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0021	0.0129	0.0129
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0998	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0443	0.0443
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0727	0.0727
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0483	0.0483
Giardia lamblia	Kinase, CMGC CDK	0.0171	0.3386	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0483	0.009
Loa Loa (eye worm)	hypothetical protein	0.007	0.1191	0.1191
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0998	0.1856
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0035	0.0443	0.0671
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0483	0.0483
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0171	0.3386	0.3386
Schistosoma mansoni	lamin	0.0027	0.0276	0.0451
Onchocerca volvulus		0.003	0.0328	0.0425
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0138	0.2674	0.544
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0483	0.0483
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0102	0.189	0.189
Brugia malayi	beta-lactamase family protein	0.0037	0.0483	0.0483
Schistosoma mansoni	hypothetical protein	0.0166	0.3292	0.9712
Echinococcus granulosus	cyclins	0.0035	0.0443	0.0671
Echinococcus multilocularis	lamin dm0	0.0027	0.0276	0.0314
Echinococcus granulosus	cyclins	0.0035	0.0443	0.0671
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0021	0.0129	0.0129
Trichomonas vaginalis	CMGC family protein kinase	0.0171	0.3386	0.673
Trichomonas vaginalis	set domain proteins, putative	0.0237	0.4816	1
Echinococcus granulosus	tar DNA binding protein	0.0064	0.1079	0.2029
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.1079	0.1079
Echinococcus multilocularis	GPCR, family 2	0.0032	0.038	0.0537
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0276	0.0276
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0305	0.0375
Brugia malayi	hypothetical protein	0.0236	0.4807	0.4807
Echinococcus multilocularis	cyclins	0.0035	0.0443	0.0671
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0265	0.0265
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.0129	0.0129
Echinococcus multilocularis	cyclins	0.0035	0.0443	0.0671
Trypanosoma brucei	cdc2-related kinase 1	0.0171	0.3386	1
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.1079	0.2029
Echinococcus granulosus	lamin	0.0027	0.0276	0.0314
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1079	0.2915
Trypanosoma cruzi	cdc2-related kinase 1	0.0171	0.3386	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0328	0.0426
Trichomonas vaginalis	CMGC family protein kinase	0.0171	0.3386	0.673
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0483	0.5
Trichomonas vaginalis	esterase, putative	0.0037	0.0483	0.009
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0443	0.0443
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.038	0.0537
Echinococcus granulosus	cyclin dependent kinase	0.0171	0.3386	0.6962
Echinococcus multilocularis	musashi	0.0027	0.0276	0.0314
Brugia malayi	Pre-SET motif family protein	0.0208	0.4193	0.4193
Echinococcus multilocularis	cyclin B	0.0035	0.0443	0.0671
Echinococcus granulosus	cyclins	0.0035	0.0443	0.0671
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0138	0.2674	0.2674
Brugia malayi	latrophilin 2 splice variant baaae	0.007	0.1191	0.1191
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0021	0.0129	0.0129
Echinococcus granulosus	geminin	0.0166	0.3292	0.6761
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0276	0.0276
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.038	0.0537
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1079	0.2915
Brugia malayi	cell division control protein 2 homolog	0.0171	0.3386	0.3386

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 31.1 %	Inhibition of of PTP1B assessed as residual enzyme activity at 100 uM	ChEMBL.	18436346

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL514430

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1011228