Detailed information for compound 101314

Basic information

Technical information
  • TDR Targets ID: 101314
  • Name: ethyl (E,4S)-4-[(6-chloro-2H-chromene-3-carbo nyl)amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pent- 2-enoate
  • MW: 418.871 | Formula: C21H23ClN2O5
  • H donors: 2 H acceptors: 3 LogP: 2.2 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)/C=C/[C@H](C[C@@H]1CCNC1=O)NC(=O)C1=Cc2c(OC1)ccc(c2)Cl
  • InChi: 1S/C21H23ClN2O5/c1-2-28-19(25)6-4-17(11-13-7-8-23-20(13)26)24-21(27)15-9-14-10-16(22)3-5-18(14)29-12-15/h3-6,9-10,13,17H,2,7-8,11-12H2,1H3,(H,23,26)(H,24,27)/b6-4+/t13-,17+/m0/s1
  • InChiKey: FUDPGCHBEDGBSA-HMBFSZGFSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E,4S)-4-[[(6-chloro-2H-1-benzopyran-3-yl)-oxomethyl]amino]-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoic acid ethyl ester
  • ethyl (E,4S)-4-[(6-chloro-2H-chromen-3-yl)carbonylamino]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate
  • (E,4S)-4-[(6-chloro-2H-chromene-3-carbonyl)amino]-5-[(3S)-2-ketopyrrolidin-3-yl]pent-2-enoic acid ethyl ester
  • 2-Pentenoic acid, 4-[[(6-chloro-2H-1-benzopyran-3-yl)carbonyl]amino]-5-[(3S)-2-oxo-3-pyrrolidinyl]-, ethyl ester, (2E,4S)-
  • AIDS-122425
  • AIDS122425

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human rhinovirus sp. Human rhinovirus A protease Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0018 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0153 0.1405 0.4183
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0021 0.0026 0.0011
Mycobacterium ulcerans bifunctional acetaldehyde-CoA/alcohol dehydrogenase 0.0021 0.0026 0.0023
Echinococcus granulosus cpg binding protein 0.0033 0.0154 0.017
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0021 0.0026 0.003
Loa Loa (eye worm) RNA binding protein 0.0065 0.0491 0.0611
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0491 0.0591
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0788 0.803 0.8027
Echinococcus granulosus neuropeptide s receptor 0.0522 0.5257 0.6539
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0196 0.0223
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0083 0.0197
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0306 0.0869
Echinococcus multilocularis neutral amino acid transporter A 0.0788 0.803 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0345 0.3402 0.4237
Loa Loa (eye worm) hypothetical protein 0.0022 0.0037 0.0046
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0037 0.0024
Brugia malayi Pre-SET motif family protein 0.0213 0.2034 0.2517
Plasmodium falciparum glutathione reductase 0.0049 0.0318 1
Brugia malayi beta-lactamase family protein 0.0153 0.1405 0.1732
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0491 0.0591
Entamoeba histolytica hypothetical protein 0.0026 0.0083 0.0223
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0318 0.0375
Echinococcus multilocularis excitatory amino acid transporter 3 0.0788 0.803 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0135 0.0146
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0153 0.1405 0.139
Echinococcus granulosus zinc finger protein 0.0022 0.0038 0.0025
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0037 0.0024
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0021 0.0026 0.0011
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0491 0.0611
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0021 0.0026 0.0009
Brugia malayi nuclear receptor NHR-88 0.0022 0.0037 0.0024
Echinococcus granulosus tumor protein p63 0.0348 0.3441 0.4273
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0021 0.0026 0.0009
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0021 0.0026 0.0023
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0058 0.0414 0.1196
Mycobacterium ulcerans beta-lactamase 0.0153 0.1405 0.3731
Echinococcus multilocularis zinc finger protein 0.0022 0.0038 0.0025
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0021 0.0026 0.0009
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0083 0.0223
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.0969 0.0953
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0209 0.0516
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0491 0.0591
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0037 0.0024
Brugia malayi Importin beta-1 subunit 0.0032 0.0147 0.0161
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.2034 0.2533
Brugia malayi Bromodomain containing protein 0.0079 0.0634 0.0769
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0037 0.0024
Echinococcus granulosus neutral amino acid transporter 0.0788 0.803 1
Trypanosoma brucei hypothetical protein, conserved 0.0153 0.1405 0.4183
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0103 0.0887 0.1085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0037 0.0046
Brugia malayi TAR-binding protein 0.0065 0.0491 0.0591
Entamoeba histolytica hypothetical protein 0.0118 0.1044 0.3499
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0037 0.0024
Loa Loa (eye worm) beta-lactamase 0.0153 0.1405 0.175
Loa Loa (eye worm) hypothetical protein 0.0022 0.0037 0.0046
Schistosoma mansoni aldehyde dehydrogenase 0.0021 0.0026 0.0011
Onchocerca volvulus 0.0153 0.1405 0.1723
Schistosoma mansoni aldehyde dehydrogenase 0.0021 0.0026 0.0011
Trypanosoma brucei glucosidase, putative 0.0038 0.0209 0.0578
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.016 0.1478 0.3927
Trichomonas vaginalis set domain proteins, putative 0.0243 0.234 0.7919
Echinococcus granulosus beta LACTamase domain containing family member 0.0153 0.1405 0.1732
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0469 0.0564
Echinococcus granulosus Excitatory amino acid transporter 0.0788 0.803 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0037 0.0024
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0209 0.0239
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0377 0.3737 0.4641
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0021 0.0026 0.0033
Echinococcus multilocularis neutral amino acid transporter A 0.0788 0.803 1
Echinococcus granulosus excitatory amino acid transporter 2 0.0788 0.803 1
Trichomonas vaginalis D-aminoacylase, putative 0.0153 0.1405 0.473
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0209 0.0654
Schistosoma mansoni hypothetical protein 0.0299 0.2926 0.363
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0338 0.3335 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0318 0.0375
Mycobacterium ulcerans hypothetical protein 0.0153 0.1405 0.3731
Schistosoma mansoni hypothetical protein 0.0118 0.1044 0.1281
Brugia malayi Bromodomain containing protein 0.0039 0.0222 0.0255
Echinococcus multilocularis excitatory amino acid transporter 2 0.0788 0.803 1
Echinococcus granulosus muscleblind protein 0.0465 0.4656 0.5789
Echinococcus granulosus geminin 0.0346 0.3418 0.4244
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0037 0.0024
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0037 0.0024
Loa Loa (eye worm) hypothetical protein 0.0153 0.1405 0.175
Mycobacterium tuberculosis Probable esterase LipL 0.0153 0.1405 0.139
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0037 0.0024
Toxoplasma gondii hypothetical protein 0.0055 0.0379 0.095
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0394 0.0469
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0037 0.0024
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0037 0.0046
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0022
Onchocerca volvulus 0.0029 0.0116 0.0112
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0037 0.0024
Brugia malayi glutathione reductase 0.0049 0.0318 0.0375
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0037 0.0024
Loa Loa (eye worm) hypothetical protein 0.0073 0.057 0.071
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0021 0.0026 0.0026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.2951 1
Chlamydia trachomatis glutamate symporter 0.0788 0.803 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0209 0.0654
Onchocerca volvulus 0.0031 0.0135 0.0136
Schistosoma mansoni hypothetical protein 0.0346 0.3418 0.4244
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0037 0.0024
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0394 0.0469
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0021 0.0026 0.0011
Brugia malayi hypothetical protein 0.0118 0.1044 0.1281
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0037 0.0024
Loa Loa (eye worm) MBCTL1 0.0056 0.0394 0.049
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.1099 0.1083
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.1344 0.1329
Treponema pallidum glutamate/aspartate transporter 0.0349 0.3454 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0802 0.0979
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0118 0.1044 0.1281
Echinococcus multilocularis muscleblind protein 0.0465 0.4656 0.5789
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA 0.0021 0.0026 0.0023
Loa Loa (eye worm) hypothetical protein 0.0056 0.0394 0.049
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.007 0.0065
Echinococcus multilocularis neuropeptide s receptor 0.0522 0.5257 0.6539
Mycobacterium ulcerans aldehyde dehydrogenase 0.0377 0.3737 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0209 0.0493
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0802 0.0979
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0037 0.0024
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.2951 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0037 0.0046
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0021 0.0026 0.0023
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0318 0.0396
Onchocerca volvulus 0.0049 0.0323 0.037
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0306 0.0869
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0037 0.0024
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0713 0.7245 0.9022
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0021 0.0026 0.0009
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0021 0.0026 0.0011
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 0.0021 0.0026 0.0023
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0021 0.0026 0.003
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0153 0.1405 0.175
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0037 0.0024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0802 0.0979
Mycobacterium leprae Probable lipase LipE 0.0153 0.1405 1
Toxoplasma gondii aldehyde dehydrogenase 0.0377 0.3737 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0338 0.3335 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0037 0.0024
Mycobacterium ulcerans aldehyde dehydrogenase 0.0377 0.3737 1
Schistosoma mansoni alpha-glucosidase 0.0149 0.1359 0.1674
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.007 0.0065
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0491 0.0591
Echinococcus multilocularis tumor protein p63 0.0348 0.3441 0.4273
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0021 0.0026 0.0026
Echinococcus granulosus sodium:dicarboxylate symporter 0.0788 0.803 1
Brugia malayi RNA, U transporter 1 0.0092 0.0767 0.0935
Onchocerca volvulus 0.0051 0.0342 0.0394
Toxoplasma gondii thioredoxin reductase 0.0049 0.0318 0.0787
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0802 0.0979
Onchocerca volvulus 0.0153 0.1405 0.1723
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0342 0.0404
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0147 0.0325
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0021 0.0026 0.0011
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA 0.0021 0.0026 0.0023
Brugia malayi follicle stimulating hormone receptor 0.0713 0.7245 0.902
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0788 0.803 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0037 0.0024
Brugia malayi Excitatory amino acid transporter 0.0788 0.803 1
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0021 0.0026 0.0023
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0173 0.1609 0.2004
Schistosoma mansoni bromodomain containing protein 0.0067 0.0508 0.0612
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0033
Schistosoma mansoni transcription factor LCR-F1 0.0118 0.1044 0.1281
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0349 0.3454 0.4288
Brugia malayi steroid hormone receptor 0.0022 0.0037 0.0024
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0377 0.3737 0.3726
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.0021 0.0026 0.0023
Schistosoma mansoni zinc finger protein 0.0022 0.0038 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0037 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0037 0.0046
Schistosoma mansoni alpha-glucosidase 0.0149 0.1359 0.1674
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0209 0.0654
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0394 0.0469
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.0969 0.0953
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.2951 1
Echinococcus multilocularis Excitatory amino acid transporter 0.0788 0.803 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0194 0.183 0.2262
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0306 0.0869
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0209 0.0654
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0037 0.0024
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0323 0.0381
Echinococcus granulosus tar DNA binding protein 0.0065 0.0491 0.0591
Loa Loa (eye worm) excitatory amino acid transporter 0.0788 0.803 1
Schistosoma mansoni hypothetical protein 0.0021 0.0032 0.0018
Brugia malayi RNA binding protein 0.0065 0.0491 0.0591
Mycobacterium tuberculosis Conserved protein 0.0153 0.1405 0.139
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0037 0.0024
Echinococcus granulosus neuropeptide receptor A26 0.0522 0.5257 0.6539
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0021 0.0026 0.0026
Onchocerca volvulus Huntingtin homolog 0.0125 0.1115 0.1361
Giardia lamblia Fructose-bisphosphate aldolase 0.0301 0.2951 1
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0788 0.803 1
Brugia malayi mbt repeat family protein 0.0049 0.0323 0.0381
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.2951 1
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0349 0.3454 0.4288
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0135 0.0146
Echinococcus multilocularis neuropeptide receptor A26 0.0522 0.5257 0.6539
Echinococcus granulosus neutral amino acid transporter A 0.0788 0.803 1
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0021 0.0026 0.0011
Loa Loa (eye worm) hypothetical protein 0.0032 0.0147 0.0183
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0021 0.0026 0.0011
Loa Loa (eye worm) hypothetical protein 0.0022 0.0037 0.0046
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0021 0.0026 0.0026
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0037 0.0024
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0318 0.0375
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0033
Brugia malayi PHD-finger family protein 0.0027 0.0095 0.0097
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0021 0.0026 0.0026
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.007 0.0065
Schistosoma mansoni hypothetical protein 0.0021 0.0026 0.0011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0037 0.0024
Echinococcus multilocularis muscleblind protein 1 0.0465 0.4656 0.5789
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0021 0.0026 0.0023
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0209 0.0654
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0021 0.0026 0.0026
Loa Loa (eye worm) transcription factor SMAD2 0.0244 0.2358 0.2937
Loa Loa (eye worm) aldehyde dehydrogenase 0.0021 0.0026 0.0033
Onchocerca volvulus 0.01 0.0851 0.103
Brugia malayi CXXC zinc finger family protein 0.0029 0.0116 0.0123
Echinococcus granulosus neutral amino acid transporter A 0.0788 0.803 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0153 0.1405 0.1732
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0037 0.0046
Loa Loa (eye worm) hypothetical protein 0.0153 0.1405 0.175
Onchocerca volvulus Huntingtin homolog 0.0125 0.1115 0.1361
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.016 0.1478 0.4403
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0323 0.0381
Echinococcus multilocularis excitatory amino acid transporter 2 0.0788 0.803 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0318 0.0396
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd 0.0021 0.0026 0.0023
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0021 0.0026 0.0023
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0021 0.0026 0.0011
Schistosoma mansoni hypothetical protein 0.0346 0.3418 0.4244
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0037 0.0024
Brugia malayi Pre-SET motif family protein 0.0031 0.0135 0.0146
Trichomonas vaginalis D-aminoacylase, putative 0.0153 0.1405 0.473
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0021 0.0026 0.0009
Brugia malayi ecdysteroid receptor 0.0022 0.0037 0.0024
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0788 0.803 1
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0021 0.0026 0.0009
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0037 0.0024
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0037 0.0024
Brugia malayi MH2 domain containing protein 0.0244 0.2358 0.2921
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.2951 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0338 0.3335 1
Leishmania major mitochondrial DNA polymerase beta 0.0338 0.3335 0.8919
Brugia malayi nuclear hormone receptor 0.0022 0.0037 0.0024
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0135 0.0293
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0318 0.0375
Loa Loa (eye worm) hypothetical protein 0.0153 0.1405 0.175
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.1099 0.1083
Loa Loa (eye worm) hypothetical protein 0.0153 0.1405 0.175
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0209 0.0654
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.2951 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0196 0.0223
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0118 0.1044 0.1281
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0802 0.0998
Mycobacterium tuberculosis Conserved hypothetical protein 0.0178 0.1667 0.1652
Brugia malayi beta-lactamase 0.0153 0.1405 0.1732
Mycobacterium ulcerans esterase/lipase LipP 0.0153 0.1405 0.3731
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0037 0.0046
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 0.2358 0.2937
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0116 0.0123
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0021 0.0026 0.003
Onchocerca volvulus 0.0243 0.234 0.2891
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0021 0.0026 0.0011
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0153 0.1405 0.1732
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0209 0.0654
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0323 0.0381
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0037 0.0024
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0116 0.0145
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0377 0.3737 0.4641
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0037 0.0024
Echinococcus multilocularis cpg binding protein 0.0033 0.0154 0.017
Mycobacterium ulcerans aldehyde dehydrogenase 0.0377 0.3737 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0323 0.0381
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0427 0.108
Loa Loa (eye worm) hypothetical protein 0.0465 0.4656 0.5798
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.2951 1
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0021 0.0026 0.0026
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0318 0.1444
Plasmodium falciparum thioredoxin reductase 0.0049 0.0318 1
Echinococcus multilocularis survival motor neuron protein 1 0.0506 0.5089 0.6329
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0788 0.803 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0135 0.0146
Leishmania major importin beta-1 subunit, putative 0.0026 0.0083 0.0176
Brugia malayi Glycosyl hydrolases family 31 protein 0.0173 0.1609 0.1986
Schistosoma mansoni survival motor neuron protein 0.0103 0.0887 0.1085
Trichomonas vaginalis D-aminoacylase, putative 0.0153 0.1405 0.473
Leishmania major aldehyde dehydrogenase, putative 0.0021 0.0026 0.0023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0802 0.0979
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0377 0.3737 1
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0021 0.0026 0.0026
Mycobacterium tuberculosis Probable hydrolase 0.0153 0.1405 0.139
Loa Loa (eye worm) hypothetical protein 0.0506 0.5089 0.6337
Trypanosoma cruzi hypothetical protein, conserved 0.0153 0.1405 0.4183
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.2951 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0083 0.0223
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0349 0.3454 0.4288
Loa Loa (eye worm) hypothetical protein 0.0051 0.0342 0.0425
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0209 0.0578
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0318 0.0375
Schistosoma mansoni cpg binding protein 0.0033 0.0154 0.017
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0323 0.0381
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0194 0.183 0.2262
Schistosoma mansoni coup transcription factor 0.0022 0.0037 0.0024
Trichomonas vaginalis penicillin-binding protein, putative 0.0153 0.1405 0.473
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0021 0.0026 0.003
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0021 0.0026 0.0023
Onchocerca volvulus 0.0153 0.1405 0.1723
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0021 0.0026 0.0026
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0323 0.0381
Loa Loa (eye worm) hypothetical protein 0.0046 0.0286 0.0356
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0209 0.0654
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0021 0.0026 0.0026
Leishmania major trypanothione reductase 0.0049 0.0318 0.0809
Loa Loa (eye worm) hypothetical protein 0.0042 0.0248 0.0309
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0153 0.1405 0.139
Schistosoma mansoni cpg binding protein 0.0029 0.0116 0.0123
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0037 0.0046
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0153 0.1405 0.139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0037 0.0046
Mycobacterium tuberculosis Probable reductase 0.0111 0.0969 0.0953
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 0.0021 0.0026 0.0023
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0491 0.0591
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.1609 0.1986
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0111 0.0969 0.6839
Brugia malayi Muscleblind-like protein 0.0465 0.4656 0.5789
Onchocerca volvulus 0.0103 0.0887 0.1075
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0323 0.037
Plasmodium vivax glutathione reductase, putative 0.0049 0.0318 0.1444
Leishmania major aldehyde dehydrogenase, putative 0.0021 0.0026 0.0023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.2951 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0153 0.1405 0.1732
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0037 0.0024
Entamoeba histolytica hypothetical protein 0.0118 0.1044 0.3499
Loa Loa (eye worm) hypothetical protein 0.004 0.0222 0.0277
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0021 0.0026 0.0011
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.1344 0.956
Echinococcus granulosus dnaJ subfamily B 0.0418 0.4168 0.518
Schistosoma mansoni importin beta-1 0.0032 0.0147 0.0161
Plasmodium vivax hypothetical protein, conserved 0.0153 0.1405 1
Entamoeba histolytica hypothetical protein 0.0118 0.1044 0.3499
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0021 0.0026 0.0011
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0209 0.0239
Mycobacterium leprae conserved hypothetical protein 0.0153 0.1405 1
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0037 0.0024
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0037 0.0024
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0491 0.0611
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0037 0.0024
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0021 0.0026 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0037 0.0024
Treponema pallidum glutamate transporter 0.0349 0.3454 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0037 0.0024
Mycobacterium tuberculosis Probable lipase LipD 0.0153 0.1405 0.139
Loa Loa (eye worm) hypothetical protein 0.0153 0.1405 0.175
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0323 0.0381
Loa Loa (eye worm) hypothetical protein 0.0022 0.0037 0.0046
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0037 0.0024
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0021 0.0026 0.0026
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0349 0.3454 0.4288
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0471 0.0566
Echinococcus multilocularis neutral amino acid transporter A 0.0788 0.803 1
Schistosoma mansoni alpha glucosidase 0.0038 0.0209 0.0239
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0021 0.0026 0.0026
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0037 0.0024
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0802 0.0979
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0788 0.803 1
Echinococcus multilocularis geminin 0.0346 0.3418 0.4244
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0153 0.1405 0.3731
Toxoplasma gondii ABC1 family protein 0.0153 0.1405 0.3716
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0037 0.0024
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0021 0.0026 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.2951 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0037 0.0046
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0037 0.0024
Schistosoma mansoni aldehyde dehydrogenase 0.0021 0.0026 0.0011
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0021 0.0026 0.0009
Loa Loa (eye worm) glutathione reductase 0.0049 0.0318 0.0396
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0147 0.0389
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0037 0.0024
Treponema pallidum fructose-bisphosphate aldolase 0.0301 0.2951 0.8533
Schistosoma mansoni aldehyde dehydrogenase 0.0021 0.0026 0.0011
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.0306 0.0869
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0021 0.0026 0.0033
Echinococcus multilocularis snurportin 1 0.0345 0.3402 0.4224
Echinococcus granulosus Excitatory amino acid transporter 0.0788 0.803 1
Plasmodium vivax importin-beta 2, putative 0.0032 0.0147 0.0093
Brugia malayi hypothetical protein 0.0506 0.5089 0.6329
Loa Loa (eye worm) hypothetical protein 0.0049 0.0323 0.0402
Mycobacterium ulcerans gamma-glutamyl phosphate reductase 0.0021 0.0026 0.0023
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.0969 0.0953
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0021 0.0026 0.0009
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0209 0.0261
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0021 0.0026 0.003
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0209 0.0654
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0037 0.0024
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0491 0.0591
Schistosoma mansoni aldehyde dehydrogenase 0.0377 0.3737 0.4641
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0318 0.0301
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0083 0.0223
Mycobacterium ulcerans hypothetical protein 0.0178 0.1667 0.4434
Brugia malayi beta-lactamase family protein 0.0153 0.1405 0.1732
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0469 0.0564
Loa Loa (eye worm) hypothetical protein 0.0125 0.1115 0.1389
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0318 0.0907
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0209 0.0654
Brugia malayi Aldehyde dehydrogenase protein 4 0.0021 0.0026 0.0011
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0147 0.0389
Brugia malayi Thioredoxin reductase 0.0049 0.0318 0.0375
Loa Loa (eye worm) hypothetical protein 0.0022 0.0037 0.0046
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0021 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0103 0.0887 0.1085
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0209 0.0654
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0209 0.0239
Echinococcus granulosus excitatory amino acid transporter 3 0.0788 0.803 1
Mycobacterium tuberculosis Conserved protein 0.0153 0.1405 0.139
Echinococcus granulosus importin subunit beta 1 0.0032 0.0147 0.0161
Leishmania major hypothetical protein, conserved 0.0153 0.1405 0.3731
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.1344 0.3568
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0037 0.0024
Mycobacterium ulcerans lipase LipD 0.0153 0.1405 0.3731
Trichomonas vaginalis esterase, putative 0.0153 0.1405 0.473
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0153 0.1405 0.1732
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0209 0.0578
Schistosoma mansoni aldehyde dehydrogenase 0.0021 0.0026 0.0011
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0147 0.0161
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.1099 0.1083
Trichomonas vaginalis penicillin-binding protein, putative 0.0153 0.1405 0.473
Entamoeba histolytica hypothetical protein 0.0118 0.1044 0.3499
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0491 0.0591
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0021 0.0026 0.0026
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0021 0.0026 0.0011
Onchocerca volvulus 0.0022 0.0037 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0802 0.0979
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0021 0.0026 0.0026
Brugia malayi hypothetical protein 0.0125 0.1115 0.137
Leishmania major aldehyde dehydrogenase, putative 0.0021 0.0026 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0037 0.0024
Schistosoma mansoni hypothetical protein 0.0418 0.4168 0.518
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0318 0.0375
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.1609 0.1986
Trypanosoma brucei trypanothione reductase 0.0049 0.0318 0.0907
Brugia malayi mbt repeat family protein 0.0049 0.0323 0.0381
Echinococcus granulosus survival motor neuron protein 1 0.0506 0.5089 0.6329
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0021 0.0026 0.0011
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0021 0.0026 0.0026
Mycobacterium ulcerans gamma-aminobutyraldehyde dehydrogenase 0.0021 0.0026 0.0023
Schistosoma mansoni hypothetical protein 0.0345 0.3402 0.4224
Mycobacterium tuberculosis Conserved protein 0.0153 0.1405 0.139
Mycobacterium ulcerans aldehyde dehydrogenase 0.0021 0.0026 0.0023
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0394 0.0469
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0037 0.0024
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0032 0.004
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0323 0.0402
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0037 0.0024
Echinococcus multilocularis Excitatory amino acid transporter 0.0788 0.803 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0037 0.0013
Loa Loa (eye worm) hypothetical protein 0.0125 0.1115 0.1389
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0037 0.0024
Echinococcus granulosus excitatory amino acid transporter 2 0.0788 0.803 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.016 0.1478 0.4403
Schistosoma mansoni aldehyde dehydrogenase 0.0377 0.3737 0.4641
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0394 0.0469
Echinococcus granulosus snurportin 1 0.0345 0.3402 0.4224
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0394 0.0469
Loa Loa (eye worm) hypothetical protein 0.0022 0.0037 0.0046
Giardia lamblia Alcohol dehydrogenase 0.0021 0.0026 0.003
Echinococcus multilocularis dnaJ subfamily B 0.0418 0.4168 0.518
Loa Loa (eye worm) hypothetical protein 0.0465 0.4656 0.5798
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.0969 0.0953
Mycobacterium tuberculosis Probable lipase LipE 0.0153 0.1405 0.139
Schistosoma mansoni cpg binding protein 0.0033 0.0154 0.017
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.1099 0.7777
Loa Loa (eye worm) hypothetical protein 0.0153 0.1405 0.175
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0802 0.0979
Loa Loa (eye worm) hypothetical protein 0.0022 0.0037 0.0046
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.0969 0.0953
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0037 0.0013
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0037 0.0013
Brugia malayi aldehyde dehydrogenase 0.0021 0.0026 0.0011
Echinococcus granulosus lysosomal alpha glucosidase 0.0173 0.1609 0.1986

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) > 100 uM 50% cytotoxic concentration required to inhibit HRV-14 infected H1HeLa cells ChEMBL. 11985469
CC50 (functional) > 100 uM 50% cytotoxic concentration required to inhibit HRV-14 infected H1HeLa cells ChEMBL. 11985469
EC50 (binding) 0 uM Ability to inactivate Human Rhinovirus 10 Protease 3C; ND is not determined ChEMBL. 11985469
EC50 (binding) = 0.16 uM Inhibition of Human Rhinovirus 14 (HRV14) Protease 3C ChEMBL. 11985469
EC50 (binding) = 0.16 uM Inhibition of Human Rhinovirus 14 (HRV14) Protease 3C ChEMBL. 11985469
EC50 (binding) = 0.46 uM 50% effective concentration required to inhibit Human Rhinovirus 10 Protease 3C ChEMBL. 11985469
EC50 (binding) = 0.46 uM 50% effective concentration required to inhibit Human Rhinovirus 10 Protease 3C ChEMBL. 11985469
EC50 (binding) = 0.65 uM 50% effective concentration required to inhibit Human Rhinovirus 2 Protease 3C ChEMBL. 11985469
EC50 (binding) = 0.65 uM 50% effective concentration required to inhibit Human Rhinovirus 2 Protease 3C ChEMBL. 11985469
EC50 (binding) = 5.1 uM 50% effective concentration required to inhibit Human Rhinovirus 1A Protease 3C ChEMBL. 11985469
EC50 (binding) = 5.1 uM 50% effective concentration required to inhibit Human Rhinovirus 1A Protease 3C ChEMBL. 11985469
K obs / 1 (binding) 0 M-1 s-1 Ability to inactivate Human Rhinovirus 1A Protease 3C; not determined ChEMBL. 11985469
K obs / 1 (binding) = 385 M-1 s-1 Ability to inactivate Human Rhinovirus 2 Protease 3C ChEMBL. 11985469
K obs / 1 (binding) = 385 M-1 s-1 Ability to inactivate Human Rhinovirus 2 Protease 3C ChEMBL. 11985469
K obs / 1 (binding) = 2200 M-1 s-1 Ability to inactivate Human Rhinovirus 16 Protease 3C ChEMBL. 11985469
K obs / 1 (binding) = 2200 M-1 s-1 Ability to inactivate Human Rhinovirus 16 Protease 3C ChEMBL. 11985469
K obs / 1 (binding) = 19700 M-1 s-1 Rate of inactivation of Human Rhinovirus 14 (HRV14) Protease 3C ChEMBL. 11985469
K obs / 1 (binding) = 19700 M-1 s-1 Rate of inactivation of Human Rhinovirus 14 (HRV14) Protease 3C ChEMBL. 11985469
ND (binding) 0 50% effective concentration required to inhibit Human Rhinovirus 16 Protease 3C; not determined ChEMBL. 11985469

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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