Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 1, group H, member 2 | Starlite/ChEMBL | References |
Homo sapiens | nuclear receptor subfamily 1, group H, member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | ecdysteroid receptor | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Onchocerca volvulus | Bile acid receptor homolog | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_134445 | All targets in OG5_134445 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | nuclear receptor subfamily 1, group H, member 3 | 387 aa | 321 aa | 28.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase R153.1, putative | 0.0063 | 0.087 | 0.1391 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0677 | 0.1082 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.0677 | 0.1082 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.5809 | 1 |
Loa Loa (eye worm) | cyclic AMP specific phosphodiesterase PDE4D5A | 0.0063 | 0.087 | 0.1391 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.0677 | 0.1082 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.008 | 0.1517 | 0.5 |
Echinococcus multilocularis | high affinity cAMP specific 3',5' cyclic | 0.0308 | 1 | 1 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.008 | 0.1517 | 0.0708 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.5809 | 1 |
Echinococcus granulosus | geminin | 0.0195 | 0.5809 | 0.5409 |
Echinococcus multilocularis | geminin | 0.0195 | 0.5809 | 0.5409 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0207 | 0.6256 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0207 | 0.6256 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.0677 | 0.1082 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.008 | 0.1517 | 0.2612 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.008 | 0.1517 | 0.5 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.008 | 0.1517 | 0.0708 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.1517 | 0.2425 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.6256 | 1 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.008 | 0.1517 | 0.0708 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.008 | 0.1517 | 0.0708 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.092 uM | Transactivation of LXRbeta | ChEMBL. | 19231176 |
EC50 (binding) | = 0.43 uM | Transactivation of LXRalpha | ChEMBL. | 19231176 |
IC50 (binding) | = 0.083 uM | Binding affinity to LXRbeta | ChEMBL. | 19231176 |
IC50 (binding) | = 0.29 uM | Binding affinity to LXRalpha | ChEMBL. | 19231176 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.