Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0096 | 0.0334 | 1 |
Loa Loa (eye worm) | DR-78 | 0.0045 | 0.0091 | 0.0093 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0045 | 0.0091 | 0.0036 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0096 | 0.0334 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0096 | 0.0334 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0091 | 0.0093 |
Schistosoma mansoni | nuclear hormone receptor | 0.0096 | 0.0334 | 1 |
Brugia malayi | tailless protein | 0.0045 | 0.0091 | 0.0037 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0122 | 0.0924 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0096 | 0.0334 | 0.0287 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0334 | 0.0342 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0096 | 0.0334 | 0.2528 |
Echinococcus granulosus | FTZ F1 alpha | 0.0096 | 0.0334 | 0.2528 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.0122 | 0.0069 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0045 | 0.0091 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.2017 | 0.954 | 0.9778 |
Brugia malayi | nuclear hormone receptor | 0.0096 | 0.0334 | 0.0287 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0091 | 0.0093 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0096 | 0.0334 | 0.2528 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.1158 | 0.1187 |
Brugia malayi | nuclear receptor NHR-88 | 0.0096 | 0.0334 | 0.0287 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0038 | 0.0055 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0334 | 0.0342 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0096 | 0.0334 | 0.0287 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0045 | 0.0091 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0334 | 0.0342 |
Schistosoma mansoni | nuclear hormone receptor | 0.0045 | 0.0091 | 0.1284 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0096 | 0.0334 | 0.0287 |
Loa Loa (eye worm) | pyruvate kinase | 0.0038 | 0.0055 | 0.0056 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0051 | 0.0117 | 0.2218 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0334 | 0.0342 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0045 | 0.0091 | 0.0325 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0091 | 0.0093 |
Echinococcus multilocularis | pyruvate kinase | 0.0038 | 0.0055 | 0.0334 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0096 | 0.0334 | 0.0342 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0334 | 0.0342 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0096 | 0.0334 | 0.0287 |
Brugia malayi | ecdysteroid receptor | 0.0096 | 0.0334 | 0.0287 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0122 | 0.2412 |
Plasmodium falciparum | pyruvate kinase | 0.0038 | 0.0055 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0096 | 0.0334 | 0.0342 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0045 | 0.0091 | 0.0648 |
Schistosoma mansoni | survival motor neuron protein | 0.0055 | 0.0136 | 0.2897 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0096 | 0.0334 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0096 | 0.0334 | 0.0287 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0038 | 0.0055 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0096 | 0.0334 | 0.2528 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0096 | 0.0334 | 0.2528 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0045 | 0.0091 | 0.0037 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0096 | 0.0334 | 0.0287 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0038 | 0.0055 | 0.5 |
Onchocerca volvulus | 0.0055 | 0.0136 | 0.0081 | |
Loa Loa (eye worm) | pyruvate kinase | 0.0038 | 0.0055 | 0.0056 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0045 | 0.0091 | 0.0325 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0051 | 0.0117 | 0.0064 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0096 | 0.0334 | 0.2528 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0091 | 0.0093 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0096 | 0.0334 | 0.0287 |
Brugia malayi | nuclear receptor RXR | 0.0051 | 0.0117 | 0.0064 |
Onchocerca volvulus | 0.0096 | 0.0334 | 0.028 | |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0096 | 0.0334 | 0.0287 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0096 | 0.0334 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0045 | 0.0091 | 0.0093 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0045 | 0.0091 | 0.0037 |
Schistosoma mansoni | nuclear receptor | 0.0045 | 0.0091 | 0.1284 |
Echinococcus multilocularis | pyruvate kinase | 0.0038 | 0.0055 | 0.0334 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0117 | 0.012 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0096 | 0.0334 | 0.0287 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0045 | 0.0091 | 0.0648 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0268 | 0.1158 | 1 |
Brugia malayi | hypothetical protein | 0.0268 | 0.1158 | 0.1137 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0268 | 0.1158 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0096 | 0.0334 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0334 | 0.0342 |
Brugia malayi | ecdysone receptor | 0.0045 | 0.0091 | 0.0037 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0038 | 0.0055 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0096 | 0.0334 | 0.2777 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0038 | 0.0055 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0096 | 0.0334 | 0.0287 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0091 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0091 | 0.0093 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.0136 | 0.2897 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0091 | 0.0093 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0045 | 0.0091 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0091 | 0.0093 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0096 | 0.0334 | 0.2777 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0096 | 0.0334 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0096 | 0.0334 | 0.0342 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0096 | 0.0334 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0045 | 0.0091 | 0.0648 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0045 | 0.0091 | 0.0648 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0096 | 0.0334 | 0.0287 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0045 | 0.0091 | 0.1284 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0096 | 0.0334 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0055 | 0.0056 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0055 | 0.0136 | 0.0083 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0096 | 0.0334 | 0.2528 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0096 | 0.0334 | 0.2528 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0117 | 0.012 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0051 | 0.0117 | 0.0064 |
Onchocerca volvulus | 0.0045 | 0.0091 | 0.0036 | |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0096 | 0.0334 | 0.2777 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0122 | 0.061 |
Brugia malayi | nuclear hormone receptor | 0.2063 | 0.9757 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0117 | 0.012 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0051 | 0.0117 | 0.0561 |
Schistosoma mansoni | nuclear receptor | 0.0045 | 0.0091 | 0.1284 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0096 | 0.0334 | 0.2777 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0096 | 0.0334 | 0.2528 |
Giardia lamblia | Pyruvate kinase | 0.0038 | 0.0055 | 0.5 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0026 | 0 | 0.5 |
Plasmodium vivax | pyruvate kinase, putative | 0.0038 | 0.0055 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0334 | 0.0342 |
Brugia malayi | hypothetical protein | 0.0045 | 0.0091 | 0.0037 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0045 | 0.0091 | 0.0325 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0096 | 0.0334 | 0.0342 |
Loa Loa (eye worm) | pyruvate kinase | 0.0038 | 0.0055 | 0.0056 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0096 | 0.0334 | 0.0287 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0045 | 0.0091 | 0.0325 |
Schistosoma mansoni | thyroid hormone receptor | 0.0096 | 0.0334 | 1 |
Onchocerca volvulus | 0.0045 | 0.0091 | 0.0036 | |
Leishmania major | pyruvate kinase | 0.0038 | 0.0055 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0117 | 0.012 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0091 | 0.0093 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0096 | 0.0334 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0096 | 0.0334 | 0.2777 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0096 | 0.0334 | 0.0287 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0096 | 0.0334 | 0.0342 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0045 | 0.0091 | 0.1284 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0122 | 0.2412 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0045 | 0.0091 | 0.0325 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0091 | 0.0093 |
Schistosoma mansoni | nuclear hormone receptor | 0.0045 | 0.0091 | 0.1284 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0096 | 0.0334 | 0.0287 |
Brugia malayi | conserved hypotetical protein | 0.0045 | 0.0091 | 0.0037 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0096 | 0.0334 | 0.2777 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0045 | 0.0091 | 0.0036 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0038 | 0.0055 | 0.5 |
Brugia malayi | hypothetical protein | 0.0045 | 0.0091 | 0.0037 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.0122 | 0.0125 |
Brugia malayi | nuclear receptor RXR | 0.0045 | 0.0091 | 0.0037 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0045 | 0.0091 | 0.0648 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0334 | 0.0342 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0096 | 0.0334 | 0.2777 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0045 | 0.0091 | 0.0037 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0096 | 0.0334 | 0.2777 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0122 | 0.0924 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0117 | 0.012 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0096 | 0.0334 | 0.0342 |
Brugia malayi | nuclear receptor NHR-88 | 0.0045 | 0.0091 | 0.0037 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0038 | 0.0055 | 0.5 |
Chlamydia trachomatis | pyruvate kinase | 0.0038 | 0.0055 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0096 | 0.0334 | 0.0287 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0096 | 0.0334 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0045 | 0.0091 | 0.0648 |
Leishmania major | pyruvate kinase | 0.0038 | 0.0055 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0045 | 0.0091 | 0.1284 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0045 | 0.0091 | 0.0037 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0051 | 0.0117 | 0.0876 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0091 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0091 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0091 | 0.0093 |
Brugia malayi | hypothetical protein | 0.0051 | 0.0117 | 0.0064 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0122 | 0.2412 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0051 | 0.0117 | 0.2218 |
Mycobacterium ulcerans | pyruvate kinase | 0.0038 | 0.0055 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0051 | 0.0117 | 0.012 |
Brugia malayi | hypothetical protein | 0.0051 | 0.0117 | 0.0064 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0038 | 0.0055 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0096 | 0.0334 | 0.028 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0038 | 0.0055 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0096 | 0.0334 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0096 | 0.0334 | 0.0287 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0096 | 0.0334 | 0.2777 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0096 | 0.0334 | 0.0342 |
Brugia malayi | nuclear receptor NHR-67 | 0.0045 | 0.0091 | 0.0037 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0045 | 0.0091 | 0.0325 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0096 | 0.0334 | 0.0342 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0045 | 0.0091 | 0.1284 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0096 | 0.0334 | 0.0287 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0122 | 0.061 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.2063 | 0.9757 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 52 % | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv at 6.25 ug/ml after 4 days by microplate alamar blue assay | ChEMBL. | 18977145 |
LC50 (ADMET) | > 28 ug ml-1 | Cytotoxicity against HEK293 cells after 72 hrs by MTT assay | ChEMBL. | 18977145 |
MIC (functional) | > 6.25 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 4 days by microplate alamar blue assay | ChEMBL. | 18977145 |
pKb (functional) | Antagonist activity at guinea pig ileum histamine H1 receptor at 0.3 x 10'4 M | ChEMBL. | 18977145 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.