Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.6648 | 0.6648 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.006 | 0.1613 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.1093 | 0.1644 |
Brugia malayi | TAR-binding protein | 0.0135 | 0.6648 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.1093 | 0.1644 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.006 | 0.1613 | 0.2427 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0056 | 0.1346 | 0.2024 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.6648 | 0.6648 |
Echinococcus granulosus | tar DNA binding protein | 0.0135 | 0.6648 | 0.6286 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.6648 | 0.6648 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0976 | 0.0976 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0135 | 0.6648 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0135 | 0.6648 | 0.6286 |
Loa Loa (eye worm) | TAR-binding protein | 0.0135 | 0.6648 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0976 | 0.0976 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0976 | 0.1468 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.006 | 0.1613 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1093 | 0.1644 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.006 | 0.1613 | 0.0706 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.006 | 0.1613 | 0.1613 |
Loa Loa (eye worm) | RNA binding protein | 0.0135 | 0.6648 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0976 | 0.0976 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.006 | 0.1613 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.6648 | 0.6648 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0976 | 0.1468 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.1093 | 0.1644 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0135 | 0.6648 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0135 | 0.6648 | 0.6648 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.006 | 0.1613 | 0.5 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.006 | 0.1613 | 0.0706 |
Echinococcus multilocularis | geminin | 0.0186 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0135 | 0.6648 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.