Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | cytoplasmic intermediate filament protein | 0.0032 | 0.1196 | 0.3499 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.2745 | 0.9774 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0327 | 0.0327 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0023 | 0.064 | 0.1262 |
Schistosoma mansoni | lamin | 0.006 | 0.2809 | 0.2809 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.006 | 0.2809 | 1 |
Echinococcus granulosus | lamin dm0 | 0.006 | 0.2809 | 0.2565 |
Schistosoma mansoni | lamin | 0.006 | 0.2809 | 0.2809 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2809 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.2348 | 0.2348 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0023 | 0.064 | 0.0324 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0023 | 0.064 | 1 |
Echinococcus granulosus | lamin | 0.006 | 0.2809 | 0.2565 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0023 | 0.064 | 0.228 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0327 | 0.0327 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.00000000053848 | 0.0000000019172 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0023 | 0.064 | 0.0324 |
Onchocerca volvulus | 0.006 | 0.2809 | 0.5 | |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0023 | 0.064 | 0.1262 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.2472 | 0.8644 |
Schistosoma mansoni | intermediate filament proteins | 0.006 | 0.2809 | 0.2809 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0023 | 0.064 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.1479 | 0.4643 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0029 | 0.1011 | 0.0707 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.2472 | 0.8802 |
Echinococcus multilocularis | bloom syndrome protein | 0.0023 | 0.064 | 0.0324 |
Echinococcus multilocularis | geminin | 0.0185 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0327 | 0.0327 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.2472 | 0.8644 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.2348 | 0.8145 |
Entamoeba histolytica | recQ family helicase, putative | 0.0023 | 0.064 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0029 | 0.1011 | 0.0707 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0023 | 0.064 | 0.5 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0023 | 0.064 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.006 | 0.2809 | 0.2565 |
Echinococcus granulosus | bloom syndrome protein | 0.0023 | 0.064 | 0.0324 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0023 | 0.064 | 0.0324 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0023 | 0.064 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 1 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0023 | 0.064 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0032 | 0.1196 | 0.4257 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.006 | 0.2809 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.2348 | 0.209 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0012 | 0.00000000053848 | 0.5 |
Onchocerca volvulus | 0.006 | 0.2809 | 0.5 | |
Brugia malayi | intermediate filament protein | 0.006 | 0.2809 | 1 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0023 | 0.064 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.2348 | 0.2348 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0023 | 0.064 | 0.5 |
Loa Loa (eye worm) | RecQ helicase | 0.0023 | 0.064 | 0.228 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0948 | 0.3373 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.2348 | 0.2348 |
Loa Loa (eye worm) | intermediate filament protein | 0.006 | 0.2809 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.2348 | 0.209 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0327 | 0.1165 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0327 | 0.1165 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0023 | 0.064 | 0.0324 |
Schistosoma mansoni | DNA helicase recq5 | 0.0023 | 0.064 | 0.064 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0012 | 0.0000000011332 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1479 | 0.5267 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0023 | 0.064 | 0.1262 |
Echinococcus multilocularis | musashi | 0.006 | 0.2809 | 0.2565 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.2348 | 0.209 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0023 | 0.064 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1011 | 0.36 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.2348 | 0.8361 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0023 | 0.064 | 0.5 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0023 | 0.064 | 0.5 |
Echinococcus multilocularis | lamin | 0.006 | 0.2809 | 0.2565 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1479 | 0.1479 |
Echinococcus granulosus | intermediate filament protein | 0.006 | 0.2809 | 0.2565 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.2348 | 0.209 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0948 | 0.3373 |
Schistosoma mansoni | DNA helicase recq1 | 0.0023 | 0.064 | 0.064 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0327 | 0.0327 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.2472 | 0.8802 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.064 | 0.228 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | Antimalarial activity against chloroquine-sensitive Plasmodium berghei ANKA infected BALB/c mice (Mus musculus) erythrocytes at 10 uM after 18 hrs as reduced hemoglobin hydrolysis | ChEMBL. | 18835067 |
Inhibition (functional) | < 5 % | Inhibition of beta-hematin formation assessed as inhibition of flavoprotein polymerization at 5 to 100 mM after 48 hrs | ChEMBL. | 18835067 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.