Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0023 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.8998 | 0.8998 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0023 | 1 | 1 |
Entamoeba histolytica | recQ family DNA helicase | 0.0011 | 0.0381 | 0.0381 |
Echinococcus granulosus | bloom syndrome protein | 0.0023 | 1 | 1 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0011 | 0.0381 | 0.0381 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0023 | 1 | 1 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0023 | 1 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0023 | 1 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0023 | 1 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.0023 | 1 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.0023 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.8998 | 0.5 |
Loa Loa (eye worm) | RecQ helicase | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0023 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.8998 | 0.8998 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0023 | 1 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0023 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.8998 | 0.5 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0023 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.8998 | 0.8998 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.8998 | 0.8958 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0023 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.8998 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0023 | 1 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0023 | 1 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0023 | 1 | 1 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0023 | 1 | 1 |
Echinococcus multilocularis | bloom syndrome protein | 0.0023 | 1 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0023 | 1 | 1 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0023 | 1 | 1 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0011 | 0.0381 | 0.0423 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.8998 | 0.5 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0381 | 0.0381 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.8998 | 0.8958 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0381 | 0.00000000841 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.8998 | 0.8958 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.8998 | 1 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0023 | 1 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.8998 | 0.8998 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 1 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0023 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 4.13 uM | Cytotoxicity against human CEM cells | ChEMBL. | 18439832 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 18439832 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.