Detailed information for compound 1013155

Basic information

Technical information
  • TDR Targets ID: 1013155
  • Name: [(3aS,5S,5aS,8aR,9S,9aS)-5,8a-dimethyl-1-meth ylidene-2,4,8-trioxo-5,5a,9,9a-tetrahydro-3aH -azuleno[6,5-b]furan-9-yl] (Z)-2-methylbut-2- enoate
  • MW: 358.385 | Formula: C20H22O6
  • H donors: 0 H acceptors: 4 LogP: 2.35 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C=C(\C(=O)O[C@H]1[C@@H]2C(=C)C(=O)O[C@@H]2C(=O)[C@H]([C@H]2[C@@]1(C)C(=O)C=C2)C)/C
  • InChi: 1S/C20H22O6/c1-6-9(2)18(23)26-17-14-11(4)19(24)25-16(14)15(22)10(3)12-7-8-13(21)20(12,17)5/h6-8,10,12,14,16-17H,4H2,1-3,5H3/b9-6-/t10-,12-,14+,16-,17-,20-/m0/s1
  • InChiKey: YPIMMVOHCVOXKT-CXMZHGGDSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(3aS,5S,5aS,8aR,9S,9aS)-5,8a-dimethyl-1-methylene-2,4,8-trioxo-5,5a,9,9a-tetrahydro-3aH-azuleno[6,5-b]furan-9-yl] (Z)-2-methylbut-2-enoate
  • (Z)-2-methylbut-2-enoic acid [(3aS,5S,5aS,8aR,9S,9aS)-5,8a-dimethyl-1-methylene-2,4,8-trioxo-5,5a,9,9a-tetrahydro-3aH-azuleno[6,5-b]furan-9-yl] ester
  • (Z)-2-methylbut-2-enoic acid [(3aS,5S,5aS,8aR,9S,9aS)-2,4,8-triketo-5,8a-dimethyl-1-methylene-5,5a,9,9a-tetrahydro-3aH-azuleno[5,6-d]furan-9-yl] ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0091 0.0409 0.1423
Schistosoma mansoni hypothetical protein 0.0036 0.0105 0.0105
Brugia malayi beta-lactamase 0.0037 0.011 0.0384
Plasmodium vivax hypothetical protein, conserved 0.0037 0.011 0.0886
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0026 0.0048 0.1183
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0161 0.0579
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0044 0.0044
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0019 0.0014 0.0014
Onchocerca volvulus Matrilysin homolog 0.0174 0.0862 0.435
Brugia malayi intermediate filament protein 0.0046 0.016 0.0557
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0242 0.1234 0.4293
Schistosoma mansoni jumonji/arid domain-containing protein 0.0033 0.0089 0.0089
Onchocerca volvulus 0.0378 0.1982 1
Schistosoma mansoni lamin 0.0046 0.016 0.016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.0641 0.0641
Onchocerca volvulus Protein ultraspiracle homolog 0.0025 0.0044 0.0223
Echinococcus multilocularis ecdysone induced protein 78C 0.0025 0.0044 0.0044
Mycobacterium ulcerans hypothetical protein 0.0037 0.011 0.0824
Loa Loa (eye worm) matrixin family protein 0.0141 0.068 0.2366
Schistosoma mansoni transient receptor potential channel 0.0063 0.0252 0.0252
Schistosoma mansoni lipoxygenase 0.007 0.0294 0.0294
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0044 0.0153
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0264 0.0264
Toxoplasma gondii PHD-finger domain-containing protein 0.0025 0.0044 0.0813
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0134 0.0641 0.0641
Loa Loa (eye worm) steroid hormone receptor 0.0025 0.0044 0.0153
Plasmodium vivax ataxin-2 like protein, putative 0.0043 0.0144 0.1156
Brugia malayi latrophilin 2 splice variant baaae 0.0165 0.0815 0.2833
Loa Loa (eye worm) hypothetical protein 0.0091 0.0409 0.1423
Loa Loa (eye worm) hypothetical protein 0.0076 0.0327 0.1139
Loa Loa (eye worm) pax transcription factor protein 2 0.0205 0.1035 0.3599
Loa Loa (eye worm) hypothetical protein 0.0032 0.0084 0.0291
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0044 0.0147 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0044 0.0153
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0243 0.1244 1
Toxoplasma gondii ABC1 family protein 0.0037 0.011 0.2314
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0044 0.0153
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0091 0.0409 0.1423
Schistosoma mansoni mixed-lineage leukemia protein mll 0.011 0.0513 0.0513
Loa Loa (eye worm) acetylcholinesterase 1 0.0541 0.2875 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0025 0.0044 0.0044
Brugia malayi Matrixin family protein 0.0071 0.0296 0.1031
Brugia malayi chromobox protein homolog 3 0.0046 0.0161 0.056
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0025 0.0044 0.0044
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0134 0.0641 0.2229
Onchocerca volvulus Bile acid receptor homolog 0.0025 0.0044 0.0223
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0161 0.0812
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0781 0.4197 0.4197
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0025 0.0044 0.0153
Onchocerca volvulus Matrilysin homolog 0.0071 0.0296 0.1495
Trichomonas vaginalis inositol monophosphatase, putative 0.0044 0.0147 0.0526
Brugia malayi Heterochromatin protein 1 0.0082 0.036 0.125
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0091 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.0316 0.1644 0.5717
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.011 0.0824
Brugia malayi Matrixin family protein 0.0185 0.0925 0.3218
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0087 0.0383 0.1422
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.007 0.0292 0.2291
Trypanosoma cruzi transcription factor btf3, putative 0.003 0.0071 0.1875
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0008 0.0068
Brugia malayi follicle stimulating hormone receptor 0.0206 0.1038 0.3611
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.008 0.0344 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.011 0.0386
Giardia lamblia Fructose-bisphosphate aldolase 0.0499 0.2645 1
Brugia malayi RNA binding protein 0.0065 0.0264 0.0919
Echinococcus granulosus FTZ F1 alpha 0.0025 0.0044 0.0044
Brugia malayi Matrixin family protein 0.0071 0.0296 0.1031
Echinococcus granulosus muscleblind protein 0.0316 0.1644 0.1644
Loa Loa (eye worm) hypothetical protein 0.0091 0.0409 0.1423
Echinococcus multilocularis lamin dm0 0.0046 0.016 0.016
Echinococcus granulosus transient receptor potential gamma protein 0.0095 0.0428 0.0428
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0044 0.0044
Schistosoma mansoni gliotactin 0.0091 0.0409 0.0409
Brugia malayi hypothetical protein 0.0209 0.1055 0.3669
Loa Loa (eye worm) ICD-1 protein 0.003 0.0071 0.0248
Echinococcus granulosus jumonji domain containing protein 0.0035 0.0098 0.0098
Schistosoma mansoni intermediate filament proteins 0.0046 0.016 0.016
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0264 0.0264
Echinococcus granulosus transcription factor btf3 0.003 0.0071 0.0071
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0499 0.2645 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0046 0.016 0.0557
Echinococcus granulosus ecdysone induced protein 78C 0.0025 0.0044 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0025 0.0044 0.0153
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.008 0.0344 0.1198
Schistosoma mansoni neuroligin 3 (S09 family) 0.0091 0.0409 0.0409
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0081 0.0355 0.0355
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0499 0.2645 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0025 0.0044 0.0044
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0044 0.0147 0.1123
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.008 0.0344 1
Mycobacterium ulcerans beta-lactamase 0.0037 0.011 0.0824
Brugia malayi CXXC zinc finger family protein 0.0052 0.0193 0.0672
Echinococcus granulosus inositol monophosphatase 1 0.0044 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0091 0.0409 0.1423
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0026 0.0052 0.1308
Loa Loa (eye worm) carboxylesterase 0.0091 0.0409 0.1423
Echinococcus multilocularis microtubule associated protein 2 0.1839 1 1
Onchocerca volvulus 0.0071 0.0296 0.1495
Loa Loa (eye worm) hypothetical protein 0.0037 0.011 0.0384
Echinococcus granulosus cpg binding protein 0.0055 0.0209 0.0209
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.011 0.0384
Loa Loa (eye worm) CXXC zinc finger family protein 0.0052 0.0193 0.0672
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0046 0.0144
Giardia lamblia PHD finger protein 15 0.0025 0.0044 0.0136
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0499 0.2645 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.0428 0.1487
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0091 0.0409 0.0409
Plasmodium falciparum ataxin-2 like protein, putative 0.0043 0.0144 0.1156
Echinococcus multilocularis cpg binding protein 0.0055 0.0209 0.0209
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.011 0.0386
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.0641 0.0641
Onchocerca volvulus Alhambra homolog 0.0025 0.0044 0.0223
Schistosoma mansoni chromobox protein 0.0082 0.036 0.036
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0044 0.0154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0025 0.0044 0.0153
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0087 0.0383 0.1422
Echinococcus multilocularis carboxylesterase 5A 0.0541 0.2875 0.2875
Brugia malayi Bromodomain containing protein 0.0025 0.0044 0.0154
Echinococcus multilocularis acetylcholinesterase 0.0541 0.2875 0.2875
Loa Loa (eye worm) hypothetical protein 0.0025 0.0044 0.0153
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0206 0.1038 0.3611
Echinococcus multilocularis chromobox protein 1 0.0082 0.036 0.036
Echinococcus granulosus GPCR family 2 0.0076 0.0327 0.0327
Brugia malayi Carboxylesterase family protein 0.0541 0.2875 1
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0255 0.1309 0.1309
Schistosoma mansoni hypothetical protein 0.0076 0.0327 0.0327
Echinococcus granulosus neuropeptide s receptor 0.1235 0.6689 0.6689
Loa Loa (eye worm) hypothetical protein 0.0209 0.1055 0.3669
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0071 0.0239
Schistosoma mansoni ap endonuclease 0.0018 0.0008 0.0008
Schistosoma mansoni inositol monophosphatase 0.0044 0.0147 0.0147
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.008 0.0344 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0134 0.0641 0.0641
Trypanosoma brucei transcription factor BTF3, putative 0.003 0.0071 0.1875
Echinococcus granulosus neuropeptide receptor A26 0.1235 0.6689 0.6689
Onchocerca volvulus 0.0081 0.0355 0.179
Brugia malayi beta-lactamase family protein 0.0037 0.011 0.0384
Brugia malayi cytoplasmic intermediate filament protein 0.0025 0.0043 0.0149
Schistosoma mansoni chromobox protein 0.0082 0.036 0.036
Loa Loa (eye worm) hypothetical protein 0.0025 0.0044 0.0153
Loa Loa (eye worm) hypothetical protein 0.0025 0.0044 0.0153
Brugia malayi ecdysteroid receptor 0.0025 0.0044 0.0153
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0264 0.0919
Loa Loa (eye worm) matrixin family protein 0.0185 0.0925 0.3218
Echinococcus granulosus lamin dm0 0.0046 0.016 0.016
Brugia malayi MH2 domain containing protein 0.0204 0.1026 0.3568
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0243 0.1244 1
Trichomonas vaginalis spcc417.12 protein, putative 0.0091 0.0409 0.152
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0025 0.0044 0.0153
Loa Loa (eye worm) hypothetical protein 0.0071 0.0296 0.1031
Brugia malayi Inositol-1 0.0044 0.0147 0.0512
Schistosoma mansoni steroid hormone receptor ad4bp 0.0025 0.0044 0.0044
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0076 0.0327 0.0327
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0044 0.0147 0.3153
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0242 0.1234 0.4293
Trypanosoma cruzi transcription factor btf3, putative 0.003 0.0071 0.1875
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0044 0.0044
Echinococcus granulosus dnaJ subfamily B 0.0741 0.3974 0.3974
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0046 0.0144
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0023 0.0023
Loa Loa (eye worm) inositol-1 0.0044 0.0147 0.0512
Brugia malayi Pax transcription factor protein 2 0.0205 0.1035 0.3599
Brugia malayi Carboxylesterase family protein 0.0091 0.0409 0.1423
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0011 0.004
Brugia malayi jmjC domain containing protein 0.0081 0.0355 0.1234
Schistosoma mansoni hypothetical protein 0.0246 0.1257 0.1257
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0101 0.046 0.046
Mycobacterium leprae PROBABLE HYDROLASE 0.007 0.0292 0.1599
Onchocerca volvulus 0.0091 0.0409 0.2064
Echinococcus granulosus tar DNA binding protein 0.0065 0.0264 0.0264
Echinococcus granulosus para nitrobenzyl esterase 0.0091 0.0409 0.0409
Schistosoma mansoni hypothetical protein 0.0165 0.0815 0.0815
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0025 0.0044 0.0044
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0147 0.4132
Brugia malayi jmjC domain containing protein 0.0033 0.0089 0.031
Brugia malayi Calcitonin receptor-like protein seb-1 0.0242 0.1234 0.4293
Loa Loa (eye worm) hypothetical protein 0.0316 0.1644 0.5717
Loa Loa (eye worm) hypothetical protein 0.0541 0.2875 1
Entamoeba histolytica hypothetical protein 0.0036 0.0105 0.0365
Loa Loa (eye worm) MH2 domain-containing protein 0.0204 0.1026 0.3568
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.011 0.011
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0008 0.0068
Brugia malayi beta-NAC-like protein 0.003 0.0071 0.0248
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0011 0.0091
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0025 0.0044 0.0044
Onchocerca volvulus 0.0036 0.0106 0.0536
Echinococcus multilocularis peregrin 0.0025 0.0044 0.0044
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0044 0.0044
Schistosoma mansoni microtubule-associated protein tau 0.1839 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0025 0.0044 0.0153
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0134 0.0641 0.0641
Loa Loa (eye worm) matrix metalloproteinase 0.0071 0.0296 0.1031
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0012 0.0012
Schistosoma mansoni acetylcholinesterase 0.0091 0.0409 0.0409
Brugia malayi Carboxylesterase family protein 0.0541 0.2875 1
Schistosoma mansoni hypothetical protein 0.0076 0.0327 0.0327
Onchocerca volvulus Huntingtin homolog 0.0209 0.1055 0.5324
Loa Loa (eye worm) hypothetical protein 0.0043 0.0144 0.05
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0025 0.0044 0.0044
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0011 0.0091
Entamoeba histolytica hypothetical protein 0.003 0.0071 0.0239
Onchocerca volvulus 0.0037 0.011 0.0556
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0028 0.0059 0.041
Brugia malayi Cytochrome P450 family protein 0.0019 0.0011 0.004
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0264 0.0264
Echinococcus multilocularis thyroid hormone receptor alpha 0.0025 0.0044 0.0044
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.0122 0.0104
Schistosoma mansoni hypothetical protein 0.0019 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0091 0.0409 0.1423
Echinococcus multilocularis BC026374 protein (S09 family) 0.0091 0.0409 0.0409
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0076 0.0327 0.0327
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0025 0.0044 0.0044
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0089 0.031
Schistosoma mansoni cpg binding protein 0.0052 0.0193 0.0193
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0243 0.1244 0.9993
Brugia malayi Matrixin family protein 0.0071 0.0296 0.1031
Onchocerca volvulus Matrix metalloproteinase homolog 0.0141 0.068 0.3433
Loa Loa (eye worm) hypothetical protein 0.0209 0.1055 0.3669
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0011 0.004
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.011 0.0386
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0022 0.003 0.003
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0025 0.0044 0.0044
Onchocerca volvulus 0.0037 0.011 0.0556
Trypanosoma cruzi PAB1-binding protein , putative 0.0043 0.0144 0.4028
Mycobacterium ulcerans carboxylesterase, LipT 0.0091 0.0409 0.3241
Leishmania major basic transcription factor 3a, putative 0.003 0.0071 0.1875
Onchocerca volvulus 0.0037 0.011 0.0556
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0122 0.0919
Echinococcus multilocularis geminin 0.0451 0.2386 0.2386
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0025 0.0044 0.0153
Trichomonas vaginalis esterase, putative 0.0037 0.011 0.0386
Entamoeba histolytica hypothetical protein 0.0036 0.0105 0.0365
Schistosoma mansoni hypothetical protein 0.0451 0.2386 0.2386
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.008 0.0344 0.2717
Loa Loa (eye worm) RNA binding protein 0.0065 0.0264 0.0919
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.011 0.0384
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0025 0.0044 0.0153
Echinococcus granulosus PHD finger protein rhinoceros 0.0025 0.0044 0.0044
Schistosoma mansoni lozenge 0.0047 0.0168 0.0168
Schistosoma mansoni lamin 0.0046 0.016 0.016
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0011 0.0025
Entamoeba histolytica hypothetical protein 0.0036 0.0105 0.0365
Loa Loa (eye worm) hypothetical protein 0.0037 0.011 0.0384
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0043 0.0142 0.0493
Leishmania major hypothetical protein, conserved 0.0037 0.011 0.3032
Onchocerca volvulus Heterochromatin protein 1 homolog 0.005 0.018 0.0909
Loa Loa (eye worm) hypothetical protein 0.0165 0.0815 0.2833
Brugia malayi hypothetical protein 0.0028 0.006 0.0209
Loa Loa (eye worm) hypothetical protein 0.0378 0.1982 0.6893
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0067 0.0232
Loa Loa (eye worm) heterochromatin protein 1 0.0082 0.036 0.125
Loa Loa (eye worm) carboxylesterase 0.0541 0.2875 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0025 0.0044 0.0044
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0101 0.046 0.046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0025 0.0044 0.0153
Onchocerca volvulus Huntingtin homolog 0.0209 0.1055 0.5324
Onchocerca volvulus 0.0052 0.0193 0.0975
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0087 0.0383 0.3081
Loa Loa (eye worm) hypothetical protein 0.0071 0.0296 0.1031
Echinococcus multilocularis acetylcholinesterase 0.0541 0.2875 0.2875
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0541 0.2875 0.2875
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0046 0.0144
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.011 0.0386
Loa Loa (eye worm) carboxylesterase 0.0091 0.0409 0.1423
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0025 0.0044 0.0153
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0499 0.2645 1
Schistosoma mansoni transcription factor btf3 0.003 0.0071 0.0071
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0255 0.1309 0.1309
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0044 0.0044
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.0147 0.0526
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0019 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0087 0.0298
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0011 0.004
Echinococcus multilocularis neuropeptide receptor A26 0.1235 0.6689 0.6689
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0101 0.0101
Onchocerca volvulus 0.0091 0.0409 0.2064
Loa Loa (eye worm) jmjC domain-containing protein 0.0051 0.019 0.0659
Brugia malayi hypothetical protein 0.0378 0.1982 0.6893
Treponema pallidum fructose-bisphosphate aldolase 0.0499 0.2645 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0044 0.0153
Schistosoma mansoni lipoxygenase 0.0101 0.046 0.046
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.011 0.3032
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0025 0.0044 0.0044
Brugia malayi steroid hormone receptor 0.0025 0.0044 0.0153
Echinococcus multilocularis Protein lozenge 0.0047 0.0168 0.0168
Brugia malayi photoreceptor-specific nuclear receptor 0.0025 0.0044 0.0153
Brugia malayi Hemopexin family protein 0.0081 0.0355 0.1234
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0025 0.0044 0.0153
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0091 0.0409 0.3241
Echinococcus multilocularis lamin 0.0046 0.016 0.016
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0071 0.0239
Trichomonas vaginalis chromobox protein, putative 0.0082 0.036 0.1332
Schistosoma mansoni hypothetical protein 0.0081 0.0355 0.0355
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0025 0.0044 0.0153
Schistosoma mansoni cpg binding protein 0.0055 0.0209 0.0209
Schistosoma mansoni jumonji/arid domain-containing protein 0.0033 0.0089 0.0089
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0091 0.0409 0.0409
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.008 0.0344 0.0344
Echinococcus granulosus chromobox protein 1 0.0082 0.036 0.036
Echinococcus multilocularis lysine specific demethylase 5A 0.003 0.0073 0.0073
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0016 0.003
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0008 0.0029
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0022 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0025 0.0044 0.0044
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0044 0.0153
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0244 0.1245 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0071 0.0239
Schistosoma mansoni ap endonuclease 0.0018 0.0008 0.0008
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0025 0.0043 0.0149
Echinococcus granulosus carboxylesterase 5A 0.0541 0.2875 0.2875
Mycobacterium tuberculosis Conserved protein 0.0037 0.011 0.0824
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0052 0.0193 0.419
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0025 0.0044 0.0153
Brugia malayi Cytochrome P450 family protein 0.0029 0.0067 0.0232
Onchocerca volvulus 0.0025 0.0044 0.0223
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0243 0.1244 0.9992
Echinococcus multilocularis dnaJ subfamily B 0.0741 0.3974 0.3974
Echinococcus granulosus chromobox protein 1 0.0082 0.036 0.036
Leishmania major cytochrome p450-like protein 0.0019 0.0011 0.0091
Brugia malayi Cytochrome P450 family protein 0.0019 0.0011 0.004
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.011 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0161 0.0579
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0105 0.0105
Echinococcus granulosus X box binding protein 1 0.0246 0.1257 0.1257
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.011 0.011
Schistosoma mansoni retinoic acid receptor RXR 0.0025 0.0044 0.0044
Loa Loa (eye worm) runx1 0.0047 0.0168 0.0584
Brugia malayi hypothetical protein 0.0043 0.0144 0.05
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0011 0.0091
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0081 0.0355 0.0355
Loa Loa (eye worm) hypothetical protein 0.0025 0.0044 0.0153
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0008 0.0008
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0039 0.0137
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0242 0.1234 0.4293
Echinococcus multilocularis inositol monophosphatase 1 0.0044 0.0147 0.0147
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.011 0.0824
Loa Loa (eye worm) hypothetical protein 0.0025 0.0044 0.0154
Brugia malayi glucose-6-phosphate dehydrogenase 0.008 0.0344 0.1198
Schistosoma mansoni RAR-like nuclear receptor 0.0025 0.0044 0.0044
Echinococcus multilocularis neuroligin 0.0091 0.0409 0.0409
Schistosoma mansoni coup transcription factor 0.0025 0.0044 0.0044
Echinococcus multilocularis transient receptor potential gamma protein 0.0095 0.0428 0.0428
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0025 0.0044 0.0044
Brugia malayi Steroid receptor seven-up type 2 0.0025 0.0044 0.0153
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0101 0.0351
Trichomonas vaginalis chromobox protein, putative 0.005 0.018 0.0651
Loa Loa (eye worm) hypothetical protein 0.0541 0.2875 1
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0091 0.0409 0.152
Toxoplasma gondii PHD-finger domain-containing protein 0.0025 0.0044 0.0813
Echinococcus granulosus acetylcholinesterase 0.0541 0.2875 0.2875
Brugia malayi Latrophilin receptor protein 2 0.0076 0.0327 0.1139
Plasmodium falciparum basic transcription factor 3b, putative 0.003 0.0071 0.0574
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0046 0.0144
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0025 0.0044 0.0044
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0044 0.0355
Loa Loa (eye worm) hypothetical protein 0.007 0.0292 0.1015
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0147 0.4132
Loa Loa (eye worm) hypothetical protein 0.0037 0.011 0.0384
Echinococcus multilocularis transient receptor potential ion channel A 0.0092 0.041 0.041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.0641 0.0641
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0147 0.4132
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0025 0.0044 0.0153
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0046 0.0144
Brugia malayi Intermediate filament tail domain containing protein 0.0046 0.016 0.0557
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0091 0.0409 0.3241
Toxoplasma gondii NAC domain-containing protein 0.003 0.0071 0.1431
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0025 0.0044 0.0223
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0264 0.0264
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0499 0.2645 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0076 0.0327 0.1139
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.011 0.0824
Entamoeba histolytica transcription factor BTF3, putative 0.003 0.0071 0.0239
Loa Loa (eye worm) beta-lactamase 0.0037 0.011 0.0384
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0076 0.0327 0.1139
Brugia malayi Carboxylesterase family protein 0.0091 0.0409 0.1423
Schistosoma mansoni jumonji domain containing protein 0.0065 0.0263 0.0263
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0076 0.0327 0.0327
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.008 0.0344 0.0344
Trichomonas vaginalis chromobox protein, putative 0.0082 0.036 0.1332
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0046 0.0144
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0025 0.0044 0.0044
Echinococcus multilocularis para nitrobenzyl esterase 0.0091 0.0409 0.0409
Echinococcus multilocularis jumonji domain containing protein 0.0035 0.0098 0.0098
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.008 0.0344 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.1202 0.9654
Loa Loa (eye worm) hypothetical protein 0.0059 0.0234 0.0815
Schistosoma mansoni transient receptor potential channel 4 0.0095 0.0428 0.0428
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0499 0.2645 1
Brugia malayi Carboxylesterase family protein 0.0091 0.0409 0.1423
Echinococcus granulosus geminin 0.0451 0.2386 0.2386
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.011 0.0824
Loa Loa (eye worm) intermediate filament protein 0.0046 0.016 0.0557
Loa Loa (eye worm) transcription factor SMAD2 0.0204 0.1026 0.3568
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.011 0.0824
Loa Loa (eye worm) hypothetical protein 0.0045 0.0156 0.0541
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0091 0.0409 0.0409
Brugia malayi Carboxylesterase family protein 0.0091 0.0409 0.1423
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0499 0.2645 1
Trypanosoma brucei PAB1-binding protein , putative 0.0043 0.0144 0.4028
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.011 0.0386
Brugia malayi beta-lactamase family protein 0.0037 0.011 0.0384
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0087 0.0383 0.3081
Onchocerca volvulus 0.0091 0.0409 0.2064
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0008 0.0008
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.011 0.0824
Schistosoma mansoni hypothetical protein 0.0741 0.3974 0.3974
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0134 0.0641 0.2229
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0046 0.0144
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.011 0.3032
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0087
Echinococcus multilocularis FTZ F1 alpha 0.0025 0.0044 0.0044
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0038 0.0117 0.0117
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.008 0.0344 0.1274
Echinococcus granulosus neuroligin 0.0091 0.0409 0.0409
Brugia malayi hypothetical protein 0.0036 0.0105 0.0364
Brugia malayi Muscleblind-like protein 0.0316 0.1644 0.5717
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0264 0.0264
Onchocerca volvulus 0.0205 0.1035 0.5221
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0134 0.0641 0.0641
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0264 0.0919
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0052 0.0193 0.1492
Loa Loa (eye worm) hypothetical protein 0.0046 0.0161 0.056
Echinococcus granulosus lamin 0.0046 0.016 0.016
Echinococcus multilocularis muscleblind protein 1 0.0316 0.1644 0.1644
Echinococcus multilocularis PHD finger protein rhinoceros 0.0025 0.0044 0.0044
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0025 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0016 0.003
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0008 0.0029
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0044 0.0153
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0244 0.1245 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0087 0.0298
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0104 0.0478 0.0478
Loa Loa (eye worm) hypothetical protein 0.0037 0.011 0.0384
Onchocerca volvulus 0.0091 0.0409 0.2064
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0025 0.0044 0.0153
Trichomonas vaginalis chromobox protein, putative 0.005 0.018 0.0651
Loa Loa (eye worm) hypothetical protein 0.0036 0.0106 0.0369
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0025 0.0044 0.0153
Brugia malayi Matrixin family protein 0.0071 0.0296 0.1031
Onchocerca volvulus 0.0091 0.0409 0.2064
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.008 0.0344 0.0344
Plasmodium falciparum phd finger protein, putative 0.0025 0.0044 0.0355
Schistosoma mansoni cpg binding protein 0.0055 0.0209 0.0209
Leishmania major hypothetical protein, conserved 0.0043 0.0144 0.4028
Loa Loa (eye worm) hypothetical protein 0.0035 0.0101 0.0351
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0044 0.0044
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0264 0.0919
Treponema pallidum hypothetical protein 0.0243 0.1244 0.4686
Schistosoma mansoni transient receptor potential channel 0.0095 0.0428 0.0428
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0044 0.0147 0.0526
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0044 0.0153
Loa Loa (eye worm) hypothetical protein 0.0025 0.0044 0.0153
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0091 0.0409 0.0409
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0044 0.0153
Echinococcus granulosus acetylcholinesterase 0.0541 0.2875 0.2875
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.011 0.3032
Echinococcus granulosus peregrin 0.0025 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0451 0.2386 0.2386
Plasmodium falciparum ataxin-2 like protein, putative 0.0043 0.0144 0.1156
Echinococcus multilocularis transcription factor btf3 0.003 0.0071 0.0071
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.011 0.0824
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0044 0.0153
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0499 0.2645 1
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0252 0.0252
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.011 0.0824
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0087 0.0383 0.1422
Echinococcus granulosus intermediate filament protein 0.0046 0.016 0.016
Onchocerca volvulus 0.0046 0.016 0.0809
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.007 0.0292 0.1015
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0252 0.0252
Echinococcus granulosus lysine specific demethylase 5A 0.0033 0.0089 0.0089
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0037 0.011 0.0384
Schistosoma mansoni BC026374 protein (S09 family) 0.0091 0.0409 0.0409
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0046 0.0144
Loa Loa (eye worm) hypothetical protein 0.0091 0.0409 0.1423
Mycobacterium ulcerans lipase LipD 0.0037 0.011 0.0824
Schistosoma mansoni inositol monophosphatase 0.0044 0.0147 0.0147
Schistosoma mansoni transient receptor potential channel 0.0063 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0104 0.0478 0.1663
Mycobacterium tuberculosis Conserved protein 0.0037 0.011 0.0824
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0264 0.0264
Echinococcus multilocularis muscleblind protein 0.0316 0.1644 0.1644
Echinococcus granulosus transient receptor potential ion channel A 0.0092 0.041 0.041
Brugia malayi nuclear receptor NHR-88 0.0025 0.0044 0.0153
Echinococcus granulosus BC026374 protein S09 family 0.0091 0.0409 0.0409
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0252 0.0252
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0087 0.0383 0.1422
Loa Loa (eye worm) hypothetical protein 0.0037 0.011 0.0384
Onchocerca volvulus 0.0046 0.016 0.0809
Mycobacterium tuberculosis Conserved protein 0.0037 0.011 0.0824
Echinococcus multilocularis musashi 0.0046 0.016 0.016
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0025 0.0044 0.0044
Echinococcus multilocularis chromobox protein 1 0.0082 0.036 0.036
Echinococcus multilocularis GPCR, family 2 0.0076 0.0327 0.0327
Schistosoma mansoni hypothetical protein 0.0076 0.0327 0.0327
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0499 0.2645 1
Brugia malayi nuclear hormone receptor 0.0025 0.0044 0.0153
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0076 0.0327 0.0327
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0499 0.2645 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.011 0.011
Toxoplasma gondii histone lysine methyltransferase SET1 0.0099 0.0449 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0409 0.1423
Echinococcus multilocularis X box binding protein 1 0.0246 0.1257 0.1257
Mycobacterium ulcerans hydrolase 0.007 0.0292 0.2291
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.011 0.0824
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0147 0.4132
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.0147 0.0526
Entamoeba histolytica hypothetical protein 0.0036 0.0105 0.0365
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0244 0.1245 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0043 0.0144 0.4028
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0103
Schistosoma mansoni hypothetical protein 0.0076 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.0378 0.1982 0.6893
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0087 0.0383 0.8515
Echinococcus multilocularis neuropeptide s receptor 0.1235 0.6689 0.6689
Brugia malayi TAR-binding protein 0.0065 0.0264 0.0919
Plasmodium vivax basic transcription factor 3b, putative 0.003 0.0071 0.0574
Toxoplasma gondii LsmAD domain-containing protein 0.0043 0.0144 0.3074
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0243 0.1244 0.9993
Loa Loa (eye worm) hypothetical protein 0.0046 0.016 0.0557
Mycobacterium tuberculosis Carboxylesterase LipT 0.0091 0.0409 0.3241
Brugia malayi PHD-finger family protein 0.0025 0.0044 0.0154

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -6.879 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.673 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.526 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.406 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.171 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.919 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.848 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.804 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.735 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.541 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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