Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0142 | 0.372 | 0.3643 |
Mycobacterium ulcerans | hypothetical protein | 0.0158 | 0.4357 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.03 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.013 | 0.324 | 0.2341 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0084 | 0.1431 | 0.5 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0084 | 0.1431 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0084 | 0.1431 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.03 | 1 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0287 | 0.9481 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.0287 | 0.9481 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0279 | 0.9161 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0084 | 0.1431 | 0.5 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0287 | 0.9481 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0227 | 0.7094 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.03 | 1 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0077 | 0.1151 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0084 | 0.1431 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0287 | 0.9481 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0077 | 0.1151 | 0.5 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0077 | 0.1151 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.