Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.3727 | 0.3387 |
Schistosoma mansoni | transient receptor potential channel | 0.0096 | 0.3727 | 0.5354 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0022 | 0.0515 | 0.059 |
Trichomonas vaginalis | set domain proteins, putative | 0.0241 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0.0515 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1632 | 0.1869 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0048 | 0.1626 | 0.1172 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.4029 | 0.4614 |
Schistosoma mansoni | transient receptor potential channel | 0.0064 | 0.2319 | 0.333 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.3778 | 0.5426 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.276 | 0.3965 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0755 | 0.0864 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.1632 | 0.2345 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.0036 | 0.1114 | 0.16 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0882 | 0.1009 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0755 | 0.1084 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0882 | 0.1266 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0882 | 0.1266 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0882 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.276 | 0.3965 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.6095 | 0.6979 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0755 | 0.1084 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0022 | 0.0515 | 0.074 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.3727 | 0.3387 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0118 | 0.0135 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.276 | 0.3161 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0096 | 0.3727 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0882 | 0.1266 |
Echinococcus granulosus | GPCR family 2 | 0.0048 | 0.1632 | 0.2345 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.014 | 0.016 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0755 | 0.1084 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.0036 | 0.1114 | 0.16 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0096 | 0.3727 | 0.5354 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0833 | 0.1197 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.014 | 0.0201 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.276 | 0.3161 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0203 | 0.0233 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.1632 | 0.2345 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0515 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0.0515 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0755 | 0.0864 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0103 | 0.4029 | 0.4614 |
Schistosoma mansoni | lamin | 0.0027 | 0.0755 | 0.1084 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0882 | 0.1266 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0097 | 0.3778 | 0.5426 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0093 | 0.3589 | 0.5154 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.3727 | 0.3387 |
Brugia malayi | RNA binding protein | 0.0074 | 0.276 | 0.3161 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.3778 | 0.5426 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0022 | 0.0515 | 0.074 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.3727 | 0.4268 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0096 | 0.3727 | 0.3727 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.014 | 0.0201 |
Trypanosoma brucei | polo-like protein kinase | 0.0096 | 0.3727 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0882 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.0515 | 0.074 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0096 | 0.3727 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.276 | 0.3965 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0212 | 0.8734 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0882 | 0.1266 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0882 | 0.1009 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.1632 | 0.2345 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0064 | 0.2319 | 0.333 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0096 | 0.3727 | 0.5353 |
Onchocerca volvulus | 0.003 | 0.0882 | 0.0882 | |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0096 | 0.3727 | 0.5354 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.0882 | 0.1266 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.0515 | 0.074 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0048 | 0.1626 | 0.1172 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0097 | 0.3778 | 0.5426 |
Echinococcus multilocularis | GPCR, family 2 | 0.0048 | 0.1632 | 0.2345 |
Echinococcus granulosus | lamin | 0.0027 | 0.0755 | 0.1084 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.3727 | 0.3387 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0097 | 0.3778 | 0.5426 |
Schistosoma mansoni | lamin | 0.0027 | 0.0755 | 0.1084 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0755 | 0.0864 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.276 | 0.3965 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0118 | 0.0135 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0097 | 0.3778 | 0.4325 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0755 | 0.0864 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0048 | 0.1632 | 0.2345 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0015 | 0.0203 | 0.0233 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0097 | 0.3778 | 0.4325 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0096 | 0.3727 | 0.5354 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0064 | 0.2319 | 0.333 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0151 | 0.6095 | 0.6979 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.6962 | 1 |
Echinococcus granulosus | geminin | 0.0171 | 0.6962 | 1 |
Echinococcus multilocularis | geminin | 0.0171 | 0.6962 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0097 | 0.3778 | 0.5426 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0755 | 0.1084 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0022 | 0.0515 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0022 | 0.0515 | 0.059 |
Schistosoma mansoni | kinase | 0.0049 | 0.1681 | 0.2415 |
Onchocerca volvulus | 0.0027 | 0.0755 | 0.0755 | |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0975 | 0.1117 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.276 | 0.3965 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0151 | 0.6095 | 0.6979 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0048 | 0.1632 | 0.1869 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.218 | 0.2496 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0882 | 0.1266 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0048 | 0.1632 | 0.1869 |
Brugia malayi | Transient-receptor-potential like protein | 0.0036 | 0.1114 | 0.1276 |
Giardia lamblia | Kinase, PLK | 0.0096 | 0.3727 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0096 | 0.3727 | 0.5353 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.276 | 0.3965 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0064 | 0.2319 | 0.333 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.1632 | 0.2345 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0096 | 0.3727 | 0.4268 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0064 | 0.2319 | 0.333 |
Onchocerca volvulus | 0.0027 | 0.0755 | 0.0755 | |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0048 | 0.1632 | 0.1869 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0097 | 0.3778 | 0.5426 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.276 | 0.3161 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.3727 | 0.3387 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0096 | 0.3727 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.4825 | 0.5525 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1114 | 0.1276 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.3727 | 0.3387 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0022 | 0.0515 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0048 | 0.1632 | 0.2345 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.276 | 0.3965 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.276 | 0.3161 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0096 | 0.3727 | 0.3387 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0096 | 0.3727 | 1 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0093 | 0.3589 | 0.5154 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0733 | 0.0839 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.6962 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.276 | 0.3161 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0096 | 0.3727 | 0.4268 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0048 | 0.1632 | 0.2345 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0048 | 0.1632 | 0.2345 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0096 | 0.3727 | 0.5353 |
Brugia malayi | Pre-SET motif family protein | 0.0212 | 0.8734 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0151 | 0.6095 | 0.6979 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0755 | 0.0864 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0755 | 0.1084 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.4825 | 0.5525 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.4825 | 0.5525 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.4029 | 0.5788 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0755 | 0.1084 |
Schistosoma mansoni | transient receptor potential channel | 0.0064 | 0.2319 | 0.333 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antimicrobial activity against Escherichia coli ATCC 35218 by microdilution method | ChEMBL. | 16180824 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.