Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.0143 | 0.5338 | 0.751 |
Loa Loa (eye worm) | TAR-binding protein | 0.0143 | 0.5338 | 0.5338 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0126 | 0.4532 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0889 | 0.0889 |
Trypanosoma brucei | trypanothione reductase | 0.005 | 0.0758 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0068 | 0.1638 | 0.1638 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0143 | 0.5338 | 0.5338 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0099 | 0.3177 | 0.447 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.005 | 0.0758 | 0.1067 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0109 | 0.3671 | 0.3671 |
Entamoeba histolytica | hypothetical protein | 0.0081 | 0.2304 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.1972 | 0.1972 |
Brugia malayi | TAR-binding protein | 0.0143 | 0.5338 | 0.5338 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.7108 | 0.7108 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0114 | 0.3907 | 0.8342 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.005 | 0.0758 | 0.1067 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0081 | 0.2304 | 0.2304 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0102 | 0.3346 | 0.4707 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.7108 | 0.7108 |
Brugia malayi | glutathione reductase | 0.005 | 0.0758 | 0.0758 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0068 | 0.1638 | 0.2304 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0009 | 0.0009 |
Loa Loa (eye worm) | fli-1 protein | 0.0237 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1972 | 0.1972 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0081 | 0.2304 | 0.3241 |
Brugia malayi | Ets-domain containing protein | 0.0078 | 0.2154 | 0.2154 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0102 | 0.3346 | 0.3346 |
Schistosoma mansoni | gabp alpha | 0.0078 | 0.2154 | 0.2154 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0114 | 0.3907 | 0.8342 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.3671 | 0.3671 |
Schistosoma mansoni | tar DNA-binding protein | 0.0143 | 0.5338 | 0.5338 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0889 | 0.0889 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0099 | 0.3177 | 0.447 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.2304 | 0.2304 |
Plasmodium falciparum | glutathione reductase | 0.005 | 0.0758 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0126 | 0.4532 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0081 | 0.2304 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0889 | 0.1251 |
Entamoeba histolytica | hypothetical protein | 0.0081 | 0.2304 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.005 | 0.0758 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0126 | 0.4532 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.0889 | 0.0889 |
Brugia malayi | Transient-receptor-potential like protein | 0.0038 | 0.0177 | 0.0177 |
Brugia malayi | Ets-domain containing protein | 0.0078 | 0.2154 | 0.2154 |
Mycobacterium tuberculosis | Probable reductase | 0.0114 | 0.3907 | 0.8342 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0081 | 0.2304 | 0.3241 |
Schistosoma mansoni | tar DNA-binding protein | 0.0143 | 0.5338 | 0.5338 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0109 | 0.3671 | 0.3671 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0889 | 0.1251 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0078 | 0.2154 | 0.3031 |
Toxoplasma gondii | thioredoxin reductase | 0.005 | 0.0758 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.3346 | 0.3346 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0114 | 0.3907 | 0.8342 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0074 | 0.1972 | 0.1972 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0068 | 0.1638 | 0.2304 |
Schistosoma mansoni | tar DNA-binding protein | 0.0143 | 0.5338 | 0.5338 |
Brugia malayi | Thioredoxin reductase | 0.005 | 0.0758 | 0.0758 |
Loa Loa (eye worm) | thioredoxin reductase | 0.005 | 0.0758 | 0.0758 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0114 | 0.3907 | 0.8342 |
Plasmodium vivax | thioredoxin reductase, putative | 0.005 | 0.0758 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0143 | 0.5338 | 0.5338 |
Entamoeba histolytica | hypothetical protein | 0.0081 | 0.2304 | 0.5 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0068 | 0.1638 | 0.2304 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0078 | 0.2154 | 0.2154 |
Plasmodium vivax | glutathione reductase, putative | 0.005 | 0.0758 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.0889 | 0.0889 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0889 | 0.0889 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0102 | 0.3346 | 0.4707 |
Schistosoma mansoni | tar DNA-binding protein | 0.0143 | 0.5338 | 0.5338 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0177 | 0.0177 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0889 | 0.1251 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0078 | 0.2154 | 0.3031 |
Echinococcus multilocularis | geminin | 0.0178 | 0.7108 | 1 |
Echinococcus granulosus | geminin | 0.0178 | 0.7108 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.6538 | 0.6538 |
Brugia malayi | hypothetical protein | 0.0167 | 0.6538 | 0.6538 |
Onchocerca volvulus | 0.0167 | 0.6538 | 0.5 | |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0114 | 0.3907 | 0.8342 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0126 | 0.4532 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.1595 | 0.1595 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.0038 | 0.0177 | 0.0249 |
Loa Loa (eye worm) | glutathione reductase | 0.005 | 0.0758 | 0.0758 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.0038 | 0.0177 | 0.0249 |
Leishmania major | trypanothione reductase | 0.005 | 0.0758 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1469 | 0.1469 |
Schistosoma mansoni | transient receptor potential channel | 0.0068 | 0.1638 | 0.1638 |
Loa Loa (eye worm) | RNA binding protein | 0.0143 | 0.5338 | 0.5338 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0068 | 0.1638 | 0.2304 |
Brugia malayi | RNA binding protein | 0.0143 | 0.5338 | 0.5338 |
Echinococcus granulosus | tar DNA binding protein | 0.0143 | 0.5338 | 0.751 |
Schistosoma mansoni | tar DNA-binding protein | 0.0143 | 0.5338 | 0.5338 |
Brugia malayi | hypothetical protein | 0.0081 | 0.2304 | 0.2304 |
Schistosoma mansoni | transient receptor potential channel | 0.0102 | 0.3346 | 0.3346 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0109 | 0.3671 | 0.3671 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.005 | 0.0758 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0889 | 0.1251 |
Schistosoma mansoni | ets-related | 0.0237 | 1 | 1 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 12444709 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.