Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0103 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0015 | 0 | 0.5 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | eyes absent homolog | 0.0089 | 0.8428 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.8428 | 0.8428 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.8428 | 0.8428 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.6283 | 0.7455 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.6283 | 0.6283 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.197 | 0.2337 |
Brugia malayi | TAR-binding protein | 0.007 | 0.6201 | 0.6201 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0015 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0089 | 0.8428 | 0.8428 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.6201 | 0.7358 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.197 | 0.3176 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.6283 | 0.6283 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 1 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.197 | 0.3176 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.6201 | 0.7358 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.6201 | 0.6201 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.197 | 0.197 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.6201 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.197 | 0.3176 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0015 | 0 | 0.5 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0015 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.6201 | 0.6201 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.197 | 0.197 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.197 | 0.2337 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.6201 | 0.7358 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0103 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.197 | 0.2337 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.6201 | 0.6201 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.197 | 0.3176 |
Brugia malayi | RNA binding protein | 0.007 | 0.6201 | 0.6201 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.6201 | 0.7358 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.197 | 0.2337 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.6201 | 0.7358 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.6201 | 0.6201 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.197 | 0.3176 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.197 | 0.3176 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.197 | 0.197 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.197 | 0.197 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.6201 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0015 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 22 ug ml-1 | Cytotoxicity against human KB cells | ChEMBL. | 469554 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.