Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0088 | 0.0733 | 0.3356 |
Plasmodium vivax | glutathione reductase, putative | 0.0205 | 0.2171 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0048 | 0.0229 | 0.3066 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0634 | 0.0761 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0088 | 0.0733 | 0.0733 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0467 | 0.5415 | 0.8837 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0071 | 0.0517 | 0.2359 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.008 | 0.0634 | 0.0761 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0088 | 0.0733 | 0.0881 |
Echinococcus granulosus | tar DNA binding protein | 0.0589 | 0.6921 | 0.8386 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0052 | 0.0287 | 0.3855 |
Brugia malayi | glutathione reductase | 0.0205 | 0.2171 | 0.2171 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0467 | 0.5415 | 0.8837 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0088 | 0.0733 | 1 |
Loa Loa (eye worm) | nuclear factor I | 0.0032 | 0.003 | 0.003 |
Brugia malayi | MH1 domain containing protein | 0.0057 | 0.0346 | 0.0346 |
Echinococcus multilocularis | lamin | 0.0054 | 0.0312 | 0.0371 |
Brugia malayi | Smad1 | 0.0057 | 0.0346 | 0.0346 |
Loa Loa (eye worm) | RNA binding protein | 0.0589 | 0.6921 | 0.6921 |
Brugia malayi | Latrophilin receptor protein 2 | 0.008 | 0.0634 | 0.0634 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0066 | 0.0453 | 0.6145 |
Plasmodium falciparum | glutathione reductase | 0.0205 | 0.2171 | 1 |
Schistosoma mansoni | Smad4 | 0.0057 | 0.0346 | 0.0412 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0057 | 0.0346 | 0.0412 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0312 | 0.0312 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0071 | 0.0517 | 0.2359 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0084 | 0.0094 |
Echinococcus granulosus | lamin dm0 | 0.0054 | 0.0312 | 0.0371 |
Brugia malayi | Thioredoxin reductase | 0.0205 | 0.2171 | 0.2171 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0071 | 0.0517 | 0.2359 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0174 | 0.1788 | 0.1788 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0205 | 0.2171 | 0.2985 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0697 | 0.8251 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0054 | 0.0312 | 0.0312 |
Onchocerca volvulus | 0.0099 | 0.0857 | 1 | |
Trypanosoma brucei | trypanothione reductase | 0.0205 | 0.2171 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0099 | 0.0857 | 0.1032 |
Schistosoma mansoni | tar DNA-binding protein | 0.0589 | 0.6921 | 0.8386 |
Brugia malayi | TAR-binding protein | 0.0589 | 0.6921 | 0.6921 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.007 | 0.0509 | 0.6922 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0071 | 0.0517 | 0.2359 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.007 | 0.0509 | 0.6922 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0088 | 0.0733 | 0.3356 |
Brugia malayi | MH2 domain containing protein | 0.0057 | 0.0346 | 0.0346 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0589 | 0.6921 | 0.6921 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.008 | 0.0634 | 0.0634 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0254 | 0.2782 | 0.2782 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0088 | 0.0733 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0589 | 0.6921 | 0.6921 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0697 | 0.8251 | 1 |
Echinococcus granulosus | smad | 0.0057 | 0.0346 | 0.0412 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.008 | 0.0634 | 0.0634 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0467 | 0.5415 | 0.8837 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0057 | 0.0346 | 0.0412 |
Schistosoma mansoni | smad | 0.0057 | 0.0346 | 0.0412 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0088 | 0.0733 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0071 | 0.0517 | 0.0619 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0519 | 0.6059 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.007 | 0.0509 | 0.6922 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.007 | 0.0509 | 0.6922 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0519 | 0.6059 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0205 | 0.2171 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0467 | 0.5415 | 0.8837 |
Echinococcus multilocularis | Smad4 | 0.0057 | 0.0346 | 0.0412 |
Schistosoma mansoni | lamin | 0.0054 | 0.0312 | 0.0371 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0519 | 0.6059 | 1 |
Schistosoma mansoni | lamin | 0.0054 | 0.0312 | 0.0371 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0088 | 0.0733 | 0.3356 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0071 | 0.0517 | 0.5 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0057 | 0.0346 | 0.0412 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0048 | 0.023 | 0.3078 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.008 | 0.0634 | 0.0761 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0066 | 0.0453 | 0.6145 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.007 | 0.0509 | 0.6922 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0052 | 0.0287 | 0.3855 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0071 | 0.0517 | 0.0374 |
Schistosoma mansoni | tar DNA-binding protein | 0.0589 | 0.6921 | 0.8386 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.003 | 0.003 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0071 | 0.0517 | 0.2359 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0071 | 0.0517 | 0.0374 |
Echinococcus multilocularis | GPCR, family 2 | 0.008 | 0.0634 | 0.0761 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0084 | 0.0094 |
Brugia malayi | MH1 domain containing protein | 0.0032 | 0.003 | 0.003 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0697 | 0.8251 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0673 | 0.7958 | 0.9645 |
Echinococcus granulosus | tumor protein p63 | 0.0673 | 0.7958 | 0.9645 |
Schistosoma mansoni | tar DNA-binding protein | 0.0589 | 0.6921 | 0.8386 |
Echinococcus multilocularis | lamin dm0 | 0.0054 | 0.0312 | 0.0371 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0634 | 0.0761 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.03 | 0.03 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0071 | 0.0517 | 0.2359 |
Brugia malayi | RNA binding protein | 0.0589 | 0.6921 | 0.6921 |
Giardia lamblia | GTOR | 0.0088 | 0.0733 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0048 | 0.0229 | 0.3066 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0057 | 0.035 | 0.4722 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0071 | 0.0517 | 0.2359 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0088 | 0.0733 | 0.3356 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0634 | 0.0761 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.003 | 0.0007 | 0.0007 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0071 | 0.0517 | 0.2359 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.007 | 0.051 | 0.2327 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0467 | 0.5415 | 0.8837 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0088 | 0.0733 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0206 | 0.219 | 0.2648 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.1788 | 0.216 |
Schistosoma mansoni | smad1 5 8 and | 0.0057 | 0.0346 | 0.0412 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0071 | 0.0517 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0059 | 0.0373 | 0.5047 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0066 | 0.0453 | 0.6145 |
Treponema pallidum | NADH oxidase | 0.0071 | 0.0517 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0084 | 0.0094 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0088 | 0.0733 | 1 |
Echinococcus multilocularis | smad | 0.0057 | 0.0346 | 0.0412 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0084 | 0.0084 |
Schistosoma mansoni | tar DNA-binding protein | 0.0589 | 0.6921 | 0.8386 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0254 | 0.2782 | 0.2782 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0057 | 0.0346 | 0.0346 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0084 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 0.2782 | 0.2782 |
Brugia malayi | MH1 domain containing protein | 0.0057 | 0.0346 | 0.0346 |
Echinococcus granulosus | intermediate filament protein | 0.0054 | 0.0312 | 0.0371 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.1788 | 0.1788 |
Brugia malayi | MH2 domain containing protein | 0.0057 | 0.0346 | 0.0346 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0519 | 0.6059 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0054 | 0.0312 | 0.0371 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.007 | 0.051 | 0.2327 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0071 | 0.0517 | 0.5 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0088 | 0.0733 | 0.3356 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.008 | 0.0634 | 0.0761 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0048 | 0.023 | 0.3078 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0071 | 0.0517 | 0.7029 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0838 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0048 | 0.023 | 0.3078 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0205 | 0.2171 | 0.2171 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0088 | 0.0733 | 0.0733 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0071 | 0.0517 | 0.5 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.007 | 0.051 | 0.2327 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0053 | 0.0293 | 0.3945 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0052 | 0.0284 | 0.0284 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0048 | 0.0229 | 0.3066 |
Mycobacterium tuberculosis | Probable reductase | 0.0467 | 0.5415 | 0.8837 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0634 | 0.0634 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0066 | 0.0453 | 0.6145 |
Echinococcus granulosus | GPCR family 2 | 0.008 | 0.0634 | 0.0761 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0053 | 0.0293 | 0.3945 |
Loa Loa (eye worm) | glutathione reductase | 0.0205 | 0.2171 | 0.2171 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0071 | 0.0517 | 0.2359 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0205 | 0.2171 | 1 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0071 | 0.0517 | 0.2359 |
Loa Loa (eye worm) | intermediate filament protein | 0.0054 | 0.0312 | 0.0312 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0088 | 0.0733 | 0.0881 |
Schistosoma mansoni | tar DNA-binding protein | 0.0589 | 0.6921 | 0.8386 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0052 | 0.0284 | 0.0284 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0088 | 0.0733 | 0.0881 |
Echinococcus multilocularis | tar DNA binding protein | 0.0589 | 0.6921 | 0.8386 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0066 | 0.0453 | 0.6145 |
Leishmania major | trypanothione reductase | 0.0205 | 0.2171 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0206 | 0.219 | 0.2648 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0057 | 0.0346 | 0.0412 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.008 | 0.0634 | 0.0761 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0066 | 0.0453 | 0.6145 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.0037 | 0.0094 | 0.0404 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0634 | 0.0761 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0838 | 1 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0057 | 0.0346 | 0.0412 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0071 | 0.0517 | 0.2359 |
Echinococcus granulosus | Smad4 | 0.0057 | 0.0346 | 0.0412 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0071 | 0.0517 | 0.2359 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0071 | 0.0517 | 0.2359 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0071 | 0.0517 | 0.0619 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0071 | 0.0517 | 0.5 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0071 | 0.0517 | 0.2359 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0071 | 0.0517 | 0.2359 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0053 | 0.0293 | 0.3945 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0071 | 0.0517 | 0.0517 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0205 | 0.2171 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0057 | 0.0346 | 0.0412 |
Brugia malayi | intermediate filament protein | 0.0054 | 0.0312 | 0.0312 |
Brugia malayi | MH1 domain containing protein | 0.0032 | 0.003 | 0.003 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0048 | 0.023 | 0.3078 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0042 | 0.0157 | 0.0695 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0054 | 0.0312 | 0.0312 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0088 | 0.0733 | 0.3356 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0066 | 0.0453 | 0.6145 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0071 | 0.0517 | 0.2359 |
Echinococcus granulosus | lamin | 0.0054 | 0.0312 | 0.0371 |
Loa Loa (eye worm) | TAR-binding protein | 0.0589 | 0.6921 | 0.6921 |
Loa Loa (eye worm) | Smad1 | 0.0057 | 0.0346 | 0.0346 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0071 | 0.0517 | 0.5 |
Echinococcus multilocularis | musashi | 0.0054 | 0.0312 | 0.0371 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0254 | 0.2782 | 0.2782 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0071 | 0.0517 | 0.0619 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0071 | 0.0517 | 0.2359 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0057 | 0.0346 | 0.0412 |
Plasmodium falciparum | thioredoxin reductase | 0.0205 | 0.2171 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0857 | 0.0857 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0057 | 0.0346 | 0.0346 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.003 | 0.0007 | 0.0007 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0071 | 0.0517 | 0.7029 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0076 | 0.0573 | 0.78 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.