Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.0902 |
Echinococcus granulosus | cpg binding protein | 0.0029 | 0.4678 | 0.801 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.0902 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0902 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0634 | 0.0987 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.5824 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.5824 | 0.5 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0004 | 0.0109 | 0.0044 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0902 |
Chlamydia trachomatis | 3'(2'),5'-bisphosphate nucleotidase CysQ | 0.0004 | 0.0066 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.8867 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0634 | 0.0987 |
Trichomonas vaginalis | diphosphonucleoside phosphohydrolase, putative | 0.0004 | 0.0066 | 0.0113 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.5824 | 0.5796 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.5824 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0032 | 0.515 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.0902 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.092 | 0.1482 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.0902 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.0634 | 0.0987 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.5824 | 0.6542 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.5824 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0006 | 0.0525 | 0.0902 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0634 | 0.0572 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.5824 | 0.5796 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.4678 | 0.4643 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0.515 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.4393 | 0.7515 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0004 | 0.0066 | 0.0113 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0004 | 0.0066 | 0.0113 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0902 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0902 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0939 | 0.1517 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0939 | 0.1517 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.0902 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.5824 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0902 |
Brugia malayi | Inositol-1 | 0.0036 | 0.5824 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.5824 | 1 |
Giardia lamblia | Hypothetical protein | 0.0004 | 0.0066 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0939 | 0.1517 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0902 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.4393 | 0.4356 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.0525 | 0.0902 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.4678 | 0.4643 |
Onchocerca volvulus | 0.0028 | 0.4393 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0902 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.4393 | 0.7515 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.5824 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0029 | 0.4678 | 0.801 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.5824 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.5824 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0004 | 0.0066 | 0.0113 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.5824 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0525 | 0.0902 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.0634 | 0.0987 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.0525 | 0.0902 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.5824 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.5824 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0902 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.5824 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.0525 | 0.0902 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of 3alpha-HSD | ChEMBL. | 19188072 | |
CC50 (functional) | = 75.1 uM/L | Cytotoxicity against human HeLa cells | ChEMBL. | 19188072 |
GI50 (functional) | = 2.6 ug ml-1 | Growth inhibition of human MCF7 cells | ChEMBL. | 19188072 |
GI50 (functional) | = 3.6 ug ml-1 | Growth inhibition of human HepG2 cells | ChEMBL. | 19188072 |
GI50 (functional) | = 13.4 uM/L | Antiproliferative activity against human K562 cells | ChEMBL. | 19188072 |
GI50 (ADMET) | = 27.1 uM/L | Antiproliferative activity against mouse L929 cells | ChEMBL. | 19188072 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.