Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.1673 | 0.3052 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1673 | 0.8001 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.1673 | 0.1394 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.1673 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.201 | 0.0405 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.201 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.1673 | 0.1394 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.201 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.1673 | 0.1394 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.201 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.201 | 0.5 |
Brugia malayi | hypothetical protein | 0.0026 | 0.201 | 0.3666 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.1673 | 0.1394 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.201 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.1673 | 0.1394 |
Onchocerca volvulus | 0.0024 | 0.1673 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.5482 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.1673 | 0.1583 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.1673 | 0.1583 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.1673 | 0.3052 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1673 | 0.8001 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.1673 | 0.3052 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1673 | 0.8001 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.201 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 1 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.1673 | 0.1394 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0324 | 0.022 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.5482 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.0324 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 1 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.1673 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.5482 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.5482 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.1673 | 0.1394 |
Brugia malayi | hypothetical protein | 0.0041 | 0.5482 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.1673 | 0.1394 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.201 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 27 % | Inhibition of Cytochrome P450 19A1 at 20 ug/mL | ChEMBL. | 3968684 |
Inhibition (binding) | = 27 % | Inhibition of Cytochrome P450 19A1 at 20 ug/mL | ChEMBL. | 3968684 |
Inhibition (binding) | = 38 % | Inhibition of bovine adreneal desmolase cytochrome P450 11A1 at 50 ug/mL | ChEMBL. | 3968684 |
Inhibition (binding) | = 38 % | Inhibition of bovine adreneal desmolase cytochrome P450 11A1 at 50 ug/mL | ChEMBL. | 3968684 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.