Detailed information for compound 1014319

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 411.405 | Formula: C22H21NO7
  • H donors: 2 H acceptors: 5 LogP: 1.49 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CO[C@]1(NC(=O)[C@@]2([C@H]1O)OC(=C(C2=O)C)/C=C/C=C/C(=O)C)C(=O)c1ccccc1
  • InChi: 1S/C22H21NO7/c1-13(24)9-7-8-12-16-14(2)17(25)21(30-16)19(27)22(29-3,23-20(21)28)18(26)15-10-5-4-6-11-15/h4-12,19,27H,1-3H3,(H,23,28)/b9-7+,12-8+/t19-,21-,22-/m1/s1
  • InChiKey: BRZMNDHMIVKXMO-QKYSSCQJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved protein 0.0109 0.0375 0.1365
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0506
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0072 0.0228 0.1913
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0005
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0135 0.0478 0.5051
Echinococcus granulosus lamin 0.0682 0.2653 0.6819
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0004 0.0005
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0006 0.0006
Brugia malayi cytochrome P450 0.0074 0.0233 0.0593
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0006 0.0006
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0074 0.0233 0.2438
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0228 0.1913
Loa Loa (eye worm) hypothetical protein 0.0109 0.0375 0.0959
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0138 0.049 0.1254
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0135 0.0478 0.0478
Brugia malayi bHLH-PAS transcription factor 0.0184 0.0671 0.1718
Loa Loa (eye worm) transcription factor SMAD2 0.0246 0.0918 0.2353
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0074 0.0233 0.0842
Echinococcus granulosus Nuclear hormone receptor HR96 0.0065 0.0199 0.0512
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0016 0.0004 0.0005
Leishmania major protein kinase, putative 0.0078 0.0251 0.2623
Loa Loa (eye worm) nuclear hormone receptor 0.0065 0.0199 0.0506
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0138 0.049 0.1254
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0375 0.3176
Schistosoma mansoni transcription factor LCR-F1 0.0376 0.1436 0.4238
Brugia malayi hypothetical protein 0.0479 0.1846 0.4742
Onchocerca volvulus 0.0138 0.049 0.1834
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0192 0.0703 0.8913
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0109 0.0375 0.1365
Leishmania major protein kinase, putative 0.0074 0.0235 0.2462
Schistosoma mansoni serine/threonine protein kinase 0.0252 0.0943 0.2783
Loa Loa (eye worm) thioredoxin reductase 0.0084 0.0274 0.0699
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0074 0.0233 0.3435
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0084 0.0274 0.0993
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0074 0.0233 0.3435
Echinococcus multilocularis ubiquitin specific protease 41 0.0077 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0669 0.2603 0.6689
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0138 0.049 0.1834
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0003 0.0006
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0012 0.0028
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0151 0.0542 0.1978
Schistosoma mansoni nuclear hormone receptor 0.0138 0.049 0.1446
Echinococcus granulosus FTZ F1 alpha 0.0138 0.049 0.126
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0138 0.049 0.049
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0065 0.0199 0.0736
Schistosoma mansoni hypothetical protein 0.0016 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0506
Schistosoma mansoni single-minded 0.0256 0.0959 0.2828
Brugia malayi ecdysteroid receptor 0.0138 0.049 0.1254
Brugia malayi Retinol dehydrogenase 12 0.0016 0.0004 0.0005
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0074 0.0233 0.3435
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0138 0.049 0.1446
Loa Loa (eye worm) hypothetical protein 0.0034 0.0075 0.0187
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0074 0.0233 0.2438
Echinococcus granulosus thyroid hormone receptor alpha 0.0065 0.0199 0.0512
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0138 0.049 0.1254
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0004 0.0013
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0375 0.1107
Schistosoma mansoni nuclear receptor 0.0065 0.0199 0.0588
Brugia malayi hypothetical protein 0.0065 0.0199 0.0506
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0056 0.0547
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0138 0.049 0.1254
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.0248 0.2597
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0056 0.0547
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0056 0.0547
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0004 0.0013
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0077 0.0248 0.0638
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.1172 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0004 0.0005
Plasmodium falciparum glutathione reductase 0.0029 0.0056 0.0547
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0004 0.0005
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0003 0.0003
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0097 0.0797
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0018 0.0013 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0138 0.049 0.1254
Schistosoma mansoni smad 0.0017 0.0006 0.0019
Echinococcus multilocularis Protein lozenge 0.006 0.0179 0.0179
Brugia malayi tailless protein 0.0065 0.0199 0.0506
Brugia malayi nuclear hormone receptor family member nhr-6 0.0065 0.0199 0.0506
Trichomonas vaginalis guanylate cyclase, putative 0.0072 0.0228 0.1913
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0003 0.0006
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0004 0.0013
Onchocerca volvulus 0.0682 0.2653 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0135 0.0478 0.1412
Leishmania major cytochrome p450-like protein 0.0119 0.0415 0.4378
Brugia malayi dehydrogenases, short chain protein 9 0.0016 0.0004 0.0005
Loa Loa (eye worm) glutathione reductase 0.0084 0.0274 0.0699
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0192 0.0703 0.257
Schistosoma mansoni retinoic acid receptor RXR 0.0138 0.049 0.1446
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0065 0.0199 0.0736
Schistosoma mansoni ap endonuclease 0.004 0.0097 0.0288
Onchocerca volvulus 0.0065 0.0199 0.0736
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0018 0.0012 0.0828
Mycobacterium ulcerans beta-lactamase 0.0109 0.0375 0.5567
Brugia malayi Nuclear hormone receptor-like 1 0.0073 0.0231 0.0586
Onchocerca volvulus 0.0682 0.2653 1
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0004 0.0013
Echinococcus granulosus oxidoreductase 0.0016 0.0004 0.0011
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0012 0.0116
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0097 0.0992
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.1172 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.0056 0.0771
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0138 0.0348
Schistosoma mansoni lamin 0.0682 0.2653 0.7828
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0097 0.0797
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0072 0.0228 1
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0056 0.0547
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0074 0.0233 0.2438
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0138 0.049 0.1254
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0375 0.3176
Brugia malayi Nuclear hormone receptor-like 1 0.0073 0.0231 0.0586
Loa Loa (eye worm) hypothetical protein 0.0138 0.049 0.1254
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0006 0.0019
Echinococcus granulosus carbonyl reductase 1 0.0016 0.0004 0.0011
Loa Loa (eye worm) dehydrogenase 0.0016 0.0004 0.0005
Echinococcus multilocularis carbonyl reductase 1 0.0016 0.0004 0.0004
Schistosoma mansoni ferritin 0.0018 0.0012 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0228 0.1913
Schistosoma mansoni coup transcription factor 0.0138 0.049 0.1446
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0056 0.0164
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0056 0.0547
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0056 0.0547
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0056 0.0547
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0138 0.049 0.049
Plasmodium falciparum glutathione reductase 0.0084 0.0274 0.2875
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0074 0.0233 0.3435
Loa Loa (eye worm) oxidoreductase 0.0016 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0317 0.12 0.3079
Toxoplasma gondii cytochrome p450 superfamily protein 0.0074 0.0233 0.2438
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0005
Echinococcus multilocularis Smad4 0.0017 0.0006 0.0006
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0074 0.0233 0.3435
Schistosoma mansoni apoferritin-2 0.0018 0.0012 0.0036
Echinococcus multilocularis retinol dehydrogenase 13 0.0016 0.0004 0.0004
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0004 0.0005
Loa Loa (eye worm) dehydrogenase 0.0016 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0109 0.0375 0.0959
Mycobacterium leprae Possible regulatory protein 0.0072 0.0228 0.2852
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0097 0.0251
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.1172 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0065 0.0199 0.0588
Loa Loa (eye worm) oxidoreductase 0.0016 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0859 0.3357 0.8626
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0056 0.0547
Schistosoma mansoni smad1 5 8 and 0.0017 0.0006 0.0019
Echinococcus multilocularis carbonyl reductase 1 0.0016 0.0004 0.0004
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0993 0.3891 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0056 0.0547
Loa Loa (eye worm) hypothetical protein 0.0073 0.0231 0.0586
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0072 0.0228 0.0228
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0004 0.0005
Loa Loa (eye worm) follicle stimulating hormone receptor 0.048 0.1849 0.4749
Echinococcus multilocularis steroid dehydrogenase 0.0016 0.0004 0.0004
Echinococcus granulosus transcription factor Dp 1 0.0078 0.0252 0.0647
Schistosoma mansoni cpg binding protein 0.0064 0.0196 0.0578
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0005
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0329 0.1249 0.1249
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0005
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0004 0.0013
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.0056 0.0771
Echinococcus multilocularis thyroid hormone receptor alpha 0.0138 0.049 0.049
Loa Loa (eye worm) hypothetical protein 0.0138 0.049 0.1254
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0004 0.0005
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0097 0.0992
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0016 0.0004 0.0005
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0138 0.0348
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0138 0.049 0.126
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0016 0.0004 0.0013
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0073 0.0231 0.0592
Brugia malayi Dehydrogenases, short chain protein 30 0.0016 0.0004 0.0005
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0375 0.3176
Echinococcus granulosus Nuclear hormone receptor HR96 0.0065 0.0199 0.0512
Loa Loa (eye worm) runx1 0.006 0.0179 0.0454
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0004 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0138 0.049 0.1254
Entamoeba histolytica hypothetical protein 0.0376 0.1436 1
Mycobacterium ulcerans esterase/lipase LipP 0.0109 0.0375 0.5567
Onchocerca volvulus Bile acid receptor homolog 0.0138 0.049 0.1834
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0073 0.0231 0.068
Loa Loa (eye worm) hypothetical protein 0.0479 0.1846 0.4742
Brugia malayi nuclear hormone receptor family member odr-7 0.0065 0.0199 0.0506
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0074 0.0233 0.0842
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0203 0.0746 0.1911
Schistosoma mansoni ap endonuclease 0.004 0.0097 0.0288
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0506
Mycobacterium leprae conserved hypothetical protein 0.0109 0.0375 0.4734
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0097 0.0343
Echinococcus granulosus intermediate filament protein 0.0682 0.2653 0.6819
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0135 0.0478 0.3311
Brugia malayi Nuclear hormone receptor E75 0.0065 0.0199 0.0506
Mycobacterium tuberculosis Probable reductase 0.0192 0.0703 0.257
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0074 0.0233 0.3435
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0015 0.0032
Loa Loa (eye worm) hypothetical protein 0.0138 0.049 0.1254
Echinococcus multilocularis transient receptor potential cation channel 0.0016 0.0004 0.0004
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0074 0.0233 0.3435
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.0375 0.0964
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0056 0.044
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0018 0.0012 0.0098
Loa Loa (eye worm) oxidoreductase 0.0016 0.0004 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.1172 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0074 0.0233 0.0842
Loa Loa (eye worm) hypothetical protein 0.0138 0.049 0.1254
Echinococcus multilocularis cpg binding protein 0.0064 0.0196 0.0196
Echinococcus multilocularis aryl hydrocarbon receptor 0.0091 0.0301 0.0301
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0138 0.049 0.1254
Echinococcus granulosus carbonyl reductase 1 0.0016 0.0004 0.0011
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0138 0.049 0.1446
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0006 0.0017
Loa Loa (eye worm) hypothetical protein 0.0479 0.1846 0.4742
Echinococcus multilocularis dnaJ subfamily B 0.0867 0.3389 0.3389
Schistosoma mansoni carbonyl reductase 0.0016 0.0004 0.0013
Loa Loa (eye worm) steroid hormone receptor 0.0138 0.049 0.1254
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0135 0.0478 0.5051
Entamoeba histolytica hypothetical protein 0.0376 0.1436 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0056 0.0056
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0077 0.0248 0.0632
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0018 0.0013 0.0038
Trichomonas vaginalis guanylate cyclase, putative 0.0072 0.0228 0.1913
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0375 0.1107
Onchocerca volvulus 0.0091 0.0301 0.112
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.1172 1
Schistosoma mansoni hypothetical protein 0.0016 0.0003 0.0007
Brugia malayi MH1 domain containing protein 0.0017 0.0006 0.001
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0097 0.065
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0138 0.049 0.126
Onchocerca volvulus Protein cycle homolog 0.0018 0.0013 0.0033
Loa Loa (eye worm) oxidoreductase 0.0016 0.0004 0.0005
Schistosoma mansoni ferritin 0.0018 0.0012 0.0036
Treponema pallidum NADH oxidase 0.0029 0.0056 0.0376
Brugia malayi glutathione reductase 0.0084 0.0274 0.0699
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0027
Leishmania major trypanothione reductase 0.0084 0.0274 0.2875
Echinococcus granulosus smad 0.0017 0.0006 0.0017
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0004 0.0013
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0016 0.0004 0.0013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.1172 1
Loa Loa (eye worm) cytochrome P450 0.0074 0.0233 0.0593
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.0248 0.2597
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0004 0.0013
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0074 0.0235 0.2462
Schistosoma mansoni survival motor neuron protein 0.0203 0.0746 0.22
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0375 0.3951
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0077 0.0248 0.2088
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0016 0.0004 0.0004
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0004 0.0013
Leishmania major cytochrome p450-like protein 0.0074 0.0233 0.2438
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0074 0.0233 0.0842
Echinococcus multilocularis ferritin 0.0018 0.0012 0.0012
Mycobacterium leprae Conserved hypothetical protein 0.0074 0.0233 0.2921
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0073 0.0231 0.0231
Brugia malayi beta-lactamase family protein 0.0109 0.0375 0.0959
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0004 0.0005
Schistosoma mansoni steroid hormone receptor ad4bp 0.0138 0.049 0.1446
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0506
Loa Loa (eye worm) hypothetical protein 0.0138 0.049 0.1254
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0004 0.0005
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0074 0.0233 0.0842
Echinococcus granulosus Smad4 0.0017 0.0006 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0138 0.049 0.1254
Echinococcus multilocularis retinol dehydrogenase 11 0.0016 0.0004 0.0004
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0004 0.0005
Brugia malayi Dehydrogenases, short chain protein 2 0.0016 0.0004 0.0005
Schistosoma mansoni ferritin 0.0018 0.0012 0.0036
Schistosoma mansoni ferritin light chain 0.0018 0.0012 0.0036
Echinococcus granulosus thioredoxin glutathione reductase 0.0085 0.0276 0.071
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0056 0.0143
Echinococcus granulosus tumor protein p63 0.0337 0.1282 0.3296
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0375 0.3951
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0006 0.001
Schistosoma mansoni zinc finger protein 0.0065 0.0199 0.0588
Mycobacterium ulcerans putative regulatory protein 0.0184 0.0671 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0138 0.049 0.1254
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.0375 0.3951
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0182 0.0462
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0074 0.0233 0.3435
Loa Loa (eye worm) hypothetical protein 0.0109 0.0375 0.0959
Giardia lamblia Fructose-bisphosphate aldolase 0.031 0.1172 1
Brugia malayi hypothetical protein 0.0018 0.0013 0.0027
Brugia malayi nuclear receptor RXR 0.0065 0.0199 0.0506
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0004 0.0013
Schistosoma mansoni ferritin 0.0018 0.0012 0.0036
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0138 0.049 0.049
Loa Loa (eye worm) hypothetical protein 0.0138 0.049 0.1254
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0097 0.0097
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.0454 0.1338
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0109 0.0375 0.1365
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0077 0.0248 0.0732
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0074 0.0233 0.0842
Brugia malayi nuclear receptor RXR 0.0073 0.0231 0.0586
Mycobacterium tuberculosis Probable hydrolase 0.0109 0.0375 0.1365
Echinococcus multilocularis musashi 0.0682 0.2653 0.2653
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0097 0.0992
Loa Loa (eye worm) hypothetical protein 0.0109 0.0375 0.0959
Toxoplasma gondii thioredoxin reductase 0.0084 0.0274 0.2875
Brugia malayi Steroid receptor seven-up type 2 0.0138 0.049 0.1254
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0074 0.0233 0.0842
Brugia malayi Cytochrome P450 family protein 0.0119 0.0415 0.1062
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0065 0.0199 0.0588
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0136 0.0402
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0018 0.0013 0.0027
Echinococcus granulosus ubiquitin specific protease 41 0.0077 0.0248 0.0638
Schistosoma mansoni smad1 5 8 and 0.0017 0.0006 0.0019
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0192 0.0703 0.257
Echinococcus multilocularis lamin dm0 0.0682 0.2653 0.2653
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0065 0.0199 0.0199
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0138 0.049 0.1254
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0005
Brugia malayi hypothetical protein 0.0376 0.1436 0.3688
Schistosoma mansoni cpg binding protein 0.0064 0.0196 0.0578
Loa Loa (eye worm) oxidoreductase 0.0016 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0005
Echinococcus granulosus cytochrome P450 2K1 0.0074 0.0233 0.0599
Brugia malayi MH1 domain containing protein 0.0017 0.0006 0.001
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0077 0.0248 0.0248
Loa Loa (eye worm) cytochrome P450 family protein 0.0213 0.0787 0.2018
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0252 0.0943 1
Schistosoma mansoni hypothetical protein 0.0376 0.1436 0.4238
Mycobacterium tuberculosis Probable lipase LipD 0.0109 0.0375 0.1365
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0074 0.0233 0.3435
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.0375 0.0959
Onchocerca volvulus 0.0109 0.0375 0.14
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0091 0.0301 0.0768
Brugia malayi Thioredoxin reductase 0.0084 0.0274 0.0699
Echinococcus multilocularis carbonyl reductase 1 0.0016 0.0004 0.0004
Brugia malayi cytoplasmic intermediate filament protein 0.0365 0.1393 0.3577
Brugia malayi MH2 domain containing protein 0.0246 0.0918 0.2353
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0004 0.0005
Brugia malayi hypothetical protein 0.0859 0.3357 0.8626
Schistosoma mansoni hypothetical protein 0.0074 0.0233 0.0688
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0056 0.5515
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0138 0.049 0.1446
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0138 0.049 0.1254
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0074 0.0233 0.0842
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0056 0.0547
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0074 0.0235 0.2462
Schistosoma mansoni cpg binding protein 0.0061 0.0182 0.0537
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0074 0.0233 0.2438
Brugia malayi nuclear receptor NHR-88 0.0138 0.049 0.1254
Brugia malayi nuclear receptor NHR-88 0.0065 0.0199 0.0506
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0138 0.049 0.1254
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0027
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0073 0.0231 0.0586
Echinococcus granulosus retinol dehydrogenase 11 0.0016 0.0004 0.0011
Echinococcus multilocularis ecdysone induced protein 78C 0.0138 0.049 0.049
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0074 0.0233 0.0842
Onchocerca volvulus 0.0203 0.0746 0.2799
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.0375 0.0959
Loa Loa (eye worm) nuclear receptor NHR-67 0.0065 0.0199 0.0506
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0074 0.0233 0.3435
Schistosoma mansoni smad1 5 8 and 0.0017 0.0006 0.0019
Echinococcus multilocularis nuclear receptor nhr 48 0.0065 0.0199 0.0199
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0004 0.0013
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.0056 0.0189
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0056 0.0547
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0138 0.0348
Treponema pallidum fructose-bisphosphate aldolase 0.031 0.1172 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0506
Brugia malayi steroid hormone receptor 0.0138 0.049 0.1254
Loa Loa (eye worm) intermediate filament protein 0.0682 0.2653 0.6817
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0097 0.0992
Loa Loa (eye worm) hypothetical protein 0.0046 0.0122 0.0307
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0138 0.049 0.1446
Brugia malayi hypothetical protein 0.0016 0.0004 0.0005
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0252 0.0943 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0506
Loa Loa (eye worm) hypoxia-induced factor 1 0.0768 0.2995 0.7697
Schistosoma mansoni retinal dehydrogenase 0.0016 0.0004 0.0013
Schistosoma mansoni hypothetical protein 0.0016 0.0003 0.0007
Brugia malayi intermediate filament protein 0.0682 0.2653 0.6817
Brugia malayi photoreceptor-specific nuclear receptor 0.0138 0.049 0.1254
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0252 0.0943 1
Schistosoma mansoni hypothetical protein 0.0867 0.3389 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0138 0.049 0.1254
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0329 0.1249 0.3211
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0213 0.0788 0.2883
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0016 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0506
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0016 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0506
Echinococcus multilocularis FTZ F1 alpha 0.0138 0.049 0.049
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0004 0.0013
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0004 0.0005
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0015 0.0038
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.0375 0.0375
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0065 0.0199 0.0199
Schistosoma mansoni Smad4 0.0017 0.0006 0.0019
Schistosoma mansoni thyroid hormone receptor 0.0138 0.049 0.1446
Loa Loa (eye worm) oxidoreductase 0.0016 0.0004 0.0005
Plasmodium vivax glutathione reductase, putative 0.0084 0.0274 0.2875
Echinococcus granulosus dual specificity protein kinase clk2 0.0252 0.0943 0.2424
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.031 0.1172 0.8155
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0252 0.0943 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0077 0.0248 0.2088
Loa Loa (eye worm) hypothetical protein 0.0138 0.049 0.1254
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0056 0.0547
Trichomonas vaginalis adenylate cyclase, putative 0.0072 0.0228 0.1913
Echinococcus granulosus GPCR family 2 0.0016 0.0003 0.0006
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0072 0.0228 0.1913
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0213 0.0788 0.2883
Toxoplasma gondii exonuclease III APE 0.004 0.0097 0.0992
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0097 0.1398
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0138 0.049 0.126
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0097 0.0992
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0074 0.0233 0.0842
Brugia malayi hypothetical protein 0.0993 0.3891 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0138 0.049 0.126
Brugia malayi beta-lactamase 0.0109 0.0375 0.0959
Echinococcus granulosus aryl hydrocarbon receptor 0.0091 0.0301 0.0773
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0138 0.049 0.049
Onchocerca volvulus 0.0049 0.0136 0.0498
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0097 0.0736
Mycobacterium tuberculosis Probable lipase LipE 0.0109 0.0375 0.1365
Loa Loa (eye worm) hypothetical protein 0.0682 0.2653 0.6817
Loa Loa (eye worm) hypothetical protein 0.0072 0.0228 0.0579
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0056 0.044
Echinococcus granulosus single minded 2 0.0184 0.0671 0.1723
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0004 0.0005
Onchocerca volvulus 0.0479 0.1846 0.6954
Onchocerca volvulus 0.0061 0.0182 0.0671
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0138 0.049 0.049
Mycobacterium tuberculosis Probable dehydrogenase 0.0192 0.0703 0.257
Brugia malayi MH2 domain containing protein 0.0017 0.0006 0.001
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0065 0.0199 0.0506
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0016 0.0004 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0138 0.049 0.1254
Brugia malayi hypothetical protein 0.0073 0.0231 0.0586
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0072 0.0228 0.1913
Trichomonas vaginalis CMGC family protein kinase 0.0252 0.0943 0.8038
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0151 0.0542 0.8068
Echinococcus granulosus hypothetical protein 0.0016 0.0004 0.0011
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0192 0.0703 0.257
Brugia malayi follicle stimulating hormone receptor 0.048 0.1849 0.4749
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0506
Schistosoma mansoni lozenge 0.006 0.0179 0.0528
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0077 0.0248 0.0638
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0016 0.0004 0.0011
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0016 0.0004 0.0004
Toxoplasma gondii ABC1 family protein 0.0109 0.0375 0.3951
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0074 0.0233 0.0842
Schistosoma mansoni cytochrome P450 0.0074 0.0233 0.0688
Schistosoma mansoni thyroid hormone receptor 0.0138 0.049 0.1446
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0077 0.0248 0.0732
Echinococcus multilocularis carbonyl reductase 1 0.0016 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0138 0.049 0.1254
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0077 0.0248 0.2088
Onchocerca volvulus 0.0109 0.0375 0.14
Brugia malayi dehydrogenases, short chain protein 2 0.0016 0.0004 0.0005
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0109 0.0375 0.5567
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0015 0.0015
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0074 0.0233 0.0842
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0135 0.0478 0.1224
Brugia malayi N-terminal motif family protein 0.0176 0.0639 0.1637
Echinococcus granulosus survival motor neuron protein 1 0.0993 0.3891 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0506
Echinococcus multilocularis expressed protein 0.0018 0.0012 0.0012
Mycobacterium ulcerans lipase LipD 0.0109 0.0375 0.5567
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0074 0.0233 0.0842
Echinococcus multilocularis thioredoxin glutathione reductase 0.0085 0.0276 0.0276
Echinococcus granulosus hypothetical protein 0.0016 0.0004 0.0011
Echinococcus multilocularis oxidoreductase 0.0016 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0506
Echinococcus granulosus dnaJ subfamily B 0.0867 0.3389 0.871
Brugia malayi Cytochrome P450 family protein 0.0119 0.0415 0.1062
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0329 0.1249 0.3206
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0138 0.049 0.126
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0138 0.049 0.1254
Echinococcus multilocularis transcription factor Dp 1 0.0078 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0073 0.0231 0.0586
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0097 0.0797
Schistosoma mansoni lamin 0.0682 0.2653 0.7828
Brugia malayi Cytochrome P450 family protein 0.0213 0.0787 0.2018
Echinococcus granulosus nuclear receptor nhr 48 0.0065 0.0199 0.0512
Brugia malayi oxidoreductase 0.0016 0.0004 0.0005
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0004 0.0005
Onchocerca volvulus Protein ultraspiracle homolog 0.0138 0.049 0.1834
Trypanosoma cruzi cytochrome P450, putative 0.0119 0.0415 0.4378
Loa Loa (eye worm) MH2 domain-containing protein 0.0246 0.0918 0.2353
Brugia malayi ecdysone receptor 0.0065 0.0199 0.0506
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0506
Plasmodium vivax thioredoxin reductase, putative 0.0084 0.0274 0.2875
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0074 0.0233 0.0842
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0004 0.0013
Echinococcus granulosus lamin dm0 0.0682 0.2653 0.6819
Echinococcus granulosus WW domain containing oxidoreductase 0.0016 0.0004 0.0011
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0004 0.0013
Mycobacterium tuberculosis Probable esterase LipL 0.0109 0.0375 0.1365
Echinococcus granulosus ferritin 0.0018 0.0012 0.0031
Loa Loa (eye worm) hypothetical protein 0.0109 0.0375 0.0959
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0365 0.1393 0.3577
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0176 0.0639 0.2397
Loa Loa (eye worm) cytochrome P450 family protein 0.0119 0.0415 0.1062
Echinococcus granulosus cpg binding protein 0.0064 0.0196 0.0503
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0252 0.0943 0.2419
Echinococcus granulosus retinol dehydrogenase 11 0.0016 0.0004 0.0011
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0074 0.0233 0.0842
Schistosoma mansoni ferritin light chain 0.0018 0.0012 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0138 0.049 0.1254
Brugia malayi MH2 domain containing protein 0.0017 0.0006 0.001
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0072 0.0228 0.1913
Trypanosoma brucei cytochrome P450, putative 0.0119 0.0415 0.4378
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0025 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0138 0.049 0.1254
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.0056 0.0771
Leishmania major protein kinase, putative 0.0252 0.0943 1
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0375 0.3176
Leishmania major protein kinase, putative 0.0252 0.0943 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0016 0.0004 0.0013
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0213 0.0788 1
Mycobacterium leprae Probable lipase LipE 0.0109 0.0375 0.4734
Entamoeba histolytica hypothetical protein 0.0376 0.1436 1
Brugia malayi hypothetical protein 0.0073 0.0231 0.0586
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.1172 1
Onchocerca volvulus 0.0065 0.0199 0.0736
Brugia malayi Nuclear hormone receptor E75 0.0065 0.0199 0.0506
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.0399 0.4201
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0016 0.0004 0.0004
Mycobacterium tuberculosis Conserved protein 0.0109 0.0375 0.1365
Echinococcus multilocularis 0.025 0.0935 0.0935
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0074 0.0233 0.0842
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0074 0.0233 0.0842
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0074 0.0233 0.3435
Echinococcus granulosus carbonyl reductase 1 0.0016 0.0004 0.0011
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0138 0.049 0.1446
Echinococcus multilocularis GPCR, family 2 0.0016 0.0003 0.0003
Schistosoma mansoni nuclear hormone receptor 0.0065 0.0199 0.0588
Leishmania major cytochrome p450-like protein 0.0074 0.0233 0.2438
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0056 0.0547
Schistosoma mansoni nuclear receptor nhr-48 0.0065 0.0199 0.0588
Schistosoma mansoni apoferritin-2 0.0018 0.0012 0.0036
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0375 0.3176
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0056 0.5515
Loa Loa (eye worm) hypothetical protein 0.0073 0.0231 0.0586
Loa Loa (eye worm) oxidoreductase 0.0016 0.0004 0.0005
Brugia malayi Protein kinase domain containing protein 0.0252 0.0943 0.2419
Plasmodium falciparum thioredoxin reductase 0.0084 0.0274 0.2875
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0074 0.0233 0.0842
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.031 0.1172 0.8155
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0097 1
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0016 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.0077 0.0248 0.0632
Mycobacterium tuberculosis Probable oxidoreductase 0.0213 0.0788 0.2883
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0097 0.0244
Schistosoma mansoni hypothetical protein 0.0034 0.0075 0.0222
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0109 0.0375 0.1365
Brugia malayi nuclear receptor NHR-67 0.0065 0.0199 0.0506
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0138 0.049 0.126
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0252 0.0943 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0135 0.0478 0.1224
Loa Loa (eye worm) beta-lactamase 0.0109 0.0375 0.0959
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0074 0.0233 0.0842
Schistosoma mansoni hypothetical protein 0.0016 0.0003 0.0007
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0074 0.0233 0.3435
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0004 0.0013
Brugia malayi hypothetical protein 0.0016 0.0004 0.0005
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0077 0.0248 0.0248
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0004 0.0005
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0252 0.0943 1
Trichomonas vaginalis esterase, putative 0.0109 0.0375 0.3176
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0072 0.0228 0.238
Echinococcus granulosus carbonyl reductase 1 0.0016 0.0004 0.0011
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0004 0.0013
Brugia malayi beta-lactamase family protein 0.0109 0.0375 0.0959
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0005
Mycobacterium ulcerans hypothetical protein 0.0109 0.0375 0.5567
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0018 0.0013 0.0027
Brugia malayi hypothetical protein 0.0018 0.0013 0.0027
Mycobacterium leprae putative cytochrome p450 0.0074 0.0233 0.2921
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0056 0.0547
Schistosoma mansoni intermediate filament proteins 0.0682 0.2653 0.7828
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0056 0.044
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0699 0.2721 1
Loa Loa (eye worm) CYP4Cod1 0.0119 0.0415 0.1062
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0074 0.0233 0.3435
Schistosoma mansoni nuclear hormone receptor 0.0065 0.0199 0.0588
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0004 0.0013
Loa Loa (eye worm) DR-78 0.0065 0.0199 0.0506
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0004 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0138 0.049 0.1254
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0072 0.0228 0.238
Trichomonas vaginalis ferritin, putative 0.0018 0.0012 0.0066
Entamoeba histolytica hypothetical protein 0.0376 0.1436 1
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0004 0.0013
Brugia malayi Intermediate filament tail domain containing protein 0.0682 0.2653 0.6817
Loa Loa (eye worm) hypothetical protein 0.0138 0.049 0.1254
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0004 0.0005
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0075 0.0187
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0005
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0192 0.0703 0.257
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0065 0.0199 0.0199
Loa Loa (eye worm) Smad1 0.0017 0.0006 0.001
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0138 0.049 0.1446
Echinococcus multilocularis retinol dehydrogenase 11 0.0016 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0109 0.0375 0.0959
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0252 0.0943 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0074 0.0233 0.2438
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0056 0.0547
Echinococcus multilocularis dual specificity protein kinase clk2 0.0252 0.0943 0.0943
Loa Loa (eye worm) hypothetical protein 0.025 0.0935 0.2399
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0056 0.0547
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0077 0.0248 0.2597
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0074 0.0233 0.3435
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0005
Brugia malayi CXXC zinc finger family protein 0.0061 0.0182 0.0462
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0056 0.0547
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0135 0.0478 0.5051
Echinococcus multilocularis transfer RNA-Lys 0.0184 0.0671 0.0671
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0138 0.049 0.1254
Onchocerca volvulus 0.0109 0.0375 0.14
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0073 0.0231 0.068
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0065 0.0199 0.0199
Echinococcus granulosus expressed protein 0.0018 0.0012 0.0031
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0119 0.0415 0.6169
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0004 0.0013
Plasmodium falciparum thioredoxin reductase 0.0029 0.0056 0.0547
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.1172 1
Leishmania major hypothetical protein, conserved 0.0109 0.0375 0.3951
Brugia malayi Smad1 0.0017 0.0006 0.001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0376 0.1436 0.1436
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0138 0.049 0.126
Brugia malayi Cytochrome P450 family protein 0.0074 0.0233 0.0593
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.0348
Echinococcus multilocularis steroid dehydrogenase 0.0016 0.0004 0.0004
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0097 0.0992
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0003 0.0003
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0018 0.0013 0.0027
Loa Loa (eye worm) hypothetical protein 0.0176 0.0639 0.1637
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0074 0.0233 0.0842
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0072 0.0228 0.1913
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0074 0.0235 0.2462
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0097 0.0244
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0074 0.0233 0.3435
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0074 0.0233 0.3435
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0376 0.1436 0.3692
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0074 0.0233 0.3435
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0065 0.0199 0.0512
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0056 0.0547
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0006 0.0017
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0056 0.0547
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0072 0.0228 0.0585
Brugia malayi nuclear hormone receptor 0.0065 0.0199 0.0506
Loa Loa (eye worm) hypothetical protein 0.0065 0.0199 0.0506
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0004 0.0013
Echinococcus multilocularis survival motor neuron protein 1 0.0993 0.3891 0.3891
Loa Loa (eye worm) cytochrome P450 family protein 0.0119 0.0415 0.1062
Echinococcus granulosus hypothetical protein 0.025 0.0935 0.2404
Loa Loa (eye worm) hypothetical protein 0.0049 0.0136 0.0344
Echinococcus multilocularis tumor protein p63 0.0337 0.1282 0.1282
Loa Loa (eye worm) hypothetical protein 0.0073 0.0231 0.0586
Brugia malayi PAS domain containing protein 0.0256 0.0959 0.2459
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0012 0.0028
Echinococcus granulosus steroid dehydrogenase 0.0016 0.0004 0.0011
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0074 0.0233 0.3435
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0682 0.2653 0.6817
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0004 0.0005
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0074 0.0233 0.3435
Plasmodium vivax serine/threonine kinase-1, putative 0.0252 0.0943 1
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0014 0.0029
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0074 0.0233 0.3435
Loa Loa (eye worm) oxidoreductase 0.0016 0.0004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0228 0.1913
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0056 0.0547
Brugia malayi orphan nuclear receptor NR2E1 0.0065 0.0199 0.0506
Mycobacterium tuberculosis Conserved protein 0.0109 0.0375 0.1365
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0016 0.0004 0.0005
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0056 0.0137
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0004 0.0005
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0072 0.0228 0.238
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0006 0.001
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0074 0.0235 0.2462
Schistosoma mansoni steroid dehydrogenase 0.0016 0.0004 0.0013
Echinococcus multilocularis lamin 0.0682 0.2653 0.2653
Schistosoma mansoni carbonyl reductase 0.0016 0.0004 0.0013
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0151 0.0542 0.6861
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0056 0.0547
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0135 0.0478 0.123
Plasmodium falciparum protein serine/threonine kinase-1 0.0252 0.0943 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0077 0.0248 0.2597
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0065 0.0199 0.0199
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0012 0.0116
Schistosoma mansoni aryl hydrocarbon receptor 0.0256 0.0959 0.2828
Echinococcus multilocularis 0.0074 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0073 0.0231 0.0586
Brugia malayi conserved hypotetical protein 0.0065 0.0199 0.0506
Brugia malayi hypoxia-induced factor 1 0.0768 0.2995 0.7697
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0025 0.0058
Schistosoma mansoni short chain dehydrogenase 0.0016 0.0004 0.0013
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0135 0.0478 0.5051
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0065 0.0199 0.0512
Loa Loa (eye worm) oxidoreductase 0.0016 0.0004 0.0005
Echinococcus multilocularis conserved hypothetical protein 0.0016 0.0004 0.0004
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0065 0.0199 0.0506
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0248 0.2088
Schistosoma mansoni carbonyl reductase 0.0016 0.0004 0.0013
Trypanosoma brucei trypanothione reductase 0.0084 0.0274 0.2875
Echinococcus granulosus ecdysone induced protein 78C 0.0138 0.049 0.126
Schistosoma mansoni RAR-like nuclear receptor 0.0138 0.049 0.1446
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0016 0.0004 0.0004
Trypanosoma cruzi cytochrome P450, putative 0.0119 0.0415 0.4378
Schistosoma mansoni hypothetical protein 0.0203 0.0746 0.22
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0027
Echinococcus multilocularis smad 0.0017 0.0006 0.0006
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0375 0.3951
Onchocerca volvulus 0.0184 0.0671 0.2515
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0005
Trypanosoma cruzi trypanothione reductase, putative 0.0084 0.0274 0.2875
Brugia malayi hypothetical protein 0.0065 0.0199 0.0506
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0005
Giardia lamblia Kinase, CMGC CLK 0.0252 0.0943 0.8038
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0016 0.0004 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0056 0.0547
Brugia malayi nuclear hormone receptor 0.0138 0.049 0.1254
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0056 0.0547
Schistosoma mansoni serine/threonine protein kinase 0.0252 0.0943 0.2783
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0077 0.0248 0.1702
Schistosoma mansoni nuclear receptor 0.0065 0.0199 0.0588
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0016 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0317 0.12 0.3079
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0138 0.049 0.049

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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