Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0032 | 0.0202 | 0.0202 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.004 | 0.0295 | 0.0295 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0032 | 0.0202 | 0.0348 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0032 | 0.0202 | 0.0348 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0044 | 0.034 | 0.0761 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0041 | 0.0302 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.016 | 0.1717 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0504 | 0.5799 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0513 | 0.0884 |
Schistosoma mansoni | coup transcription factor | 0.0032 | 0.0202 | 0.0202 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.015 | 0.1591 | 0.1591 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0041 | 0.0302 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0055 | 0.0468 | 1 |
Brugia malayi | hypothetical protein | 0.0017 | 0.002 | 0.0035 |
Echinococcus granulosus | cpg binding protein | 0.0064 | 0.0573 | 0.0573 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0041 | 0.0302 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0055 | 0.0468 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0032 | 0.0202 | 0.0202 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0025 | 0.0109 | 0.0109 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0198 | 0.0342 |
Schistosoma mansoni | chromobox protein | 0.0073 | 0.0685 | 0.0685 |
Schistosoma mansoni | survival motor neuron protein | 0.0054 | 0.0455 | 0.0455 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0202 | 0.0348 |
Brugia malayi | Smad1 | 0.0034 | 0.0225 | 0.0388 |
Brugia malayi | nuclear hormone receptor | 0.0032 | 0.0202 | 0.0348 |
Schistosoma mansoni | alpha-glucosidase | 0.0156 | 0.1671 | 0.1671 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0032 | 0.0202 | 0.0202 |
Loa Loa (eye worm) | hypothetical protein | 0.0296 | 0.3322 | 0.5729 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0.0046 | 0.0182 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0032 | 0.0202 | 0.0202 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0296 | 0.3322 | 0.5729 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0032 | 0.0202 | 0.0017 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0303 | 0.4139 |
Echinococcus multilocularis | GPCR, family 2 | 0.0097 | 0.0968 | 0.0968 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0032 | 0.0202 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.002 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0302 | 0.0521 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.0613 | 0.1058 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0613 | 0.0613 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0202 | 0.0348 |
Echinococcus multilocularis | chromobox protein 1 | 0.0073 | 0.0685 | 0.0685 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.006 | 0.0532 | 0.0918 |
Echinococcus granulosus | chromobox protein 1 | 0.0073 | 0.0685 | 0.0685 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0032 | 0.0202 | 0.0202 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0032 | 0.0202 | 0.0348 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0202 | 0.0348 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0097 | 0.0968 | 0.1669 |
Onchocerca volvulus | Huntingtin homolog | 0.0137 | 0.1437 | 0.6637 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.0613 | 0.1058 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0302 | 0.4762 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.014 | 0.0242 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0302 | 0.4762 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0059 | 0.0513 | 0.0884 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.016 | 0.1717 | 0.1717 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.004 | 0.0295 | 0.4013 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0859 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0041 | 0.0302 | 0.0411 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0041 | 0.0302 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0097 | 0.0968 | 0.0968 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0031 | 0.019 | 0.0327 |
Echinococcus granulosus | GPCR family 2 | 0.0097 | 0.0968 | 0.0968 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0032 | 0.0202 | 0.0348 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.0613 | 0.1058 |
Schistosoma mansoni | hypothetical protein | 0.016 | 0.1717 | 0.1717 |
Echinococcus granulosus | FTZ F1 alpha | 0.0032 | 0.0202 | 0.0202 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0026 | 0.0121 | 0.1337 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0019 | 0.0046 | 0.0182 |
Entamoeba histolytica | hypothetical protein | 0.016 | 0.1717 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.002 | 0.0035 |
Echinococcus granulosus | intermediate filament protein | 0.0059 | 0.0513 | 0.0513 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0017 | 0.002 | 0.002 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0032 | 0.0202 | 0.0202 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0032 | 0.0202 | 0.0202 |
Leishmania major | hypothetical protein, conserved | 0.0055 | 0.0468 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0303 | 0.4139 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0202 | 0.0348 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0032 | 0.0202 | 0.0348 |
Brugia malayi | steroid hormone receptor | 0.0032 | 0.0202 | 0.0348 |
Leishmania major | DNA polymerase kappa, putative | 0.0041 | 0.0302 | 0.0411 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0182 | 0.1971 | 0.1971 |
Brugia malayi | hypothetical protein | 0.0055 | 0.0468 | 0.0807 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.014 | 0.0242 |
Loa Loa (eye worm) | intermediate filament protein | 0.0059 | 0.0513 | 0.0884 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0041 | 0.0302 | 0.0521 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0025 | 0.0109 | 0.0109 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0034 | 0.0225 | 0.0225 |
Schistosoma mansoni | hypothetical protein | 0.0097 | 0.0968 | 0.0968 |
Echinococcus multilocularis | cpg binding protein | 0.0064 | 0.0573 | 0.0573 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0264 | 0.2943 | 0.2943 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0055 | 0.0468 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0041 | 0.0302 | 0.4762 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0109 | 0.0109 |
Loa Loa (eye worm) | nuclear factor I | 0.0019 | 0.0043 | 0.0074 |
Echinococcus granulosus | geminin | 0.0357 | 0.4056 | 0.4056 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0504 | 0.5799 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0032 | 0.0202 | 0.0348 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0041 | 0.0302 | 0.0302 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0017 | 0.002 | 0.0035 |
Leishmania major | DNA polymerase eta, putative | 0.0041 | 0.0302 | 0.0411 |
Brugia malayi | Heterochromatin protein 1 | 0.0073 | 0.0685 | 0.118 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0032 | 0.0202 | 0.0202 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0097 | 0.0968 | 0.1669 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0032 | 0.0202 | 0.0202 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0097 | 0.0968 | 0.0968 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0613 | 0.0613 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0045 | 0.0348 | 0.4822 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0202 | 0.0348 |
Onchocerca volvulus | 0.0032 | 0.0202 | 0.0017 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0302 | 0.4762 |
Schistosoma mansoni | hypothetical protein | 0.0357 | 0.4056 | 0.4056 |
Brugia malayi | MH2 domain containing protein | 0.0034 | 0.0225 | 0.0388 |
Brugia malayi | hypothetical protein | 0.0017 | 0.002 | 0.0035 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0032 | 0.0202 | 0.0348 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0026 | 0.0121 | 0.1337 |
Brugia malayi | MH1 domain containing protein | 0.0019 | 0.0043 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.2943 | 0.5076 |
Brugia malayi | hypothetical protein | 0.016 | 0.1716 | 0.2959 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0032 | 0.0202 | 0.0202 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0118 | 0.1216 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0034 | 0.0225 | 0.0388 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0302 | 0.4762 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0055 | 0.0468 | 0.1875 |
Schistosoma mansoni | hypothetical protein | 0.021 | 0.2303 | 0.2303 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0182 | 0.1971 | 0.3399 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0097 | 0.0968 | 0.1669 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0041 | 0.0302 | 0.0302 |
Trichomonas vaginalis | chromobox protein, putative | 0.0044 | 0.034 | 0.4707 |
Schistosoma mansoni | thyroid hormone receptor | 0.0032 | 0.0202 | 0.0202 |
Schistosoma mansoni | cpg binding protein | 0.0064 | 0.0573 | 0.0573 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0018 | 0.0036 | 0.0062 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0769 | 0.894 | 0.894 |
Onchocerca volvulus | 0.016 | 0.1716 | 0.8133 | |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0019 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.015 | 0.1591 | 0.2743 |
Onchocerca volvulus | 0.0059 | 0.0513 | 0.1684 | |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0034 | 0.0225 | 0.0225 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0026 | 0.0121 | 0.1337 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0307 | 0.3454 | 0.5956 |
Schistosoma mansoni | intermediate filament proteins | 0.0059 | 0.0513 | 0.0513 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0128 | 0.1334 | 0.1334 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0307 | 0.3454 | 0.5956 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0032 | 0.0202 | 0.0348 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0032 | 0.0202 | 0.0348 |
Schistosoma mansoni | hypothetical protein | 0.0357 | 0.4056 | 0.4056 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0189 | 0.2064 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0073 | 0.0685 | 0.0685 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0769 | 0.894 | 0.894 |
Echinococcus multilocularis | geminin | 0.0357 | 0.4056 | 0.4056 |
Schistosoma mansoni | smad1 5 8 and | 0.0034 | 0.0225 | 0.0225 |
Trichomonas vaginalis | chromobox protein, putative | 0.0073 | 0.0685 | 1 |
Echinococcus multilocularis | musashi | 0.0059 | 0.0513 | 0.0513 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0182 | 0.1971 | 0.1971 |
Schistosoma mansoni | hypothetical protein | 0.0097 | 0.0968 | 0.0968 |
Schistosoma mansoni | chromobox protein | 0.0073 | 0.0685 | 0.0685 |
Loa Loa (eye worm) | acetyltransferase | 0.0152 | 0.1621 | 0.2796 |
Brugia malayi | MH2 domain containing protein | 0.0034 | 0.0225 | 0.0388 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0032 | 0.0202 | 0.0348 |
Schistosoma mansoni | nuclear hormone receptor | 0.0032 | 0.0202 | 0.0202 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0032 | 0.0202 | 0.0348 |
Brugia malayi | hypothetical protein | 0.0137 | 0.1437 | 0.2478 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0041 | 0.0302 | 0.005 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0026 | 0.0121 | 0.1337 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.016 | 0.1717 | 0.1717 |
Schistosoma mansoni | smad | 0.0034 | 0.0225 | 0.0225 |
Brugia malayi | chromobox protein homolog 3 | 0.0041 | 0.0303 | 0.0523 |
Brugia malayi | hypothetical protein | 0.016 | 0.1717 | 0.2962 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0041 | 0.0304 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0097 | 0.0968 | 0.0968 |
Loa Loa (eye worm) | hypothetical protein | 0.0307 | 0.3454 | 0.5956 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.004 | 0.0295 | 0.4013 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.004 | 0.0295 | 0.0509 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0032 | 0.0202 | 0.0202 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0032 | 0.0202 | 0.0348 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0017 | 0.002 | 0.002 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0031 | 0.019 | 0.0327 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0032 | 0.0202 | 0.0348 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.004 | 0.0295 | 0.0295 |
Echinococcus multilocularis | dna polymerase eta | 0.0041 | 0.0302 | 0.0302 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0032 | 0.0202 | 0.0202 |
Echinococcus multilocularis | dna polymerase kappa | 0.0041 | 0.0302 | 0.0302 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0302 | 0.4762 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.004 | 0.0295 | 0.4013 |
Echinococcus multilocularis | lamin | 0.0059 | 0.0513 | 0.0513 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0041 | 0.0302 | 0.4122 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.004 | 0.0295 | 0.4013 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.002 | 0.0035 |
Trichomonas vaginalis | chromobox protein, putative | 0.0073 | 0.0685 | 1 |
Schistosoma mansoni | cpg binding protein | 0.006 | 0.0532 | 0.0532 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0182 | 0.1971 | 0.3399 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0032 | 0.0202 | 0.0348 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.004 | 0.0295 | 0.4013 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0153 | 0.0264 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0032 | 0.0202 | 0.0348 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0032 | 0.0202 | 0.0348 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0613 | 0.0613 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0032 | 0.0202 | 0.0348 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0041 | 0.0304 | 0.0059 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.015 | 0.1591 | 0.1591 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0032 | 0.0202 | 0.0348 |
Onchocerca volvulus | Huntingtin homolog | 0.0137 | 0.1437 | 0.6637 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0302 | 0.4762 |
Onchocerca volvulus | 0.0105 | 0.1063 | 0.4633 | |
Schistosoma mansoni | hypothetical protein | 0.0859 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0097 | 0.0968 | 0.0968 |
Echinococcus granulosus | lamin | 0.0059 | 0.0513 | 0.0513 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0041 | 0.0302 | 0.0411 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0045 | 0.0348 | 0.0348 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 0.1716 | 0.2959 |
Echinococcus granulosus | Smad4 | 0.0034 | 0.0225 | 0.0225 |
Schistosoma mansoni | alpha-glucosidase | 0.0156 | 0.1671 | 0.1671 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0468 | 0.0807 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.004 | 0.0295 | 0.4013 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0054 | 0.0455 | 0.0784 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.0613 | 0.1058 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0302 | 0.4762 |
Loa Loa (eye worm) | Smad1 | 0.0034 | 0.0225 | 0.0388 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.0613 | 0.0613 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0032 | 0.0202 | 0.0348 |
Onchocerca volvulus | 0.006 | 0.0532 | 0.1789 | |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0026 | 0.0121 | 0.1337 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0041 | 0.0302 | 0.0302 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0017 | 0.002 | 0.0035 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0026 | 0.0121 | 0.1337 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0029 | 0.0161 | 0.1956 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.004 | 0.0295 | 0.0509 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0032 | 0.0202 | 0.0202 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.0303 | 0.0563 |
Echinococcus multilocularis | Smad4 | 0.0034 | 0.0225 | 0.0225 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.0613 | 0.1058 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0148 | 0.1571 | 0.1571 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.0613 | 0.0613 |
Loa Loa (eye worm) | histone methyltransferase | 0.0019 | 0.0038 | 0.0066 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0034 | 0.0225 | 0.0388 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0028 | 0.0153 | 0.0153 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0055 | 0.0468 | 1 |
Brugia malayi | N-terminal motif family protein | 0.0189 | 0.2064 | 0.356 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0202 | 0.0348 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0032 | 0.0202 | 0.0202 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.016 | 0.1717 | 0.1717 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0613 | 0.0613 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0032 | 0.0202 | 0.0348 |
Brugia malayi | MH1 domain containing protein | 0.0019 | 0.0043 | 0.0074 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0152 | 0.1621 | 0.2796 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.015 | 0.1591 | 0.1591 |
Brugia malayi | RNA binding protein | 0.0067 | 0.0613 | 0.1058 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.021 | 0.2303 | 0.3972 |
Echinococcus granulosus | dna polymerase kappa | 0.0041 | 0.0302 | 0.0302 |
Schistosoma mansoni | smad1 5 8 and | 0.0034 | 0.0225 | 0.0225 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0017 | 0.002 | 0.0035 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0034 | 0.0225 | 0.0388 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.004 | 0.0295 | 0.4013 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0032 | 0.0202 | 0.0348 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0307 | 0.3454 | 0.5956 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0041 | 0.0302 | 0.0411 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.015 | 0.1591 | 0.1591 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.05 | 0.0862 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0041 | 0.0302 | 0.0411 |
Echinococcus granulosus | chromobox protein 1 | 0.0073 | 0.0685 | 0.0685 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0055 | 0.0468 | 1 |
Schistosoma mansoni | lamin | 0.0059 | 0.0513 | 0.0513 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0152 | 0.1621 | 0.1621 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0032 | 0.0202 | 0.0202 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0041 | 0.0302 | 0.4762 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0034 | 0.0225 | 0.0225 |
Onchocerca volvulus | 0.0054 | 0.0455 | 0.1375 | |
Entamoeba histolytica | hypothetical protein | 0.016 | 0.1717 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0034 | 0.0225 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0043 | 0.0074 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0237 | 0.0409 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0032 | 0.0202 | 0.0348 |
Loa Loa (eye worm) | hypothetical protein | 0.021 | 0.2303 | 0.3972 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0032 | 0.0202 | 0.0348 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.0455 | 0.0455 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0032 | 0.0202 | 0.0202 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.002 | 0.0035 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0032 | 0.0202 | 0.0202 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.0613 | 0.0613 |
Schistosoma mansoni | DNA polymerase eta | 0.0041 | 0.0302 | 0.0302 |
Schistosoma mansoni | cpg binding protein | 0.0064 | 0.0573 | 0.0573 |
Schistosoma mansoni | lamin | 0.0059 | 0.0513 | 0.0513 |
Brugia malayi | MH2 domain containing protein | 0.0504 | 0.5799 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0769 | 0.894 | 0.894 |
Brugia malayi | nuclear receptor RXR | 0.0017 | 0.002 | 0.0035 |
Schistosoma mansoni | Smad4 | 0.0034 | 0.0225 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.002 | 0.0035 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0017 | 0.002 | 0.002 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0302 | 0.4762 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0041 | 0.0302 | 0.4122 |
Echinococcus multilocularis | smad | 0.0034 | 0.0225 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0202 | 0.0348 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0097 | 0.0968 | 0.0968 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0032 | 0.0202 | 0.0202 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0029 | 0.0161 | 0.1956 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.1437 | 0.2478 |
Brugia malayi | ecdysteroid receptor | 0.0032 | 0.0202 | 0.0348 |
Trypanosoma brucei | glucosidase, putative | 0.004 | 0.0295 | 0.4538 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0032 | 0.0202 | 0.0202 |
Brugia malayi | hypothetical protein | 0.0264 | 0.2943 | 0.5076 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0019 | 0.0038 | 0.0038 |
Brugia malayi | CXXC zinc finger family protein | 0.006 | 0.0532 | 0.0918 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.1437 | 0.2478 |
Trichomonas vaginalis | chromobox protein, putative | 0.0044 | 0.034 | 0.4707 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0032 | 0.0202 | 0.0017 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0055 | 0.0468 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0032 | 0.0202 | 0.0202 |
Echinococcus granulosus | dna polymerase eta | 0.0041 | 0.0302 | 0.0302 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0032 | 0.0202 | 0.0202 |
Echinococcus granulosus | lamin dm0 | 0.0059 | 0.0513 | 0.0513 |
Echinococcus multilocularis | lamin dm0 | 0.0059 | 0.0513 | 0.0513 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0041 | 0.0302 | 0.0302 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0026 | 0.0121 | 0.1337 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0302 | 0.4762 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0026 | 0.0121 | 0.1337 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.004 | 0.0295 | 0.4013 |
Brugia malayi | nuclear receptor NHR-88 | 0.0032 | 0.0202 | 0.0348 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.004 | 0.0295 | 0.4013 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0041 | 0.0302 | 0.0411 |
Schistosoma mansoni | alpha glucosidase | 0.004 | 0.0295 | 0.0295 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0032 | 0.0202 | 0.0202 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.015 | 0.1591 | 0.1591 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0032 | 0.0202 | 0.0202 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0032 | 0.0202 | 0.0202 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0032 | 0.0202 | 0.0202 |
Entamoeba histolytica | hypothetical protein | 0.016 | 0.1717 | 1 |
Trypanosoma brucei | unspecified product | 0.0041 | 0.0302 | 0.4762 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.015 | 0.1591 | 0.2743 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0028 | 0.0153 | 0.0153 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0032 | 0.0202 | 0.0202 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0045 | 0.0348 | 0.0572 |
Echinococcus granulosus | smad | 0.0034 | 0.0225 | 0.0225 |
Onchocerca volvulus | 0.0059 | 0.0513 | 0.1684 | |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0059 | 0.0513 | 0.0884 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0045 | 0.0348 | 0.4822 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.015 | 0.1591 | 0.1591 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0182 | 0.1971 | 0.1971 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0041 | 0.0302 | 0.4762 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0968 | 0.1669 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.015 | 0.1591 | 0.1591 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0264 | 0.2943 | 0.2943 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0302 | 0.4762 |
Schistosoma mansoni | hypothetical protein | 0.0097 | 0.0968 | 0.0968 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0017 | 0.002 | 0.002 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0041 | 0.0302 | 0.4762 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0303 | 0.0523 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0034 | 0.0225 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.2064 | 0.356 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0073 | 0.0685 | 0.118 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0045 | 0.0348 | 0.0572 |
Brugia malayi | intermediate filament protein | 0.0059 | 0.0513 | 0.0884 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0034 | 0.0225 | 0.0225 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0041 | 0.0302 | 0.0521 |
Brugia malayi | MH1 domain containing protein | 0.0034 | 0.0225 | 0.0388 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0032 | 0.0202 | 0.0202 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0152 | 0.1621 | 0.1621 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0041 | 0.0302 | 0.0411 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0041 | 0.0302 | 0.0521 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 48.1 % | Analgesic activity in Swiss albino mouse assessed as effect on reaction time for tail withdrawal administered at equimolar oral dose relative to 10 mg/kg fluribiprofen after 4 hrs by tail immersion method | ChEMBL. | 18023930 |
MIC (functional) | = 25 ug ml-1 | Antibacterial activity against sEscherichia coli ATCC 25922 by cup plate method | ChEMBL. | 18023930 |
MIC (functional) | = 50 ug ml-1 | Antimicrobial activity against Candida albicans ATCC 2091 by cup plate method | ChEMBL. | 18023930 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.