Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0153 | 0.0816 | 0.0801 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0113 | 0.0531 | 0.0515 |
Brugia malayi | nuclear receptor RXR | 0.0113 | 0.0531 | 0.0515 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0153 | 0.0816 | 0.0801 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0157 | 0.014 |
Schistosoma mansoni | thyroid hormone receptor | 0.0153 | 0.0816 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0153 | 0.0816 | 0.0801 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0153 | 0.0816 | 0.0801 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0153 | 0.0816 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0153 | 0.0816 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0153 | 0.0816 | 0.0801 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0153 | 0.0816 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0054 | 0.0114 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0113 | 0.0531 | 0.6428 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0153 | 0.0816 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0153 | 0.0816 | 0.0801 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0153 | 0.0816 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0153 | 0.0816 | 0.0801 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0272 | 0.3194 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0153 | 0.0816 | 0.0801 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.0751 | 0.0735 |
Loa Loa (eye worm) | hypothetical protein | 0.1452 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0272 | 0.3194 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0153 | 0.0816 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 0.0114 | 0.1211 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0153 | 0.0816 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0272 | 0.3194 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0153 | 0.0816 | 0.0801 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0157 | 0.014 |
Schistosoma mansoni | coup transcription factor | 0.0153 | 0.0816 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0153 | 0.0816 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0157 | 0.014 |
Onchocerca volvulus | Bile acid receptor homolog | 0.1452 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.0272 | 0.0256 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0153 | 0.0816 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0153 | 0.0816 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0113 | 0.0531 | 0.0515 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0153 | 0.0816 | 0.0801 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0272 | 0.3194 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0114 | 0.0097 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0816 | 0.0801 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0531 | 0.0515 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0113 | 0.0531 | 0.6428 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0153 | 0.0816 | 0.0801 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0054 | 0.0114 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0816 | 0.0801 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0153 | 0.0816 | 0.0801 |
Schistosoma mansoni | thyroid hormone receptor | 0.0153 | 0.0816 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0272 | 0.3194 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 0.0114 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.0272 | 0.0256 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0153 | 0.0816 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0153 | 0.0816 | 0.0801 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0816 | 0.0801 |
Brugia malayi | steroid hormone receptor | 0.0153 | 0.0816 | 0.0801 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0157 | 0.014 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0153 | 0.0816 | 1 |
Brugia malayi | hypothetical protein | 0.0113 | 0.0531 | 0.0515 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0153 | 0.0816 | 0.0801 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.0272 | 0.0256 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0022 | 0.0068 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0153 | 0.0816 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0531 | 0.0515 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0816 | 0.0801 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0153 | 0.0816 | 0.0801 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0153 | 0.0816 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0153 | 0.0816 | 0.0801 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0153 | 0.0816 | 0.0801 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.0272 | 0.0256 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0022 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0816 | 0.0801 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0153 | 0.0816 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0153 | 0.0816 | 0.0801 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0113 | 0.0531 | 0.6428 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.0272 | 0.0256 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0531 | 0.0515 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0153 | 0.0816 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0153 | 0.0816 | 0.0801 |
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 0.0114 | 0.1211 |
Brugia malayi | nuclear receptor NHR-88 | 0.0153 | 0.0816 | 0.0801 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0153 | 0.0816 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.0272 | 0.3194 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0153 | 0.0816 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0153 | 0.0816 | 1 |
Brugia malayi | hypothetical protein | 0.0113 | 0.0531 | 0.0515 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0113 | 0.0531 | 0.0515 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0153 | 0.0816 | 0.0801 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0531 | 0.0515 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0153 | 0.0816 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0153 | 0.0816 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0022 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0816 | 0.0801 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0113 | 0.0531 | 0.6428 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.0751 | 0.0735 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0153 | 0.0816 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 0.0114 | 0.1211 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.0751 | 0.0735 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0531 | 0.0515 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0153 | 0.0816 | 0.0801 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0153 | 0.0816 | 0.0801 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0153 | 0.0816 | 0.0801 |
Schistosoma mansoni | nuclear hormone receptor | 0.0153 | 0.0816 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0153 | 0.0816 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0816 | 0.0801 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.0272 | 0.3194 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0054 | 0.0114 | 0.0097 |
Echinococcus granulosus | FTZ F1 alpha | 0.0153 | 0.0816 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0153 | 0.0816 | 0.0801 |
Onchocerca volvulus | 0.0153 | 0.0816 | 0.0801 | |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.0272 | 0.0256 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0153 | 0.0816 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0153 | 0.0816 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0153 | 0.0816 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0153 | 0.0816 | 0.0801 |
Brugia malayi | nuclear hormone receptor | 0.0153 | 0.0816 | 0.0801 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0153 | 0.0816 | 0.0801 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 47.1 uM | Cytotoxicity against human H9 cells after 4 days | ChEMBL. | 17190445 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.