Detailed information for compound 1014566

Basic information

Technical information
  • TDR Targets ID: 1014566
  • Name: 2-[5-acetyl-4-[(4-chlorophenyl)methyl]-7-fluo ro-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]ace tic acid
  • MW: 399.843 | Formula: C22H19ClFNO3
  • H donors: 1 H acceptors: 3 LogP: 3.98 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CC1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1C(=O)C)F
  • InChi: 1S/C22H19ClFNO3/c1-12(26)18-9-16(24)10-19-17-7-4-14(8-20(27)28)21(17)25(22(18)19)11-13-2-5-15(23)6-3-13/h2-3,5-6,9-10,14H,4,7-8,11H2,1H3,(H,27,28)
  • InChiKey: YYAWOSLKARYYMV-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-[5-acetyl-4-(4-chlorobenzyl)-7-fluoro-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acid
  • 2-[4-[(4-chlorophenyl)methyl]-5-ethanoyl-7-fluoro-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]ethanoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens prostaglandin D2 receptor (DP) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis rhodopsin orphan GPCR prostaglandin D2 receptor (DP) 359 aa 312 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica kinesin, putative 0.0427 0.0676 0.3971
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.001 0.001
Brugia malayi G-protein coupled receptor 0.0017 0.0013 0.0009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0532 0.0847 0.0842
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0009
Schistosoma mansoni neuropeptide f receptor 76f 0.0017 0.0013 0.0013
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.0039
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0217 0.0336 0.0943
Schistosoma mansoni opsin-like receptor 0.0017 0.0013 0.0013
Mycobacterium tuberculosis Conserved protein 0.0035 0.0042 0.011
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.0348 0.0915
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0102 0.0155
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0013 0.0013
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0838 0.1342 0.1336
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0532 0.0847 0.136
Mycobacterium leprae Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB 0.0217 0.0336 0.0883
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0015 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0009
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.0636 0.0636
Schistosoma mansoni cpg binding protein 0.0028 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0217 0.0336 0.0329
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.0039
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0013 0.0013
Echinococcus granulosus orexin receptor type 2 0.0017 0.0013 0.0013
Brugia malayi Serotonin receptor 0.0017 0.0013 0.0009
Brugia malayi hypothetical protein 0.0017 0.0013 0.0009
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0217 0.0336 0.0336
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0017 0.0013 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0009
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0013 0.0013
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.2356 0.38 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Loa Loa (eye worm) beta-lactamase 0.0035 0.0042 0.0039
Echinococcus granulosus g protein coupled receptor 0.0017 0.0013 0.0013
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0015 0.0008
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0838 0.1342 0.3532
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0217 0.0336 0.033
Echinococcus multilocularis voltage gated potassium channel 0.0012 0.0004 0.0004
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0042 0.9137
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.0007 0.1535
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0073 0.0102 0.0566
Brugia malayi Dopamine receptor protein 1 0.0017 0.0013 0.0009
Echinococcus granulosus dnaJ subfamily B 0.0402 0.0636 0.0636
Plasmodium falciparum kinesin-5 0.0427 0.0676 0.0926
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0011 0.0006
Schistosoma mansoni hypothetical protein 0.0016 0.001 0.001
Brugia malayi beta-lactamase 0.0035 0.0042 0.0039
Onchocerca volvulus 0.0035 0.0042 0.4352
Brugia malayi RE15519p 0.0017 0.0013 0.0009
Brugia malayi Carboxyl transferase domain containing protein 0.5967 0.9649 1
Echinococcus granulosus hypothetical protein 0.0017 0.0013 0.0013
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0015 0.0012
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0058 0.0079 0.0079
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0017 0.0013 0.0009
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0838 0.1342 0.3532
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0073 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.0039
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0217 0.0336 0.0455
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.2356 0.38 0.6139
Loa Loa (eye worm) hypothetical protein 0.0217 0.0336 0.0344
Echinococcus granulosus 7tm_1 domain containing protein 0.0017 0.0013 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0013
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0017 0.0013 0.0013
Chlamydia trachomatis acetyl-CoA carboxylase biotin carboxyl carrier protein 0.0217 0.0336 0.0943
Echinococcus granulosus neuropeptide FF receptor 2 0.0017 0.0013 0.0013
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0015 0.0009
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0013 0.0013
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0042 0.011
Brugia malayi Dopamine receptor protein 2 0.0017 0.0013 0.0009
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.2356 0.38 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0013 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0013 0.0013
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0217 0.0336 0.0336
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0217 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Trypanosoma brucei unspecified product 0.0019 0.0015 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0015 0.0012
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0217 0.0336 0.0532
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0013 0.0009
Mycobacterium ulcerans beta-lactamase 0.0035 0.0042 0.011
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0015 0.004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0017 0.0013 0.0013
Brugia malayi AKH receptor 0.0017 0.0013 0.0009
Giardia lamblia DINP protein human, muc B family 0.0019 0.0015 0.0049
Leishmania major phosphopantetheinyl transferase-like protein 0.0016 0.0011 0.0004
Trypanosoma brucei acetyl-CoA carboxylase 0.6184 1 1
Echinococcus multilocularis Biotin lipoyl attachment 0.0217 0.0336 0.0336
Mycobacterium tuberculosis Conserved protein 0.0035 0.0042 0.011
Echinococcus granulosus neuropeptide s receptor 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0015 0.0012
Brugia malayi neuropeptide F receptor 0.0017 0.0013 0.0009
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.2356 0.38 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0042 0.0056
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0042 0.011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0015 0.0013
Echinococcus granulosus fmrfamide receptor 0.0017 0.0013 0.0013
Toxoplasma gondii pyruvate carboxylase 0.2356 0.38 0.3795
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.005 0.005
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.001 0.001
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0217 0.0336 0.0336
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0013 0.0013
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0217 0.0336 0.0455
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0013 0.0013
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0532 0.0847 0.0847
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0013 0.0013
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0217 0.0336 0.0532
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0042 0.9137
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0017 0.0013 0.0013
Brugia malayi Latrophilin receptor protein 2 0.0016 0.001 0.0007
Toxoplasma gondii kinesin motor domain-containing protein 0.0427 0.0676 0.067
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0015 0.0015
Schistosoma mansoni aspartate carbamoyltransferase 0.0532 0.0847 0.0847
Schistosoma mansoni hypothetical protein 0.0402 0.0636 0.0636
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0217 0.0336 0.0532
Echinococcus multilocularis somatostatin receptor 0.0017 0.0013 0.0013
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0042 0.011
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0017 0.0013 0.0009
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Brugia malayi hypothetical protein 0.0017 0.0013 0.0009
Schistosoma mansoni acetyl-CoA carboxylase 0.6184 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.005 0.005
Schistosoma mansoni alpha-1 adrenergic receptor 0.0017 0.0013 0.0013
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0017 0.0013 0.0009
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0056 0.0056
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0217 0.0336 0.0329
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0013 0.0013
Trypanosoma cruzi acetyl-CoA carboxylase 0.3828 0.6185 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0013 0.0013
Echinococcus multilocularis L aminoadipate semialdehyde 0.0058 0.0079 0.0079
Schistosoma mansoni kinesin eg-5 0.0427 0.0676 0.0676
Schistosoma mansoni growth hormone secretagogue receptor 0.0017 0.0013 0.0013
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.2356 0.38 0.3796
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0058 0.0079 0.0078
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0838 0.1342 0.3871
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0532 0.0847 0.0847
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.6184 1 1
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0042 0.011
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.286 0.4616 0.4616
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0013 0.0013
Mycobacterium leprae Probable biotinylated protein homolog TB7.3 0.0217 0.0336 0.0883
Echinococcus granulosus L aminoadipate semialdehyde 0.0058 0.0079 0.0079
Echinococcus granulosus g-protein coupled receptor 0.0017 0.0013 0.0013
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0042 0.9137
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.0039
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0217 0.0336 0.0883
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0014 0.0007 0.0007
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0217 0.0336 0.033
Loa Loa (eye worm) hypothetical protein 0.0217 0.0336 0.0344
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0009
Echinococcus granulosus G protein coupled receptor 139 0.0017 0.0013 0.0013
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0217 0.0336 0.0329
Schistosoma mansoni biogenic amine receptor 0.0017 0.0013 0.0013
Loa Loa (eye worm) kinesin-like protein KLP2 0.0427 0.0676 0.0697
Brugia malayi sulfakinin receptor protein 0.0017 0.0013 0.0009
Schistosoma mansoni neuropeptide receptor 0.0017 0.0013 0.0013
Schistosoma mansoni biogenic amine receptor 0.0017 0.0013 0.0013
Echinococcus granulosus Biotin lipoyl attachment 0.0217 0.0336 0.0336
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.005 0.0048
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0838 0.1342 0.2161
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0017 0.0013 0.0009
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0532 0.0847 0.2229
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0013 0.0013
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0014 0.0007 0.0003
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.4475 0.7232 1
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0016 0.0011 0.034
Echinococcus granulosus neuropeptide receptor 0.0017 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0017 0.0013 0.0013
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0042 0.011
Leishmania major hypothetical protein, conserved 0.0035 0.0042 0.0035
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0015 0.004
Brugia malayi G protein-coupled receptor F59B2.13 0.0017 0.0013 0.0009
Schistosoma mansoni neuropeptide receptor 0.0017 0.0013 0.0013
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.0007 0.1535
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0013 0.0013
Schistosoma mansoni myosin xvIII 0.0017 0.0013 0.0013
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0016 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0016 0.0011 0.0004
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0013 0.0013
Brugia malayi hypothetical protein 0.0017 0.0013 0.0009
Schistosoma mansoni hypothetical protein 0.0033 0.0039 0.0039
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0042 0.011
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0016 0.0011 0.0006
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.2356 0.38 0.38
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0217 0.0336 0.0883
Brugia malayi larval opioid receptor 0.0017 0.0013 0.0009
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0013 0.0013
Leishmania major carbamoyl-phosphate synthase, putative 0.0532 0.0847 0.0841
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0013 0.0013
Echinococcus granulosus alpha 1A adrenergic receptor 0.0017 0.0013 0.0013
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0013 0.0013
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0016 0.0011 0.0004
Echinococcus multilocularis orexin receptor type 2 0.0017 0.0013 0.0013
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0017 0.0013 0.0013
Mycobacterium leprae conserved hypothetical protein 0.0016 0.0011 0.003
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0042 0.0039
Chlamydia trachomatis dihydrolipoamide acetyltransferase 0.0217 0.0336 0.0943
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0013 0.0013
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.6184 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0012 0.0004 0.0004
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0838 0.1342 0.2161
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0013 0.0013
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0532 0.0847 0.1163
Echinococcus multilocularis neuropeptide s receptor 0.0017 0.0013 0.0013
Giardia lamblia Kinesin-5 0.0427 0.0676 0.3971
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0013 0.0013
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.2356 0.38 0.3796
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0838 0.1342 0.3532
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0042 0.0056
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0042 0.0039
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0013 0.0013
Echinococcus granulosus neuropeptide receptor 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Brugia malayi hypothetical protein 0.0017 0.0013 0.0009
Brugia malayi Dopamine receptor 0.0017 0.0013 0.0009
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0217 0.0336 0.0883
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.0007 0.1535
Entamoeba histolytica acetyl-coA carboxylase, putative 0.1055 0.1693 1
Schistosoma mansoni neuropeptide receptor 0.0017 0.0013 0.0013
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0013 0.0009
Echinococcus multilocularis neuropeptide receptor A26 0.0017 0.0013 0.0013
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0532 0.0847 0.136
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0217 0.0336 0.0455
Brugia malayi G protein-coupled receptor 0.0017 0.0013 0.0009
Echinococcus granulosus tachykinin peptides receptor 99D 0.0017 0.0013 0.0013
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0217 0.0336 0.0532
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0102 0.0155
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0042 0.011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0838 0.1342 0.1336
Entamoeba histolytica hypothetical protein 0.0016 0.0011 0.0026
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0042 0.0048
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0004 0.0004
Schistosoma mansoni adenoreceptor 0.0017 0.0013 0.0013
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0015 0.004
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0013 0.0013
Echinococcus granulosus g protein coupled receptor 0.0017 0.0013 0.0013
Echinococcus multilocularis G-protein coupled receptor, putative 0.0017 0.0013 0.0013
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0042 0.9137
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0016 0.0011 0.003
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.2356 0.38 1
Echinococcus multilocularis kinesin family 1 0.3287 0.5308 0.5308
Schistosoma mansoni hypothetical protein 0.0119 0.0177 0.0177
Echinococcus granulosus sex peptide receptor 0.0017 0.0013 0.0013
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.2356 0.38 0.38
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0056 0.0056
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0838 0.1342 0.3532
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0003
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0013 0.0013
Plasmodium falciparum carbamoyl phosphate synthetase 0.0532 0.0847 0.1163
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0082 0.0082
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0015 0.3361
Loa Loa (eye worm) hypothetical protein 0.0217 0.0336 0.0344
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Onchocerca volvulus 0.0028 0.0031 0.2687
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0009
Echinococcus multilocularis serotonin receptor 0.0017 0.0013 0.0013
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0217 0.0336 0.0943
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0013 0.0009
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0017 0.0013 0.0013
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0015 0.0013
Trichomonas vaginalis dullard protein, putative 0.0014 0.0007 0.1535
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0015 0.0049
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0016 0.0011 0.003
Echinococcus multilocularis 0.0014 0.0007 0.0007
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0017 0.0013 0.0013
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0017 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0119 0.0177 0.0177
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.005 0.0048
Schistosoma mansoni amine GPCR 0.0017 0.0013 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0013
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0053 0.0053
Echinococcus granulosus dna polymerase kappa 0.0019 0.0015 0.0015
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0072 0.0065
Brugia malayi hypothetical protein 0.0017 0.0013 0.0009
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0013 0.0013
Chlamydia trachomatis biotin carboxylase 0.2139 0.3449 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0013 0.0013
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0015 0.0009
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0217 0.0336 0.0532
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0838 0.1342 0.3532
Schistosoma mansoni amine GPCR 0.0017 0.0013 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0013 0.0013
Echinococcus granulosus dna polymerase eta 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0017 0.0013 0.0013
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0217 0.0336 0.0329
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Echinococcus granulosus GPCR family 2 0.0016 0.001 0.001
Brugia malayi G-protein coupled receptor 0.0017 0.0013 0.0009
Leishmania major acetyl-CoA carboxylase, putative 0.6184 1 1
Schistosoma mansoni opsin-like receptor 0.0017 0.0013 0.0013
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0838 0.1342 0.3532
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0017 0.0013 0.0009
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0013 0.0013
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.2356 0.38 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0017 0.0013 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0009
Echinococcus multilocularis G protein coupled receptor 139 0.0017 0.0013 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0064 0.0063
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0013 0.0013
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0013 0.0013
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0838 0.1342 0.1337
Schistosoma mansoni amine GPCR 0.0017 0.0013 0.0013
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0013 0.0013
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0015 0.0015
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.4475 0.7232 1
Echinococcus granulosus dro:myosuppressin receptor 0.0017 0.0013 0.0013
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0838 0.1342 0.1336
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.001 0.001
Brugia malayi putative neuropeptide receptor 0.0017 0.0013 0.0009
Leishmania major carboxylase, putative 0.2356 0.38 0.3795
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0017 0.0013 0.0009
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0838 0.1342 0.1342
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0003
Schistosoma mansoni hypothetical protein 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Onchocerca volvulus 0.0035 0.0042 0.4352
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0012
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0013 0.0013
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0073 0.0102 0.0102
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Echinococcus multilocularis allatostatin A receptor 0.0017 0.0013 0.0013
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0064 0.0063
Echinococcus granulosus voltage gated potassium channel 0.0012 0.0004 0.0004
Mycobacterium tuberculosis Conserved protein 0.0035 0.0042 0.011
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.2356 0.38 0.38
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0013 0.0013
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0013 0.0013
Echinococcus granulosus somatostatin receptor 0.0017 0.0013 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0013
Trichomonas vaginalis dullard protein, putative 0.0014 0.0007 0.1535
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0217 0.0336 0.0532
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0016 0.0011 0.003
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0017 0.0013 0.0013
Leishmania major DNA polymerase eta, putative 0.0019 0.0015 0.0008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.0039
Schistosoma mansoni histamine h1 receptor 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0217 0.0336 0.0532
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0013
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0217 0.0336 0.0455
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.2356 0.38 0.3795
Echinococcus multilocularis g-protein coupled receptor 0.0017 0.0013 0.0013
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0014 0.0007 0.0007
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0015 0.0015
Brugia malayi beta-lactamase family protein 0.0035 0.0042 0.0039
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0013 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0013
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0017 0.0013 0.0009
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0013 0.0013
Echinococcus multilocularis dna polymerase eta 0.0019 0.0015 0.0015
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Toxoplasma gondii carbamoylphosphate synthetase 0.0532 0.0847 0.0841
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0016 0.0011 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0009
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0017 0.0013 0.0013
Plasmodium vivax kinesin-5 0.0427 0.0676 0.0926
Brugia malayi GnHR receptor homolog 0.0017 0.0013 0.0009
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0217 0.0336 0.0329
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0031 0.0028
Trypanosoma brucei unspecified product 0.1549 0.2493 0.2488
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0217 0.0336 0.033
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.2356 0.38 0.6139
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0217 0.0336 0.0883
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0217 0.0336 0.0883
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0012 0.0004 0.0004
Brugia malayi follicle stimulating hormone receptor 0.0017 0.0013 0.0009
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.2356 0.38 0.38
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0009
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0046 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0064 0.0063
Mycobacterium ulcerans lipase LipD 0.0035 0.0042 0.011
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide acyltransferase E2 component 0.0217 0.0336 0.0883
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0532 0.0847 0.2229
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0046 1
Echinococcus multilocularis sex peptide receptor 0.0017 0.0013 0.0013
Echinococcus granulosus peptide allatostatin:somatostatin 0.0017 0.0013 0.0013
Schistosoma mansoni opsin-like receptor 0.0017 0.0013 0.0013
Mycobacterium ulcerans pyruvate carboxylase 0.2356 0.38 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0042 0.0042
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0017 0.0013 0.0013
Trichomonas vaginalis esterase, putative 0.0035 0.0042 0.9137
Schistosoma mansoni amine GPCR 0.0017 0.0013 0.0013
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0042 0.0042
Mycobacterium leprae Probable lipase LipE 0.0035 0.0042 0.011
Treponema pallidum pyruvate carboxylase subunit B 0.0217 0.0336 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0017 0.0013 0.0013
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0017 0.0013 0.0009
Brugia malayi Melatonin receptor type 1A 0.0017 0.0013 0.0009
Brugia malayi hypothetical protein 0.0017 0.0013 0.0009
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0017 0.0013 0.0013
Schistosoma mansoni amine GPCR 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0217 0.0336 0.0344
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0217 0.0336 0.0329
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0073 0.0102 0.0102
Leishmania major DNA polymerase kappa, putative 0.0019 0.0015 0.0008
Brugia malayi putative neuropeptide receptor NPR1 0.0017 0.0013 0.0009
Mycobacterium ulcerans hypothetical protein 0.0217 0.0336 0.0883
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0217 0.0336 0.0336
Trichomonas vaginalis dullard protein, putative 0.0014 0.0007 0.1535
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0017 0.0013 0.0009
Echinococcus multilocularis serotonin receptor 0.0017 0.0013 0.0013
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0015 0.004
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0017 0.0013 0.0013
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0017 0.0013 0.0013
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0838 0.1342 0.1342
Schistosoma mansoni biogenic amine receptor 0.0017 0.0013 0.0013
Echinococcus granulosus 7TM GPCR rhodopsin 0.0017 0.0013 0.0013
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0016 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0033 0.0039 0.0037
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0015 0.3361
Brugia malayi beta-lactamase family protein 0.0035 0.0042 0.0039
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0838 0.1342 0.1342
Echinococcus multilocularis neuropeptide FF receptor 2 0.0017 0.0013 0.0013
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0217 0.0336 0.0344
Brugia malayi Kinesin motor domain containing protein 0.0427 0.0676 0.0697
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0838 0.1342 0.3532
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0015 0.0009
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Echinococcus granulosus g protein coupled receptor 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0073 0.0102 0.0102
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0073 0.0102 0.0102
Brugia malayi Tachykinin-like peptides receptor 99D 0.0017 0.0013 0.0009
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0217 0.0336 0.0455
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0013 0.0013
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.5967 0.9649 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.001 0.001
Echinococcus multilocularis geminin 0.0119 0.0177 0.0177
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0042 0.9137
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0013
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.2356 0.38 1
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0013 0.0013
Schistosoma mansoni cpg binding protein 0.003 0.0033 0.0033
Brugia malayi hypothetical protein 0.0017 0.0013 0.0009
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0017 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.0035 0.0041 0.0039
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0015 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0009
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0102 0.0097
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Echinococcus granulosus kinesin family 1 0.3287 0.5308 0.5308
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0013 0.0013
Wolbachia endosymbiont of Brugia malayi branched-chain alpha-keto acid dehydrogenase subunit E2 0.0217 0.0336 0.0883
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0217 0.0336 0.0329
Schistosoma mansoni neuropeptide receptor 0.0017 0.0013 0.0013
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.0007 0.1535
Brugia malayi neuropeptide F receptor 0.0017 0.0013 0.0009
Brugia malayi Serotonin receptor 0.0017 0.0013 0.0009
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0013 0.0013
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.1055 0.1693 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0017 0.0013 0.0013
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0017 0.0013 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0004 0.0004
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0838 0.1342 0.3532
Mycobacterium ulcerans hypothetical protein 0.0035 0.0042 0.011
Echinococcus granulosus CTD small phosphatase protein like 0.0014 0.0007 0.0007
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0042 0.011
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0042 0.0042
Echinococcus granulosus geminin 0.0119 0.0177 0.0177
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0017 0.0013 0.0013
Brugia malayi hypothetical protein 0.0017 0.0013 0.0009
Brugia malayi CXXC zinc finger family protein 0.0028 0.0031 0.0028
Onchocerca volvulus 0.0058 0.0079 1
Brugia malayi hypothetical protein 0.0017 0.0013 0.0009
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.001 0.001
Schistosoma mansoni DNA polymerase eta 0.0019 0.0015 0.0015
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0217 0.0336 0.0329
Echinococcus granulosus allatostatin A receptor 0.0017 0.0013 0.0013
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0838 0.1342 0.2161
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0039 0.0037
Schistosoma mansoni cpg binding protein 0.003 0.0033 0.0033
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0217 0.0336 0.033
Loa Loa (eye worm) TYRA-2 protein 0.0017 0.0013 0.0009
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0217 0.0336 0.0329
Echinococcus multilocularis cpg binding protein 0.003 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0017 0.0013 0.0013
Brugia malayi ORL1-like opioid receptor 0.0017 0.0013 0.0009
Echinococcus granulosus cpg binding protein 0.003 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0217 0.0336 0.0336
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0217 0.0336 0.0336
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0017 0.0013 0.0013
Brugia malayi hypothetical protein 0.0017 0.0013 0.0009
Toxoplasma gondii ABC1 family protein 0.0035 0.0042 0.0035
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0014 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.6184 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0042 0.0036
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0058 0.0079 0.0078
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0838 0.1342 0.3532
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0217 0.0336 0.0336
Schistosoma mansoni hypothetical protein 0.0017 0.0013 0.0013
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0015 0.0013
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0838 0.1342 0.3532
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0014 0.0007 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0015 0.0009
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0015 0.0009
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0016 0.0011 0.003
Schistosoma mansoni hypothetical protein 0.0013 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0838 0.1342 0.3532
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0013 0.0013
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0016 0.001 0.001
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0217 0.0336 0.0344
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.2356 0.38 1
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0042 0.011
Echinococcus granulosus neuropeptide receptor A26 0.0017 0.0013 0.0013
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0014 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.0039
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0007
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0838 0.1342 0.3532
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0013 0.0013
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0073 0.0102 0.0096
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0015 0.0013
Echinococcus granulosus serotonin receptor 0.0017 0.0013 0.0013
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0064 0.0063
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0009
Schistosoma mansoni pyruvate carboxylase 0.2356 0.38 0.38
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0042 0.011
Onchocerca volvulus 0.0035 0.0042 0.4352

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.1 nM Inhibition of prostaglandin DP receptor ChEMBL. 18570365

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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