Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 1 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 1 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 1 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 1 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.