Detailed information for compound 1014822

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 346.464 | Formula: C20H30N2O3
  • H donors: 0 H acceptors: 0 LogP: 2.69 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCN1C[C@H]2[C@H](CC[C@@H]1CN2Cc1ccc(cc1OC)OC)OC
  • InChi: 1S/C20H30N2O3/c1-5-10-21-14-18-19(24-3)9-7-16(21)13-22(18)12-15-6-8-17(23-2)11-20(15)25-4/h5-6,8,11,16,18-19H,1,7,9-10,12-14H2,2-4H3/t16-,18+,19+/m1/s1
  • InChiKey: UHYKRQZIKNQPFD-NEWSRXKRSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.0062 0.0062
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0138 0.0856 0.0856
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0164 0.0151
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0293 0.19 0.19
Schistosoma mansoni loxhd1 0.0019 0.0059 0.0059
Brugia malayi glutamate synthase 0.0138 0.0856 0.0856
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0086 0.0509 0.0485
Schistosoma mansoni signal transduction protein lnk-related 0.0015 0.003 0.003
Plasmodium vivax cysteine repeat modular protein 2, putative 0.0014 0.0025 0.0024
Schistosoma mansoni cell polarity protein 0.0015 0.0027 0.0027
Loa Loa (eye worm) TK/EPH protein kinase 0.0081 0.0475 0.0475
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0519 0.3419 0.3401
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0519 0.3419 0.3401
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0059 0.0059
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0138 0.0856 0.0855
Mycobacterium ulcerans ferredoxin reductase 0.0138 0.0856 0.2443
Echinococcus multilocularis growth factor receptor bound protein 2 0.0029 0.0127 0.0127
Echinococcus granulosus tyrosine protein kinase Src64B 0.0034 0.0159 0.0159
Echinococcus granulosus RUN 0.0019 0.0059 0.0059
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0015 0.0027 0.0027
Onchocerca volvulus 0.006 0.0332 0.0982
Trichomonas vaginalis glutathione reductase, putative 0.0519 0.3419 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0034 0.0159 0.0159
Loa Loa (eye worm) SRC-1 0.0034 0.0159 0.0159
Loa Loa (eye worm) programmed cell death 8 0.0138 0.0856 0.0856
Brugia malayi tRNA modification GTPase TrmE family protein 0.0015 0.003 0.003
Echinococcus granulosus NCK adaptor protein 0.0029 0.0127 0.0127
Schistosoma mansoni microtubule-associated protein tau 0.1391 0.928 0.928
Echinococcus multilocularis transfer RNA-Ala 0.0015 0.0027 0.0027
Echinococcus multilocularis RUN 0.0019 0.0059 0.0059
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0138 0.0856 0.2464
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0138 0.0856 0.0856
Schistosoma mansoni hypothetical protein 0.0015 0.003 0.003
Schistosoma mansoni tyrosine kinase 0.0034 0.0159 0.0159
Schistosoma mansoni tensin 0.0015 0.003 0.003
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.0027 0.0014
Loa Loa (eye worm) STAT protein 0.0015 0.003 0.003
Echinococcus granulosus growth factor receptor bound protein 2 0.0029 0.0127 0.0127
Trypanosoma cruzi trypanothione reductase, putative 0.0519 0.3419 0.3401
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0138 0.0856 0.0831
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0849 0.5634 0.5634
Loa Loa (eye worm) guanylate kinase 0.0015 0.0027 0.0027
Onchocerca volvulus 0.0015 0.0027 0.0005
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0519 0.3419 0.3401
Mycobacterium tuberculosis Probable oxidoreductase 0.0519 0.3419 0.341
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0519 0.3419 0.3401
Giardia lamblia Glutamate synthase 0.0138 0.0856 0.2447
Loa Loa (eye worm) hypothetical protein 0.0138 0.0856 0.0856
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0375 0.0375
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0015 0.0027 0.0027
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0138 0.0856 0.0856
Brugia malayi SH2 domain containing protein 0.002 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0061 0.0343 0.0343
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0015 0.003 0.003
Echinococcus granulosus SH2 domain containing adapter protein F 0.0015 0.003 0.003
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0138 0.0856 0.0831
Echinococcus granulosus src region 0.0015 0.0027 0.0027
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0138 0.0856 0.0831
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0027
Schistosoma mansoni rab6-interacting 0.0019 0.0059 0.0059
Onchocerca volvulus 0.002 0.0062 0.0117
Entamoeba histolytica SH2-protein kinase domain containing protein 0.002 0.0062 0.0441
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.003
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0015 0.0027 0.0005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0262 0.0249
Leishmania major NADH dehydrogenase, putative 0.0138 0.0856 0.0831
Brugia malayi SH2 domain containing protein 0.0015 0.003 0.003
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0343 0.0318
Echinococcus granulosus tyrosine protein kinase Lyn 0.0034 0.0159 0.0159
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0519 0.3419 0.3418
Entamoeba histolytica hypothetical protein 0.0015 0.0027 0.002
Onchocerca volvulus 0.0061 0.0343 0.1016
Onchocerca volvulus 0.0058 0.0319 0.0939
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0034 0.0159 0.0159
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0249 0.0249
Entamoeba histolytica hypothetical protein, conserved 0.0015 0.0027 0.002
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0519 0.3419 1
Entamoeba histolytica hypothetical protein 0.0037 0.0181 0.1875
Schistosoma mansoni hypothetical protein 0.0017 0.0041 0.0041
Entamoeba histolytica hypothetical protein 0.0015 0.0027 0.002
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0519 0.3419 1
Plasmodium vivax acetyl-CoA synthetase, putative 0.0015 0.0027 0.0026
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0015 0.0027 0.0027
Brugia malayi GCC2 and GCC3 family protein 0.0014 0.0025 0.0025
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0138 0.0856 0.0856
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0015 0.0027 0.0002
Echinococcus granulosus geminin 0.0176 0.1114 0.1114
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.002 0.0062 0.0062
Leishmania major trypanothione reductase 0.1498 1 1
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0138 0.0856 0.0833
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0138 0.0856 0.0843
Loa Loa (eye worm) histone methyltransferase 0.002 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0014 0.0025 0.0025
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0138 0.0856 0.0831
Plasmodium falciparum ferrodoxin reductase-like protein 0.0138 0.0856 0.0833
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0015 0.0027 0.0027
Echinococcus multilocularis tyrosine protein kinase shark 0.002 0.0062 0.0062
Brugia malayi Src substrate cortactin 0.0015 0.0027 0.0027
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0169 0.0169
Echinococcus granulosus expressed protein 0.0015 0.0027 0.0027
Echinococcus multilocularis signal transduction protein lnk realted 0.0015 0.003 0.003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0343 0.0343
Brugia malayi Pre-SET motif family protein 0.0061 0.0343 0.0343
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0138 0.0856 0.0843
Brugia malayi Variant SH3 domain containing protein 0.0015 0.003 0.003
Schistosoma mansoni sorting nexin 0.0015 0.0027 0.0027
Onchocerca volvulus 0.0479 0.3148 1
Brugia malayi SH2 domain containing protein 0.0015 0.003 0.003
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0041 0.0041
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0138 0.0856 0.0831
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0015 0.0027 0.0027
Schistosoma mansoni glutamate synthase 0.0138 0.0856 0.0856
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0138 0.0856 0.2443
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.003
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0138 0.0856 0.2464
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0034 0.0159 0.0159
Plasmodium falciparum thioredoxin reductase 0.0519 0.3419 0.3402
Schistosoma mansoni growth factor receptor-bound protein 0.0029 0.0127 0.0127
Schistosoma mansoni tensin 0.0015 0.003 0.003
Echinococcus granulosus dnaJ subfamily B 0.0825 0.5472 0.5472
Loa Loa (eye worm) hypothetical protein 0.003 0.0134 0.0134
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0015 0.003 0.003
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0343 0.0343
Trichomonas vaginalis mercuric reductase, putative 0.0519 0.3419 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0249 0.0249
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.003
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0138 0.0856 1
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0138 0.0856 0.0843
Schistosoma mansoni hypothetical protein 0.0019 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.0059
Brugia malayi GCC2 and GCC3 family protein 0.0014 0.0025 0.0025
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0445 0.2918 0.2899
Echinococcus granulosus SH2 motif 0.0015 0.003 0.003
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0138 0.0856 0.0831
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0138 0.0856 0.0831
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0025
Echinococcus multilocularis nostrin 0.0015 0.0027 0.0027
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0178 0.0165
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0519 0.3419 1
Entamoeba histolytica BAR/SH3 domain containing protein 0.0015 0.0027 0.002
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0262 0.0693
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0015 0.0027 0.0027
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0138 0.0856 0.2464
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0027 0.0027
Onchocerca volvulus 0.0015 0.003 0.0013
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0375 0.0375
Echinococcus multilocularis tyrosine protein kinase ABL1 0.002 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0062
Schistosoma mansoni tyrosine kinase 0.0034 0.0159 0.0159
Trypanosoma cruzi NADH dehydrogenase, putative 0.0138 0.0856 0.0831
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0138 0.0856 0.0831
Mycobacterium ulcerans NADH dehydrogenase 0.0138 0.0856 0.2443
Loa Loa (eye worm) hypothetical protein 0.0227 0.1457 0.1457
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0027 0.0027
Brugia malayi SRC-1 0.0034 0.0159 0.0159
Schistosoma mansoni lipoxygenase 0.0115 0.0703 0.0703
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.003
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0027 0.0027
Echinococcus multilocularis ephrin type A receptor 4 A 0.0079 0.046 0.046
Echinococcus multilocularis tyrosine protein kinase Abl 0.0034 0.0159 0.0159
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0029 0.0127 0.0127
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0519 0.3419 0.3401
Schistosoma mansoni hypothetical protein 0.0017 0.0041 0.0041
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.0027 0.0014
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.028 0.028
Plasmodium vivax SET domain protein, putative 0.0061 0.0343 0.0341
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0014 0.0025 0.0024
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0015 0.003 0.0013
Schistosoma mansoni SH2A 0.0015 0.003 0.003
Echinococcus granulosus histone acetyltransferase KAT2B 0.0285 0.1844 0.1844
Onchocerca volvulus 0.0015 0.0027 0.0005
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0138 0.0856 0.2443
Plasmodium falciparum histone acetyltransferase GCN5 0.0079 0.0461 0.0436
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0015 0.0027 0.0027
Schistosoma mansoni cpg binding protein 0.0058 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.003
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0027 0.0028
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0138 0.0856 0.0833
Treponema pallidum NADH oxidase 0.0519 0.3419 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0027
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0015 0.003 0.003
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0138 0.0856 1
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0138 0.0856 0.0855
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0249 0.0249
Entamoeba histolytica acetyltransferase, GNAT family 0.0079 0.0461 0.5241
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0041 0.0041
Brugia malayi STAT protein, DNA binding domain containing protein 0.0015 0.003 0.003
Echinococcus multilocularis expressed protein 0.0015 0.0027 0.0027
Echinococcus multilocularis dnaJ subfamily B 0.0825 0.5472 0.5472
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0027 0.0027
Echinococcus multilocularis GPCR, family 2 0.0017 0.0041 0.0041
Brugia malayi Protein kinase domain containing protein 0.002 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0025
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0138 0.0856 0.0856
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0034 0.0159 0.0159
Echinococcus granulosus SH2 motif 0.0015 0.003 0.003
Brugia malayi acetyltransferase, GNAT family protein 0.0293 0.19 0.19
Loa Loa (eye worm) thyroid receptor interactor 0.0015 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0017 0.0041 0.0041
Brugia malayi Doublecortin family protein 0.0019 0.0059 0.0059
Onchocerca volvulus 0.0019 0.0059 0.0107
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0138 0.0856 0.0856
Echinococcus granulosus fch and double sh3 domains protein 2 0.0015 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0015 0.003 0.003
Toxoplasma gondii NADPH-glutathione reductase 0.0519 0.3419 0.3402
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0041 0.0041
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0138 0.0856 0.0833
Echinococcus multilocularis endophilin A3 0.0015 0.0027 0.0027
Brugia malayi hypothetical protein 0.0037 0.0181 0.0181
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0138 0.0856 0.0856
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0262 0.0693
Schistosoma mansoni growth factor receptor-bound protein 0.0029 0.0127 0.0127
Trypanosoma brucei C-8 sterol isomerase, putative 0.0445 0.2918 0.2899
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0519 0.3419 1
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0015 0.0027 0.0027
Entamoeba histolytica SH2 domain containing protein 0.0015 0.003 0.0049
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0015 0.003 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0027 0.0027
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0138 0.0856 0.2443
Onchocerca volvulus 0.0015 0.0027 0.0006
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0027
Echinococcus granulosus tyrosine protein kinase Blk 0.002 0.0062 0.0062
Brugia malayi SH2 domain containing protein 0.0015 0.003 0.003
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.0027 0.0014
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0138 0.0856 0.0831
Echinococcus granulosus microtubule associated protein 2 0.1391 0.928 0.928
Brugia malayi Variant SH3 domain containing protein 0.0029 0.0127 0.0127
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0015 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.003
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.0062 0.0062
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0138 0.0856 0.0856
Toxoplasma gondii histone lysine methyltransferase SET1 0.0119 0.073 0.0706
Echinococcus multilocularis intersectin 2 0.0015 0.0027 0.0027
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0164 0.0151
Schistosoma mansoni hypothetical protein 0.0015 0.0027 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.0138 0.0856 0.0831
Schistosoma mansoni nck2/grb4 0.0029 0.0127 0.0127
Giardia lamblia Histone acetyltransferase GCN5 0.0079 0.0461 0.1282
Mycobacterium ulcerans dehydrogenase 0.0138 0.0856 0.2443
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0519 0.3419 0.3402
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0319 0.0319
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0027 0.0027
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0015 0.0027 0.0027
Brugia malayi Tyrosine-protein kinase abl-1 0.0034 0.0159 0.0159
Echinococcus granulosus expressed conserved protein 0.0015 0.003 0.003
Echinococcus granulosus tyrosine kinase 0.002 0.0062 0.0062
Plasmodium falciparum thioredoxin reductase 0.1498 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0181 0.0181
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0034 0.0159 0.0159
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0041 0.0041
Brugia malayi hypothetical protein 0.0019 0.0059 0.0059
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0138 0.0856 0.2464
Brugia malayi Pre-SET motif family protein 0.0421 0.2758 0.2758
Loa Loa (eye worm) hypothetical protein 0.0029 0.0127 0.0127
Schistosoma mansoni tyrosine kinase 0.002 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0176 0.1114 0.1114
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0065 0.0065
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0015 0.003 0.003
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0138 0.0856 0.2464
Echinococcus multilocularis tensin 0.0015 0.003 0.003
Trichomonas vaginalis set domain proteins, putative 0.0479 0.3148 0.9202
Leishmania major C-8 sterol isomerase-like protein 0.0445 0.2918 0.2899
Onchocerca volvulus 0.0015 0.003 0.0013
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0138 0.0856 0.2443
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0015 0.003 0.0013
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0034 0.0159 0.0159
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0034 0.0159 0.0159
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0519 0.3419 0.3401
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0041 0.0041
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0293 0.19 0.19
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0262 0.0236
Onchocerca volvulus 0.002 0.0062 0.0117
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.0027 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0343 0.0343
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0034 0.0159 0.0159
Mycobacterium ulcerans hypothetical protein 0.0138 0.0856 0.2443
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0138 0.0856 0.0831
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.0062 0.0062
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0138 0.0856 0.0831
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0375 0.0375
Entamoeba histolytica hypothetical protein, conserved 0.0015 0.0027 0.002
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0027 0.0027
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0138 0.0856 0.2443
Brugia malayi Peripheral plasma membrane protein CASK 0.0015 0.0027 0.0027
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0027 0.0027
Echinococcus granulosus epidermal growth factor receptor kinase 0.0015 0.0027 0.0027
Onchocerca volvulus 0.0015 0.0027 0.0006
Echinococcus multilocularis tyrosine protein kinase Srms 0.002 0.0062 0.0062
Onchocerca volvulus 0.0015 0.003 0.0013
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0519 0.3419 0.3401
Plasmodium falciparum glutathione reductase 0.0519 0.3419 0.3402
Echinococcus multilocularis endonuclease reverse transcriptase 0.0014 0.0025 0.0025
Mycobacterium ulcerans hypothetical protein 0.0049 0.0262 0.0693
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0249 0.0249
Trichomonas vaginalis glutamate synthase, putative 0.0138 0.0856 0.2464
Schistosoma mansoni lipoxygenase 0.008 0.047 0.047
Trypanosoma cruzi NADH dehydrogenase, putative 0.0138 0.0856 0.0831
Schistosoma mansoni tyrosine kinase 0.0034 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0037 0.0178 0.0178
Trypanosoma brucei trypanothione reductase 0.1498 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0034 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.003
Mycobacterium ulcerans monoxygenase 0.0138 0.0856 0.2443
Entamoeba histolytica hypothetical protein 0.0015 0.0027 0.002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0027 0.0014
Plasmodium vivax cysteine repeat modular protein 3, putative 0.0014 0.0025 0.0024
Brugia malayi Fes/CIP4 homology domain containing protein 0.0015 0.0027 0.0027
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0059 0.0034
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0262 0.0693
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0249 0.0249
Brugia malayi SH2 domain containing protein 0.0015 0.003 0.003
Echinococcus granulosus tyrosine protein kinase Srms 0.002 0.0062 0.0062
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0015 0.0027 0.0027
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.0027 0.0027
Mycobacterium ulcerans glutamate synthase subunit beta 0.0138 0.0856 0.2443
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.006 0.006
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0178 0.0445
Echinococcus multilocularis tyrosine protein kinase Blk 0.002 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0049 0.0262 0.0262
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0138 0.0856 0.2443
Entamoeba histolytica hypothetical protein 0.0015 0.0027 0.002
Loa Loa (eye worm) hypothetical protein 0.0037 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0049 0.0262 0.0262
Plasmodium vivax thioredoxin reductase, putative 0.1498 1 1
Brugia malayi Spectrin alpha chain 0.0015 0.0027 0.0027
Echinococcus granulosus tyrosine protein kinase Src42A 0.0015 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0036 0.0169 0.0169
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0034 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.003
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0027
Onchocerca volvulus 0.0015 0.0027 0.0005
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0059 0.0059
Schistosoma mansoni tyrosine kinase 0.002 0.0062 0.0062
Entamoeba histolytica hypothetical protein 0.0015 0.0027 0.002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.0041
Trichomonas vaginalis apoptosis inducing factor, putative 0.0138 0.0856 0.2464
Loa Loa (eye worm) hypothetical protein 0.0037 0.0178 0.0178
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0015 0.003 0.003
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0262 0.0693
Echinococcus granulosus Spectrin alpha actinin 0.0015 0.0027 0.0027
Echinococcus granulosus tyrosine protein kinase shark 0.002 0.0062 0.0062
Giardia lamblia Thioredoxin reductase 0.0138 0.0856 0.2447
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.0062 0.0062
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.0703 0.0703
Schistosoma mansoni sulfide quinone reductase 0.0138 0.0856 0.0856
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.0027 0.0027
Schistosoma mansoni run and tbc1 domain containing 0.0015 0.0027 0.0027
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0138 0.0856 0.2443
Schistosoma mansoni dynamin-associated protein 0.0015 0.0027 0.0027
Onchocerca volvulus Putative cortactin 0.0015 0.0027 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0519 0.3419 0.3401
Mycobacterium tuberculosis Probable reductase 0.0138 0.0856 0.0843
Schistosoma mansoni ephrin receptor 0.0065 0.0364 0.0364
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0015 0.003 0.003
Echinococcus granulosus ephrin type A receptor 4 A 0.0079 0.046 0.046
Echinococcus granulosus intersectin 2 0.0015 0.0027 0.0027
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0138 0.0856 0.0843
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0138 0.0856 0.0856
Brugia malayi SH3 domain containing protein 0.0015 0.0027 0.0027
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0034 0.0159 0.0159
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0519 0.3419 0.3401
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0027 0.0028
Schistosoma mansoni sorbin 0.0015 0.0027 0.0027
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0138 0.0856 0.2443
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0034 0.0159 0.0159
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0262 0.0262
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.0062 0.0062
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0164 0.0151
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0015 0.003 0.003
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.0027 0.0027
Echinococcus granulosus hypothetical protein 0.0015 0.003 0.003
Schistosoma mansoni cpg binding protein 0.0061 0.0341 0.0341
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0138 0.0856 0.0833
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0015 0.003 0.003
Brugia malayi SH2 domain containing protein 0.0015 0.003 0.003
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0319 0.0319
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0138 0.0856 0.0856
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0262 0.285
Echinococcus multilocularis tensin 0.0015 0.003 0.003
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0015 0.003 0.003
Schistosoma mansoni glutamate synthase 0.0138 0.0856 0.0856
Onchocerca volvulus 0.002 0.0062 0.0117
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0138 0.0856 0.2464
Echinococcus multilocularis cpg binding protein 0.0061 0.0341 0.0341
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.0062 0.0062
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0262 0.0693
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0015 0.003 0.003
Onchocerca volvulus 0.002 0.0062 0.0117
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0519 0.3419 0.3402
Entamoeba histolytica hypothetical protein 0.0037 0.0181 0.1875
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0138 0.0856 0.2443
Trypanosoma cruzi trypanothione reductase, putative 0.1498 1 1
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0262 0.0262
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0249 0.0249
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0519 0.3419 0.3402
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0027 0.0014
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0181 0.0181
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0138 0.0856 0.0856
Loa Loa (eye worm) acetyltransferase 0.0293 0.19 0.19
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0027
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0025 0.0024
Echinococcus multilocularis tyrosine kinase 0.002 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.003
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0059 0.0058
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0262 0.285
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0138 0.0856 0.0856
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0027
Brugia malayi TAR-binding protein 0.0066 0.0375 0.0375
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0262 0.0249
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0027
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0138 0.0856 1
Schistosoma mansoni formin binding protein and related proteins 0.0015 0.0027 0.0027
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0034 0.0159 0.0159
Brugia malayi Protein kinase domain containing protein 0.002 0.0062 0.0062
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0041 0.0041
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0015 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0059 0.0059
Entamoeba histolytica hypothetical protein 0.0015 0.0027 0.002
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0015 0.003 0.003
Onchocerca volvulus 0.002 0.0062 0.0117
Echinococcus multilocularis SH2 motif 0.0015 0.003 0.003
Brugia malayi RNA binding protein 0.0066 0.0375 0.0375
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.0062 0.0062
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0262 0.0693
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0027 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0375 0.0375
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0138 0.0856 0.0843
Schistosoma mansoni tensin-related 0.0015 0.003 0.003
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0421 0.2758 0.2758
Echinococcus multilocularis NCK adaptor protein 0.0029 0.0127 0.0127
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0015 0.0027 0.0002
Echinococcus granulosus glutamate synthase 0.0138 0.0856 0.0856
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0138 0.0856 0.0843
Leishmania major hypothetical protein, conserved 0.0138 0.0856 0.0831
Echinococcus multilocularis 0.0015 0.003 0.003
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0343 0.0343
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0059 0.0059
Echinococcus multilocularis SH2 motif 0.0015 0.003 0.003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0519 0.3419 0.3401
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0063 0.0063
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0138 0.0856 0.0856
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0049 0.0262 0.0262
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0519 0.3419 0.341
Loa Loa (eye worm) TK protein kinase 0.002 0.0062 0.0062
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0519 0.3419 0.3401
Schistosoma mansoni sulfide quinone reductase 0.0138 0.0856 0.0856
Echinococcus multilocularis tyrosine protein kinase Fyn 0.002 0.0062 0.0062
Schistosoma mansoni suppressor of cytokine signaling 0.0015 0.003 0.003
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0059 0.0059
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0041 0.0041
Echinococcus multilocularis SH2 domain containing protein 7 0.0015 0.003 0.003
Loa Loa (eye worm) RNA binding protein 0.0066 0.0375 0.0375
Entamoeba histolytica hypothetical protein 0.0015 0.0027 0.002
Brugia malayi CXXC zinc finger family protein 0.0058 0.0319 0.0319
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0375 0.0375
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0015 0.0027 0.0027
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0015 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0169 0.0169
Onchocerca volvulus 0.0019 0.0059 0.0107
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0027 0.0027
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0027 0.0027
Onchocerca volvulus 0.0049 0.0262 0.0758
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0138 0.0856 0.2443
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0015 0.003 0.003
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.0062 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0027 0.0027
Brugia malayi GCC2 and GCC3 family protein 0.0014 0.0025 0.0025
Schistosoma mansoni Dab2-interacting protein-like 0.0015 0.0027 0.0027
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0027 0.0027
Loa Loa (eye worm) protein-tyrosine kinase 0.0015 0.0027 0.0027
Onchocerca volvulus 0.0015 0.003 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.0445 0.2918 0.2918
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.003
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0262 0.0236
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0015 0.003 0.003
Echinococcus granulosus suppressor of cytokine signaling 6 0.0015 0.003 0.003
Echinococcus granulosus signal transduction protein lnk realted 0.0015 0.003 0.003
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0029 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.0037 0.0178 0.0178
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0015 0.0027 0.0027
Echinococcus granulosus tyrosine protein kinase Fyn 0.0034 0.0159 0.0159
Entamoeba histolytica BAR/SH3 domain containing protein 0.0015 0.0027 0.002
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.003
Brugia malayi ephrin receptor 1 precursor 0.0033 0.0152 0.0152
Echinococcus granulosus SHC transforming protein 3 0.0015 0.003 0.003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0041 0.0041
Leishmania major hypothetical protein, conserved 0.0138 0.0856 0.0831
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.0027 0.0014
Trypanosoma brucei hypothetical protein, conserved 0.0138 0.0856 0.0831
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0138 0.0856 0.0833
Brugia malayi RhoGAP domain containing protein 0.0015 0.003 0.003
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.028 0.028
Brugia malayi Tensin 0.0015 0.003 0.003
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0027 0.0027
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.0027 0.0014
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0445 0.2918 0.2918
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0181 0.0181
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0249 0.0249
Brugia malayi Variant SH3 domain containing protein 0.0015 0.003 0.003
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0519 0.3419 0.3419
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0138 0.0856 0.0833
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0015 0.0027 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.0138 0.0856 0.0831
Brugia malayi Protein kinase domain containing protein 0.002 0.0062 0.0062
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0029 0.0127 0.0127
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0519 0.3419 0.3419
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0381 0.2493 0.2493
Loa Loa (eye worm) thioredoxin reductase 0.1498 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0027 0.0027
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0138 0.0856 0.0856
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0519 0.3419 0.3419
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0015 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0027 0.0027
Echinococcus multilocularis Spectrin alpha actinin 0.0015 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0037 0.0181 0.0181
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0027 0.0027
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0015 0.0027 0.0027
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.003
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0262 0.285
Toxoplasma gondii selenide, water dikinase 0.0138 0.0856 0.0833
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0015 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0025
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0343 0.0343
Onchocerca volvulus 0.0015 0.0027 0.0005
Echinococcus granulosus tyrosine protein kinase Fyn 0.0034 0.0159 0.0159
Loa Loa (eye worm) SH2 domain-containing protein 0.0015 0.003 0.003
Onchocerca volvulus 0.0015 0.003 0.0013
Echinococcus granulosus cpg binding protein 0.0061 0.0341 0.0341
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0015 0.0027 0.0027
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0041 0.0041
Entamoeba histolytica hypothetical protein 0.0037 0.0181 0.1875
Brugia malayi Myosin tail family protein 0.0015 0.0027 0.0027
Brugia malayi Guanylate kinase family protein 0.0015 0.0027 0.0027
Onchocerca volvulus 0.0138 0.0856 0.266
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0262 0.0693
Onchocerca volvulus 0.002 0.0062 0.0117
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0249 0.0249
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0164 0.0151
Trichomonas vaginalis glutamate synthase, putative 0.0138 0.0856 0.2464
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0015 0.003 0.003
Brugia malayi hypothetical protein 0.0019 0.0059 0.0059
Plasmodium vivax glutathione reductase, putative 0.1498 1 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0138 0.0856 0.0843
Entamoeba histolytica protein kinase, putative 0.0015 0.0027 0.002
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0138 0.0856 0.0843
Schistosoma mansoni GTPase activating protein 0.0015 0.003 0.003
Echinococcus granulosus SH2 domain containing protein 7 0.0015 0.003 0.003
Echinococcus multilocularis c src tyrosine kinase 0.0034 0.0159 0.0159
Brugia malayi Sex muscle abnormal protein 5 0.0029 0.0127 0.0127
Brugia malayi hypothetical protein 0.0015 0.003 0.003
Echinococcus granulosus endophilin A3 0.0015 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0052 0.028 0.028
Onchocerca volvulus 0.0015 0.0027 0.0005
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0138 0.0856 0.0833
Schistosoma mansoni vav2 0.0015 0.003 0.003
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0343 0.0343
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.002 0.0062 0.0062
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0138 0.0856 0.0856
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0015 0.0027 0.0027
Echinococcus granulosus tyrosine protein kinase ABL1 0.002 0.0062 0.0062
Echinococcus granulosus nostrin 0.0015 0.0027 0.0027
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0138 0.0856 0.2443
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0262 0.0693
Echinococcus multilocularis N chimaerin 0.0015 0.003 0.003
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0034 0.0159 0.0159
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0138 0.0856 0.2464
Onchocerca volvulus 0.0015 0.003 0.0013
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0138 0.0856 0.2443
Trichomonas vaginalis p67phox protein, putative 0.0015 0.0027 0.0027
Echinococcus multilocularis microtubule associated protein 2 0.1391 0.928 0.928
Loa Loa (eye worm) oxidoreductase 0.0015 0.0027 0.0027
Schistosoma mansoni tensin 0.0015 0.003 0.003
Toxoplasma gondii propionate-CoA ligase 0.0015 0.0027 0.0002
Brugia malayi Thioredoxin reductase 0.1498 1 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0178 0.0177
Echinococcus multilocularis thioredoxin glutathione reductase 0.1498 1 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0519 0.3419 0.3401
Schistosoma mansoni hypothetical protein 0.0825 0.5472 0.5472
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0027 0.0027
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0519 0.3419 0.3419
Trypanosoma brucei NADH dehydrogenase 0.0138 0.0856 0.0831
Echinococcus granulosus tar DNA binding protein 0.0066 0.0375 0.0375
Echinococcus granulosus endonuclease reverse transcriptase 0.0014 0.0025 0.0025
Schistosoma mansoni apoptosis stimulating of P53 0.0015 0.0027 0.0027
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0138 0.0856 1
Echinococcus granulosus thioredoxin glutathione reductase 0.1498 1 1
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0015 0.0027 0.0022
Chlamydia trachomatis thioredoxin reductase 0.0138 0.0856 0.2091
Schistosoma mansoni C-fyn 0.0015 0.0027 0.0027
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.0027 0.0002
Echinococcus granulosus tyrosine kinase 0.002 0.0062 0.0062
Schistosoma mansoni tensin-related 0.0015 0.003 0.003
Echinococcus multilocularis glutamate synthase 0.0138 0.0856 0.0856
Entamoeba histolytica protein kinase, putative 0.0015 0.003 0.0049
Echinococcus granulosus tyrosine protein kinase Fps85D 0.002 0.0062 0.0062
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0519 0.3419 1
Brugia malayi protein-tyrosine kinase 0.002 0.0062 0.0062
Echinococcus granulosus suppressor of cytokine signaling 7 0.0015 0.003 0.003
Toxoplasma gondii thioredoxin reductase 0.1498 1 1
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0025 0.0024
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0034 0.0159 0.0159
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0138 0.0856 0.2464
Giardia lamblia NADH oxidase lateral transfer candidate 0.0519 0.3419 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0519 0.3419 0.3401
Loa Loa (eye worm) hypothetical protein 0.0015 0.003 0.003
Onchocerca volvulus 0.0015 0.0027 0.0006
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0041 0.0041
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0381 0.2493 0.2493
Schistosoma mansoni rab6-interacting 0.0019 0.0059 0.0059
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.028 0.028
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0519 0.3419 0.3418
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0519 0.3419 0.3401
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0178 0.0153
Echinococcus multilocularis SHC transforming protein 3 0.0015 0.003 0.003
Brugia malayi SH2 domain containing protein 0.002 0.0062 0.0062
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0262 0.0262
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0138 0.0856 0.2464
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0519 0.3419 0.3401
Entamoeba histolytica thioredoxin reductase, putative 0.0138 0.0856 1
Echinococcus granulosus N chimaerin 0.0015 0.003 0.003
Loa Loa (eye worm) TK/ABL protein kinase 0.002 0.0062 0.0062
Loa Loa (eye worm) glutathione reductase 0.1498 1 1
Echinococcus granulosus tensin 0.0015 0.003 0.003
Echinococcus granulosus c src tyrosine kinase 0.0034 0.0159 0.0159
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0262 0.0693
Brugia malayi hypothetical protein 0.002 0.0062 0.0062
Schistosoma mansoni adapter molecule crk 0.0029 0.0127 0.0127
Schistosoma mansoni polycystin 1-related 0.0019 0.0059 0.0059
Loa Loa (eye worm) p53BP2 0.0015 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0176 0.1114 0.1114
Schistosoma mansoni cpg binding protein 0.0061 0.0341 0.0341
Schistosoma mansoni tyrosine kinase 0.0034 0.0159 0.0159
Schistosoma mansoni hypothetical protein 0.0017 0.0041 0.0041
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0015 0.003 0.0049
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0262 0.0236
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0138 0.0856 0.0843
Plasmodium vivax ferrodoxin reductase, putative 0.0138 0.0856 0.0855
Onchocerca volvulus 0.0015 0.0027 0.0006
Loa Loa (eye worm) TK/FER protein kinase 0.002 0.0062 0.0062
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0015 0.003 0.003
Echinococcus multilocularis SH2 motif 0.0015 0.003 0.003
Brugia malayi Variant SH3 domain containing protein 0.0029 0.0127 0.0127
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0138 0.0856 0.0856
Trichomonas vaginalis bromodomain-containing protein, putative 0.0086 0.0509 0.1444
Loa Loa (eye worm) SH2 domain-containing protein 0.0015 0.003 0.003
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0519 0.3419 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0343 0.0343
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0519 0.3419 0.3401
Entamoeba histolytica hypothetical protein 0.0015 0.0027 0.002
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0086 0.0509 0.0485
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0059 0.0059
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0041 0.0041
Schistosoma mansoni suppressor of cytokine signaling 0.0015 0.003 0.003
Brugia malayi Protein kinase domain containing protein 0.002 0.0062 0.0062
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0138 0.0856 0.0843
Brugia malayi SH2 domain containing protein 0.0015 0.003 0.003
Schistosoma mansoni eps8-related protein 0.0015 0.0027 0.0027
Loa Loa (eye worm) SH2 domain-containing protein 0.0015 0.003 0.003
Entamoeba histolytica unconventional myosin IB 0.0015 0.0027 0.002
Schistosoma mansoni dreadlocks/dock 0.0015 0.0027 0.0027
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0015 0.003 0.003
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0027 0.0027
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0519 0.3419 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0178 0.0178
Echinococcus granulosus histone acetyltransferase KAT2B 0.0086 0.0509 0.0509
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0519 0.3419 0.341
Leishmania major hypothetical protein, conserved 0.0138 0.0856 0.0831
Brugia malayi GCC2 and GCC3 family protein 0.0014 0.0025 0.0025
Schistosoma mansoni disulfide oxidoreductase 0.0138 0.0856 0.0856
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0086 0.0509 0.0508
Brugia malayi cytokine inducible SH2-containing protein 5 0.0015 0.003 0.003
Brugia malayi SH2 domain containing protein 0.0015 0.003 0.003
Brugia malayi protein-tyrosine kinase 0.0015 0.0027 0.0027
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0086 0.0509 0.1444
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0375 0.0375
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.1498 1 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0519 0.3419 0.341
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0027 0.0014
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0138 0.0856 0.2464
Brugia malayi Protein kinase domain containing protein 0.002 0.0062 0.0062
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0138 0.0856 0.0843
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0015 0.003 0.003
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0027 0.0027
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0138 0.0856 0.0856
Loa Loa (eye worm) hypothetical protein 0.006 0.0332 0.0332
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0015 0.003 0.003
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0015 0.003 0.003
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.0027 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0249 0.0249
Schistosoma mansoni glutamate synthase 0.0138 0.0856 0.0856
Entamoeba histolytica disulphide oxidoreductase, putative 0.0138 0.0856 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0065 0.0065
Entamoeba histolytica hypothetical protein 0.0037 0.0181 0.1875
Echinococcus multilocularis geminin 0.0176 0.1114 0.1114
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0138 0.0856 0.2447
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.0703 0.0703
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0015 0.003 0.003
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0027 0.0027
Schistosoma mansoni shc transforming protein 0.0015 0.003 0.003
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0059 0.0059
Echinococcus granulosus tyrosine protein kinase Fyn 0.0034 0.0159 0.0159
Schistosoma mansoni hypothetical protein 0.0015 0.0027 0.0027
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0059 0.0059
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0027 0.0027
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0375 0.0375
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0125 0.077 0.077
Plasmodium falciparum glutathione reductase 0.1498 1 1
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0138 0.0856 1
Echinococcus granulosus GPCR family 2 0.0017 0.0041 0.0041

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 49 % Cytotoxicity against human A427 cells at 20 uM after 96 hrs by crystal violet staining relative to control ChEMBL. 19081725
Activity (functional) = 63 % Cytotoxicity against human 5637 cells at 20 uM after 96 hrs by crystal violet staining relative to control ChEMBL. 19081725
Activity (functional) = 79 % Cytotoxicity against human MCF7 cells after 96 hrs at 20 uM by crystal violet staining relative to control ChEMBL. 19081725
Activity (functional) = 84 % Cytotoxicity against human DAN-G cells after 96 hrs at 20 uM by crystal violet staining relative to control ChEMBL. 19081725
Activity (functional) = 87 % Cytotoxicity against human RT4 cells at 20 uM after 96 hrs by crystal violet staining relative to control ChEMBL. 19081725
IC50 (functional) = 18.9 uM Cytotoxicity against human A427 cells after 96 hrs by crystal violet staining relative to control ChEMBL. 19081725
Inhibition (binding) = 37 % Displacement of [3H](+)-pentazocine from opioid sigma1 receptor in guinea pig brain homogenate at 1 uM ChEMBL. 19081725

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19081725

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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