Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Ovis aries | Cyclooxygenase-2 | Starlite/ChEMBL | References |
Ovis aries | Cyclooxygenase-1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0095 | 0.7593 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0095 | 0.7593 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0095 | 0.7593 | 0.5 |
Onchocerca volvulus | 0.0095 | 0.7593 | 0.5 | |
Onchocerca volvulus | Peroxidase homolog | 0.0095 | 0.7593 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0062 | 0.3968 | 0.5227 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0045 | 0.2033 | 0.5 |
Onchocerca volvulus | 0.0095 | 0.7593 | 0.5 | |
Echinococcus granulosus | peroxidasin | 0.0095 | 0.7593 | 1 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0045 | 0.2033 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0045 | 0.2033 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0095 | 0.7593 | 0.5 |
Chlamydia trachomatis | glutamine binding protein | 0.0045 | 0.2033 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0062 | 0.3968 | 0.5227 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0095 | 0.7593 | 0.5 |
Onchocerca volvulus | 0.0095 | 0.7593 | 0.5 | |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0045 | 0.2033 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0095 | 0.7593 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0045 | 0.2033 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0062 | 0.3968 | 0.5227 |
Echinococcus multilocularis | peroxidasin | 0.0095 | 0.7593 | 1 |
Schistosoma mansoni | peroxidasin | 0.0095 | 0.7593 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.