Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | chemokine (C-C motif) receptor 4 | 360 aa | 316 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1118 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0 | 0.5 |
Echinococcus multilocularis | protein patched | 0.046 | 0.3784 | 0.3784 |
Echinococcus multilocularis | protein dispatched 1 | 0.046 | 0.3784 | 0.3784 |
Echinococcus granulosus | Protein patched homolog 1 | 0.046 | 0.3784 | 0.3784 |
Brugia malayi | CHE-14 protein | 0.046 | 0.3784 | 0.2156 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.046 | 0.3784 | 0.3784 |
Schistosoma mansoni | patched 1 | 0.046 | 0.3784 | 0.3784 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1118 | 1 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1118 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.046 | 0.3784 | 0.2156 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1118 | 1 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1118 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1118 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1118 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.046 | 0.3784 | 0.7379 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1118 | 1 | 1 |
Schistosoma mansoni | retinal rod rhodopsin-sensitive cgmp 3'5'-cyclic phosphodiesterase | 0.0279 | 0.2076 | 0.2076 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.046 | 0.3784 | 0.3784 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0524 | 0.4391 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0524 | 0.4391 | 0.5 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.046 | 0.3784 | 0.2156 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.046 | 0.3784 | 0.3784 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.046 | 0.3784 | 0.3784 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0524 | 0.4391 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1118 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0524 | 0.4391 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.046 | 0.3784 | 0.3784 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antagonist activity at mouse CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis by bioluminescent assay | ChEMBL. | 18539035 | |
IC50 (functional) | = 0.51 uM | Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells by [35S]GTPgammaS binding assay | ChEMBL. | 18539035 |
Inhibition (binding) | = 0 % | Displacement of [125I]CCl22 from human CCR4 receptor expressed in mouse B300-19 cells at 1 uM by SPA | ChEMBL. | 18539035 |
Inhibition (functional) | = 10 % | Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells at 1 uM by [35S]GTPgammaS binding assay | ChEMBL. | 18539035 |
Inhibition (functional) | = 12 % | Antagonist activity at human CCR4 receptor expressed in mouse B300-19 cells assessed as CCL22-induced chemotaxis at 1 uM by bioluminescent assay | ChEMBL. | 18539035 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.