TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 482.82 | Formula: C24H17BrClNOS
H donors: 1 H acceptors: 1 LogP: 7.78 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)S/C(=C/c1c[nH]c2c1cc(Cl)cc2)/C(=O)c1ccc(cc1)Br
InChi: 1S/C24H17BrClNOS/c1-15-2-9-20(10-3-15)29-23(24(28)16-4-6-18(25)7-5-16)12-17-14-27-22-11-8-19(26)13-21(17)22/h2-14,27H,1H3/b23-12+
InChiKey: POOBYRHZKAWOFR-FSJBWODESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	unc 13 (munc13)	0.0072	0.1743	0.164
Loa Loa (eye worm)	TK protein kinase	0.0034	0.0615	0.0615
Schistosoma mansoni	serine/threonine protein kinase	0.0073	0.1794	0.1459
Trichomonas vaginalis	AGC family protein kinase	0.0077	0.1916	0.1452
Loa Loa (eye worm)	TK/INSR protein kinase	0.0048	0.1028	0.1028
Leishmania major	protein kinase A catalytic subunit isoform 1	0.0121	0.3231	0.5
Brugia malayi	protein kinase C II.	0.0281	0.806	1
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0073	0.1794	0.1709
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0073	0.1794	0.1794
Entamoeba histolytica	protein kinase, putative	0.0077	0.1916	0.4154
Entamoeba histolytica	hypothetical protein	0.0065	0.1556	0.3095
Loa Loa (eye worm)	hypothetical protein	0.0337	0.9762	0.9762
Echinococcus granulosus	unc 13 munc13	0.0072	0.1743	0.164
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 1	0.0121	0.3231	1
Loa Loa (eye worm)	SRC-1	0.0038	0.0724	0.0724
Echinococcus multilocularis	insulin receptor	0.0048	0.1028	0.0694
Schistosoma mansoni	serine/threonine kinase	0.0073	0.1794	0.1459
Echinococcus multilocularis	serine threonine protein kinase	0.0196	0.5498	0.6609
Entamoeba histolytica	protein kinase, putative	0.0073	0.1794	0.3796
Loa Loa (eye worm)	hypothetical protein	0.0272	0.7785	0.7785
Schistosoma mansoni	atypical protein kinase C	0.0226	0.6402	0.7739
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0143	0.3906	1
Schistosoma mansoni	tyrosine kinase	0.008	0.1993	0.173
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.008	0.1993	0.1972
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0121	0.3231	0.361
Schistosoma mansoni	serine/threonine protein kinase	0.0069	0.1657	0.1273
Loa Loa (eye worm)	hypothetical protein	0.0065	0.1556	0.1556
Echinococcus granulosus	tyrosine kinase	0.0034	0.0615	0.0148
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0073	0.1794	0.1709
Entamoeba histolytica	protein kinase, putative	0.0073	0.1794	0.3796
Schistosoma mansoni	serine/threonine protein kinase	0.0262	0.7474	0.9201
Schistosoma mansoni	tyrosine kinase	0.0048	0.1028	0.0414
Echinococcus multilocularis		0.0045	0.0952	0.0594
Schistosoma mansoni	rac gtpase activating protein	0.0065	0.1556	0.1134
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0069	0.1668	0.1542
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0125	0.3353	0.8377
Onchocerca volvulus		0.0189	0.5297	0.5883
Onchocerca volvulus		0.0185	0.5175	0.5681
Echinococcus granulosus	Rac GTPase activating protein 1	0.0065	0.1556	0.1394
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0038	0.0724	0.0292
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0121	0.3231	0.361
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0069	0.1657	0.1528
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0034	0.0615	0.0148
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0038	0.0724	0.0292
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0041	0.0825	0.0427
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0038	0.0724	0.0292
Trichomonas vaginalis	AGC family protein kinase	0.0077	0.1916	0.1452
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0034	0.0615	0.0148
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0072	0.1743	0.164
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0038	0.0724	0.0292
Brugia malayi	Protein kinase c protein 2	0.0192	0.5361	0.6651
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0038	0.0724	0.0292
Brugia malayi	p70 ribosomal S6 kinase beta	0.0073	0.1794	0.2226
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0067	0.1613	0.1468
Brugia malayi	diacylglycerol kinase	0.0065	0.1556	0.193
Entamoeba histolytica	protein kinase, putative	0.0077	0.1916	0.4154
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0073	0.1794	0.1794
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0048	0.1028	0.0694
Schistosoma mansoni	tyrosine kinase	0.0078	0.1936	0.1653
Trypanosoma brucei	protein kinase A catalytic subunit, putative	0.0121	0.3231	1
Echinococcus multilocularis	protein kinase c epsilon type	0.0281	0.806	1
Entamoeba histolytica	diacylglycerol kinase, putative	0.0065	0.1556	0.3095
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0189	0.5277	0.6547
Loa Loa (eye worm)	hypothetical protein	0.007	0.1678	0.1678
Echinococcus granulosus	epidermal growth factor receptor	0.008	0.1993	0.1972
Loa Loa (eye worm)	hypothetical protein	0.012	0.3199	0.3199
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0073	0.1794	0.1794
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0073	0.1794	0.1794
Echinococcus granulosus	RNA directed DNA polymerase	0.0117	0.3096	0.3431
Echinococcus multilocularis	N chimaerin	0.0069	0.1668	0.1542
Entamoeba histolytica	diacylglycerol kinase, putative	0.0065	0.1556	0.3095
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0209	0.5897	0.7138
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0121	0.3231	0.361
Loa Loa (eye worm)	hypothetical protein	0.012	0.3199	0.3199
Brugia malayi	Hr1 repeat family protein	0.0073	0.1794	0.2226
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0069	0.1668	0.1542
Brugia malayi	Protein kinase domain containing protein	0.0048	0.1028	0.1275
Loa Loa (eye worm)	hypothetical protein	0.0272	0.7785	0.7785
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0038	0.0724	0.0292
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0038	0.0724	0.0292
Brugia malayi	cAMP-dependent protein kinase catalytic subunit, putative	0.0121	0.3231	0.4009
Schistosoma mansoni	diacylglycerol kinase theta	0.0065	0.1556	0.1134
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0038	0.0724	0.0292
Echinococcus multilocularis	protein kinase c iota type	0.022	0.6222	0.7567
Echinococcus multilocularis	epidermal growth factor receptor	0.0148	0.4044	0.4686
Schistosoma mansoni	serine/threonine protein kinase	0.0121	0.3231	0.3418
Trichomonas vaginalis	AGC family protein kinase	0.0073	0.1794	0.0659
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0077	0.1916	0.1916
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0121	0.3231	0.5
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0121	0.3231	0.3231
Echinococcus granulosus	N chimaerin	0.0069	0.1668	0.1542
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0073	0.1794	0.1709
Schistosoma mansoni	protein kinase C mu	0.0065	0.1556	0.1134
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0032	0.0558	0.0073
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0032	0.0558	0.0073
Giardia lamblia	Kinase, AGC PKA	0.0121	0.3231	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.008	0.1993	0.1972
Echinococcus granulosus	Protein kinase C brain isozyme	0.0262	0.7474	0.9224
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0073	0.1794	0.1794
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	0.0121	0.3231	0.5
Brugia malayi	protein-tyrosine kinase	0.0034	0.0615	0.0763
Echinococcus granulosus	NDR protein kinase	0.0073	0.1794	0.1709
Brugia malayi	RhoGAP domain containing protein	0.0065	0.1556	0.193
Echinococcus granulosus	protein kinase c epsilon type	0.0281	0.806	1
Echinococcus granulosus	Diacylglycerol kinase theta	0.0065	0.1556	0.1394
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0073	0.1794	0.1794
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0038	0.0724	0.0292
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0156	0.4288	0.4288
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0069	0.1657	0.1528
Trichomonas vaginalis	AGC family protein kinase	0.0077	0.1916	0.1452
Schistosoma mansoni	hypothetical protein	0.0065	0.1556	0.1134
Schistosoma mansoni	tyrosine kinase	0.0048	0.1028	0.0414
Loa Loa (eye worm)	TK protein kinase	0.0031	0.0503	0.0503
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0069	0.1668	0.1287
Loa Loa (eye worm)	hypothetical protein	0.0065	0.1556	0.1556
Loa Loa (eye worm)	hypothetical protein	0.0121	0.3231	0.3231
Echinococcus granulosus	epidermal growth factor receptor	0.0148	0.4044	0.4686
Echinococcus multilocularis	enhancer of mRNA decapping protein 4	0.0118	0.313	0.3476
Loa Loa (eye worm)	raf kinase	0.0065	0.1556	0.1556
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0072	0.1743	0.164
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0069	0.1668	0.1287
Schistosoma mansoni	tyrosine kinase	0.008	0.1993	0.173
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0038	0.0724	0.0292
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0281	0.806	0.806
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0038	0.0724	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1743	0.1743
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0038	0.0724	0.0292
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0065	0.1556	0.1556
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 2	0.0121	0.3231	1
Echinococcus granulosus	serine:threonine protein kinase N2	0.0139	0.3784	0.4341
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0073	0.1794	0.1709
Brugia malayi	diacylglycerol kinase	0.0065	0.1556	0.193
Trichomonas vaginalis	AGC family protein kinase	0.0077	0.1916	0.1452
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0038	0.0724	0.0292
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0038	0.0724	0.0292
Brugia malayi	SRC-1	0.0038	0.0724	0.0898
Schistosoma mansoni	protein kinase C	0.0072	0.1743	0.1389
Trichomonas vaginalis	AGC family protein kinase	0.0077	0.1916	0.1452
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0123	0.33	0.33
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0073	0.1794	0.1709
Toxoplasma gondii	AGC kinase	0.0073	0.1794	0.1423
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0073	0.1794	0.1709
Schistosoma mansoni	diacylglycerol kinase theta	0.0065	0.1556	0.1134
Echinococcus granulosus	protein kinase c iota type	0.022	0.6222	0.7567
Trichomonas vaginalis	AGC family protein kinase	0.0073	0.1794	0.0659
Brugia malayi	Pleckstrin Homology Domain	0.007	0.1678	0.2082
Schistosoma mansoni	tyrosine kinase	0.0148	0.4044	0.4526
Echinococcus granulosus	raf serine:threonine protein kinase	0.0067	0.1613	0.1468
Echinococcus granulosus	protein kinase C gamma type	0.0196	0.5498	0.6609
Trichomonas vaginalis	AGC family protein kinase	0.0077	0.1916	0.1452
Echinococcus multilocularis	RNA directed DNA polymerase	0.0117	0.3096	0.3431
Brugia malayi	RhoGEF domain containing protein	0.0065	0.1556	0.193
Schistosoma mansoni	unc-13 (munc13)	0.0072	0.1743	0.1389
Echinococcus granulosus	enhancer of mRNA decapping protein 4	0.0118	0.313	0.3476
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0065	0.1556	0.1394
Leishmania major	protein kinase A catalytic subunit isoform 2	0.0121	0.3231	0.5
Schistosoma mansoni	protein kinase C mu	0.0189	0.5277	0.6206
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0073	0.1794	0.1709
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	0.0121	0.3231	0.5
Loa Loa (eye worm)	hypothetical protein	0.0182	0.5073	0.5073
Brugia malayi	C1-like domain containing protein	0.0189	0.5277	0.6547
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0121	0.3231	0.3231
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0038	0.0724	0.0292
Schistosoma mansoni	serine/threonine protein kinase	0.0073	0.1794	0.1459
Echinococcus multilocularis	protein kinase c eta type	0.0065	0.1556	0.1394
Loa Loa (eye worm)	hypothetical protein	0.0272	0.7785	0.7785
Schistosoma mansoni	tyrosine kinase	0.0078	0.1936	0.1653
Schistosoma mansoni	serine/threonine protein kinase	0.0073	0.1794	0.1459
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0126	0.3384	0.3384
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0121	0.3231	0.361
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0148	0.4044	0.4044
Loa Loa (eye worm)	hypothetical protein	0.0065	0.1556	0.1556
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0121	0.3231	0.361
Brugia malayi	protein kinase C3,putative	0.015	0.4108	0.5097
Brugia malayi	Ras association domain family 1 isoform A	0.0065	0.1556	0.193
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0121	0.3231	0.361
Echinococcus granulosus	serine:threonine protein kinase N2	0.0073	0.1794	0.1709
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0189	0.5277	0.5277
Schistosoma mansoni	serine/threonine protein kinase	0.0281	0.806	1
Brugia malayi	RhoGAP domain containing protein	0.0069	0.1668	0.2069
Onchocerca volvulus		0.012	0.3199	0.241
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0121	0.3231	0.361
Loa Loa (eye worm)	hypothetical protein	0.0065	0.1556	0.1556
Onchocerca volvulus		0.0272	0.7785	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.1556	0.1556
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0069	0.1668	0.1668
Loa Loa (eye worm)	hypothetical protein	0.0065	0.1556	0.1556
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0034	0.0615	0.0148
Schistosoma mansoni	serine/threonine protein kinase	0.0069	0.1657	0.1273
Schistosoma mansoni	serine/threonine protein kinase	0.0121	0.3231	0.3418
Schistosoma mansoni	serine/threonine protein kinase	0.0067	0.1613	0.1211
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	0.0121	0.3231	0.5
Echinococcus granulosus	insulin receptor	0.0048	0.1028	0.0694
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0121	0.3231	0.5
Echinococcus granulosus	protein kinase c eta type	0.0065	0.1556	0.1394
Brugia malayi	Protein kinase domain containing protein	0.0073	0.1794	0.2226
Brugia malayi	Protein kinase domain containing protein	0.0077	0.1916	0.2378
Schistosoma mansoni	serine/threonine protein kinase	0.0262	0.7474	0.9201
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0065	0.1556	0.1556
Brugia malayi	Variant SH3 domain containing protein	0.0069	0.1668	0.2069
Brugia malayi	Furin-like cysteine rich region family protein	0.0148	0.4044	0.5018
Echinococcus granulosus	myotubularin protein 13	0.007	0.1678	0.1555
Trichomonas vaginalis	AGC family protein kinase	0.0121	0.3231	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0034	0.0615	0.0148
Toxoplasma gondii	AGC kinase	0.0121	0.3231	1
Trichomonas vaginalis	AGC family protein kinase	0.0077	0.1916	0.1452
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0065	0.1556	0.1556
Loa Loa (eye worm)	hypothetical protein	0.0189	0.5297	0.5297
Trichomonas vaginalis	AGC family protein kinase	0.0077	0.1916	0.1452
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0065	0.1556	0.1394
Leishmania major	protein kinase A catalytic subunit	0.0121	0.3231	0.5
Toxoplasma gondii	AGC kinase	0.0121	0.3231	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0034	0.0615	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0117	0.3096	0.3096
Schistosoma mansoni	serine/threonine protein kinase	0.0073	0.1794	0.1459
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	0.0121	0.3231	0.5
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0125	0.3353	0.8377
Brugia malayi	Protein kinase domain containing protein	0.0073	0.1794	0.2226
Schistosoma mansoni	tyrosine kinase	0.0078	0.1936	0.1653
Toxoplasma gondii	protein kinase, cAMP-dependent, catalytic chain	0.0121	0.3231	1
Brugia malayi	Protein kinase domain containing protein	0.0069	0.1657	0.2056
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0117	0.3096	0.3431
Loa Loa (eye worm)	hypothetical protein	0.0185	0.5175	0.5175
Trichomonas vaginalis	AGC family protein kinase	0.0073	0.1794	0.0659
Schistosoma mansoni	vav2	0.0073	0.179	0.1453
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0262	0.7474	0.9224
Schistosoma mansoni	serine/threonine protein kinase	0.0121	0.3231	0.3418
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0073	0.1794	0.1709
Echinococcus multilocularis	myotubularin protein 13	0.007	0.1678	0.1555
Schistosoma mansoni	unc-13 (munc13)	0.0072	0.1743	0.1389
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0038	0.0724	0.0292
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0048	0.1028	0.0694

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	= 1 uM	Growth inhibition of human K562 cells expressing p210Bcr/Abl after 96 hrs by trypan blue exclusion assay	ChEMBL.	20188579
GI50 (functional)	= 1 uM	Growth inhibition of human DU145 cells after 96 hrs by trypan blue exclusion assay	ChEMBL.	20188579

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1242602

Bibliographic References

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Detailed information for compound 1014620