Detailed information for compound 1015622

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 751.914 | Formula: C42H53N7O6
  • H donors: 5 H acceptors: 7 LogP: 5.36 Rotable bonds: 21
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(C[C@H](C(=O)N([C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1ccccn1)Cc1c[nH]c2c1cccc2)C)NC(=O)N1CCCCCC1)C
  • InChi: 1S/C42H53N7O6/c1-28(2)23-35(47-42(55)49-21-13-4-5-14-22-49)40(52)48(3)37(25-30-27-44-33-19-10-9-18-32(30)33)39(51)45-34(26-31-17-11-12-20-43-31)38(50)46-36(41(53)54)24-29-15-7-6-8-16-29/h6-12,15-20,27-28,34-37,44H,4-5,13-14,21-26H2,1-3H3,(H,45,51)(H,46,50)(H,47,55)(H,53,54)/t34-,35-,36+,37+/m1/s1
  • InChiKey: JRIMJDBQLCYMGG-MDOFDWFASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0031 0.0172 0.0143
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0051 0.0711
Schistosoma mansoni lamin 0.0027 0.0136 0.0119
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0214 0.0413
Brugia malayi Protein kinase domain containing protein 0.01 0.0906 0.1751
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0214 0.0809
Schistosoma mansoni inositol monophosphatase 0.0036 0.0223 0.0207
Mycobacterium tuberculosis Probable oxidoreductase 0.0143 0.1365 0.6111
Echinococcus granulosus intermediate filament protein 0.0027 0.0136 0.0119
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.025 0.2506 0.2494
Echinococcus granulosus lamin dm0 0.0027 0.0136 0.0119
Brugia malayi Thioredoxin reductase 0.0056 0.0444 0.0857
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0172 0.0332
Loa Loa (eye worm) thioredoxin reductase 0.0056 0.0444 0.0857
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0158 0.153 0.2957
Mycobacterium ulcerans glutaminase 0.0303 0.3066 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0032
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0172 0.0155
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0172 0.0143
Loa Loa (eye worm) hypothetical protein 0.0027 0.0136 0.0262
Brugia malayi hypothetical protein 0.0016 0.0017 0.0032
Brugia malayi nuclear receptor NHR-88 0.0031 0.0172 0.0332
Echinococcus multilocularis musashi 0.0027 0.0136 0.0119
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0172 0.0155
Loa Loa (eye worm) hypothetical protein 0.0031 0.0172 0.0332
Schistosoma mansoni ferritin 0.0018 0.0038 0.0021
Schistosoma mansoni hypothetical protein 0.0158 0.153 0.1516
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0129 0.1213 0.8849
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0129 0.1213 0.5407
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0068 0.0565 0.6011
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.025 0.2506 0.4844
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.01 0.0906 0.1751
Entamoeba histolytica protein kinase domain containing protein 0.01 0.0906 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0172 0.0332
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0197 0.018
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0146 0.1847
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0223 0.2014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0214 0.1901
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0273 0.275 0.5315
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.01 0.0906 1
Brugia malayi beta-lactamase family protein 0.0035 0.0214 0.0413
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0172 0.0155
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0214 0.058
Schistosoma mansoni tar DNA-binding protein 0.0273 0.275 0.2738
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0068 0.0565 0.6011
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0051 0.0711
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0172 0.0155
Brugia malayi Inositol-1 0.0036 0.0223 0.0432
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0068 0.0565 1
Brugia malayi beta-lactamase family protein 0.0035 0.0214 0.0413
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0143 0.1365 0.6111
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0172 0.0155
Schistosoma mansoni tar DNA-binding protein 0.0273 0.275 0.2738
Echinococcus granulosus ferritin 0.0018 0.0038 0.0021
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0146 0.111
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0214 0.0809
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0214 0.058
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0231 0.2308 0.4461
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0051 0.0043
Echinococcus multilocularis thioredoxin glutathione reductase 0.0056 0.0444 0.0428
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0197 0.018
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0051 0.0043
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0172 0.0155
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0214 0.0413
Loa Loa (eye worm) hypothetical protein 0.0031 0.0172 0.0332
Schistosoma mansoni hypothetical protein 0.0158 0.153 0.1516
Schistosoma mansoni tar DNA-binding protein 0.0273 0.275 0.2738
Schistosoma mansoni ferritin light chain 0.0018 0.0038 0.0021
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0197 0.018
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.0051 0.0043
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0197 0.018
Entamoeba histolytica hypothetical protein 0.0042 0.0294 0.1038
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0172 0.0332
Echinococcus multilocularis lamin dm0 0.0027 0.0136 0.0119
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0223 0.0612
Brugia malayi ecdysteroid receptor 0.0031 0.0172 0.0332
Loa Loa (eye worm) hypothetical protein 0.0035 0.0214 0.0413
Giardia lamblia Kinase, CMGC CLK 0.0068 0.0565 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0214 0.058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.025 0.2506 0.2494
Loa Loa (eye worm) hypothetical protein 0.0031 0.0172 0.0332
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0146 0.1847
Loa Loa (eye worm) hypothetical protein 0.0158 0.153 0.2957
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0032
Loa Loa (eye worm) hypothetical protein 0.0027 0.013 0.0252
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0172 0.0155
Echinococcus granulosus lamin 0.0027 0.0136 0.0119
Schistosoma mansoni ferritin 0.0018 0.0038 0.0021
Schistosoma mansoni inositol monophosphatase 0.0036 0.0223 0.0207
Schistosoma mansoni hypothetical protein 0.0954 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0172 0.0332
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0172 0.0155
Brugia malayi intermediate filament protein 0.0027 0.0136 0.0262
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0172 0.0143
Loa Loa (eye worm) glutathione reductase 0.0056 0.0444 0.0857
Brugia malayi glutaminase DH11.1 0.0303 0.3066 0.5927
Loa Loa (eye worm) hypothetical protein 0.0031 0.0172 0.0332
Loa Loa (eye worm) hypothetical protein 0.0031 0.0172 0.0332
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0051 0.0061
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0223 0.2014
Brugia malayi Latrophilin receptor protein 2 0.0158 0.153 0.2957
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0172 0.0155
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0056 0.0444 0.1867
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0129 0.1213 0.5407
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0068 0.0565 0.1092
Leishmania major hypothetical protein, conserved 0.0035 0.0214 0.1901
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0172 0.0155
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0214 0.0197
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0172 0.0155
Brugia malayi Protein kinase domain containing protein 0.0068 0.0565 0.1092
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0906 0.089
Onchocerca volvulus 0.0035 0.0214 0.031
Mycobacterium tuberculosis Probable reductase 0.0129 0.1213 0.5407
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0172 0.0155
Loa Loa (eye worm) TAR-binding protein 0.0273 0.275 0.5315
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0565 0.0549
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0146 0.1847
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0223 0.2014
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0172 0.0332
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0172 0.0332
Loa Loa (eye worm) hypothetical protein 0.0031 0.0172 0.0332
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0158 0.153 0.1516
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0136 0.0262
Schistosoma mansoni hypothetical protein 0.0158 0.153 0.1516
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0172 0.0332
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0146 0.1847
Mycobacterium ulcerans lipase LipD 0.0035 0.0214 0.058
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0068 0.0565 0.6011
Brugia malayi RNA recognition motif domain containing protein 0.0273 0.275 0.5315
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0017 0.0032
Loa Loa (eye worm) beta-lactamase 0.0035 0.0214 0.0413
Trichomonas vaginalis set domain proteins, putative 0.0263 0.2649 0.862
Echinococcus multilocularis dual specificity 0.01 0.0906 0.089
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0214 0.0809
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.01 0.0906 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0051 0.0035
Onchocerca volvulus 0.0035 0.0214 0.031
Schistosoma mansoni ferritin light chain 0.0018 0.0038 0.0021
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.05 0.5174 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0214 0.0809
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.01 0.0906 1
Echinococcus granulosus hypothetical protein 0.0067 0.0554 0.0538
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0129 0.1213 0.5407
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0172 0.0332
Loa Loa (eye worm) hypothetical protein 0.05 0.5174 1
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0565 0.1739
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0172 0.0332
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.0051 0.0043
Echinococcus granulosus tar DNA binding protein 0.0273 0.275 0.2738
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.025 0.2506 0.2494
Loa Loa (eye worm) glutaminase 2 0.0303 0.3066 0.5927
Schistosoma mansoni intermediate filament proteins 0.0027 0.0136 0.0119
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0172 0.0143
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0214 0.1901
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0172 0.0332
Echinococcus granulosus GPCR family 2 0.0158 0.153 0.1516
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0214 0.058
Echinococcus multilocularis ferritin 0.0018 0.0038 0.0021
Entamoeba histolytica hypothetical protein 0.01 0.0906 1
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0172 0.0155
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0172 0.0155
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0197 0.018
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0051 0.5
Brugia malayi glutathione reductase 0.0056 0.0444 0.0857
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.025 0.2506 0.2494
Brugia malayi Pre-SET motif family protein 0.0231 0.2308 0.4461
Leishmania major hypothetical protein, conserved 0.0028 0.0146 0.111
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0068 0.0565 0.6011
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0223 0.0207
Mycobacterium ulcerans beta-lactamase 0.0035 0.0214 0.058
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0172 0.0155
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0146 0.111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0172 0.0332
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0172 0.0332
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0172 0.0155
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0172 0.0155
Brugia malayi nuclear receptor RXR 0.0016 0.0017 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0172 0.0332
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0223 0.0612
Loa Loa (eye worm) pigment dispersing factor receptor c 0.05 0.5174 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0172 0.0155
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0146 0.111
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0197 0.018
Leishmania major protein kinase, putative 0.0068 0.0565 0.6011
Onchocerca volvulus 0.0263 0.2649 1
Onchocerca volvulus 0.0035 0.0214 0.031
Brugia malayi nuclear hormone receptor 0.0031 0.0172 0.0332
Mycobacterium leprae Probable lipase LipE 0.0035 0.0214 0.1323
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0172 0.0155
Trichomonas vaginalis esterase, putative 0.0035 0.0214 0.058
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0051 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0172 0.0332
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0158 0.153 0.1516
Loa Loa (eye worm) hypothetical protein 0.0099 0.0895 0.1729
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0136 0.0262
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0172 0.0155
Echinococcus granulosus expressed protein 0.0018 0.0038 0.0021
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0172 0.0155
Schistosoma mansoni ferritin 0.0018 0.0038 0.0021
Brugia malayi Pre-SET motif family protein 0.0033 0.0197 0.038
Loa Loa (eye worm) hypothetical protein 0.0035 0.0214 0.0413
Trypanosoma brucei trypanothione reductase 0.0056 0.0444 0.4591
Mycobacterium tuberculosis Conserved protein 0.0035 0.0214 0.0809
Brugia malayi Calcitonin receptor-like protein seb-1 0.05 0.5174 1
Loa Loa (eye worm) glutaminase 0.0303 0.3066 0.5927
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0017 0.0032
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.01 0.0906 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0184 0.1095
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0214 0.0809
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0172 0.0332
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0172 0.0155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0172 0.0332
Schistosoma mansoni hypothetical protein 0.0342 0.3487 0.3476
Treponema pallidum NADH oxidase 0.002 0.0051 1
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0214 0.0809
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0214 0.3163
Entamoeba histolytica hypothetical protein 0.0042 0.0294 0.1038
Echinococcus granulosus thioredoxin glutathione reductase 0.0056 0.0444 0.0428
Plasmodium vivax glutathione reductase, putative 0.0056 0.0444 0.7638
Leishmania major trypanothione reductase 0.0056 0.0444 0.4591
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0172 0.0332
Schistosoma mansoni ferritin 0.0018 0.0038 0.0021
Brugia malayi hypothetical protein 0.0028 0.0146 0.0283
Mycobacterium ulcerans hypothetical protein 0.0035 0.0214 0.058
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0051 0.0035
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0214 0.0197
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0143 0.1365 0.6111
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0068 0.0565 0.6011
Loa Loa (eye worm) inositol-1 0.0036 0.0223 0.0432
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0184 0.0167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0172 0.0332
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0172 0.0332
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0223 0.0612
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0214 0.0197
Schistosoma mansoni tar DNA-binding protein 0.0273 0.275 0.2738
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0172 0.0155
Loa Loa (eye worm) hypothetical protein 0.0067 0.0554 0.1071
Plasmodium vivax serine/threonine kinase-1, putative 0.0068 0.0565 1
Echinococcus multilocularis geminin 0.0954 1 1
Loa Loa (eye worm) RNA binding protein 0.0273 0.275 0.5315
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0197 0.2833
Trichomonas vaginalis glutaminase, putative 0.0303 0.3066 1
Onchocerca volvulus 0.0033 0.0197 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0172 0.0332
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0184 0.0669
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0214 0.0197
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0017 0.0032
Plasmodium vivax thioredoxin reductase, putative 0.0056 0.0444 0.7638
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0136 0.0262
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0158 0.153 0.1516
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0294 0.0278
Brugia malayi hypothetical protein 0.0016 0.0017 0.0032
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0143 0.1365 1
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0565 0.0549
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0172 0.0155
Schistosoma mansoni apoferritin-2 0.0018 0.0038 0.0021
Brugia malayi latrophilin 2 splice variant baaae 0.0342 0.3487 0.674
Schistosoma mansoni glutaminase 0.0303 0.3066 0.3055
Schistosoma mansoni hypothetical protein 0.0954 1 1
Toxoplasma gondii thioredoxin reductase 0.0056 0.0444 0.7638
Echinococcus multilocularis dual specificity protein kinase clk2 0.0068 0.0565 0.0549
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0197 0.018
Entamoeba histolytica hypothetical protein 0.0042 0.0294 0.1038
Mycobacterium tuberculosis Conserved protein 0.0035 0.0214 0.0809
Leishmania major protein kinase, putative 0.0068 0.0565 0.6011
Schistosoma mansoni coup transcription factor 0.0031 0.0172 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0172 0.0332
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0032
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0172 0.0155
Loa Loa (eye worm) hypothetical protein 0.0033 0.0197 0.038
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0223 0.0207
Loa Loa (eye worm) hypothetical protein 0.0031 0.0172 0.0332
Loa Loa (eye worm) hypothetical protein 0.0028 0.0146 0.0283
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.0051 0.0043
Echinococcus multilocularis GPCR, family 2 0.0158 0.153 0.1516
Echinococcus multilocularis tar DNA binding protein 0.0273 0.275 0.2738
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0294 0.0278
Echinococcus multilocularis 0.0067 0.0554 0.0538
Brugia malayi hypothetical protein 0.0018 0.0039 0.0075
Loa Loa (eye worm) hypothetical protein 0.0099 0.0895 0.1729
Entamoeba histolytica hypothetical protein 0.0042 0.0294 0.1038
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.025 0.2506 0.4844
Schistosoma mansoni hypothetical protein 0.0158 0.153 0.1516
Loa Loa (eye worm) hypothetical protein 0.0035 0.0214 0.0413
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0172 0.0155
Mycobacterium tuberculosis Probable dehydrogenase 0.0129 0.1213 0.5407
Plasmodium vivax SET domain protein, putative 0.0033 0.0197 0.2833
Loa Loa (eye worm) latrophilin receptor protein 2 0.0158 0.153 0.2957
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0129 0.1213 0.5407
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0051 0.0035
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0214 0.058
Echinococcus multilocularis expressed protein 0.0018 0.0038 0.0021
Loa Loa (eye worm) hypothetical protein 0.0342 0.3487 0.674
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0214 0.0809
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0214 0.0809
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.025 0.2506 0.2494
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0223 0.335
Brugia malayi hypothetical protein 0.0042 0.0294 0.0569
Echinococcus multilocularis lamin 0.0027 0.0136 0.0119
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.025 0.2506 0.2494
Schistosoma mansoni lamin 0.0027 0.0136 0.0119
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0214 0.1323
Loa Loa (eye worm) hypothetical protein 0.0035 0.0214 0.0413
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0172 0.0155
Brugia malayi beta-lactamase 0.0035 0.0214 0.0413
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0214 0.058
Entamoeba histolytica protein kinase, putative 0.01 0.0906 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0948 0.9939 0.9939
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0172 0.0155
Schistosoma mansoni tar DNA-binding protein 0.0273 0.275 0.2738
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0172 0.0155
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.025 0.2506 0.2494
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0294 0.0278
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0158 0.153 0.1516
Brugia malayi RNA binding protein 0.0273 0.275 0.5315
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0214 0.058
Entamoeba histolytica protein kinase, putative 0.01 0.0906 1
Schistosoma mansoni hypothetical protein 0.0042 0.0294 0.0278
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0223 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0172 0.0155
Loa Loa (eye worm) hypothetical protein 0.0035 0.0214 0.0413
Plasmodium falciparum glutathione reductase 0.0056 0.0444 0.7638
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0214 0.1901
Echinococcus granulosus dual specificity 0.01 0.0906 0.089
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0223 0.0612
Brugia malayi TAR-binding protein 0.0273 0.275 0.5315
Plasmodium falciparum protein serine/threonine kinase-1 0.0068 0.0565 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0172 0.0332
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0172 0.0332
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0068 0.0565 0.6011
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.221 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0172 0.0332
Loa Loa (eye worm) hypothetical protein 0.0035 0.0214 0.0413
Toxoplasma gondii ABC1 family protein 0.0035 0.0214 0.3163
Plasmodium falciparum thioredoxin reductase 0.0056 0.0444 0.7638
Schistosoma mansoni apoferritin-2 0.0018 0.0038 0.0021
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0223 0.2014
Trypanosoma cruzi trypanothione reductase, putative 0.0056 0.0444 0.4591
Echinococcus granulosus dual specificity protein kinase clk2 0.0068 0.0565 0.0549
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0172 0.0332
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0032
Brugia malayi steroid hormone receptor 0.0031 0.0172 0.0332

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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