Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0486 | 0.36 | 0.36 |
Loa Loa (eye worm) | S-methyl-5'-thioadenosine phosphorylase MTAP | 0.0252 | 0.1552 | 0.1991 |
Echinococcus granulosus | uridine phosphorylase 1 | 0.0252 | 0.1552 | 0.1552 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1216 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0559 | 0.4243 | 0.4243 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0252 | 0.1552 | 0.1235 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0335 | 0.2278 | 0.1988 |
Trypanosoma brucei | trypanothione reductase | 0.0335 | 0.2278 | 1 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0505 | 0.3768 | 0.3768 |
Toxoplasma gondii | thioredoxin reductase | 0.0335 | 0.2278 | 1 |
Schistosoma mansoni | adapter molecule crk | 0.011 | 0.0306 | 0.0306 |
Schistosoma mansoni | tyrosine kinase | 0.0559 | 0.4243 | 0.4243 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0559 | 0.4243 | 0.4243 |
Brugia malayi | Variant SH3 domain containing protein | 0.011 | 0.0306 | 0.0306 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0559 | 0.4243 | 0.4243 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.011 | 0.0306 | 0.0306 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0085 | 0.0092 | 0.0092 |
Leishmania major | methylthioadenosine phosphorylase, putative | 0.0252 | 0.1552 | 0.6211 |
Plasmodium vivax | glutathione reductase, putative | 0.0335 | 0.2278 | 1 |
Treponema pallidum | pfs protein (pfs) | 0.0252 | 0.1552 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1216 | 1 | 1 |
Echinococcus multilocularis | NCK adaptor protein | 0.011 | 0.0306 | 0.0306 |
Echinococcus granulosus | tyrosine kinase | 0.0505 | 0.3768 | 0.3768 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.1216 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0559 | 0.4243 | 0.4243 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0252 | 0.1552 | 0.1552 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0505 | 0.3768 | 0.3768 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0505 | 0.3768 | 0.3768 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0559 | 0.4243 | 0.4243 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0505 | 0.3768 | 0.3768 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.011 | 0.0306 | 0.0306 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1216 | 1 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0116 | 0.0362 | 0.0362 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0335 | 0.2278 | 0.2278 |
Giardia lamblia | 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase | 0.0252 | 0.1552 | 0.1235 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1216 | 1 | 1 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0252 | 0.1552 | 0.4728 |
Mycobacterium leprae | probable uridine phosphorylase | 0.0252 | 0.1552 | 0.1235 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1216 | 1 | 1 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.011 | 0.0306 | 0.0393 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.1216 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0252 | 0.1552 | 0.1235 |
Schistosoma mansoni | tyrosine kinase | 0.0559 | 0.4243 | 0.4243 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1216 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0559 | 0.4243 | 0.4243 |
Echinococcus granulosus | tyrosine protein kinase HCK | 0.0449 | 0.3282 | 0.3282 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0252 | 0.1552 | 0.1235 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1216 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0335 | 0.2278 | 1 |
Plasmodium vivax | purine nucleoside phosphorylase, putative | 0.0252 | 0.1552 | 0.6211 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0129 | 0.0474 | 0.0474 |
Brugia malayi | Variant SH3 domain containing protein | 0.011 | 0.0306 | 0.0306 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0252 | 0.1552 | 0.4728 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1216 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0252 | 0.1552 | 0.4728 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0559 | 0.4243 | 0.4243 |
Brugia malayi | Thioredoxin reductase | 0.0335 | 0.2278 | 0.2278 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0964 | 0.7794 | 0.7794 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0129 | 0.0474 | 0.0474 |
Schistosoma mansoni | nck2/grb4 | 0.011 | 0.0306 | 0.0306 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0559 | 0.4243 | 0.4243 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0252 | 0.1552 | 0.1235 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.011 | 0.0306 | 0.0306 |
Echinococcus granulosus | methylthioadenosine phosphorylase | 0.0252 | 0.1552 | 0.1552 |
Schistosoma mansoni | uridine phosphorylase | 0.0252 | 0.1552 | 0.1552 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0335 | 0.2278 | 0.2923 |
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | 0.0252 | 0.1552 | 0.6211 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0129 | 0.0474 | 0.0474 |
Giardia lamblia | 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase | 0.0252 | 0.1552 | 0.1235 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1216 | 1 | 1 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0252 | 0.1552 | 0.1552 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1216 | 1 | 1 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.1216 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.1216 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1216 | 1 | 1 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0252 | 0.1552 | 0.6211 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.011 | 0.0306 | 0.0306 |
Loa Loa (eye worm) | uridine phosphorylase | 0.0252 | 0.1552 | 0.1991 |
Plasmodium falciparum | thioredoxin reductase | 0.0335 | 0.2278 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0252 | 0.1552 | 0.1235 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0252 | 0.1552 | 0.6211 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0335 | 0.2278 | 0.2278 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.011 | 0.0306 | 0.0393 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1216 | 1 | 1 |
Brugia malayi | protein-tyrosine kinase | 0.0505 | 0.3768 | 0.3768 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0559 | 0.4243 | 0.4243 |
Echinococcus multilocularis | tyrosine protein kinase HCK | 0.0449 | 0.3282 | 0.3282 |
Mycobacterium tuberculosis | Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase | 0.0252 | 0.1552 | 0.1235 |
Loa Loa (eye worm) | hypothetical protein | 0.0964 | 0.7794 | 1 |
Schistosoma mansoni | uridine phosphorylase | 0.0252 | 0.1552 | 0.1552 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.1216 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0129 | 0.0474 | 0.0474 |
Entamoeba histolytica | protein kinase, putative | 0.0449 | 0.3282 | 1 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.011 | 0.0306 | 0.0306 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0129 | 0.0474 | 0.0474 |
Brugia malayi | MTAP | 0.0252 | 0.1552 | 0.1552 |
Treponema pallidum | uridine phosphorylase (udp) | 0.0252 | 0.1552 | 1 |
Echinococcus multilocularis | uridine phosphorylase 1 | 0.0252 | 0.1552 | 0.1552 |
Loa Loa (eye worm) | TK protein kinase | 0.0505 | 0.3768 | 0.4835 |
Loa Loa (eye worm) | SRC-1 | 0.0559 | 0.4243 | 0.5444 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0116 | 0.0362 | 0.0362 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0129 | 0.0474 | 0.0474 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0559 | 0.4243 | 0.4243 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0306 | 0.0393 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0252 | 0.1552 | 0.4728 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0964 | 0.7794 | 0.7794 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0116 | 0.0362 | 0.0362 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0252 | 0.1552 | 0.1235 |
Brugia malayi | glutathione reductase | 0.0335 | 0.2278 | 0.2278 |
Giardia lamblia | UPL-1 | 0.0252 | 0.1552 | 0.1235 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0559 | 0.4243 | 0.4243 |
Loa Loa (eye worm) | TK protein kinase | 0.0449 | 0.3282 | 0.4211 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0252 | 0.1552 | 0.1235 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0252 | 0.1552 | 0.4728 |
Plasmodium falciparum | purine nucleoside phosphorylase | 0.0252 | 0.1552 | 0.6211 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.1216 | 1 | 1 |
Chlamydia trachomatis | AMP nucleosidase | 0.0252 | 0.1552 | 1 |
Echinococcus granulosus | inosine guanosine and xanthosine phosphorylase | 0.0964 | 0.7794 | 0.7794 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0335 | 0.2278 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0129 | 0.0474 | 0.0474 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0252 | 0.1552 | 0.6211 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0252 | 0.1552 | 0.6211 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0559 | 0.4243 | 0.4243 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0559 | 0.4243 | 0.4243 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.1216 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0335 | 0.2278 | 0.2923 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1216 | 1 | 1 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0085 | 0.0092 | 0.0092 |
Leishmania major | trypanothione reductase | 0.0335 | 0.2278 | 1 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.1216 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0252 | 0.1552 | 0.1235 |
Entamoeba histolytica | MTA/SAH nucleosidase, putative | 0.0252 | 0.1552 | 0.4728 |
Plasmodium falciparum | glutathione reductase | 0.0335 | 0.2278 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0559 | 0.4243 | 0.4243 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0116 | 0.0362 | 0.5 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0252 | 0.1552 | 0.4728 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0559 | 0.4243 | 0.4243 |
Echinococcus granulosus | NCK adaptor protein | 0.011 | 0.0306 | 0.0306 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0252 | 0.1552 | 0.1235 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0116 | 0.0362 | 0.5 |
Mycobacterium ulcerans | bifunctional Mta/Sah nucleosidase Mtn | 0.0252 | 0.1552 | 0.1235 |
Leishmania major | nucleoside phosphorylase-like protein | 0.0252 | 0.1552 | 0.6211 |
Trypanosoma brucei | uridine phosphorylase | 0.0252 | 0.1552 | 0.6211 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0252 | 0.1552 | 0.6211 |
Brugia malayi | uridine phosphorylase family protein | 0.0252 | 0.1552 | 0.1552 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0252 | 0.1552 | 0.1235 |
Toxoplasma gondii | phosphorylase family protein | 0.0252 | 0.1552 | 0.6211 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.011 | 0.0306 | 0.0306 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0559 | 0.4243 | 0.4243 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0252 | 0.1552 | 0.1552 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1216 | 1 | 1 |
Toxoplasma gondii | phosphorylase family protein | 0.0252 | 0.1552 | 0.6211 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0486 | 0.36 | 0.36 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0559 | 0.4243 | 0.4243 |
Toxoplasma gondii | Purine nucleoside phosphorylase | 0.0252 | 0.1552 | 0.6211 |
Mycobacterium ulcerans | 5'-methylthioadenosine phosphorylase | 0.0252 | 0.1552 | 0.1235 |
Echinococcus granulosus | c src tyrosine kinase | 0.0129 | 0.0474 | 0.0474 |
Schistosoma mansoni | tyrosine kinase | 0.0129 | 0.0474 | 0.0474 |
Treponema pallidum | purine nucleoside phosphorylase (deoD) | 0.0252 | 0.1552 | 1 |
Echinococcus multilocularis | methylthioadenosine phosphorylase | 0.0252 | 0.1552 | 0.1552 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0252 | 0.1552 | 0.1235 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0505 | 0.3768 | 0.3768 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0116 | 0.0362 | 0.0362 |
Brugia malayi | SRC-1 | 0.0559 | 0.4243 | 0.4243 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of FGFR2 at 10 uM by ELISA | ChEMBL. | 18610999 | |
Inhibition (binding) | Inhibition of EGFR at 10 uM by ELISA | ChEMBL. | 18610999 | |
Inhibition (binding) | Inhibition of cKit at 10 uM by ELISA | ChEMBL. | 18610999 | |
Inhibition (binding) | Inhibition of FGFR1 at 10 uM by ELISA | ChEMBL. | 18610999 | |
Inhibition (binding) | = 64 % | Inhibition of KDR at 10 uM by ELISA | ChEMBL. | 18610999 |
Inhibition (binding) | = 74.4 % | Inhibition of c-Src at 10 uM by ELISA | ChEMBL. | 18610999 |
Inhibition (binding) | = 84.6 % | Inhibition of c-Met at 10 uM by ELISA | ChEMBL. | 18610999 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.