Detailed information for compound 1016823

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 428.263 | Formula: C17H15F6O4P
  • H donors: 1 H acceptors: 1 LogP: 6.31 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: F[P-](F)(F)(F)(F)F.COc1ccc(cc1)c1ccc2c([o+]1)cc(c(c2)OC)O
  • InChi: 1S/C17H14O4.F6P/c1-19-13-6-3-11(4-7-13)15-8-5-12-9-17(20-2)14(18)10-16(12)21-15;1-7(2,3,4,5)6/h3-10H,1-2H3;/q;-1/p+1
  • InChiKey: VSKQKUCLLQJNLR-UHFFFAOYSA-O  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tar DNA binding protein 0.0062 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0062 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 1 1
Echinococcus granulosus lamin dm0 0.0027 0.2561 0.2353
Loa Loa (eye worm) TAR-binding protein 0.0062 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.724 0.724
Schistosoma mansoni tar DNA-binding protein 0.0062 1 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.2561 0.2561
Echinococcus multilocularis tar DNA binding protein 0.0062 1 1
Onchocerca volvulus 0.0027 0.2561 0.5
Brugia malayi intermediate filament protein 0.0027 0.2561 0.2561
Echinococcus multilocularis lamin 0.0027 0.2561 0.2353
Loa Loa (eye worm) hypothetical protein 0.0027 0.2561 0.2561
Schistosoma mansoni lamin 0.0027 0.2561 0.2353
Schistosoma mansoni hypothetical protein 0.0033 0.4015 0.3848
Loa Loa (eye worm) hypothetical protein 0.0049 0.724 0.724
Schistosoma mansoni tar DNA-binding protein 0.0062 1 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.2561 0.2353
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.2561 0.2561
Echinococcus multilocularis lamin dm0 0.0027 0.2561 0.2353
Onchocerca volvulus 0.0027 0.2561 0.5
Loa Loa (eye worm) intermediate filament protein 0.0027 0.2561 0.2561
Brugia malayi TAR-binding protein 0.0062 1 1
Echinococcus granulosus lamin 0.0027 0.2561 0.2353
Loa Loa (eye worm) hypothetical protein 0.0026 0.246 0.246
Loa Loa (eye worm) hypothetical protein 0.0033 0.4015 0.4015
Schistosoma mansoni tar DNA-binding protein 0.0062 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0271 0.0271
Schistosoma mansoni lamin 0.0027 0.2561 0.2353
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.4015 0.4015
Loa Loa (eye worm) RNA binding protein 0.0062 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0271 0.0271
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0271 0.0271
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.724 0.724
Echinococcus granulosus intermediate filament protein 0.0027 0.2561 0.2353
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.724 0.724
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0271 0.0271
Echinococcus multilocularis musashi 0.0027 0.2561 0.2353

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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