Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0066 | 0.0607 | 0.0607 |
Echinococcus granulosus | acetylcholinesterase | 0.0872 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0147 | 0.1554 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0.0025 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.1554 | 0.1533 |
Loa Loa (eye worm) | hypothetical protein | 0.0872 | 1 | 1 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0186 | 0.2008 | 0.1989 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0147 | 0.1554 | 0.1533 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0047 | 0.0388 | 0.0025 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0147 | 0.1554 | 0.1533 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0025 | 0.5 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0025 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.0025 | 0.0249 |
Onchocerca volvulus | 0.0147 | 0.1554 | 0.7853 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0551 | 0.0551 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0147 | 0.1554 | 0.1554 |
Brugia malayi | Melibiase family protein | 0.0066 | 0.0607 | 0.0584 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.023 | 0.2521 | 0.2502 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.1554 | 0.1533 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.1216 | 0.1194 |
Echinococcus multilocularis | acetylcholinesterase | 0.0872 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.1216 | 0.1194 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.1554 | 0.1533 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.0551 | 0.0528 |
Brugia malayi | mbt repeat family protein | 0.0047 | 0.0388 | 0.0364 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0099 | 0.0992 | 0.0992 |
Onchocerca volvulus | 0.0047 | 0.0388 | 0.0025 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0872 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.1554 | 0.1533 |
Echinococcus granulosus | geminin | 0.0165 | 0.176 | 0.1739 |
Echinococcus multilocularis | geminin | 0.0165 | 0.176 | 0.1739 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0551 | 0.0551 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0872 | 1 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0099 | 0.0992 | 0.0992 |
Brugia malayi | hypothetical protein | 0.0147 | 0.1554 | 0.1533 |
Onchocerca volvulus | 0.0147 | 0.1554 | 0.7853 | |
Brugia malayi | hypothetical protein | 0.023 | 0.2521 | 0.2502 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.0551 | 0.0528 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0384 | 0.0384 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0054 | 0.0464 | 0.044 |
Loa Loa (eye worm) | carboxylesterase | 0.0147 | 0.1554 | 0.1533 |
Brugia malayi | N-terminal motif family protein | 0.0175 | 0.1873 | 0.1853 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0384 | 0.036 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0025 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0147 | 0.1554 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0147 | 0.1554 | 0.1554 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0384 | 0.0384 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0047 | 0.0388 | 0.0364 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0147 | 0.1554 | 1 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0047 | 0.0388 | 0.0364 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0186 | 0.2008 | 0.1989 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0147 | 0.1554 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.0025 | 0.0025 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0047 | 0.0388 | 0.0388 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0872 | 1 | 1 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0054 | 0.0464 | 0.044 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.1554 | 0.1533 |
Brugia malayi | RNA binding protein | 0.0061 | 0.0551 | 0.0528 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.0099 | 0.0992 | 0.097 |
Schistosoma mansoni | acetylcholinesterase | 0.0147 | 0.1554 | 0.1554 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0047 | 0.0388 | 0.0364 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0047 | 0.0388 | 0.0364 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0047 | 0.0388 | 0.0388 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0147 | 0.1554 | 0.1533 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0099 | 0.0992 | 0.0992 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.1554 | 0.1533 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.176 | 0.176 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.176 | 0.176 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0047 | 0.0388 | 0.0388 |
Echinococcus multilocularis | neuroligin | 0.0147 | 0.1554 | 0.1533 |
Onchocerca volvulus | 0.0147 | 0.1554 | 0.7853 | |
Schistosoma mansoni | hypothetical protein | 0.0287 | 0.3187 | 0.3187 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0551 | 0.0551 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0.0025 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.1873 | 0.1853 |
Brugia malayi | mbt repeat family protein | 0.0047 | 0.0388 | 0.0364 |
Echinococcus granulosus | acetylcholinesterase | 0.0872 | 1 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0099 | 0.0992 | 0.0992 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0147 | 0.1554 | 0.1554 |
Loa Loa (eye worm) | carboxylesterase | 0.0147 | 0.1554 | 0.1533 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.0099 | 0.0992 | 0.097 |
Loa Loa (eye worm) | carboxylesterase | 0.0872 | 1 | 1 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0175 | 0.1873 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0147 | 0.1554 | 0.1533 |
Onchocerca volvulus | 0.0147 | 0.1554 | 0.7853 | |
Brugia malayi | TAR-binding protein | 0.0061 | 0.0551 | 0.0528 |
Echinococcus multilocularis | acetylcholinesterase | 0.0872 | 1 | 1 |
Schistosoma mansoni | gliotactin | 0.0147 | 0.1554 | 0.1554 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.023 | 0.2521 | 0.2502 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0464 | 0.044 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0147 | 0.1554 | 0.1533 |
Brugia malayi | Carboxylesterase family protein | 0.0147 | 0.1554 | 0.1533 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.0551 | 0.0528 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0066 | 0.0607 | 0.0607 |
Loa Loa (eye worm) | hypothetical protein | 0.023 | 0.2521 | 0.2502 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0054 | 0.0464 | 0.044 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.0099 | 0.0992 | 0.097 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0.0025 | 0.5 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0047 | 0.0388 | 0.0364 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0147 | 0.1554 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.0551 | 0.0528 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0388 | 0.0364 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0054 | 0.0464 | 0.044 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0147 | 0.1554 | 0.1533 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0.0025 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0147 | 0.1554 | 0.1554 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0607 | 0.0584 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0147 | 0.1554 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.1554 | 0.1533 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0054 | 0.0464 | 0.0464 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.0551 | 0.0528 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0054 | 0.0464 | 0.044 |
Brugia malayi | Carboxylesterase family protein | 0.0147 | 0.1554 | 0.1533 |
Brugia malayi | Carboxylesterase family protein | 0.0147 | 0.1554 | 0.1533 |
Toxoplasma gondii | melibiase subfamily protein | 0.0099 | 0.0992 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0551 | 0.0551 |
Loa Loa (eye worm) | MBCTL1 | 0.0054 | 0.0464 | 0.044 |
Echinococcus granulosus | neuroligin | 0.0147 | 0.1554 | 0.1533 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.1216 | 0.1194 |
Loa Loa (eye worm) | hypothetical protein | 0.0872 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0147 | 0.1554 | 0.1533 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0872 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.0551 | 0.0528 |
Onchocerca volvulus | 0.0147 | 0.1554 | 0.7853 | |
Brugia malayi | Carboxylesterase family protein | 0.0872 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0551 | 0.0551 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0147 | 0.1554 | 0.1554 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.0025 | 0.0249 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.