Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0695 | 1 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0086 | 0.065 | 0.0727 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0056 | 0.0195 | 0.2431 |
Echinococcus multilocularis | GPCR, family 2 | 0.022 | 0.2705 | 0.321 |
Brugia malayi | MH2 domain containing protein | 0.0367 | 0.496 | 0.4935 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0193 | 0.2286 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0193 | 0.2286 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0475 | 0.6623 | 0.6607 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0367 | 0.496 | 0.496 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.065 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0475 | 0.6623 | 0.6623 |
Brugia malayi | Probable ClpP-like protease | 0.0086 | 0.065 | 0.0604 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0086 | 0.065 | 0.0002 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0056 | 0.0195 | 0.0177 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.065 | 0.0002 |
Schistosoma mansoni | hypothetical protein | 0.022 | 0.2705 | 0.321 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.022 | 0.2705 | 0.2705 |
Schistosoma mansoni | tar DNA-binding protein | 0.0586 | 0.8324 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0586 | 0.8324 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0586 | 0.8324 | 0.8324 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0586 | 0.8324 | 0.8316 |
Brugia malayi | TAR-binding protein | 0.0586 | 0.8324 | 0.8316 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0086 | 0.065 | 0.0727 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0086 | 0.0655 | 0.0733 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0367 | 0.496 | 0.496 |
Brugia malayi | hypothetical protein | 0.0193 | 0.2286 | 0.2249 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0086 | 0.065 | 0.0727 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0086 | 0.065 | 0.0727 |
Brugia malayi | Isocitrate dehydrogenase | 0.0086 | 0.065 | 0.0604 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0086 | 0.065 | 0.0727 |
Brugia malayi | hypothetical protein | 0.0124 | 0.1238 | 0.1195 |
Schistosoma mansoni | tar DNA-binding protein | 0.0586 | 0.8324 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.022 | 0.2705 | 0.2669 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0056 | 0.0195 | 0.0177 |
Loa Loa (eye worm) | TAR-binding protein | 0.0586 | 0.8324 | 0.8324 |
Brugia malayi | isocitrate dehydrogenase | 0.0086 | 0.065 | 0.0604 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.065 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0193 | 0.2286 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.022 | 0.2705 | 0.321 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.065 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0475 | 0.6623 | 0.7945 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0086 | 0.065 | 0.0727 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.022 | 0.2705 | 0.2669 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0086 | 0.065 | 0.0727 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.022 | 0.2705 | 0.321 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.065 | 0.065 |
Echinococcus granulosus | GPCR family 2 | 0.022 | 0.2705 | 0.321 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0086 | 0.065 | 0.0002 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0086 | 0.065 | 0.0727 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.065 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0086 | 0.065 | 0.0727 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.2705 | 0.2705 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.065 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0193 | 0.2286 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0086 | 0.0655 | 0.0733 |
Brugia malayi | RNA binding protein | 0.0586 | 0.8324 | 0.8316 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.022 | 0.2705 | 0.321 |
Schistosoma mansoni | hypothetical protein | 0.022 | 0.2705 | 0.321 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0086 | 0.0655 | 0.0733 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.2286 | 0.2286 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0086 | 0.065 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0193 | 0.2286 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0086 | 0.065 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0695 | 1 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0086 | 0.065 | 0.2687 |
Echinococcus multilocularis | tar DNA binding protein | 0.0586 | 0.8324 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0193 | 0.2286 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0086 | 0.065 | 0.065 |
Schistosoma mansoni | hypothetical protein | 0.022 | 0.2705 | 0.321 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0695 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0586 | 0.8324 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0193 | 0.2286 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0086 | 0.065 | 0.0002 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.022 | 0.2705 | 0.321 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0193 | 0.2286 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0586 | 0.8324 | 0.8324 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0086 | 0.065 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0056 | 0.0195 | 0.2431 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0086 | 0.065 | 0.0727 |
Schistosoma mansoni | hypothetical protein | 0.022 | 0.2705 | 0.321 |
Schistosoma mansoni | tar DNA-binding protein | 0.0586 | 0.8324 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0586 | 0.8324 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.