Detailed information for compound 1016037

Basic information

Technical information
  • TDR Targets ID: 1016037
  • Name: methyl (E)-3-[3-hydroxy-5-[(2S,3R,4S,5S,6R)-3 ,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]ox yphenyl]prop-2-enoate
  • MW: 356.325 | Formula: C16H20O9
  • H donors: 5 H acceptors: 6 LogP: -0.31 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@@H](Oc2cc(/C=C/C(=O)OC)cc(c2)O)[C@@H]([C@H]([C@@H]1O)O)O
  • InChi: 1S/C16H20O9/c1-23-12(19)3-2-8-4-9(18)6-10(5-8)24-16-15(22)14(21)13(20)11(7-17)25-16/h2-6,11,13-18,20-22H,7H2,1H3/b3-2+/t11-,13-,14+,15-,16-/m1/s1
  • InChiKey: ZROOQFAPMUQERH-JGWMVUGPSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl (E)-3-[3-hydroxy-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-phenyl]prop-2-enoate
  • (E)-3-[3-hydroxy-5-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]phenyl]prop-2-enoic acid methyl ester
  • (E)-3-[3-hydroxy-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxy-phenyl]acrylic acid methyl ester
  • methyl (E)-3-[3-hydroxy-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-phenyl]prop-2-enoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans chitinase/cellulase 0.0062 0.0394 1
Onchocerca volvulus 0.0037 0.0073 0.0192
Loa Loa (eye worm) CUTiclin-Like family member 0.0037 0.0073 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1619 0.2733
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0053 0.009
Brugia malayi von Willebrand factor type A domain containing protein 0.0037 0.0073 0.0073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0037 0.0073 0.0073
Brugia malayi AKH receptor 0.0032 0.0014 0.0014
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0014 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0159 0.1619 0.1619
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0032 0.0014 0.0014
Echinococcus multilocularis C type lectin domian containing protein 0.0063 0.041 0.0513
Echinococcus multilocularis protein will die slowly 0.0279 0.3133 0.3921
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0032 0.0014 0.0017
Echinococcus granulosus g-protein coupled receptor 0.0032 0.0014 0.0014
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0014 0.0017
Trypanosoma cruzi CYC2-like cyclin, putative 0.005 0.0234 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0032 0.0014 0.0014
Brugia malayi G-protein coupled receptor 0.0032 0.0014 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0014 0.0014
Onchocerca volvulus 0.0037 0.0073 0.0192
Onchocerca volvulus 0.0063 0.041 0.127
Schistosoma mansoni neuropeptide receptor 0.0032 0.0014 0.0014
Schistosoma mansoni opsin-like receptor 0.0032 0.0014 0.0014
Brugia malayi von Willebrand Factor 0.0037 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0063 0.041 0.041
Toxoplasma gondii rhoptry neck protein RON9 0.0063 0.041 0.8117
Giardia lamblia High cysteine membrane protein Group 2 0.0306 0.347 1
Brugia malayi proprotein convertase 2 0.0518 0.6139 0.6139
Echinococcus granulosus histone lysine n methyltransferase setd8 0.007 0.0493 0.0493
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0032 0.0014 0.0014
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0037 0.0073 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1619 0.2733
Onchocerca volvulus Putative endochitinase 0.0073 0.053 0.1655
Trichomonas vaginalis cyclin A, putative 0.005 0.0234 0.0395
Schistosoma mansoni amine GPCR 0.0032 0.0014 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase seto7 0.007 0.0493 0.0493
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0053 0.009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0053 0.009
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0037 0.0073 0.0458
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0035 0.0053 0.0067
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0032 0.0014 0.0014
Trichomonas vaginalis cyclin B, putative 0.005 0.0234 0.0395
Loa Loa (eye worm) TYRA-2 protein 0.0032 0.0014 0.0014
Onchocerca volvulus 0.0063 0.041 0.127
Onchocerca volvulus 0.0279 0.3133 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0014 0.0014
Onchocerca volvulus Putative endochitinase 0.0073 0.053 0.1655
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0014 0.0017
Entamoeba histolytica hypothetical protein, conserved 0.0037 0.0073 0.1386
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0073 0.0458
Entamoeba histolytica elongation factor-2 kinase, putative 0.0037 0.0073 0.1386
Echinococcus granulosus allatostatin A receptor 0.0032 0.0014 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0053 0.009
Echinococcus granulosus voltage dependent calcium channel subunit 0.0037 0.0073 0.0073
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0053 0.009
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0032 0.0014 0.0017
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0037 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Onchocerca volvulus 0.0063 0.041 0.127
Brugia malayi Zona pellucida-like domain containing protein 0.0037 0.0073 0.0073
Echinococcus granulosus g protein coupled receptor 0.0032 0.0014 0.0014
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0032 0.0014 0.0014
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0032 0.0014 0.0014
Schistosoma mansoni neuropeptide f receptor 76f 0.0032 0.0014 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0053 0.009
Brugia malayi neuroendocrine convertase 1 precursor 0.0518 0.6139 0.6139
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0159 0.1619 0.2733
Loa Loa (eye worm) hypothetical protein 0.0063 0.041 0.041
Brugia malayi hypothetical protein 0.0032 0.0014 0.0014
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0061 0.0061
Plasmodium falciparum subtilisin-like protease 3 0.0035 0.0053 0.1082
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Brugia malayi Subtilase family protein 0.0035 0.0053 0.0053
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0194 0.2063 0.3483
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Entamoeba histolytica cyclin, putative 0.005 0.0234 0.4421
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.0014 0.0017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Onchocerca volvulus 0.005 0.0234 0.0707
Brugia malayi Immunoglobulin I-set domain containing protein 0.0037 0.0073 0.0073
Schistosoma mansoni biogenic amine receptor 0.0032 0.0014 0.0014
Echinococcus multilocularis neuropeptide receptor 0.0032 0.0014 0.0017
Brugia malayi Serotonin receptor 0.0032 0.0014 0.0014
Brugia malayi hypothetical protein 0.0032 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0053 0.009
Brugia malayi Zona pellucida-like domain containing protein 0.0037 0.0073 0.0073
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Brugia malayi pregnancy-associated plasma protein-A 0.0063 0.041 0.041
Brugia malayi von Willebrand factor type A domain containing protein 0.0037 0.0073 0.0073
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0053 0.009
Echinococcus multilocularis fmrfamide receptor 0.0032 0.0014 0.0017
Brugia malayi hypothetical protein 0.0063 0.041 0.041
Onchocerca volvulus 0.0063 0.041 0.127
Loa Loa (eye worm) subtilase 0.0035 0.0053 0.0053
Loa Loa (eye worm) WD40 repeat protein 0.0279 0.3133 0.3133
Giardia lamblia G2/mitotic-specific cyclin B 0.005 0.0234 0.0675
Schistosoma mansoni hypothetical protein 0.0032 0.0014 0.0014
Schistosoma mansoni cyclin B 0.005 0.0234 0.0234
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0014 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0053 0.009
Schistosoma mansoni site-1 peptidase (S08 family) 0.0035 0.0053 0.0053
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0035 0.0053 0.0053
Schistosoma mansoni biogenic amine receptor 0.0032 0.0014 0.0014
Schistosoma mansoni histamine h1 receptor 0.0032 0.0014 0.0014
Trypanosoma cruzi cyclin, putative 0.005 0.0234 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0032 0.0014 0.0017
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0037 0.0073 0.0458
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0159 0.1619 0.2733
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0014 0.0014
Echinococcus granulosus furin 0.0824 1 1
Treponema pallidum hypothetical protein 0.0037 0.0073 0.5
Schistosoma mansoni hypothetical protein 0.0036 0.0061 0.0061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0014 0.0014
Echinococcus multilocularis histone lysine n methyltransferase setd8 0.007 0.0493 0.0617
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0014 0.0014
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.005 0.0234 0.3797
Onchocerca volvulus 0.0037 0.0073 0.0192
Plasmodium vivax thrombospondin-related anonymous protein 0.0037 0.0073 0.0458
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.027 0.027
Schistosoma mansoni amine GPCR 0.0032 0.0014 0.0014
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0014 0.0017
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0159 0.1619 0.2733
Schistosoma mansoni amine GPCR 0.0032 0.0014 0.0014
Brugia malayi von Willebrand factor type A domain containing protein 0.0037 0.0073 0.0073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0014 0.0017
Onchocerca volvulus 0.0063 0.041 0.127
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0037 0.0073 0.0458
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0014 0.0014
Loa Loa (eye worm) G-protein coupled receptor 0.0032 0.0014 0.0014
Echinococcus granulosus alpha 1A adrenergic receptor 0.0032 0.0014 0.0014
Onchocerca volvulus Putative endochitinase 0.0073 0.053 0.1655
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0014 0.0014
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0032 0.0014 0.0014
Brugia malayi ORL1-like opioid receptor 0.0032 0.0014 0.0014
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0032 0.0014 0.0014
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Trichomonas vaginalis cyclin B, putative 0.005 0.0234 0.0395
Loa Loa (eye worm) hypothetical protein 0.0063 0.041 0.041
Onchocerca volvulus 0.0063 0.041 0.127
Loa Loa (eye worm) hypothetical protein 0.0063 0.041 0.041
Echinococcus granulosus fmrfamide receptor 0.0032 0.0014 0.0014
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0501 0.5924 0.7415
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0194 0.2063 0.3483
Echinococcus granulosus dro:myosuppressin receptor 0.0032 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1619 0.2733
Brugia malayi G-protein coupled receptor 0.0032 0.0014 0.0014
Echinococcus multilocularis neuropeptide FF receptor 2 0.0032 0.0014 0.0017
Schistosoma mansoni neuropeptide receptor 0.0032 0.0014 0.0014
Onchocerca volvulus Putative endochitinase 0.0073 0.053 0.1655
Loa Loa (eye worm) hypothetical protein 0.0036 0.0061 0.0061
Schistosoma mansoni neuropeptide receptor 0.0032 0.0014 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0053 0.009
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Echinococcus granulosus neuropeptide receptor A26 0.0032 0.0014 0.0014
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0014 0.0017
Schistosoma mansoni hypothetical protein 0.0032 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1619 0.2733
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0032 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1619 0.2733
Loa Loa (eye worm) cuticular endochitinase 0.0073 0.053 0.053
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Loa Loa (eye worm) neuropeptide F receptor 0.0032 0.0014 0.0014
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0014 0.0014
Brugia malayi larval opioid receptor 0.0032 0.0014 0.0014
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.0014 0.0017
Schistosoma mansoni hypothetical protein 0.0037 0.0073 0.0073
Loa Loa (eye worm) endoprotease bli-4 0.0824 1 1
Echinococcus granulosus Furin 1 0.0194 0.2063 0.2063
Brugia malayi putative neuropeptide receptor 0.0032 0.0014 0.0014
Schistosoma mansoni alpha-1 adrenergic receptor 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0032 0.0014 0.0014
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0063 0.041 0.041
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0053 0.009
Schistosoma mansoni adenoreceptor 0.0032 0.0014 0.0014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0063 0.041 0.041
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0053 0.009
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0032 0.0014 0.0017
Brugia malayi follicle stimulating hormone receptor 0.0032 0.0014 0.0014
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0037 0.0073 0.0458
Echinococcus granulosus 7tm_1 domain containing protein 0.0032 0.0014 0.0014
Echinococcus multilocularis c4b binding protein beta chain 0.0063 0.041 0.0513
Brugia malayi Cyclin, N-terminal domain containing protein 0.005 0.0234 0.0234
Mycobacterium ulcerans chitinase/cellulase 0.0062 0.0394 1
Schistosoma mansoni amine GPCR 0.0032 0.0014 0.0014
Echinococcus multilocularis neuropeptide receptor 0.0032 0.0014 0.0017
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0032 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Onchocerca volvulus 0.0037 0.0073 0.0192
Echinococcus multilocularis sex peptide receptor 0.0032 0.0014 0.0017
Loa Loa (eye worm) chitinase I 0.0073 0.053 0.053
Echinococcus multilocularis G protein coupled receptor 139 0.0032 0.0014 0.0017
Plasmodium falciparum subtilisin-like protease 1 0.0035 0.0053 0.1082
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.0014 0.0014
Echinococcus multilocularis G protein coupled receptor kinase 1 0.009 0.0747 0.0935
Echinococcus granulosus beta-adrenergic receptor kinase 0.0101 0.0878 0.0878
Brugia malayi von Willebrand factor type A domain containing protein 0.0037 0.0073 0.0073
Brugia malayi Sushi domain 0.0063 0.041 0.041
Schistosoma mansoni hypothetical protein 0.0279 0.3133 0.3133
Brugia malayi hypothetical protein 0.0063 0.041 0.041
Mycobacterium leprae Possible secreted protease 0.0035 0.0053 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1619 0.2733
Onchocerca volvulus 0.0063 0.041 0.127
Brugia malayi Melatonin receptor type 1A 0.0032 0.0014 0.0014
Schistosoma mansoni furin-1 (S08 family) 0.0358 0.4129 0.4129
Schistosoma mansoni growth hormone secretagogue receptor 0.0032 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0032 0.0014 0.0014
Trichomonas vaginalis cyclins, putative 0.005 0.0234 0.0395
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0035 0.0053 0.0053
Brugia malayi hypothetical protein 0.0063 0.041 0.041
Echinococcus granulosus serotonin receptor 0.0032 0.0014 0.0014
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0014 0.0014
Echinococcus granulosus neuroendocrine convertase 2 0.0518 0.6139 0.6139
Echinococcus multilocularis dro:myosuppressin receptor 0.0032 0.0014 0.0017
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0014 0.0017
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0014 0.0017
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0037 0.0073 0.0124
Loa Loa (eye worm) hypothetical protein 0.0035 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0037 0.0073 0.0073
Brugia malayi hypothetical protein 0.0032 0.0014 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0053 0.009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0501 0.5924 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0032 0.0014 0.0014
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0032 0.0014 0.0014
Brugia malayi putative neuropeptide receptor NPR1 0.0032 0.0014 0.0014
Entamoeba histolytica chitinase, putative 0.0073 0.053 1
Echinococcus multilocularis membrane bound transcription factor site 1 0.0035 0.0053 0.0067
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Brugia malayi G protein-coupled receptor 0.0032 0.0014 0.0014
Echinococcus multilocularis neuropeptide s receptor 0.0032 0.0014 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1619 0.2733
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0824 1 1
Plasmodium falciparum SET domain protein, putative 0.007 0.0493 1
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0037 0.0073 0.0092
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.0014 0.0014
Echinococcus granulosus g protein coupled receptor 0.0032 0.0014 0.0014
Brugia malayi von Willebrand factor type A domain containing protein 0.0037 0.0073 0.0073
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0032 0.0014 0.0014
Echinococcus multilocularis serotonin receptor 0.0032 0.0014 0.0017
Leishmania major chitinase 0.0073 0.053 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0032 0.0014 0.0014
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0037 0.0073 0.0073
Toxoplasma gondii microneme protein MIC2 0.0037 0.0073 0.0458
Plasmodium falciparum subtilisin-like protease 2 0.0035 0.0053 0.1082
Trichomonas vaginalis cyclin B, putative 0.005 0.0234 0.0395
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0053 0.009
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0035 0.0053 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0014 0.0014
Loa Loa (eye worm) neuropeptide F receptor 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.005 0.0234 0.0234
Schistosoma mansoni c4b-binding protein beta chain 0.0063 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.0037 0.0073 0.0073
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.0014 0.0014
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0037 0.0073 0.1491
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0014 0.0017
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0035 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1619 0.2733
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0194 0.2063 0.3483
Trichomonas vaginalis cyclins, putative 0.005 0.0234 0.0395
Trichomonas vaginalis hypothetical protein 0.0159 0.1619 0.2733
Trypanosoma cruzi cyclin, putative 0.005 0.0234 1
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0035 0.0053 0.0053
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0878 0.0878
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Echinococcus granulosus g protein coupled receptor 0.0032 0.0014 0.0014
Plasmodium vivax SET domain protein, putative 0.007 0.0493 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0194 0.2063 0.3483
Brugia malayi Dopamine receptor protein 2 0.0032 0.0014 0.0014
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0035 0.0053 0.0053
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0194 0.2063 0.3483
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Echinococcus multilocularis allatostatin A receptor 0.0032 0.0014 0.0017
Brugia malayi Endochitinase 0.0073 0.053 0.053
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Leishmania major cyclin 0.005 0.0234 0.3797
Trichomonas vaginalis cyclins, putative 0.005 0.0234 0.0395
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.0014 0.0014
Toxoplasma gondii rhoptry neck protein RON1 0.0063 0.041 0.8117
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0053 0.009
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0037 0.0073 0.1491
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0037 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0323 0.3685 0.3685
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0037 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0037 0.0073 0.0073
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.0014 0.0017
Schistosoma mansoni site-1 peptidase (S08 family) 0.0035 0.0053 0.0053
Echinococcus multilocularis fmrfamide receptor 0.0032 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Echinococcus granulosus neuropeptide Y receptor 0.0032 0.0014 0.0014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0014 0.0017
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0014 0.0014
Giardia lamblia Furin precursor putative serine protease 0.0159 0.1619 0.4666
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0053 0.009
Echinococcus granulosus neuropeptides capa receptor 0.0032 0.0014 0.0014
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0032 0.0014 0.0014
Brugia malayi endochitinase 0.0073 0.053 0.053
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Brugia malayi hypothetical protein 0.0063 0.041 0.041
Trichomonas vaginalis WD repeat domain, putative 0.0279 0.3133 0.5289
Onchocerca volvulus Putative endochitinase 0.0073 0.053 0.1655
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0037 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0063 0.041 0.041
Brugia malayi hypothetical protein 0.0032 0.0014 0.0014
Onchocerca volvulus 0.0063 0.041 0.127
Echinococcus granulosus protein will die slowly 0.0279 0.3133 0.3133
Brugia malayi hypothetical protein 0.0037 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0194 0.2063 0.2063
Onchocerca volvulus 0.0037 0.0073 0.0192
Echinococcus granulosus cyclin B 0.005 0.0234 0.0234
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0194 0.2063 0.3483
Echinococcus granulosus neuropeptide receptor 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Echinococcus granulosus tachykinin peptides receptor 99D 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Echinococcus granulosus G protein coupled receptor kinase 1 0.009 0.0747 0.0747
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0014 0.0017
Plasmodium falciparum apical sushi protein 0.0063 0.041 0.8321
Brugia malayi hypothetical protein 0.0032 0.0014 0.0014
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0032 0.0014 0.0014
Echinococcus granulosus collagen alpha 1VII chain 0.0037 0.0073 0.0073
Brugia malayi hypothetical protein 0.0032 0.0014 0.0014
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.0014 0.0014
Trichomonas vaginalis cyclin B, putative 0.005 0.0234 0.0395
Echinococcus granulosus neuropeptide s receptor 0.0032 0.0014 0.0014
Trypanosoma cruzi cyclin 6, putative 0.005 0.0234 1
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.0014 0.0017
Brugia malayi hypothetical protein 0.0032 0.0014 0.0014
Echinococcus multilocularis neuroendocrine convertase 2 0.0518 0.6139 0.7683
Schistosoma mansoni amine GPCR 0.0032 0.0014 0.0014
Brugia malayi hypothetical protein 0.0032 0.0014 0.0014
Echinococcus multilocularis somatostatin receptor 0.0032 0.0014 0.0017
Brugia malayi celfurPC protein 0.0664 0.799 0.799
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0053 0.009
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Echinococcus granulosus sex peptide receptor 0.0032 0.0014 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0053 0.009
Loa Loa (eye worm) hypothetical protein 0.0824 1 1
Schistosoma mansoni biogenic amine receptor 0.0032 0.0014 0.0014
Brugia malayi von Willebrand factor type A domain containing protein 0.0037 0.0073 0.0073
Brugia malayi hypothetical protein 0.0063 0.041 0.041
Brugia malayi RE15519p 0.0032 0.0014 0.0014
Echinococcus granulosus peptide allatostatin:somatostatin 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0052 0.027 0.027
Treponema pallidum 76K protein 0.0037 0.0073 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0032 0.0014 0.0014
Brugia malayi hypothetical protein 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0037 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0037 0.0073 0.0073
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0032 0.0014 0.0014
Entamoeba histolytica hypothetical protein 0.0037 0.0073 0.1386
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Echinococcus granulosus G protein coupled receptor 139 0.0032 0.0014 0.0014
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0032 0.0014 0.0017
Echinococcus granulosus orexin receptor type 2 0.0032 0.0014 0.0014
Echinococcus multilocularis Furin 1 0.0194 0.2063 0.2582
Loa Loa (eye worm) hypothetical protein 0.0037 0.0073 0.0073
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Echinococcus granulosus hypothetical protein 0.0032 0.0014 0.0014
Echinococcus multilocularis orexin receptor type 2 0.0032 0.0014 0.0017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0014 0.0014
Echinococcus multilocularis serotonin receptor 0.0032 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.005 0.0234 0.0234
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0101 0.0878 0.0878
Echinococcus granulosus biogenic amine 5HT receptor 0.0032 0.0014 0.0014
Brugia malayi endochitinase 0.0073 0.053 0.053
Onchocerca volvulus 0.0063 0.041 0.127
Echinococcus multilocularis neuropeptide receptor A26 0.0032 0.0014 0.0017
Echinococcus granulosus neuropeptide receptor 0.0032 0.0014 0.0014
Plasmodium falciparum thrombospondin-related anonymous protein 0.0037 0.0073 0.1491
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0053 0.009
Echinococcus multilocularis cyclin B 0.005 0.0234 0.0293
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0501 0.5924 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0032 0.0014 0.0014
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0014 0.0014
Echinococcus granulosus biogenic amine 5HT receptor 0.0032 0.0014 0.0014
Loa Loa (eye worm) proprotein convertase 2 0.0194 0.2063 0.2063
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0053 0.009
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0037 0.0073 0.0073
Onchocerca volvulus 0.0037 0.0073 0.0192
Brugia malayi von Willebrand factor type A domain containing protein 0.0037 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Echinococcus multilocularis 0.0664 0.799 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0032 0.0014 0.0014
Echinococcus granulosus somatostatin receptor 0.0032 0.0014 0.0014
Echinococcus granulosus c4b binding protein beta chain 0.0063 0.041 0.041
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0037 0.0073 0.0092
Brugia malayi neuropeptide F receptor 0.0032 0.0014 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0053 0.009
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0014 0.0014
Mycobacterium tuberculosis Possible chitinase 0.0062 0.0394 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0053 0.009
Onchocerca volvulus 0.0035 0.0053 0.0127
Brugia malayi G protein-coupled receptor F59B2.13 0.0032 0.0014 0.0014
Onchocerca volvulus 0.0063 0.041 0.127
Brugia malayi Dopamine receptor 0.0032 0.0014 0.0014
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0032 0.0014 0.0014
Trypanosoma brucei mitotic cyclin 6 0.005 0.0234 1
Echinococcus granulosus membrane bound transcription factor site 1 0.0035 0.0053 0.0053
Echinococcus multilocularis g-protein coupled receptor 0.0032 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0037 0.0073 0.0073
Echinococcus granulosus neuropeptides capa receptor 0.0032 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0053 0.009
Brugia malayi von Willebrand factor type A domain containing protein 0.0037 0.0073 0.0073
Brugia malayi hypothetical protein 0.0063 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Loa Loa (eye worm) CUTiclin family member 0.0037 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0063 0.041 0.041
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0014 0.0014
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0037 0.0073 0.0073
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0053 0.009
Brugia malayi sulfakinin receptor protein 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Schistosoma mansoni neuropeptide receptor 0.0032 0.0014 0.0014
Loa Loa (eye worm) melatonin receptor type 1A 0.0032 0.0014 0.0014
Entamoeba histolytica hypothetical protein, conserved 0.0037 0.0073 0.1386
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0037 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0037 0.0073 0.0073
Brugia malayi Tachykinin-like peptides receptor 99D 0.0032 0.0014 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0053 0.009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0014 0.0017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0053 0.009
Brugia malayi GnHR receptor homolog 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0062 0.0394 0.0394
Schistosoma mansoni opsin-like receptor 0.0032 0.0014 0.0014
Schistosoma mansoni opsin-like receptor 0.0032 0.0014 0.0014
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0032 0.0014 0.0017
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0037 0.0073 0.0073
Echinococcus multilocularis G-protein coupled receptor, putative 0.0032 0.0014 0.0017
Plasmodium vivax apical sushi protein, putative 0.0063 0.041 0.8117
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1619 0.2733
Schistosoma mansoni myosin xvIII 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0063 0.041 0.041
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0053 0.009
Brugia malayi Dopamine receptor protein 1 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0063 0.041 0.041
Trichomonas vaginalis cyclins, putative 0.005 0.0234 0.0395
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0035 0.0053 0.009
Echinococcus granulosus neuropeptide FF receptor 2 0.0032 0.0014 0.0014
Onchocerca volvulus 0.0037 0.0073 0.0192
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0032 0.0014 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0053 0.009
Loa Loa (eye worm) microfilarial chitinase 0.0062 0.0394 0.0394
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0878 0.0878
Brugia malayi hypothetical protein 0.0032 0.0014 0.0014
Toxoplasma gondii histone lysine methyltransferase SET8 0.007 0.0493 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0032 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.007 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0014
Brugia malayi Serotonin receptor 0.0032 0.0014 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0014 0.0014
Brugia malayi neuropeptide F receptor 0.0032 0.0014 0.0014
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.027 0.027
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0032 0.0014 0.0017
Echinococcus multilocularis beta adrenergic receptor kinase 0.0101 0.0878 0.1099
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0501 0.5924 0.5924
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1619 0.2733
Brugia malayi Will die slowly protein 0.0279 0.3133 0.3133
Brugia malayi Cyclin, N-terminal domain containing protein 0.005 0.0234 0.0234
Echinococcus granulosus C type lectin domian containing protein 0.0063 0.041 0.041
Brugia malayi Protein set-1 0.007 0.0493 0.0493
Brugia malayi hypothetical protein 0.0063 0.041 0.041
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.1619 0.2733
Brugia malayi GCC2 and GCC3 family protein 0.0063 0.041 0.041
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0035 0.0053 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.0032 0.0014 0.0014

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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