Detailed information for compound 1015530

Basic information

Technical information
  • TDR Targets ID: 1015530
  • Name: 1-hydroxy-10,12-dimethoxy-8-methyl-4-[(2S,3S, 4R,5S,6R)-3,4,5-trihydroxy-4,6-dimethyloxan-2 -yl]naphtho[1,2-c]isochromen-6-one
  • MW: 496.506 | Formula: C27H28O9
  • H donors: 4 H acceptors: 5 LogP: 2.46 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2c(c3c1c(O)ccc3[C@@H]1O[C@H](C)[C@@H]([C@@]([C@H]1O)(C)O)O)oc(=O)c1c2c(OC)cc(c1)C
  • InChi: 1S/C27H28O9/c1-11-8-15-19(17(9-11)33-4)14-10-18(34-5)21-16(28)7-6-13(20(21)22(14)36-26(15)31)23-25(30)27(3,32)24(29)12(2)35-23/h6-10,12,23-25,28-30,32H,1-5H3/t12-,23+,24+,25+,27-/m1/s1
  • InChiKey: BJPYMDSMDBCKEP-QSMCFSHASA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-hydroxy-10,12-dimethoxy-8-methyl-4-[(2S,3S,4R,5S,6R)-3,4,5-trihydroxy-4,6-dimethyl-tetrahydropyran-2-yl]naphtho[1,2-c]isochromen-6-one
  • 1-hydroxy-10,12-dimethoxy-8-methyl-4-[(2S,3S,4R,5S,6R)-3,4,5-trihydroxy-4,6-dimethyl-2-tetrahydropyranyl]-6-naphtho[1,2-c]isochromenone
  • 1-hydroxy-10,12-dimethoxy-8-methyl-4-[(2S,3S,4R,5S,6R)-3,4,5-trihydroxy-4,6-dimethyl-oxan-2-yl]naphtho[1,2-c]isochromen-6-one
  • C6491_SIGMA

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0163 0.0144
Mycobacterium ulcerans beta-lactamase 0.0035 0.0319 0.0343
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.061 0.7751 1
Leishmania major DNA damage repair protein, putative 0.0014 0.005 0.0036
Mycobacterium ulcerans hypothetical protein 0.0023 0.0163 0.0144
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.005 0.0036
Schistosoma mansoni rotamase 0.004 0.0385 0.0365
Brugia malayi Pre-SET motif family protein 0.0029 0.024 0.0279
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0309 0.0367
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0518 0.0498
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0319 0.0299
Onchocerca volvulus 0.0012 0.0021 0.0063
Giardia lamblia PHD finger protein 15 0.0028 0.0232 0.0346
Onchocerca volvulus 0.0035 0.0319 0.0953
Trypanosoma brucei chrX additional, unordered contigs 0.0014 0.005 0.0036
Entamoeba histolytica hypothetical protein 0.0043 0.0425 0.0511
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.062 0.7879 1
Trypanosoma brucei protein kinase, putative 0.0051 0.0518 0.0631
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.061 0.7751 1
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0068 0.0737 0.091
Echinococcus multilocularis flap endonuclease 1 0.0031 0.027 0.0249
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0811 0.1004
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0257 0.0299
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0257 0.0299
Trichomonas vaginalis glutaminase, putative 0.031 0.3879 1
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2005 0.4807
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0227 0.0206
Loa Loa (eye worm) hypothetical protein 0.0019 0.011 0.0113
Echinococcus multilocularis GPCR, family 2 0.0019 0.011 0.0089
Schistosoma mansoni hypothetical protein 0.0014 0.004 0.0019
Schistosoma mansoni hypothetical protein 0.0041 0.0396 0.0375
Echinococcus multilocularis dna polymerase eta 0.0077 0.0864 0.0845
Schistosoma mansoni microtubule-associated protein tau 0.0784 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.3127 0.7918
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0373 0.0447
Loa Loa (eye worm) GMP reductase 0.0269 0.3348 0.4234
Loa Loa (eye worm) hypothetical protein 0.0017 0.0087 0.0084
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.212 0.5127
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0466 0.0531
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0518 0.0631
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0396 0.0477
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0257 0.0299
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0163 0.0113
Entamoeba histolytica hypothetical protein 0.0119 0.1409 0.2427
Mycobacterium ulcerans hypothetical protein 0.0035 0.0319 0.0343
Toxoplasma gondii IMP dehydrogenas 0.062 0.7879 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.011 0.0089
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0518 0.0891
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0232 0.0211
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0853 0.0834
Trichomonas vaginalis rotamase, putative 0.0039 0.0373 0.0285
Treponema pallidum ribonuclease H (rnhA) 0.0068 0.0737 0.5
Echinococcus granulosus expressed protein 0.004 0.0385 0.0365
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0853 0.0834
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0087 0.0048
Trypanosoma brucei unspecified product 0.0032 0.0279 0.0327
Loa Loa (eye worm) hypothetical protein 0.0077 0.0864 0.1073
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.011 0.0113
Schistosoma mansoni phosphoglucomutase 0.0068 0.0737 0.0717
Mycobacterium tuberculosis Conserved protein 0.0035 0.0319 0.0313
Onchocerca volvulus Ribonuclease H1 homolog 0.0068 0.0737 0.22
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0119 0.1409 0.2427
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.027 0.0285
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.3127 0.7918
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0252 0.3127 0.3953
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0466 0.0566
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0319 0.0313
Trichomonas vaginalis esterase, putative 0.0035 0.0319 0.0136
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.004 0.0019
Brugia malayi RNA binding protein 0.0076 0.0853 0.1058
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1728 0.2173
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2005 0.4807
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0279 0.3476 0.4294
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0319 0.0343
Echinococcus granulosus GPCR family 2 0.0019 0.011 0.0089
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.011 0.0089
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.062 0.7879 0.7875
Onchocerca volvulus Putative GMP reductase 0.0269 0.3348 1
Brugia malayi beta-lactamase family protein 0.0035 0.0319 0.0379
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0309 0.0289
Schistosoma mansoni hypothetical protein 0.0043 0.0425 0.0405
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.024 0.022
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0853 0.1058
Onchocerca volvulus 0.0023 0.0163 0.0486
Leishmania major inosine-5-monophosphate dehydrogenase 0.062 0.7879 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0495 0.0603
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0518 0.0631
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0232 0.0268
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0518 0.0498
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0279 0.0327
Schistosoma mansoni terminal deoxycytidyl transferase 0.0047 0.0466 0.0446
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.024 0.0278
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0466 0.0566
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.027 0.0316
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0257 0.0268
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0163 0.0113
Brugia malayi polk-prov protein 0.0014 0.005 0.0037
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0373 0.0447
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.062 0.7879 1
Trypanosoma cruzi GMP reductase 0.062 0.7879 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0297 0.3709 0.4693
Loa Loa (eye worm) IMP dehydrogenase 1 0.062 0.7879 1
Brugia malayi hypothetical protein 0.0043 0.0425 0.0514
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0466 0.0566
Loa Loa (eye worm) hypothetical protein 0.0041 0.0396 0.0477
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0518 0.0498
Loa Loa (eye worm) hypothetical protein 0.006 0.0642 0.079
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.3127 0.7918
Brugia malayi beta-lactamase family protein 0.0035 0.0319 0.0379
Trypanosoma brucei unspecified product 0.0032 0.0279 0.0327
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.062 0.7879 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0279 0.0327
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0047 0.0466 0.0446
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.005 0.0036
Loa Loa (eye worm) hypothetical protein 0.0297 0.3709 0.4693
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0466 0.0566
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0319 0.0299
Brugia malayi hypothetical protein 0.003 0.0257 0.03
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2005 0.4807
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0822 0.0803
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.3127 0.7918
Schistosoma mansoni hypothetical protein 0.0019 0.011 0.0089
Loa Loa (eye worm) hypothetical protein 0.0035 0.0319 0.0379
Trypanosoma brucei unspecified product 0.0073 0.0811 0.1004
Loa Loa (eye worm) hypothetical protein 0.0028 0.0232 0.0268
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0163 0.0144
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0425 0.0405
Brugia malayi follicle stimulating hormone receptor 0.0455 0.5746 0.7285
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0319 0.0136
Loa Loa (eye worm) hypothetical protein 0.0023 0.0163 0.018
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0021 0.0063
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.0864 0.1073
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0373 0.0409
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.3127 0.7918
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0518 0.0498
Loa Loa (eye worm) hypothetical protein 0.0023 0.0163 0.018
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.024 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0466 0.0566
Mycobacterium leprae Probable lipase LipE 0.0035 0.0319 0.0202
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0319 0.0313
Mycobacterium tuberculosis Conserved protein 0.0035 0.0319 0.0313
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0163 0.0179
Schistosoma mansoni hypothetical protein 0.0331 0.415 0.4138
Brugia malayi hypothetical protein 0.002 0.0117 0.0123
Leishmania major DNA polymerase eta, putative 0.0045 0.0448 0.0543
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0047 0.0466 0.0566
Mycobacterium ulcerans lipase LipD 0.0035 0.0319 0.0343
Brugia malayi Bromodomain containing protein 0.0028 0.0232 0.0268
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0466 0.0566
Brugia malayi glutaminase DH11.1 0.031 0.3879 0.4909
Echinococcus multilocularis dna polymerase kappa 0.0047 0.0466 0.0446
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.024 0.022
Brugia malayi beta-lactamase 0.0035 0.0319 0.0379
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0232 0.0211
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0014 0.005 0.0036
Brugia malayi RNase H family protein 0.0068 0.0737 0.0911
Brugia malayi GMP reductase 0.0269 0.3348 0.4234
Mycobacterium tuberculosis Conserved protein 0.0035 0.0319 0.0313
Toxoplasma gondii ribonuclease HI protein 0.0068 0.0737 0.091
Onchocerca volvulus 0.0035 0.0319 0.0953
Schistosoma mansoni hypothetical protein 0.0019 0.011 0.0089
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0163 0.018
Schistosoma mansoni glutaminase 0.031 0.3879 0.3866
Brugia malayi RNase H family protein 0.0068 0.0737 0.0911
Loa Loa (eye worm) hypothetical protein 0.0029 0.024 0.0279
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0853 0.0834
Loa Loa (eye worm) beta-lactamase 0.0035 0.0319 0.0379
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.027 0.0316
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0163 0.0144
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2005 0.4807
Onchocerca volvulus 0.0029 0.024 0.0718
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.0864 0.1072
Leishmania major hypothetical protein, conserved 0.003 0.0257 0.0299
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0163 0.0179
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0163 0.0144
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0425 0.0405
Trichomonas vaginalis ribonuclease H1, putative 0.0068 0.0737 0.1293
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0518 0.0632
Plasmodium falciparum phd finger protein, putative 0.0028 0.0232 0.0235
Schistosoma mansoni hypothetical protein 0.0019 0.011 0.0089
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0087 0.0047
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0319 0.0343
Trichomonas vaginalis rotamase, putative 0.004 0.0385 0.0319
Onchocerca volvulus 0.0231 0.2857 0.8533
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0518 0.0631
Loa Loa (eye worm) hypothetical protein 0.0017 0.0087 0.0084
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0518 0.0686
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0319 0.0379
Brugia malayi jmjC domain containing protein 0.0034 0.0309 0.0367
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0455 0.5746 0.7285
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0163 0.018
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0163 0.0144
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0047 0.0466 0.0544
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0163 0.018
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0319 0.0313
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0269 0.3348 0.4234
Trypanosoma brucei ribonuclease H1 0.0068 0.0737 0.091
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0385 0.0319
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.3127 0.7918
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0373 0.0447
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.011 0.0113
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.005 0.0036
Echinococcus granulosus dna polymerase kappa 0.0047 0.0466 0.0446
Echinococcus granulosus dna polymerase eta 0.0077 0.0864 0.0845
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0163 0.0144
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0319 0.0313
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0466 0.0566
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2005 0.4807
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.062 0.7879 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.005 0.0037
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2857 0.7169
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0385 0.0463
Trypanosoma cruzi GMP reductase 0.062 0.7879 1
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.062 0.7879 1
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0014 0.005 0.0036
Toxoplasma gondii ABC1 family protein 0.0035 0.0319 0.0378
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0252 0.3127 0.3953
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0269 0.3348 0.4234
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0518 0.0498
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0466 0.0566
Echinococcus granulosus flap endonuclease 1 0.0031 0.027 0.0249
Schistosoma mansoni hypothetical protein 0.0028 0.0232 0.0211
Echinococcus granulosus jumonji domain containing protein 0.004 0.0376 0.0356
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0853 0.1058
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.062 0.7879 1
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0466 0.0531
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0518 0.0631
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0518 0.0686
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0087 0.0048
Loa Loa (eye worm) hypothetical protein 0.0035 0.0319 0.0379
Loa Loa (eye worm) hypothetical protein 0.0017 0.0087 0.0084
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0853 0.0834
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0309 0.0289
Leishmania major DNA polymerase kappa, putative 0.0014 0.005 0.0036
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0047 0.0466 0.0446
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0385 0.0463
Loa Loa (eye worm) hypothetical protein 0.0017 0.0087 0.0084
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0518 0.0631
Brugia malayi MH2 domain containing protein 0.0144 0.1728 0.2173
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0047 0.0466 0.0501
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0232 0.0267
Brugia malayi Pre-SET motif family protein 0.0203 0.2494 0.3147
Giardia lamblia DINP protein human, muc B family 0.0047 0.0466 0.0793
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0279 0.0327
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.005 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0466 0.0566
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0319 0.0378
Loa Loa (eye worm) RNA binding protein 0.0076 0.0853 0.1058
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0257 0.0268
Mycobacterium ulcerans glutaminase 0.031 0.3879 0.489
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0373 0.0447
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0518 0.0686
Loa Loa (eye worm) glutaminase 2 0.031 0.3879 0.4909
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0319 0.0313
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.011 0.0089
Entamoeba histolytica hypothetical protein 0.0043 0.0425 0.0511
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0319 0.0299
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0518 0.0631
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0232 0.0235
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0853 0.0834
Schistosoma mansoni DNA polymerase eta 0.0077 0.0864 0.0845
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0853 0.1058
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0319 0.0379
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0279 0.3476 0.4376
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0087 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.212 0.5127
Leishmania major hypothetical protein, conserved 0.0035 0.0319 0.0378
Trypanosoma brucei DNA polymerase eta, putative 0.0077 0.0864 0.1072
Echinococcus multilocularis expressed protein 0.004 0.0385 0.0365
Trypanosoma brucei GMP reductase 0.062 0.7879 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0319 0.0136
Loa Loa (eye worm) hypothetical protein 0.0017 0.0087 0.0084
Leishmania major DNA polymerase eta, putative 0.0077 0.0864 0.1072
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.024 0.022
Plasmodium falciparum flap endonuclease 1 0.0031 0.027 0.0285
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0021 0.0063
Schistosoma mansoni hypothetical protein 0.0253 0.3138 0.3124
Echinococcus multilocularis peregrin 0.0028 0.0232 0.0211
Echinococcus granulosus peregrin 0.0028 0.0232 0.0211
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.011 0.0089
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.005 0.0036
Echinococcus granulosus ribonuclease H1 0.0068 0.0737 0.0717
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.034 0.4266 0.5371
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0319 0.0299
Brugia malayi jmjC domain containing protein 0.0093 0.107 0.1335
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0232 0.0211
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0309 0.0289
Loa Loa (eye worm) hypothetical protein 0.0023 0.0163 0.018
Loa Loa (eye worm) glutaminase 0.031 0.3879 0.4909
Trypanosoma cruzi ribonuclease H1, putative 0.0068 0.0737 0.091
Schistosoma mansoni hypothetical protein 0.0331 0.415 0.4138
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0373 0.0447
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0073 0.0811 0.1004
Loa Loa (eye worm) hypothetical protein 0.0035 0.0319 0.0379
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0163 0.0144
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.034 0.4266 0.5318
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0257 0.0299
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0642 0.079
Giardia lamblia Ribonuclease H 0.0068 0.0737 0.1309
Trypanosoma cruzi ribonuclease H1, putative 0.0068 0.0737 0.091
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0309 0.0289
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.107 0.1051
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.2775 0.346
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0319 0.0313
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.107 0.1051
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0466 0.0566
Trichomonas vaginalis DNA polymerase eta, putative 0.0047 0.0466 0.0544
Entamoeba histolytica Flap nuclease, putative 0.0031 0.027 0.0209
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0466 0.0566
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.004 0.0019
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0047 0.0466 0.0566
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0466 0.0566
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2005 0.4807
Schistosoma mansoni hypothetical protein 0.0019 0.011 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0466 0.0566
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0232 0.0267
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.062 0.7879 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0047 0.0466 0.0591
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0642 0.079
Schistosoma mansoni DNA polymerase IV / kappa 0.0014 0.005 0.0029
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0853 0.0834
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0466 0.0566
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0425 0.0405
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1728 0.2173
Giardia lamblia DNA repair protein RAD52 0.042 0.5295 1
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.062 0.7879 0.7875
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0466 0.0566
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.061 0.7751 0.9837
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0319 0.0136
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.005 0.0036
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.2005 0.5988
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.062 0.7879 0.7875
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0319 0.0136
Brugia malayi MAP kinase sur-1 0.0051 0.0518 0.0632
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0448 0.0543
Trypanosoma brucei RNA helicase, putative 0.0253 0.3138 0.3966
Entamoeba histolytica hypothetical protein 0.0043 0.0425 0.0511
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.024 0.022
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.062 0.7879 1
Trypanosoma brucei unspecified product 0.0047 0.0466 0.0566
Plasmodium vivax SET domain protein, putative 0.0029 0.024 0.0247
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.005 0.0036
Brugia malayi Flap endonuclease-1 0.0031 0.027 0.0317
Brugia malayi TAR-binding protein 0.0076 0.0853 0.1058
Echinococcus granulosus tar DNA binding protein 0.0076 0.0853 0.0834
Schistosoma mansoni phosphoglucomutase 0.0068 0.0737 0.0717
Onchocerca volvulus Alhambra homolog 0.0028 0.0232 0.0692
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0466 0.0566
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0518 0.0631
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0319 0.0378
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.005 0.0036
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0257 0.0268
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.062 0.7879 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0045 0.0448 0.0543
Leishmania major ribonuclease H1, putative 0.0068 0.0737 0.091
Trypanosoma brucei ingi protein (ORF1) 0.0073 0.0811 0.1004
Echinococcus granulosus geminin 0.0331 0.415 0.4138
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0642 0.079
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.027 0.0317
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0163 0.0179
Loa Loa (eye worm) hypothetical protein 0.0035 0.0319 0.0379
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0376 0.0356
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0518 0.0631
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.027 0.0316
Loa Loa (eye worm) hypothetical protein 0.0035 0.0319 0.0379
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.024 0.022
Trypanosoma brucei ingi protein (ORF1) 0.0073 0.0811 0.1004
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0466 0.0566
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0624 0.0767
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.027 0.0419
Leishmania major guanosine monophosphate reductase 0.062 0.7879 1
Brugia malayi PHD-finger family protein 0.0028 0.0232 0.0268
Loa Loa (eye worm) hypothetical protein 0.0035 0.0319 0.0379
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0319 0.0136
Schistosoma mansoni flap endonuclease-1 0.0028 0.0231 0.021
Echinococcus multilocularis microtubule associated protein 2 0.0784 1 1
Entamoeba histolytica hypothetical protein 0.0043 0.0425 0.0511
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0319 0.0349
Brugia malayi RNase H family protein 0.0068 0.0737 0.0911
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0087 0.0016
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0021 0.0063
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0047 0.0466 0.0446
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.042 0.5295 1
Leishmania major DNA polymerase kappa, putative 0.0047 0.0466 0.0566
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.005 0.0036
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0319 0.0378
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.024 0.022
Onchocerca volvulus 0.0035 0.0319 0.0953
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0319 0.0202
Echinococcus multilocularis geminin 0.0331 0.415 0.4138
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.0466 0.0501
Schistosoma mansoni phosphoglucomutase 0.0068 0.0737 0.0717
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0466 0.0566
Loa Loa (eye worm) hypothetical protein 0.003 0.0257 0.03
Echinococcus multilocularis ribonuclease H1 0.0068 0.0737 0.0717
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0319 0.0313
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.027 0.0316
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2494 0.3147
Brugia malayi Latrophilin receptor protein 2 0.0019 0.011 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.005 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.2005 0.4807
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0518 0.0686

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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