Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0216 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0216 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0216 | 1 | 1 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0216 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0216 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0216 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.7233 | 0.7451 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.7233 | 0.7451 |
Plasmodium falciparum | lysophospholipase, putative | 0.0216 | 1 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.7233 | 0.7451 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0216 | 1 | 1 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.7233 | 0.7451 |
Mycobacterium ulcerans | hypothetical protein | 0.0216 | 1 | 1 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.7233 | 0.7451 |
Brugia malayi | amidase | 0.021 | 0.9706 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0216 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0216 | 1 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.021 | 0.9706 | 1 |
Leishmania major | monoglyceride lipase, putative | 0.0216 | 1 | 0.5 |
Plasmodium vivax | PST-A protein | 0.0216 | 1 | 0.5 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0216 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.7233 | 0.7451 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.9706 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.7233 | 0.7451 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.7233 | 0.7451 |
Plasmodium falciparum | lysophospholipase, putative | 0.0216 | 1 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.7233 | 0.7451 |
Mycobacterium ulcerans | lysophospholipase | 0.0216 | 1 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0216 | 1 | 0.5 |
Schistosoma mansoni | amidase | 0.021 | 0.9706 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0216 | 1 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Plasmodium falciparum | esterase, putative | 0.0216 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.7233 | 0.7451 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0216 | 1 | 0.5 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0216 | 1 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.021 | 0.9706 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.021 | 0.9706 | 1 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0216 | 1 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.7233 | 0.7451 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.021 | 0.9706 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.7233 | 0.7451 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.021 | 0.9706 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.7233 | 0.7451 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.82 uM | Inhibition of human recombinant AChE by Ellman's method | ChEMBL. | 18396354 |
IC50 (binding) | = 1.82 uM | Inhibition of human AChE using acetylthiocholine iodide as substrate by Ellman's assay | ChEMBL. | 21397996 |
IC50 (binding) | > 10 uM | Inhibition of human BChE using butyrylthiocholine iodide as substrate by Ellman's method | ChEMBL. | 21397996 |
IC50 (binding) | > 100 uM | Inhibition of human serum BChE by Ellman's method | ChEMBL. | 18396354 |
Inhibition (binding) | Inhibition of human AChE-induced beta-amyloid (1-40) aggregation at 100 uM by thioflavin-T based fluorimetric assay | ChEMBL. | 21397996 | |
Inhibition (binding) | Inhibition of human recombinant BACE-1 using M-2420 as substrate up to 4 uM incubated for 1 hr prior to substrate addition measured after 15 mins by FRET assay | ChEMBL. | 24681980 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.