Detailed information for compound 1014836

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 308.33 | Formula: C15H20N2O5
  • H donors: 4 H acceptors: 5 LogP: -2.38 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: N[C@H](C(=O)O)C[C@H](C(=O)O)CCC(=O)NCc1ccccc1
  • InChi: 1S/C15H20N2O5/c16-12(15(21)22)8-11(14(19)20)6-7-13(18)17-9-10-4-2-1-3-5-10/h1-5,11-12H,6-9,16H2,(H,17,18)(H,19,20)(H,21,22)/t11-,12+/m1/s1
  • InChiKey: HMSFZCZUJKRFNW-NEPJUHHUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 Starlite/ChEMBL References
Rattus norvegicus Glutamate receptor ionotropic kainate 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis neutral amino acid transporter A Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 Get druggable targets OG5_127034 All targets in OG5_127034
Echinococcus granulosus sodium:dicarboxylate symporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis neutral amino acid transporter A Get druggable targets OG5_126739 All targets in OG5_126739
Theileria parva glutamate transporter, putative Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus Excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus neutral amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus excitatory amino acid transporter 2 Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus Excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus neutral amino acid transporter A Get druggable targets OG5_126739 All targets in OG5_126739
Chlamydia trachomatis glutamate symporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis NMDA receptor Get druggable targets OG5_127034 All targets in OG5_127034
Schistosoma japonicum Glutamate receptor delta-2 subunit precursor, putative Get druggable targets OG5_127034 All targets in OG5_127034
Echinococcus multilocularis excitatory amino acid transporter 2 Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus excitatory amino acid transporter 3 Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis neutral amino acid transporter A Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 Get druggable targets OG5_127034 All targets in OG5_127034
Echinococcus multilocularis excitatory amino acid transporter 3 Get druggable targets OG5_126739 All targets in OG5_126739
Schistosoma mansoni glutamate receptor kainate Get druggable targets OG5_127034 All targets in OG5_127034
Echinococcus multilocularis Excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Schistosoma japonicum Glutamate receptor, ionotropic kainate 3 precursor, putative Get druggable targets OG5_127034 All targets in OG5_127034
Echinococcus granulosus glutamate receptor ionotropic kainate 3 Get druggable targets OG5_127034 All targets in OG5_127034
Echinococcus granulosus neutral amino acid transporter A Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis excitatory amino acid transporter 2 Get druggable targets OG5_126739 All targets in OG5_126739
Schistosoma japonicum expressed protein Get druggable targets OG5_127034 All targets in OG5_127034
Brugia malayi Excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus glutamate receptor ionotropic kainate Get druggable targets OG5_127034 All targets in OG5_127034
Onchocerca volvulus Excitatory amino acid transporter homolog Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus excitatory amino acid transporter 2 Get druggable targets OG5_126739 All targets in OG5_126739
Schistosoma japonicum Glutamate receptor, ionotropic kainate 1 precursor, putative Get druggable targets OG5_127034 All targets in OG5_127034
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 Get druggable targets OG5_127034 All targets in OG5_127034
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter Get druggable targets OG5_126739 All targets in OG5_126739
Schistosoma japonicum ko:K05614 solute carrier family 1 (glial high affinity glutamate transporter),, putative Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis Excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Schistosoma mansoni glutamate receptor kainate Get druggable targets OG5_127034 All targets in OG5_127034
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 Get druggable targets OG5_127034 All targets in OG5_127034
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 Get druggable targets OG5_127034 All targets in OG5_127034
Echinococcus multilocularis glutamate receptor ionotropic kainate Get druggable targets OG5_127034 All targets in OG5_127034
Schistosoma japonicum expressed protein Get druggable targets OG5_127034 All targets in OG5_127034
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 Get druggable targets OG5_127034 All targets in OG5_127034
Schistosoma japonicum ko:K05613 solute carrier family 1 (glial high affinity glutamate transporter),, putative Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus multilocularis sodium:dicarboxylate symporter Get druggable targets OG5_126739 All targets in OG5_126739
Loa Loa (eye worm) excitatory amino acid transporter Get druggable targets OG5_126739 All targets in OG5_126739
Schistosoma japonicum Excitatory amino acid transporter 2, putative Get druggable targets OG5_126739 All targets in OG5_126739
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 Get druggable targets OG5_127034 All targets in OG5_127034
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Drosophila melanogaster Glutamate receptor IA Glutamate receptor ionotropic kainate 1   949 aa 913 aa 34.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.2042 0.2476
Plasmodium falciparum glutathione reductase 0.0017 0.0015 0.0185
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0507 0.6468
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0507 0.0798
Schistosoma mansoni hypothetical protein 0.0079 0.0773 0.0937
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0234 0.298
Loa Loa (eye worm) hypothetical protein 0.0035 0.0234 0.0368
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.008
Mycobacterium ulcerans hypothetical protein 0.0035 0.0234 0.2429
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0015 0.0286
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0234 0.093
Onchocerca volvulus Huntingtin homolog 0.0122 0.1292 0.7444
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0004 0.0004
Loa Loa (eye worm) excitatory amino acid transporter 0.0152 0.1656 0.2606
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0439 0.0532
Loa Loa (eye worm) hypothetical protein 0.008 0.0784 0.1234
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0015 0.0286
Loa Loa (eye worm) glutamate receptor 1 0.003 0.0178 0.028
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0051 0.0051
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0091 0.0916 0.1111
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0398 0.508
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0015 0.0286
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0507 0.6402
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0251 0.285 0.4487
Brugia malayi Glutamate receptor 1 precursor 0.003 0.0178 0.028
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0257 0.0312
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0773 0.1216
Echinococcus multilocularis tar DNA binding protein 0.0132 0.1411 0.1411
Plasmodium falciparum thioredoxin reductase 0.0017 0.0015 0.0185
Echinococcus multilocularis neutral amino acid transporter A 0.0152 0.1656 0.1656
Schistosoma mansoni gliotactin 0.0091 0.0916 0.1111
Mycobacterium leprae Probable lipase LipE 0.0035 0.0234 0.0757
Toxoplasma gondii ABC1 family protein 0.0035 0.0234 0.298
Brugia malayi Bromodomain containing protein 0.0077 0.0742 0.1168
Echinococcus granulosus acetylcholinesterase 0.054 0.6353 0.7705
Brugia malayi MH2 domain containing protein 0.0016 0.0004 0.0006
Schistosoma mansoni hypothetical protein 0.0171 0.1889 0.2291
Onchocerca volvulus 0.0091 0.0916 0.4802
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0784 0.4688
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0152 0.1656 0.1656
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0234 0.4607
Schistosoma mansoni zinc finger protein 0.002 0.0054 0.0066
Schistosoma mansoni ATP-binding cassette transporter 0.003 0.0178 0.0216
Loa Loa (eye worm) hypothetical protein 0.0052 0.0439 0.0691
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0015 0.0185
Echinococcus multilocularis acetylcholinesterase 0.054 0.6353 0.6353
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0773 0.0773
Toxoplasma gondii exonuclease III APE 0.0057 0.0507 0.6468
Brugia malayi latrophilin 2 splice variant baaae 0.0171 0.1889 0.2973
Echinococcus granulosus geminin 0.0362 0.4197 0.509
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.054 0.6353 0.7705
Schistosoma mansoni ap endonuclease 0.0057 0.0507 0.0615
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0507 0.6468
Echinococcus multilocularis Excitatory amino acid transporter 0.0152 0.1656 0.1656
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0257 0.0257
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0023 0.0028
Echinococcus multilocularis neuroligin 0.0091 0.0916 0.0916
Loa Loa (eye worm) carboxylesterase 0.0091 0.0916 0.1442
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0507 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0784 1
Onchocerca volvulus 0.0091 0.0916 0.4802
Schistosoma mansoni hypothetical protein 0.0021 0.0067 0.0082
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0015 0.0015
Brugia malayi glutathione reductase 0.0048 0.0398 0.0627
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0015 0.0286
Loa Loa (eye worm) glutamate receptor 2 0.003 0.0178 0.028
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0023 0.0023
Schistosoma mansoni DNA helicase recq1 0.002 0.0051 0.0061
Trypanosoma brucei trypanothione reductase 0.0048 0.0398 0.7854
Schistosoma mansoni neuroligin 3 (S09 family) 0.0091 0.0916 0.1111
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0234 0.0283
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0051 0.0999
Loa Loa (eye worm) hypothetical protein 0.0122 0.1292 0.2034
Loa Loa (eye worm) TAR-binding protein 0.0132 0.1411 0.2221
Brugia malayi PHD-finger family protein 0.0026 0.012 0.0189
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0023 0.0028
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.003 0.0048
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0398 0.1586
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0184 0.2042 0.3214
Loa Loa (eye worm) hypothetical protein 0.0091 0.0916 0.1442
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0146 0.1865
Echinococcus multilocularis zinc finger protein 0.002 0.0054 0.0054
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0004 0.0004
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0091 0.0916 0.0916
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0015 0.0286
Leishmania major trypanothione reductase 0.0048 0.0398 0.7854
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0152 0.1656 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0091 0.0916 0.0916
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0091 0.011
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0234 0.2429
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0067 0.0106
Brugia malayi Thioredoxin reductase 0.0048 0.0398 0.0627
Chlamydia trachomatis neutral amino acid transporter 0.0067 0.0629 0.3742
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0184 0.2042 0.2476
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0773 0.0937
Echinococcus granulosus glutamate NMDA receptor subunit 0.003 0.0178 0.0216
Loa Loa (eye worm) RNA binding protein 0.0132 0.1411 0.2221
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0015 0.0185
Loa Loa (eye worm) hypothetical protein 0.0044 0.0341 0.0536
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0015 0.0286
Schistosoma mansoni hypothetical protein 0.0362 0.4197 0.509
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0015 0.0286
Echinococcus granulosus excitatory amino acid transporter 2 0.0152 0.1656 0.2008
Echinococcus granulosus sodium:dicarboxylate symporter 0.0152 0.1656 0.2008
Trypanosoma cruzi ISWI complex protein 0.0016 0.0001 0.002
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.0784 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0507 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0552 0.0552
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0507 0.0615
Loa Loa (eye worm) hypothetical protein 0.0122 0.1292 0.2034
Echinococcus granulosus microtubule associated protein 2 0.0696 0.8245 1
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0049 0.0399 0.0399
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0152 0.1656 0.6595
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0036
Schistosoma mansoni zinc finger protein 0.0016 0.0001 0.0001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0015 0.0286
Schistosoma mansoni glutamate receptor AMPA 0.003 0.0178 0.0216
Trypanosoma brucei ISWI complex protein 0.0016 0.0001 0.002
Schistosoma mansoni glutamate receptor AMPA 0.003 0.0178 0.0216
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.2042 0.2476
Schistosoma mansoni DNA helicase recq5 0.002 0.0051 0.0061
Schistosoma mansoni tar DNA-binding protein 0.0132 0.1411 0.1711
Loa Loa (eye worm) hypothetical protein 0.0091 0.0916 0.1442
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0507 1
Echinococcus multilocularis acetylcholinesterase 0.054 0.6353 0.6353
Loa Loa (eye worm) hypothetical protein 0.0091 0.0916 0.1442
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0234 0.4607
Echinococcus multilocularis tumor protein p63 0.0354 0.41 0.41
Echinococcus granulosus neuroligin 0.0091 0.0916 0.1111
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.0449 0.2622
Brugia malayi Glutamate receptor 2 precursor 0.003 0.0178 0.028
Plasmodium falciparum thioredoxin reductase 0.0048 0.0398 0.508
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0051 0.0734
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0234 0.0757
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0004 0.0006
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0784 0.4688
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0234 0.0283
Echinococcus granulosus Smad4 0.0016 0.0004 0.0004
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0398 0.0483
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0015 0.0286
Schistosoma mansoni smad 0.0016 0.0004 0.0004
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0251 0.285 0.4487
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0015 0.0286
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0051 0.0401
Mycobacterium tuberculosis Conserved protein 0.0035 0.0234 0.093
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.0507 0.3001
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.0784 0.5527
Toxoplasma gondii hypothetical protein 0.0028 0.0146 0.1865
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0067 0.0629 0.0629
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0234 0.2429
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0507 0.202
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0091 0.011
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0051 0.008
Echinococcus granulosus carboxylesterase 5A 0.054 0.6353 0.7705
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0111 0.115 0.8704
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0051 0.0646
Schistosoma mansoni hypothetical protein 0.0079 0.0773 0.0937
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.0784 0.0951
Echinococcus granulosus Excitatory amino acid transporter 0.0152 0.1656 0.2008
Brugia malayi Carboxylesterase family protein 0.054 0.6353 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0234 0.0368
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0004 0.0004
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0234 0.093
Echinococcus granulosus glutamate receptor 2 0.0036 0.0248 0.0301
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0015 0.0023
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0398 0.0398
Schistosoma mansoni tar DNA-binding protein 0.0132 0.1411 0.1711
Schistosoma mansoni acetylcholinesterase 0.0091 0.0916 0.1111
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0015 0.0018
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0015 0.0185
Echinococcus granulosus excitatory amino acid transporter 2 0.0152 0.1656 0.2008
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0398 0.7854
Echinococcus multilocularis excitatory amino acid transporter 2 0.0152 0.1656 0.1656
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0152 0.1656 0.1656
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0073 0.07 0.0849
Echinococcus multilocularis neutral amino acid transporter A 0.0152 0.1656 0.1656
Onchocerca volvulus 0.0091 0.0916 0.4802
Schistosoma mansoni tar DNA-binding protein 0.0132 0.1411 0.1711
Trichomonas vaginalis esterase, putative 0.0035 0.0234 0.2429
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0234 0.093
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0015 0.0286
Brugia malayi hypothetical protein 0.0122 0.1292 0.2034
Echinococcus multilocularis BC026374 protein (S09 family) 0.0091 0.0916 0.0916
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0234 0.2429
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0784 0.853
Echinococcus multilocularis NMDA receptor 0.0049 0.0399 0.0399
Schistosoma mansoni BC026374 protein (S09 family) 0.0091 0.0916 0.1111
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0051 0.008
Mycobacterium ulcerans carboxylesterase, LipT 0.0091 0.0916 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0091 0.0916 0.1111
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0015 0.0185
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.0449 0.1787
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0234 0.0368
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.0784 0.0951
Echinococcus multilocularis GPCR, family 2 0.0079 0.0773 0.0773
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0234 0.2429
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.115 0.4582
Brugia malayi hypothetical protein 0.0091 0.0916 0.1442
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.115 0.4582
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0051 0.008
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.0784 0.0784
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0507 0.0798
Plasmodium falciparum glutathione reductase 0.0048 0.0398 0.508
Echinococcus granulosus acetylcholinesterase 0.054 0.6353 0.7705
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0132 0.1411 0.2221
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0507 0.5461
Echinococcus granulosus neutral amino acid transporter 0.0152 0.1656 0.2008
Loa Loa (eye worm) hypothetical protein 0.054 0.6353 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0091 0.0091
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0004
Echinococcus granulosus glutamate receptor 2 0.0025 0.0112 0.0136
Schistosoma mansoni ap endonuclease 0.0057 0.0507 0.0615
Echinococcus granulosus tar DNA binding protein 0.0132 0.1411 0.1711
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0507 0.5461
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.0773 0.0937
Loa Loa (eye worm) carboxylesterase 0.054 0.6353 1
Loa Loa (eye worm) transcription factor SMAD2 0.0233 0.2637 0.415
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.0773 0.0773
Loa Loa (eye worm) glutathione reductase 0.0048 0.0398 0.0627
Loa Loa (eye worm) hypothetical protein 0.0251 0.285 0.4487
Brugia malayi Smad1 0.0016 0.0004 0.0006
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0073 0.07 0.07
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0015 0.0286
Schistosoma mansoni glutamate receptor kainate 0.0068 0.063 0.0765
Echinococcus multilocularis neutral amino acid transporter A 0.0152 0.1656 0.1656
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0073 0.07 0.0849
Mycobacterium tuberculosis Carboxylesterase LipT 0.0091 0.0916 0.365
Echinococcus multilocularis microtubule associated protein 2 0.0696 0.8245 0.8245
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0051 0.0646
Brugia malayi MH1 domain containing protein 0.0016 0.0004 0.0006
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.115 0.4582
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0234 0.0368
Treponema pallidum glutamate/aspartate transporter 0.0067 0.0629 0.7983
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0773 0.1216
Brugia malayi MH1 domain containing protein 0.0016 0.0004 0.0006
Schistosoma mansoni glutamate receptor kainate 0.0068 0.063 0.0765
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0552 0.067
Loa Loa (eye worm) MH2 domain-containing protein 0.0233 0.2637 0.415
Schistosoma mansoni glutamate receptor kainate 0.003 0.0178 0.0216
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0051 0.0999
Brugia malayi Carboxylesterase family protein 0.0091 0.0916 0.1442
Trichomonas vaginalis spcc417.12 protein, putative 0.0091 0.0916 1
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0091 0.0916 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0234 0.093
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.13 0.5178
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0234 0.0283
Brugia malayi TAR-binding protein 0.0132 0.1411 0.2221
Echinococcus multilocularis Excitatory amino acid transporter 0.0152 0.1656 0.1656
Brugia malayi RNA binding protein 0.0132 0.1411 0.2221
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0051 0.0061
Echinococcus granulosus bloom syndrome protein 0.002 0.0051 0.0061
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0234 0.093
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.2042 0.2476
Brugia malayi Carboxylesterase family protein 0.0091 0.0916 0.1442
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0184 0.2042 0.2476
Plasmodium vivax glutathione reductase, putative 0.0048 0.0398 0.508
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0001
Onchocerca volvulus 0.0091 0.0916 0.4802
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0049 0.0399 0.0399
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0015 0.0058
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0152 0.1656 0.2008
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0234 0.0234
Schistosoma mansoni tar DNA-binding protein 0.0132 0.1411 0.1711
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0004 0.0004
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0091 0.0916 0.365
Schistosoma mansoni glutamate receptor NMDA 0.003 0.0178 0.0216
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0073 0.07 0.07
Loa Loa (eye worm) hypothetical protein 0.0091 0.0916 0.1442
Mycobacterium ulcerans beta-lactamase 0.0035 0.0234 0.2429
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0073 0.07 0.0849
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0184 0.2042 0.3214
Loa Loa (eye worm) carboxylesterase 0.0091 0.0916 0.1442
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0067 0.0629 0.0762
Brugia malayi MH2 domain containing protein 0.0233 0.2637 0.415
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0234 0.4607
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0015 0.0286
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0067 0.0629 0.0629
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0146 0.1865
Loa Loa (eye worm) hypothetical protein 0.0035 0.0234 0.0368
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0398 0.0627
Echinococcus multilocularis geminin 0.0362 0.4197 0.4197
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0036 0.0248 0.0248
Echinococcus granulosus zinc finger protein 0.002 0.0054 0.0066
Schistosoma mansoni microtubule-associated protein tau 0.0696 0.8245 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0507 1
Brugia malayi Carboxylesterase family protein 0.0091 0.0916 0.1442
Brugia malayi beta-lactamase family protein 0.0035 0.0234 0.0368
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0051 0.0401
Loa Loa (eye worm) hypothetical protein 0.0039 0.0287 0.0453
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0023 0.0028
Echinococcus multilocularis Smad4 0.0016 0.0004 0.0004
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0784 1
Echinococcus multilocularis glutamate receptor 2 0.0036 0.0248 0.0248
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0234 0.2429
Schistosoma mansoni bromodomain containing protein 0.0065 0.0597 0.0724
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0091 0.0916 0.1111
Echinococcus multilocularis glutamate receptor 2 0.0025 0.0112 0.0112
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0091 0.0916 0.365
Brugia malayi beta-lactamase family protein 0.0035 0.0234 0.0368
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0051 0.008
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0234 0.093
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0449 0.0544
Loa Loa (eye worm) hypothetical protein 0.0042 0.0317 0.0499
Echinococcus multilocularis glutamate receptor 2 0.003 0.0178 0.0178
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0004
Echinococcus granulosus smad 0.0016 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0362 0.4197 0.509
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0507 0.5461
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0091 0.0916 0.1111
Brugia malayi Carboxylesterase family protein 0.0091 0.0916 0.1442
Onchocerca volvulus 0.0091 0.0916 0.4802
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0184 0.2042 0.2042
Mycobacterium tuberculosis Conserved protein 0.0035 0.0234 0.093
Echinococcus multilocularis smad 0.0016 0.0004 0.0004
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.115 0.4582
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.0449 0.1787
Schistosoma mansoni hypothetical protein 0.0079 0.0773 0.0937
Loa Loa (eye worm) Smad1 0.0016 0.0004 0.0006
Echinococcus granulosus para nitrobenzyl esterase 0.0091 0.0916 0.1111
Loa Loa (eye worm) acetylcholinesterase 1 0.054 0.6353 1
Treponema pallidum glutamate transporter 0.0067 0.0629 0.7983
Loa Loa (eye worm) hypothetical protein 0.0091 0.0916 0.1442
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0015 0.0286
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0784 1
Brugia malayi Bromodomain containing protein 0.0039 0.0287 0.0451
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0015 0.0286
Brugia malayi Probable ClpP-like protease 0.008 0.0784 0.1234
Chlamydia trachomatis glutamate symporter 0.0152 0.1656 1
Leishmania major hypothetical protein, conserved 0.0035 0.0234 0.4607
Schistosoma mansoni hypothetical protein 0.0079 0.0773 0.0937
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0051 0.0051
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0507 1
Brugia malayi Carboxylesterase family protein 0.054 0.6353 1
Echinococcus granulosus tumor protein p63 0.0354 0.41 0.4973
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0023 0.0028
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0234 0.2429
Echinococcus multilocularis excitatory amino acid transporter 2 0.0152 0.1656 0.1656
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0067 0.0629 0.0762
Echinococcus multilocularis carboxylesterase 5A 0.054 0.6353 0.6353
Brugia malayi RNA recognition motif domain containing protein 0.0132 0.1411 0.2221
Echinococcus multilocularis excitatory amino acid transporter 3 0.0152 0.1656 0.1656
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0004
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0449 0.0449
Trypanosoma cruzi ISWI complex protein 0.0016 0.0001 0.002
Echinococcus granulosus GPCR family 2 0.0079 0.0773 0.0937
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.13 1
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0036 0.0248 0.0301
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0051 0.0401
Loa Loa (eye worm) hypothetical protein 0.0091 0.0916 0.1442
Echinococcus granulosus neutral amino acid transporter A 0.0152 0.1656 0.2008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0234 0.0368
Loa Loa (eye worm) RecQ helicase 0.002 0.0051 0.008
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0507 0.0507
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0049 0.0399 0.0484
Brugia malayi Excitatory amino acid transporter 0.0152 0.1656 0.2606
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0023 0.0028
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0015 0.0286
Brugia malayi Calcitonin receptor-like protein seb-1 0.0251 0.285 0.4487
Mycobacterium tuberculosis Conserved protein 0.0035 0.0234 0.093
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0051 0.0646
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0773 0.1216
Loa Loa (eye worm) hypothetical protein 0.0035 0.0234 0.0368
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0234 0.2429
Brugia malayi MH2 domain containing protein 0.0016 0.0004 0.0006
Echinococcus multilocularis bloom syndrome protein 0.002 0.0051 0.0051
Echinococcus granulosus excitatory amino acid transporter 3 0.0152 0.1656 0.2008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0015 0.0286
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0051 0.0061
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.251 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0916 0.1442
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.054 0.6353 1
Onchocerca volvulus 0.0052 0.0439 0.1443
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0146 0.1712
Onchocerca volvulus Huntingtin homolog 0.0122 0.1292 0.7444
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0023 0.0028
Toxoplasma gondii thioredoxin reductase 0.0048 0.0398 0.508
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0004 0.0004
Brugia malayi beta-lactamase 0.0035 0.0234 0.0368
Mycobacterium tuberculosis Probable reductase 0.0111 0.115 0.4582
Echinococcus granulosus neutral amino acid transporter A 0.0152 0.1656 0.2008
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0015 0.0185
Echinococcus granulosus Excitatory amino acid transporter 0.0152 0.1656 0.2008
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.13 0.5178
Loa Loa (eye worm) hypothetical protein 0.0035 0.0234 0.0368
Loa Loa (eye worm) beta-lactamase 0.0035 0.0234 0.0368
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0507 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.0784 0.4688
Schistosoma mansoni Smad4 0.0016 0.0004 0.0004
Echinococcus granulosus BC026374 protein S09 family 0.0091 0.0916 0.1111
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.13 0.5178
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0051 0.0646
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.115 0.4582
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.003 0.0178 0.0178
Leishmania major hypothetical protein, conserved 0.0016 0.0001 0.002
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0049 0.0399 0.0484
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0184 0.2042 0.2042
Loa Loa (eye worm) hypothetical protein 0.0171 0.1889 0.2973
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0784 0.853
Schistosoma mansoni glutamate receptor NMDA 0.0036 0.0248 0.0301
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0015 0.0018
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0152 0.1656 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0051 0.0999
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0073 0.07 0.07
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0234 0.093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0773 0.1216
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0023 0.0023
Mycobacterium ulcerans lipase LipD 0.0035 0.0234 0.2429
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0784 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0015 0.0185
Schistosoma mansoni tar DNA-binding protein 0.0132 0.1411 0.1711
Loa Loa (eye worm) hypothetical protein 0.0072 0.0689 0.1085

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3 Inhibition of glutamate-induced depolarization in human EAAT1 expressed in HEK293 cells by FMP assay ChEMBL. 18578477
IC50 (binding) = 3 Inhibition of glutamate-induced depolarization in human EAAT3 expressed in HEK293 cells by FMP assay ChEMBL. 18578477
IC50 (binding) = 3.5 Inhibition of glutamate-induced depolarization in human EAAT2 expressed in HEK293 cells by FMP assay ChEMBL. 18578477
IC50 (binding) = 300 uM Inhibition of glutamate-induced depolarization in human EAAT2 expressed in HEK293 cells by FMP assay ChEMBL. 18578477
IC50 (binding) = 1000 uM Inhibition of glutamate-induced depolarization in human EAAT1 expressed in HEK293 cells by FMP assay ChEMBL. 18578477
IC50 (binding) = 1000 uM Inhibition of glutamate-induced depolarization in human EAAT3 expressed in HEK293 cells by FMP assay ChEMBL. 18578477
Ki (binding) = 2.5 Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells ChEMBL. 18578477
Ki (binding) = 4.14 Displacement of [3H]CGP 39653 from NMDA receptor in rat synaptosomes ChEMBL. 18578478
Ki (binding) = 4.67 Displacement of [3H]SYM2081 from rat recombinant iGluR7 ChEMBL. 18578478
Ki (binding) = 6.86 Displacement of [3H]SYM2081 from rat recombinant iGluR5 ChEMBL. 18578478
Ki (binding) = 138 nM Displacement of [3H]SYM2081 from rat recombinant iGluR5 ChEMBL. 18578478
Ki (binding) = 3000 nM Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells ChEMBL. 18578477
Ki (binding) = 21400 nM Displacement of [3H]SYM2081 from rat recombinant iGluR7 ChEMBL. 18578478
Ki (binding) > 100000 nM Displacement of [3H]SYM2081 from rat recombinant iGluR6 ChEMBL. 18578478
Ki (binding) = 72 uM Displacement of [3H]CGP 39653 from NMDA receptor in rat synaptosomes ChEMBL. 18578478
Ki (binding) = 410 uM Inhibition of [3H]D-Asp uptake at human EAAT2 in HEK293 cells ChEMBL. 18578477
Ki (binding) = 1000 uM Inhibition of [3H]D-Asp uptake at EAAT1 in HEK293 cells ChEMBL. 18578477
pKi (binding) = 2.5 uM Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cells ChEMBL. 18578477
pKi (binding) = 3 uM Inhibition of [3H]D-Asp uptake at EAAT1 in HEK293 cells ChEMBL. 18578477
pKi (binding) = 3.4 uM Inhibition of [3H]D-Asp uptake at human EAAT2 in HEK293 cells ChEMBL. 18578477

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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