Detailed information for compound 101369

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 368.451 | Formula: C16H24N4O4S
  • H donors: 3 H acceptors: 4 LogP: 0.87 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cc(N2CCC(CC2)O)c(cc1C(=O)N=C(N)N)S(=O)(=O)C
  • InChi: 1S/C16H24N4O4S/c1-3-10-8-13(20-6-4-11(21)5-7-20)14(25(2,23)24)9-12(10)15(22)19-16(17)18/h8-9,11,21H,3-7H2,1-2H3,(H4,17,18,19,22)
  • InChiKey: ZYFUTGXZXXXYOA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Oryctolagus cuniculus Sodium/hydrogen exchanger Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi sodium/hydrogen exchanger 3 family protein Get druggable targets OG5_127664 All targets in OG5_127664
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127664 All targets in OG5_127664
Loa Loa (eye worm) sodium/hydrogen exchanger Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus granulosus sodium:hydrogen exchanger 2 (nhe2) Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) Get druggable targets OG5_127664 All targets in OG5_127664
Onchocerca volvulus Sodium\/hydrogen exchanger homolog Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus multilocularis sodium:hydrogen exchanger Get druggable targets OG5_127664 All targets in OG5_127664
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127664 All targets in OG5_127664
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus granulosus sodium:hydrogen exchanger Get druggable targets OG5_127664 All targets in OG5_127664
Giardia lamblia Sodium/hydrogen exchanger 3 Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus granulosus sodium:hydrogen exchanger Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus multilocularis sodium:hydrogen exchanger Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) Get druggable targets OG5_127664 All targets in OG5_127664
Loa Loa (eye worm) sodium/hydrogen exchanger 3 family protein Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 Get druggable targets OG5_127664 All targets in OG5_127664
Onchocerca volvulus Sodium\/hydrogen exchanger homolog Get druggable targets OG5_127664 All targets in OG5_127664
Schistosoma japonicum Sodium/hydrogen exchanger 2, putative Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 Get druggable targets OG5_127664 All targets in OG5_127664
Onchocerca volvulus Sodium\/hydrogen exchanger homolog Get druggable targets OG5_127664 All targets in OG5_127664
Schistosoma japonicum ko:K03316 monovalent cation:H+ antiporter, CPA1 family, putative Get druggable targets OG5_127664 All targets in OG5_127664
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) Get druggable targets OG5_127664 All targets in OG5_127664
Schistosoma mansoni sodium/hydrogen exchanger 2 (nhe2) Get druggable targets OG5_127664 All targets in OG5_127664
Loa Loa (eye worm) NHE-3 Get druggable targets OG5_127664 All targets in OG5_127664
Schistosoma japonicum Sodium/hydrogen exchanger 2, putative Get druggable targets OG5_127664 All targets in OG5_127664
Schistosoma mansoni sodium/hydrogen exchanger Get druggable targets OG5_127664 All targets in OG5_127664
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.0196 0.7557 1
Schistosoma mansoni alpha glucosidase 0.0038 0.0925 0.1398
Entamoeba histolytica cysteine proteinase 2 0.0027 0.0425 0.2315
Echinococcus multilocularis cpg binding protein 0.0061 0.1863 0.2828
Brugia malayi steroid hormone receptor 0.0031 0.0616 0.0616
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0425 0.2315
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0578 0.0873
Entamoeba histolytica cysteine protease, putative 0.0027 0.0425 0.2315
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.1474 0.1521
Trypanosoma brucei glucosidase, putative 0.0038 0.0925 0.1079
Loa Loa (eye worm) hypothetical protein 0.01 0.3499 0.3499
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.0081 0.27 0.4097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0616 0.0616
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0425 0.034
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0616 0.0616
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0425 0.2315
Loa Loa (eye worm) hypothetical protein 0.0031 0.0616 0.0616
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0616 0.0616
Entamoeba histolytica cysteine proteinase, putative 0.0051 0.1474 1
Brugia malayi Cathepsin L-like precursor 0.0051 0.1474 0.1474
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0425 0.034
Schistosoma mansoni cathepsin F (C01 family) 0.0051 0.1474 0.2228
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.659 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0925 0.0903
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.7557 1
Trichomonas vaginalis set domain proteins, putative 0.0231 0.9005 1
Trypanosoma cruzi cysteine peptidase, putative 0.0196 0.7557 1
Loa Loa (eye worm) TAR-binding protein 0.0135 0.4971 0.4971
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0925 0.5979
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.1474 0.1521
Schistosoma mansoni sodium/hydrogen exchanger 3 (nhe3) 0.0019 0.0109 0.0164
Brugia malayi Cathepsin L-like precursor 0.0034 0.0759 0.0759
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0578 0.0873
Entamoeba histolytica cysteine protease, putative 0.0027 0.0425 0.2315
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.01 0.3499 0.5309
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0616 0.0616
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.1474 0.1521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.1474 0.1521
Schistosoma mansoni tar DNA-binding protein 0.0135 0.4971 0.7512
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0102 0.0155
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.7557 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.1474 0.1521
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0616 0.0931
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0616 0.0935
Schistosoma mansoni cpg binding protein 0.0061 0.1863 0.2816
Schistosoma mansoni hypothetical protein 0.0023 0.0283 0.0427
Loa Loa (eye worm) sodium/hydrogen exchanger 3 family protein 0.01 0.3499 0.3499
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.01 0.3499 0.5309
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.1474 0.1521
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0616 0.0616
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0616 0.0571
Echinococcus multilocularis sodium:hydrogen exchanger 0.01 0.3499 0.5309
Loa Loa (eye worm) hypothetical protein 0.003 0.0578 0.0578
Schistosoma mansoni hypothetical protein 0.008 0.2692 0.4068
Entamoeba histolytica cysteine protease, putative 0.0027 0.0425 0.2315
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0616 0.0935
Echinococcus multilocularis GPCR, family 2 0.008 0.2692 0.4085
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0616 0.0616
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0425 0.0406
Plasmodium vivax vivapain-1 0.0027 0.0425 0.2747
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0616 0.0931
Entamoeba histolytica cysteine protease, putative 0.0027 0.0425 0.2315
Loa Loa (eye worm) sodium-hydrogen exchanger NHE1 0.0019 0.0109 0.0109
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0616 0.0935
Echinococcus granulosus cathepsin L 0.0027 0.0425 0.0645
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.1479 0.193
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0051 0.1474 0.1521
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0925 0.5979
Onchocerca volvulus 0.0051 0.1474 0.1535
Onchocerca volvulus Cathepsin L homolog 0.0051 0.1474 0.1535
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0616 0.0935
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0092 0.0092
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.01 0.3499 0.5309
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0925 0.0903
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.1474 0.1521
Loa Loa (eye worm) RNA binding protein 0.0135 0.4971 0.4971
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.1474 0.1924
Loa Loa (eye worm) hypothetical protein 0.0034 0.0759 0.0759
Entamoeba histolytica cysteine protease, putative 0.0027 0.0425 0.2315
Entamoeba histolytica cysteine protease, putative 0.0027 0.0425 0.2315
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0616 0.0616
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.1479 0.1824
Schistosoma mansoni tar DNA-binding protein 0.0135 0.4971 0.7512
Brugia malayi hypothetical protein 0.0033 0.071 0.071
Loa Loa (eye worm) hypothetical protein 0.0052 0.1479 0.1479
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0102 0.0155
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0425 0.0642
Plasmodium vivax SET domain protein, putative 0.003 0.0578 0.3798
Echinococcus multilocularis cysteine protease 0.0051 0.1474 0.2237
Schistosoma mansoni alpha-glucosidase 0.0149 0.5576 0.8427
Loa Loa (eye worm) hypothetical protein 0.0031 0.0616 0.0616
Brugia malayi hypothetical protein 0.0019 0.0109 0.0109
Entamoeba histolytica cysteine protease, putative 0.0027 0.0425 0.2315
Trypanosoma cruzi Na/H antiporter-like protein, putative 0.0019 0.0109 0.011
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0123 0.0187
Echinococcus granulosus sodium:hydrogen exchanger 7 0.0019 0.0109 0.0165
Brugia malayi Calcitonin receptor-like protein seb-1 0.0254 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0759 0.4761
Echinococcus granulosus sodium:hydrogen exchanger 0.01 0.3499 0.5309
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0925 0.2136
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.2692 0.4085
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0051 0.1474 0.9964
Echinococcus granulosus cathepsin l cysteine peptidase 0.0051 0.1474 0.2237
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0925 0.0903
Brugia malayi Cathepsin L-like precursor 0.0017 0.0025 0.0025
Brugia malayi RNA binding protein 0.0135 0.4971 0.4971
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0123 0.002
Brugia malayi sodium/hydrogen exchanger 3 family protein 0.01 0.3499 0.3499
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.7557 1
Mycobacterium leprae probable conserved integral membrane transport protein 0.0019 0.0109 0.5
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0616 0.0935
Plasmodium vivax vivapain-3 0.0027 0.0425 0.2747
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.3254 0.4918
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0578 0.0877
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0027 0.0425 0.053
Plasmodium vivax sodium/hydrogen exchanger 1, putative 0.0019 0.0109 0.0572
Echinococcus multilocularis mitochondrial sodium:hydrogen exchanger 9B2 0.0019 0.0109 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.7557 1
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0425 0.0425
Loa Loa (eye worm) hypothetical protein 0.0031 0.0616 0.0616
Schistosoma mansoni Slc9a7 protein 0.0019 0.0109 0.0164
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0025 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.1474 0.1521
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0616 0.0616
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0616 0.0616
Echinococcus granulosus cathepsin l1 0.0034 0.0759 0.1151
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0425 0.0642
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0578 0.0873
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0925 0.1404
Schistosoma mansoni cpg binding protein 0.0057 0.1726 0.2608
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.7557 1
Onchocerca volvulus 0.0051 0.1474 0.1535
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0616 0.0931
Trypanosoma cruzi cysteine peptidase, putative 0.0196 0.7557 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0925 0.1404
Echinococcus granulosus cathepsin l1 0.0051 0.1474 0.2237
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.01 0.3499 0.5309
Echinococcus granulosus cysteine protease 0.0027 0.0425 0.0645
Echinococcus granulosus tar DNA binding protein 0.0135 0.4971 0.7543
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0616 0.0616
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0616 0.0931
Loa Loa (eye worm) hypothetical protein 0.0034 0.0759 0.0759
Schistosoma mansoni tar DNA-binding protein 0.0135 0.4971 0.7512
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.01 0.3499 0.3811
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0123 0.0187
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0123 0.0123
Brugia malayi Latrophilin receptor protein 2 0.008 0.2692 0.2692
Onchocerca volvulus 0.01 0.3521 0.3835
Brugia malayi Cathepsin L-like cysteine proteinase 0.0034 0.0759 0.0759
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0123 1
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0616 0.0935
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0616 0.0616
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0017 0.0025 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0616 0.0616
Leishmania major cathepsin L-like protease 0.0196 0.7557 1
Schistosoma mansoni tar DNA-binding protein 0.0135 0.4971 0.7512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.1474 0.1521
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0051 0.1474 0.1521
Trypanosoma cruzi cysteine protease, putative 0.0027 0.0425 0.053
Loa Loa (eye worm) hypothetical protein 0.008 0.2692 0.2692
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.7557 1
Entamoeba histolytica cysteine protease, putative 0.0027 0.0425 0.2315
Onchocerca volvulus 0.003 0.0578 0.0527
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0925 0.0903
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0616 0.0931
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0578 0.0877
Plasmodium vivax vivapain-2 0.0051 0.1474 0.9966
Onchocerca volvulus 0.0051 0.1474 0.1535
Brugia malayi Cathepsin L-like precursor 0.0051 0.1474 0.1474
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0616 0.0935
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0925 0.1195
Echinococcus granulosus cpg binding protein 0.0061 0.1863 0.2828
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0123 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0051 0.1474 0.2237
Plasmodium falciparum cysteine proteinase falcipain 1 0.0027 0.0425 0.2307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0759 0.0716
Schistosoma mansoni hypothetical protein 0.008 0.2692 0.4068
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0051 0.1474 0.1474
Loa Loa (eye worm) hypothetical protein 0.0031 0.0616 0.0616
Leishmania major hypothetical protein, conserved 0.0052 0.1479 0.184
Echinococcus granulosus sodium:hydrogen exchanger 2 (nhe2) 0.0081 0.27 0.4097
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0283 0.0429
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0616 0.0935
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0616 0.0931
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.3254 0.4938
Loa Loa (eye worm) fibroinase 0.0051 0.1474 0.1474
Schistosoma mansoni sodium/hydrogen exchanger 2 (nhe2) 0.01 0.3499 0.5287
Leishmania major cysteine peptidase A (CPA) 0.0051 0.1474 0.1834
Loa Loa (eye worm) hypothetical protein 0.01 0.3499 0.3499
Schistosoma mansoni hypothetical protein 0.0019 0.0109 0.0164
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.1474 0.1521
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.7557 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0759 0.0716
Loa Loa (eye worm) hypothetical protein 0.0174 0.6618 0.6618
Leishmania major cathepsin L-like protease 0.0196 0.7557 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.1474 0.1521
Leishmania major cathepsin L-like protease 0.0051 0.1474 0.1834
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.01 0.3499 0.3811
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0051 0.1474 0.9964
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0123 0.0123
Brugia malayi Pre-SET motif family protein 0.003 0.0578 0.0578
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.048 0.0729
Trypanosoma cruzi cysteine peptidase, putative 0.0196 0.7557 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.4479 0.6768
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0925 0.0903
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0759 0.1147
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.7834 0.7834
Onchocerca volvulus Sodium\/hydrogen exchanger homolog 0.01 0.3499 0.3811
Loa Loa (eye worm) cysteine protease 0.0051 0.1474 0.1474
Brugia malayi Cathepsin L-like precursor 0.0051 0.1474 0.1474
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0425 0.0425
Schistosoma mansoni hypothetical protein 0.008 0.2692 0.4068
Schistosoma mansoni hypothetical protein 0.008 0.2692 0.4068
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.1479 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0616 0.0931
Echinococcus granulosus cathepsin L cysteine proteinase 0.0051 0.1474 0.2237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.1474 0.1521
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0616 0.0616
Loa Loa (eye worm) hypothetical protein 0.0034 0.0759 0.0759
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.1726 0.1726
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0616 0.0935
Schistosoma mansoni alpha-glucosidase 0.0149 0.5576 0.8427
Brugia malayi Glycosyl hydrolases family 31 protein 0.0173 0.659 0.659
Echinococcus multilocularis cysteine protease 0.0051 0.1474 0.2237
Loa Loa (eye worm) hypothetical protein 0.0031 0.0616 0.0616
Entamoeba histolytica cysteine proteinase 1, putative 0.0027 0.0425 0.2315
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0425 0.0406
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.3254 0.4938
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0616 0.0616
Echinococcus granulosus sodium:hydrogen exchanger 0.01 0.3499 0.5309
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.3254 0.4938
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.3254 0.3254
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0616 0.0616
Onchocerca volvulus 0.0051 0.1474 0.1535
Onchocerca volvulus 0.0051 0.1474 0.1535
Echinococcus multilocularis cathepsin L cysteine protease 0.0051 0.1474 0.2237
Entamoeba histolytica cysteine protease, putative 0.0027 0.0425 0.2315
Brugia malayi latrophilin 2 splice variant baaae 0.0174 0.6618 0.6618
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0616 0.0935
Plasmodium falciparum cysteine proteinase falcipain 3 0.0051 0.1474 0.9964
Leishmania major cathepsin L-like protease 0.0051 0.1474 0.1834
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0123 0.013
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0616 0.0935
Entamoeba histolytica cysteine proteinase, putative 0.0051 0.1474 1
Leishmania major cathepsin L-like protease 0.0051 0.1474 0.1834
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.2692 0.4085
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0102 0.0102
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0425 0.053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.1474 0.1521
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.1474 0.1521
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0254 1 1
Leishmania major cathepsin L-like protease 0.0051 0.1474 0.1834
Schistosoma mansoni sodium/hydrogen exchanger 0.01 0.3499 0.5287
Schistosoma mansoni ap endonuclease 0.0019 0.0123 0.0186
Echinococcus multilocularis cathepsin L cysteine protease 0.0051 0.1474 0.2237
Brugia malayi Cathepsin L-like precursor 0.0034 0.0759 0.0759
Loa Loa (eye worm) hypothetical protein 0.0031 0.0616 0.0616
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0578 0.0873
Schistosoma mansoni hypothetical protein 0.0174 0.6618 1
Echinococcus granulosus mitochondrial sodium:hydrogen exchanger 9B2 0.0019 0.0109 0.0165
Plasmodium vivax vivapain-2 0.0051 0.1474 0.9966
Brugia malayi ecdysteroid receptor 0.0031 0.0616 0.0616
Brugia malayi Cathepsin L-like precursor 0.0051 0.1474 0.1474
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.1479 0.3586
Echinococcus granulosus lysosomal alpha glucosidase 0.0173 0.659 1
Brugia malayi Papain family cysteine protease containing protein 0.0051 0.1474 0.1474
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0616 0.0616
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.1479 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.1474 0.1521
Schistosoma mansoni coup transcription factor 0.0031 0.0616 0.0931
Loa Loa (eye worm) ctsf protein 0.0051 0.1474 0.1474
Loa Loa (eye worm) hypothetical protein 0.0019 0.0109 0.0109
Echinococcus multilocularis sodium:hydrogen exchanger 0.01 0.3499 0.5309
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0616 0.0616
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0123 1
Loa Loa (eye worm) hypothetical protein 0.01 0.3499 0.3499
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.659 1
Onchocerca volvulus Cathepsin F homolog 0.0051 0.1474 0.1535
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.1479 1
Onchocerca volvulus 0.0057 0.1726 0.1818
Leishmania major cathepsin L-like protease 0.0051 0.1474 0.1834
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.7557 1
Schistosoma mansoni cathepsin s 0.0017 0.0025 0.0038
Schistosoma mansoni hypothetical protein 0.0019 0.0109 0.0164
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0616 0.0931
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0616 0.0616
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0925 0.1096
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0616 0.0931
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0425 0.0642
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0616 0.0931
Onchocerca volvulus 0.0051 0.1474 0.1535
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0578 0.0877
Brugia malayi CXXC zinc finger family protein 0.0057 0.1726 0.1726
Brugia malayi Cathepsin L-like precursor 0.0051 0.1474 0.1474
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0616 0.0931
Onchocerca volvulus 0.0031 0.0616 0.0571
Onchocerca volvulus Cathepsin L homolog 0.0051 0.1474 0.1535
Brugia malayi cathepsin F-like cysteine proteinase 0.0017 0.0025 0.0025
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0123 0.0107
Trypanosoma cruzi cysteine proteinase, putative 0.0027 0.0425 0.053
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0616 0.0571
Brugia malayi nuclear receptor NHR-88 0.0031 0.0616 0.0616
Brugia malayi hypothetical protein 0.0052 0.1479 0.1479
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0925 0.0903
Loa Loa (eye worm) hypothetical protein 0.0254 1 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0616 0.0571
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0425 0.2315
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.7557 1
Loa Loa (eye worm) sodium/hydrogen exchanger 0.01 0.3499 0.3499
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0616 0.0935
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0123 0.0107
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.7557 1
Brugia malayi Pre-SET motif family protein 0.0203 0.7834 0.7834
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0925 0.0925
Entamoeba histolytica cysteine protease, putative 0.0027 0.0425 0.2315
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.1474 0.1521
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0616 0.0935
Echinococcus multilocularis tar DNA binding protein 0.0135 0.4971 0.7543
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.1474 0.1521
Brugia malayi Sodium/hydrogen exchanger 8 0.0019 0.0109 0.0109
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0616 0.0616
Schistosoma mansoni ap endonuclease 0.0019 0.0123 0.0186
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.1474 0.1521
Loa Loa (eye worm) hypothetical protein 0.0051 0.1474 0.1474
Brugia malayi Cathepsin L-like precursor 0.0051 0.1474 0.1474
Trypanosoma cruzi cruzipain precursor, putative 0.0196 0.7557 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.2692 0.2692
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0123 0.013
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0925 0.0903
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.1474 0.1521
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.2692 0.2692
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0616 0.0616
Entamoeba histolytica cysteine protease, putative 0.0051 0.1474 1
Entamoeba histolytica cysteine protease, putative 0.0027 0.0425 0.2315
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0179 0.6842 0.905
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0616 0.0616
Entamoeba histolytica cysteine protease, putative 0.0027 0.0425 0.2315
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0283 0.0429
Onchocerca volvulus 0.0034 0.0759 0.0731
Toxoplasma gondii histone lysine methyltransferase SET1 0.011 0.3932 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0925 0.0903
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0425 0.2315
Loa Loa (eye worm) hypothetical protein 0.0031 0.0616 0.0616
Brugia malayi TAR-binding protein 0.0135 0.4971 0.4971
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.1479 0.193
Entamoeba histolytica cysteine protease, putative 0.0027 0.0425 0.2315
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0616 0.0935
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.3254 0.4938
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.1474 0.1521
Trypanosoma cruzi Na/H antiporter-like protein, putative 0.0019 0.0109 0.011
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0925 0.0925
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0123 0.5
Giardia lamblia Sodium/hydrogen exchanger 3 0.01 0.3499 1
Echinococcus multilocularis sodium:hydrogen exchanger 2 (nhe2) 0.01 0.3499 0.5309
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0196 0.7557 1
Schistosoma mansoni cathepsin F (C01 family) 0.0051 0.1474 0.2228
Loa Loa (eye worm) hypothetical protein 0.0031 0.0616 0.0616
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.3254 0.3254
Toxoplasma gondii exonuclease III APE 0.0019 0.0123 0.0038
Schistosoma mansoni tar DNA-binding protein 0.0135 0.4971 0.7512
Echinococcus granulosus sodium:hydrogen exchanger 2 nhe2 0.01 0.3499 0.5309
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.2692 0.4085
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0616 0.0616
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0616 0.0616
Echinococcus granulosus GPCR family 2 0.008 0.2692 0.4085
Echinococcus multilocularis sodium:hydrogen exchanger 7 0.0019 0.0109 0.0165
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0578 0.1227
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0925 0.1195
Onchocerca volvulus 0.0231 0.9005 1
Onchocerca volvulus 0.0051 0.1474 0.1535
Trypanosoma cruzi sodium/hydrogen exchanger, putative 0.0019 0.0109 0.011
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0173 0.659 0.659
Trypanosoma cruzi cysteine proteinase, putative 0.0027 0.0425 0.053
Trypanosoma cruzi sodium/hydrogen exchanger, putative 0.0019 0.0109 0.011
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0135 0.4971 0.4971
Echinococcus granulosus cathepsin L cysteine protease 0.0027 0.0425 0.0645
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0616 0.0935
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0616 0.0616
Toxoplasma gondii cathepsin CPL 0.0051 0.1474 0.3573
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.3254 0.4918
Loa Loa (eye worm) hypothetical protein 0.0019 0.0109 0.0109
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.1474 0.1521
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0616 0.0935
Brugia malayi sodium/hydrogen exchanger 3 family protein 0.0019 0.0109 0.0109
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0616 0.0931
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.1474 0.1521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.1474 0.1521
Plasmodium vivax unspecified product 0.0027 0.0425 0.2747
Loa Loa (eye worm) NHE-3 0.01 0.3499 0.3499
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0123 0.0673
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.1474 0.1474
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0616 0.0935
Brugia malayi RNA recognition motif domain containing protein 0.0135 0.4971 0.4971
Trypanosoma cruzi major cysteine proteinase, putative 0.0154 0.5792 0.7656
Brugia malayi cathepsin L-like precursor 0.0034 0.0759 0.0759
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0616 0.0935
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.2692 0.4085
Echinococcus multilocularis cathepsin L 0.0027 0.0425 0.0645
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.3254 0.4918
Schistosoma mansoni cpg binding protein 0.0061 0.1863 0.2816
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0051 0.1474 0.2237
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0925 0.0903
Brugia malayi nuclear hormone receptor 0.0031 0.0616 0.0616

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 41 nM Inhibition of 5-N-(ethyl isopropyl)-amiloride[EIPA]-sensitive Na+ uptake into acidified rabbit erythrocytes. ChEMBL. 9207943
IC50 (functional) = 41 nM Inhibition of 5-N-(ethyl isopropyl)-amiloride[EIPA]-sensitive Na+ uptake into acidified rabbit erythrocytes. ChEMBL. 9207943

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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