Detailed information for compound 1015462

Basic information

Technical information
  • TDR Targets ID: 1015462
  • Name: [2-hydroxy-3-[[(2R,3R,4R,5S,6R)-2,4,5-trihydr oxy-6-(hydroxymethyl)oxan-3-yl]amino]propyl]- trimethylazanium
  • MW: 295.353 | Formula: C12H27N2O6+
  • H donors: 6 H acceptors: 5 LogP: -2.9 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H]1O[C@@H](O)[C@@H]([C@H]([C@@H]1O)O)NCC(C[N+](C)(C)C)O
  • InChi: 1S/C12H27N2O6/c1-14(2,3)5-7(16)4-13-9-11(18)10(17)8(6-15)20-12(9)19/h7-13,15-19H,4-6H2,1-3H3/q+1/t7?,8-,9-,10-,11-,12-/m1/s1
  • InChiKey: RWKHWCXMRSXBCY-LVZGIILASA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-hydroxy-3-[[(2R,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]amino]propyl]-trimethyl-ammonium
  • [2-hydroxy-3-[[(2R,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)-3-tetrahydropyranyl]amino]propyl]-trimethylammonium
  • [2-hydroxy-3-[[(2R,3R,4R,5S,6R)-2,4,5-trihydroxy-6-methylol-tetrahydropyran-3-yl]amino]propyl]-trimethyl-ammonium
  • [2-hydroxy-3-[[(2R,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]amino]propyl]-trimethyl-azanium

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus expressed protein 0.0018 0.0064 0.0101
Mycobacterium ulcerans Type I modular polyketide synthase 0.0053 0.0503 0.2526
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.1762 0.4507
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0079 0.0833 0.1055
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0042 0.0373 0.0439
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0508 0.0856
Onchocerca volvulus 0.0253 0.3035 1
Mycobacterium ulcerans dehydrogenase 0.0023 0.0129 0.0633
Trichomonas vaginalis mercuric reductase, putative 0.0087 0.0938 0.3026
Mycobacterium ulcerans acetyl-CoA synthetase 0.0015 0.0028 0.0118
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0064 0.0646 0.109
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0053 0.0503 0.0638
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0129 0.032
Onchocerca volvulus 0.0078 0.0823 0.2644
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0023 0.0129 0.0633
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0087 0.0938 0.3102
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0248 0.0413
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0823 0.0819
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0823 0.2644
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.1054 0.1784
Loa Loa (eye worm) hypothetical protein 0.0053 0.0508 0.0856
Mycobacterium tuberculosis Probable reductase 0.0572 0.7082 0.8975
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.002 0.0095 0.012
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0322 0.1056
Onchocerca volvulus 0.002 0.0095 0.0224
Schistosoma mansoni hypothetical protein 0.0036 0.0296 0.0292
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0023 0.0129 0.0212
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0087 0.0938 0.2394
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0053 0.0503 0.0638
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0823 0.2644
Loa Loa (eye worm) hypothetical protein 0.0478 0.589 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0087 0.0938 0.4727
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0018 0.0064 0.0046
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0077
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0023 0.0129 0.032
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0015 0.0028 0.0118
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0087 0.0938 0.2394
Mycobacterium ulcerans glutamate synthase subunit beta 0.0023 0.0129 0.0633
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0296 0.0375
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0087 0.0938 0.2394
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0023 0.0129 0.0164
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0056 0.0545 0.069
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0087 0.0938 0.3102
Trichomonas vaginalis esterase, putative 0.0078 0.0823 0.2644
Giardia lamblia Glutamate synthase 0.0023 0.0129 0.1017
Loa Loa (eye worm) fatty acid synthase 0.0052 0.0494 0.0833
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0028 0.0118
Toxoplasma gondii NADPH-glutathione reductase 0.0087 0.0938 0.3102
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0248 0.0808
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0028 0.0118
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0087 0.0938 0.3102
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0029 0.02 0.0651
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0051 0.0486 0.0583
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0053 0.0503 0.0605
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0023 0.0129 0.0212
Giardia lamblia Thioredoxin reductase 0.0023 0.0129 0.1017
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0087 0.0938 0.2394
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0023 0.0129 0.032
Mycobacterium tuberculosis Conserved hypothetical protein 0.0169 0.1979 0.2508
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0038 0.0322 0.0408
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0087 0.0938 0.3102
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0087 0.0938 0.1586
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0042 0.0373 0.1867
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0043 0.0382 0.0484
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.002 0.0095 0.0459
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0028 0.004
Chlamydia trachomatis thioredoxin reductase 0.0023 0.0129 0.1339
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0023 0.0129 0.0338
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0078 0.0823 0.1043
Onchocerca volvulus 0.0023 0.0129 0.0338
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0023 0.0129 0.0415
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0087 0.0938 0.2394
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0087 0.0938 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0038 0.0322 0.1056
Plasmodium falciparum thioredoxin reductase 0.0087 0.0938 0.3102
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0078 0.0823 0.1043
Echinococcus granulosus glutamate synthase 0.0023 0.0129 0.0212
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0508 0.0856
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0636 0.7891 1
Brugia malayi RNA binding protein 0.0066 0.0676 0.1141
Brugia malayi Methyltransferase-like protein 4 0.0016 0.0038 0.0057
Mycobacterium ulcerans monoxygenase 0.0023 0.0129 0.0633
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0038 0.0034
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0676 0.0672
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.005 0.0077
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0087 0.0938 0.0934
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0023 0.0129 0.0212
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0023 0.0129 0.0415
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0015 0.0028 0.0078
Echinococcus multilocularis cpg binding protein 0.0032 0.0244 0.0406
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0676 0.1141
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1054 0.1051
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0056 0.0545 0.069
Trichomonas vaginalis glutathione reductase, putative 0.0087 0.0938 0.3026
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0572 0.7082 0.8975
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.058 0.1913
Echinococcus multilocularis muscleblind protein 1 0.0478 0.589 1
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0069 0.0109
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0572 0.7082 0.8975
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0087 0.0938 0.2394
Toxoplasma gondii ABC1 family protein 0.0078 0.0823 0.272
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.005 0.0077
Echinococcus granulosus thioredoxin glutathione reductase 0.0254 0.3047 0.517
Loa Loa (eye worm) beta-lactamase 0.0078 0.0823 0.139
Loa Loa (eye worm) hypothetical protein 0.0015 0.0028 0.004
Mycobacterium tuberculosis Probable hydrolase 0.0078 0.0823 0.1043
Schistosoma mansoni ferritin light chain 0.0018 0.0064 0.0059
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0023 0.0129 0.0338
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0087 0.0938 0.2394
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0023 0.0129 0.0212
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0486 0.2439
Schistosoma mansoni cpg binding protein 0.0032 0.0244 0.0239
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.005 0.0077
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.002 0.0095 0.0086
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0251 0.3013 0.3819
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0873 0.9253
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0079 0.0833 0.1055
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0051 0.0486 0.2439
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0023 0.0129 0.0212
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0023 0.0129 0.0338
Mycobacterium tuberculosis Probable oxidoreductase 0.0636 0.7891 1
Mycobacterium ulcerans polyketide synthase Pks13 0.0079 0.0833 0.4194
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.0516 0.0869
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0023 0.0129 0.0212
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0051 0.0483 0.0612
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0486 0.0818
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0248 0.0243
Mycobacterium ulcerans beta-lactamase 0.0078 0.0823 0.4144
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0248 0.0413
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0064 0.065 0.0824
Toxoplasma gondii hypothetical protein 0.0028 0.0194 0.063
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0676 0.1141
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0017 0.0046 0.0059
Trypanosoma brucei trypanothione reductase 0.0251 0.3013 0.7716
Schistosoma mansoni peptidase Clp (S14 family) 0.0082 0.0873 0.0869
Loa Loa (eye worm) glutathione reductase 0.0251 0.3013 0.5112
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0023 0.0129 0.032
Mycobacterium tuberculosis Probable thioesterase TesA 0.0044 0.0392 0.0497
Echinococcus granulosus GPCR family 2 0.0017 0.005 0.0077
Schistosoma mansoni hypothetical protein 0.0017 0.005 0.0045
Loa Loa (eye worm) RNA binding protein 0.0066 0.0676 0.1141
Loa Loa (eye worm) hypothetical protein 0.0038 0.0322 0.054
Toxoplasma gondii hypothetical protein 0.0052 0.0493 0.1624
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0087 0.0938 0.2394
Leishmania major hypothetical protein, conserved 0.0023 0.0129 0.032
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0023 0.0129 0.032
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.0823 0.139
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.002 0.0095 0.012
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0082 0.0873 0.9301
Onchocerca volvulus 0.003 0.0222 0.0644
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0023 0.0129 0.0338
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.0028 0.004
Onchocerca volvulus 0.0051 0.0486 0.1524
Trichomonas vaginalis apoptosis inducing factor, putative 0.0023 0.0129 0.0338
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0028 0.006
Leishmania major NADH dehydrogenase, putative 0.0023 0.0129 0.032
Brugia malayi glutamate synthase 0.0023 0.0129 0.0212
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0248 0.0243
Treponema pallidum thioredoxin reductase (trxB) 0.0023 0.0129 0.0752
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0087 0.0938 0.2394
Mycobacterium ulcerans polyketide synthase 0.0056 0.0545 0.2736
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0028 0.006
Loa Loa (eye worm) hypothetical protein 0.0078 0.0823 0.139
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0321 0.3904 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.005 0.0077
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0087 0.0938 0.2394
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.0516 0.0654
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0636 0.7891 1
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0023 0.0129 0.1933
Schistosoma mansoni disulfide oxidoreductase 0.0023 0.0129 0.0125
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0023 0.0129 0.0338
Loa Loa (eye worm) hypothetical protein 0.0015 0.0028 0.004
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0028 0.0118
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0064 0.03
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0023 0.0129 0.0415
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0087 0.0938 0.2394
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0023 0.0129 0.0212
Loa Loa (eye worm) hypothetical protein 0.0478 0.589 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0023 0.0129 0.0415
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0087 0.0938 1
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0023 0.0129 0.0164
Onchocerca volvulus 0.0107 0.1187 0.3855
Trypanosoma cruzi trypanothione reductase, putative 0.0087 0.0938 0.2394
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0296 0.0375
Plasmodium falciparum ferrodoxin reductase-like protein 0.0023 0.0129 0.0415
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0873 0.2885
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0053 0.0503 0.0848
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0873 0.4396
Mycobacterium ulcerans Type I modular polyketide synthase 0.0053 0.0503 0.2526
Mycobacterium leprae conserved hypothetical protein 0.0078 0.0823 0.1011
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0676 0.1141
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1054 0.1051
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.002 0.0095 0.0459
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0087 0.0938 0.4727
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0028 0.0118
Brugia malayi Pre-SET motif family protein 0.0032 0.0248 0.0413
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0028 0.006
Loa Loa (eye worm) hypothetical protein 0.0078 0.0823 0.139
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0572 0.7082 0.8975
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0023 0.0129 0.0338
Trypanosoma brucei NADH dehydrogenase 0.0023 0.0129 0.032
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0023 0.0129 0.0415
Giardia lamblia NADH oxidase lateral transfer candidate 0.0087 0.0938 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0035 0.0278 0.0318
Toxoplasma gondii type I fatty acid synthase, putative 0.0058 0.0571 0.1883
Onchocerca volvulus 0.0032 0.0248 0.0731
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.002 0.0095 0.012
Trichomonas vaginalis ferritin, putative 0.0018 0.0064 0.0119
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.0516 0.0869
Loa Loa (eye worm) hypothetical protein 0.0078 0.0823 0.139
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.002 0.0095 0.012
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.002 0.0095 0.0154
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0023 0.0129 0.0129
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.0516 0.0654
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0498 0.6134 0.7774
Echinococcus multilocularis muscleblind protein 0.0478 0.589 1
Treponema pallidum NADH oxidase 0.0087 0.0938 1
Mycobacterium ulcerans hypothetical protein 0.0051 0.0486 0.2439
Mycobacterium tuberculosis Conserved protein 0.0078 0.0823 0.1043
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0023 0.0129 0.1017
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0873 0.2885
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.0028 0.0023
Brugia malayi TAR-binding protein 0.0066 0.0676 0.1141
Echinococcus granulosus muscleblind protein 0.0478 0.589 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.2648 0.4492
Trichomonas vaginalis glutamate synthase, putative 0.0023 0.0129 0.0338
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0486 0.0818
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0023 0.0129 0.0338
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0087 0.0938 0.2394
Brugia malayi CXXC zinc finger family protein 0.003 0.0222 0.0369
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0023 0.0129 0.0212
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0023 0.0129 0.0212
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0051 0.0486 0.2439
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0028 0.006
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0023 0.0129 0.1339
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0038 0.0322 0.1609
Mycobacterium ulcerans thioesterase TesA 0.0044 0.0392 0.1964
Schistosoma mansoni hypothetical protein 0.0017 0.005 0.0045
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0015 0.0028 0.0078
Mycobacterium ulcerans NADH dehydrogenase 0.0023 0.0129 0.0633
Toxoplasma gondii thioredoxin reductase 0.0251 0.3013 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0676 0.0672
Loa Loa (eye worm) hypothetical protein 0.0051 0.0486 0.0818
Plasmodium vivax glutathione reductase, putative 0.0251 0.3013 1
Toxoplasma gondii propionate-CoA ligase 0.0015 0.0028 0.0078
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0023 0.0129 0.0212
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0023 0.0129 0.0415
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0222 0.0369
Trypanosoma cruzi NADH dehydrogenase, putative 0.0023 0.0129 0.032
Mycobacterium ulcerans hypothetical protein 0.0023 0.0129 0.0633
Mycobacterium leprae Polyketide synthase Pks13 0.0079 0.0833 0.1024
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0018 0.0066 0.0084
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0023 0.0129 0.1339
Loa Loa (eye worm) hypothetical protein 0.0032 0.0248 0.0413
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0028 0.0035
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0087 0.0938 0.2394
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0087 0.0938 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0028 0.006
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0023 0.0129 0.0633
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0087 0.0938 0.2394
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0508 0.0856
Schistosoma mansoni ferritin 0.0018 0.0064 0.0059
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0486 0.0818
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0023 0.0129 0.0164
Onchocerca volvulus 0.0078 0.0823 0.2644
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0082 0.0873 0.1074
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0056 0.0545 0.0657
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0015 0.0028 0.0118
Schistosoma mansoni glutamate synthase 0.0023 0.0129 0.0125
Schistosoma mansoni sulfide quinone reductase 0.0023 0.0129 0.0125
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.1054 0.1784
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0023 0.0129 0.1339
Loa Loa (eye worm) hypothetical protein 0.0038 0.0322 0.054
Brugia malayi beta-lactamase family protein 0.0078 0.0823 0.139
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0028 0.004
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0028 0.006
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0572 0.7082 0.8975
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0023 0.0129 0.1933
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0087 0.0938 0.3102
Leishmania major hypothetical protein, conserved 0.0016 0.0038 0.0086
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0023 0.0129 0.0212
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0051 0.0486 0.0583
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0023 0.0129 0.0633
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0028 0.006
Trypanosoma cruzi NADH dehydrogenase, putative 0.0023 0.0129 0.032
Schistosoma mansoni hypothetical protein 0.0017 0.005 0.0045
Leishmania major mitochondrial DNA polymerase beta 0.0321 0.3904 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.005 0.0077
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0028 0.0035
Mycobacterium ulcerans polyketide synthase MbtD 0.0016 0.0042 0.019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.1054 0.1784
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0028 0.004
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0028 0.0118
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0078 0.0823 0.1043
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0023 0.0129 0.032
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0676 0.0672
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0023 0.0129 0.032
Leishmania major 4-coumarate:coa ligase-like protein 0.0051 0.0486 0.1235
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.0823 0.4144
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0667 0.0663
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0018 0.0064 0.0634
Echinococcus multilocularis GPCR, family 2 0.0017 0.005 0.0077
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0044 0.0392 0.0464
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0023 0.0129 0.032
Onchocerca volvulus 0.0078 0.0823 0.2644
Schistosoma mansoni hypothetical protein 0.0017 0.005 0.0045
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0028 0.004
Mycobacterium leprae Probable lipase LipE 0.0078 0.0823 0.1011
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0676 0.0672
Mycobacterium tuberculosis Conserved protein 0.0016 0.0038 0.0048
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0409 0.1038
Schistosoma mansoni sulfide quinone reductase 0.0023 0.0129 0.0125
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.0873 0.2885
Plasmodium vivax acetyl-CoA synthetase, putative 0.0015 0.0028 0.0078
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0023 0.0129 0.0633
Entamoeba histolytica disulphide oxidoreductase, putative 0.0023 0.0129 0.1933
Trypanosoma cruzi trypanothione reductase, putative 0.0251 0.3013 0.7716
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0023 0.0129 0.032
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0486 0.2439
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.0823 0.0819
Brugia malayi Pre-SET motif family protein 0.0222 0.2648 0.4492
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0023 0.0129 0.0164
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.0028 0.0078
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0636 0.7891 1
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0015 0.0028 0.0118
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0028 0.0118
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.1054 0.1784
Schistosoma mansoni apoferritin-2 0.0018 0.0064 0.0059
Mycobacterium ulcerans polyketide synthase Pks9 0.0035 0.0278 0.1384
Plasmodium vivax thioredoxin reductase, putative 0.0251 0.3013 1
Leishmania major hypothetical protein, conserved 0.0023 0.0129 0.032
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.0823 0.139
Plasmodium vivax hypothetical protein, conserved 0.0078 0.0823 0.272
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0248 0.0243
Loa Loa (eye worm) thioredoxin reductase 0.0251 0.3013 0.5112
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0023 0.0129 0.0212
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0296 0.0375
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0023 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0036 0.0296 0.0496
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0023 0.0129 0.0212
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0087 0.0938 0.2394
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0486 0.2439
Brugia malayi Probable ClpP-like protease 0.0082 0.0873 0.1475
Loa Loa (eye worm) hypothetical protein 0.0078 0.0823 0.139
Plasmodium falciparum thioredoxin reductase 0.0251 0.3013 1
Plasmodium falciparum glutathione reductase 0.0251 0.3013 1
Leishmania major hypothetical protein, conserved 0.0078 0.0823 0.2099
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0023 0.0129 0.0415
Plasmodium falciparum glutathione reductase 0.0087 0.0938 0.3102
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0676 0.1141
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0095 0.0459
Echinococcus granulosus ferritin 0.0018 0.0064 0.0101
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0676 0.0672
Mycobacterium tuberculosis Conserved protein 0.0078 0.0823 0.1043
Onchocerca volvulus 0.0064 0.065 0.2069
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0534 0.1358
Mycobacterium tuberculosis Conserved protein 0.0078 0.0823 0.1043
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0051 0.0486 0.2439
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0194 0.149
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0023 0.0129 0.032
Loa Loa (eye worm) acyl carrier protein 0.0024 0.0144 0.0236
Brugia malayi Thioredoxin reductase 0.0251 0.3013 0.5112
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0056 0.0545 0.069
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0023 0.0129 0.1933
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0023 0.0129 0.1933
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0051 0.0486 0.2439
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0042 0.0373 0.1867
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0823 0.2099
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0034 0.0269 0.088
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0021 0.0107 0.0135
Schistosoma mansoni ferritin 0.0018 0.0064 0.0059
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0023 0.0129 0.0633
Loa Loa (eye worm) hypothetical protein 0.0082 0.0873 0.1475
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0087 0.0938 0.1189
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0035 0.0278 0.1384
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0053 0.0503 0.0638
Mycobacterium leprae Probable polyketide synthase Pks1 0.0056 0.0545 0.0657
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0321 0.3904 1
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0023 0.0129 0.0212
Leishmania major hypothetical protein, conserved 0.0023 0.0129 0.032
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0064 0.0081
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0017 0.0046 0.0024
Brugia malayi beta-lactamase family protein 0.0078 0.0823 0.139
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.0028 0.0035
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0321 0.3904 1
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0129 0.032
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0409 0.1038
Echinococcus multilocularis ferritin 0.0018 0.0064 0.0101
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0016 0.0042 0.0053
Echinococcus multilocularis expressed protein 0.0018 0.0064 0.0101
Loa Loa (eye worm) hypothetical protein 0.0078 0.0823 0.139
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0082 0.0873 0.1475
Brugia malayi AMP-binding enzyme family protein 0.0064 0.065 0.1097
Schistosoma mansoni ferritin 0.0018 0.0064 0.0059
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0194 0.063
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.0028 0.0035
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0087 0.0938 0.2394
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0248 0.0243
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0015 0.0028 0.006
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0028 0.0035
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0224 0.0374
Echinococcus granulosus tar DNA binding protein 0.0066 0.0676 0.1141
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.0028 0.004
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0064 0.03
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0409 0.1038
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.002 0.0095 0.0459
Mycobacterium ulcerans Type I modular polyketide synthase 0.0053 0.0503 0.2526
Loa Loa (eye worm) hypothetical protein 0.0023 0.0129 0.0212
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0823 0.2099
Mycobacterium ulcerans thioesterase 0.0044 0.0392 0.1964
Loa Loa (eye worm) hypothetical protein 0.0038 0.0322 0.054
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0028 0.0118
Echinococcus multilocularis thioredoxin glutathione reductase 0.0254 0.3047 0.517
Loa Loa (eye worm) hypothetical protein 0.0051 0.0486 0.0818
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0023 0.0129 0.0415
Mycobacterium ulcerans ferredoxin reductase 0.0023 0.0129 0.0633
Echinococcus granulosus cpg binding protein 0.0032 0.0244 0.0406
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0023 0.0129 0.0338
Schistosoma mansoni ferritin 0.0018 0.0064 0.0059
Brugia malayi glutathione reductase 0.0251 0.3013 0.5112
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0023 0.0129 0.1933
Mycobacterium ulcerans lipase LipD 0.0078 0.0823 0.4144
Brugia malayi Muscleblind-like protein 0.0478 0.589 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.0873 0.9301
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0248 0.0413
Brugia malayi Latrophilin receptor protein 2 0.0017 0.005 0.0077
Schistosoma mansoni apoferritin-2 0.0018 0.0064 0.0059
Mycobacterium ulcerans polyketide synthase 0.0053 0.0503 0.2526
Onchocerca volvulus Fatty acid synthase homolog 0.0095 0.1038 0.3359
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0023 0.0129 0.0415
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0064 0.0081
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.003 0.0216 0.0274
Leishmania major 4-coumarate:coa ligase-like protein 0.0051 0.0486 0.1235
Schistosoma mansoni methyltransferase-related 0.0016 0.0038 0.0033
Mycobacterium tuberculosis Probable esterase LipL 0.0078 0.0823 0.1043
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.0516 0.0621
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0064 0.065 0.1097
Toxoplasma gondii selenide, water dikinase 0.0023 0.0129 0.0415
Schistosoma mansoni glutamate synthase 0.0023 0.0129 0.0125
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0023 0.0129 0.0338
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0409 0.1038
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0873 0.2885
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0023 0.0129 0.0633
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.0823 0.139
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0023 0.0129 0.0164
Schistosoma mansoni glutamate synthase 0.0023 0.0129 0.0125
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.1054 0.1784
Mycobacterium ulcerans fatty acid synthase Fas 0.0017 0.0046 0.0213
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0028 0.006
Loa Loa (eye worm) oxidoreductase 0.0015 0.0028 0.004
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0023 0.0129 0.0212
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0152 0.1762 0.4507
Toxoplasma gondii type I fatty acid synthase, putative 0.0037 0.0311 0.102
Loa Loa (eye worm) hypothetical protein 0.0038 0.0322 0.054
Loa Loa (eye worm) hypothetical protein 0.0051 0.0486 0.0818
Leishmania major 4-coumarate:coa ligase-like protein 0.0051 0.0486 0.1235
Plasmodium vivax ferrodoxin reductase, putative 0.0023 0.0129 0.0415
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.1762 0.4507
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0486 0.0616
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0087 0.0938 0.1586
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0087 0.0938 0.1586
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0823 0.2644
Entamoeba histolytica thioredoxin reductase, putative 0.0023 0.0129 0.1933
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0064 0.0646 0.109
Loa Loa (eye worm) hypothetical protein 0.0029 0.021 0.035
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.005 0.0077
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0194 0.0211
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0015 0.0028 0.0118
Loa Loa (eye worm) programmed cell death 8 0.0023 0.0129 0.0212
Mycobacterium tuberculosis Probable lipase LipD 0.0078 0.0823 0.1043
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.0823 0.2644
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0028 0.004
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0023 0.0129 0.0129
Mycobacterium tuberculosis Probable dehydrogenase 0.0572 0.7082 0.8975
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0087 0.0938 0.4727
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.0823 0.4144
Mycobacterium tuberculosis Hypothetical protein 0.0016 0.0038 0.0048
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0038 0.0316 0.04
Loa Loa (eye worm) hypothetical protein 0.0091 0.0983 0.1662
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0053 0.0503 0.2526
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0023 0.0129 0.032
Schistosoma mansoni cpg binding protein 0.003 0.0222 0.0217
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0028 0.0035
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0056 0.0545 0.2736
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.0823 0.139
Mycobacterium ulcerans hypothetical protein 0.0169 0.1979 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0572 0.7082 0.8972
Plasmodium vivax SET domain protein, putative 0.0032 0.0248 0.0808
Schistosoma mansoni hypothetical protein 0.0023 0.0129 0.0125
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1054 0.1051
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0296 0.0496
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0013 0.0001 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.0296 0.0375
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.1054 0.1784
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0053 0.0503 0.0605
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0129 0.032
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.0823 0.2644
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0023 0.0129 0.032
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0082 0.0873 0.1475
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0023 0.0129 0.0338
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0056 0.0545 0.0657
Trichomonas vaginalis set domain proteins, putative 0.0253 0.3035 1
Leishmania major trypanothione reductase 0.0251 0.3013 0.7716
Entamoeba histolytica acyl-CoA synthetase, putative 0.0057 0.0553 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0056 0.0545 0.2736
Loa Loa (eye worm) hypothetical protein 0.0038 0.0322 0.054
Schistosoma mansoni ferritin light chain 0.0018 0.0064 0.0059
Mycobacterium ulcerans hypothetical protein 0.0078 0.0823 0.4144
Echinococcus multilocularis glutamate synthase 0.0023 0.0129 0.0212
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0038 0.0322 0.3403
Brugia malayi beta-lactamase 0.0078 0.0823 0.139
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0023 0.0129 0.0212
Entamoeba histolytica acyl-CoA synthetase, putative 0.0051 0.0486 0.872
Mycobacterium tuberculosis Probable lipase LipE 0.0078 0.0823 0.1043
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0873 0.4396
Treponema pallidum oxidoreductase 0.0023 0.0129 0.0752
Entamoeba histolytica acyl-coA synthetase, putative 0.0051 0.0486 0.872
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.01 0.11 0.1861
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0023 0.0129 0.0633
Schistosoma mansoni cpg binding protein 0.0032 0.0244 0.0239
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0051 0.0483 0.0612
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.0873 0.9301
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0194 0.063
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.002 0.0095 0.0459
Loa Loa (eye worm) hypothetical protein 0.0078 0.0823 0.139
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.0823 0.2099
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0051 0.0486 0.0616
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0023 0.0129 0.0164
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0023 0.0129 0.0129
Trichomonas vaginalis glutamate synthase, putative 0.0023 0.0129 0.0338

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 50 % Antiinvasive activity in human HT1080 cells at 20 ug/ml after 48 hrs ChEMBL. 19375915
Activity (functional) = 60 % Inhibition of ERK expression in phorbol myristate acetate-stimulated human HT1080 cells at 60 ug/ml by Western blotting relative to control ChEMBL. 19375915
Inhibition (binding) = 50 % Inhibition of MMP9 gelatinolytic activity in phorbol myristate acetate-stimulated human HT1080 cells at 60 ug/ml by gelatin zymography relative to control ChEMBL. 19375915
Inhibition (binding) = 60 % Inhibition of AP1 gene promoter activity in phorbol myristate acetate-stimulated human HT1080 cells at 60 ug/ml by luciferase reporter gene assay ChEMBL. 19375915
Inhibition (binding) = 62 % Inhibition of MMP2 gelatinolytic activity in phorbol myristate acetate-stimulated human HT1080 cells at 60 ug/ml by gelatin zymography relative to control ChEMBL. 19375915
Inhibition (functional) = 70 % Inhibition of cell migration in human HT1080 cells at 60 ug/ml ChEMBL. 19375915

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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