TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 545.651 | Formula: C26H35N5O6S
H donors: 3 H acceptors: 6 LogP: 2.97 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC1(C)CCCC1)NC(=O)c1ccc(cc1)NS(=O)(=O)c1nccn1C
InChi: 1S/C26H35N5O6S/c1-4-21-22(20(32)16-37-21)29-24(34)19(15-26(2)11-5-6-12-26)28-23(33)17-7-9-18(10-8-17)30-38(35,36)25-27-13-14-31(25)3/h7-10,13-14,19,21-22,30H,4-6,11-12,15-16H2,1-3H3,(H,28,33)(H,29,34)/t19-,21-,22+/m0/s1
InChiKey: OZAJPIULESPARZ-ILWGZMRPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin S	Starlite/ChEMBL	References
Homo sapiens	cathepsin K	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	281 aa	226 aa	34.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.1072	0.085
Trypanosoma cruzi	cysteine peptidase, putative	0.0028	0.0596	0.0362
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.1218	0.1359
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.1051	0.1172
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0037	0.0922	0.0696
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0041	0.1072	0.0624
Toxoplasma gondii	cathepsin CPL	0.0054	0.1522	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1218	0.1359
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0293	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1522	0.3966
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1218	0.1359
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1522	0.3966
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1522	0.1097
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0028	0.0596	0.1126
Brugia malayi	serine/threonine-protein kinase plk-2	0.0094	0.2933	0.3155
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.1522	0.1311
Brugia malayi	jmjC domain containing protein	0.0096	0.2999	0.323
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1522	0.1554
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0855	0.0796
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0855	0.0627
Brugia malayi	MH2 domain containing protein	0.0143	0.4672	0.513
Schistosoma mansoni	cathepsin s	0.0018	0.0243	0.0271
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.1522	0.1311
Onchocerca volvulus		0.0054	0.1522	0.1626
Echinococcus granulosus	cysteine protease	0.0028	0.0596	0.0665
Trypanosoma cruzi	cruzipain precursor, putative	0.0054	0.1522	0.1311
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1522	0.1097
Schistosoma mansoni	cathepsin F (C01 family)	0.0054	0.1522	0.1699
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0645	0.072
Loa Loa (eye worm)	cysteine protease	0.0054	0.1522	0.1554
Plasmodium vivax	unspecified product	0.0028	0.0596	0.2757
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1522	0.3966
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0054	0.1522	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1522	0.3966
Schistosoma mansoni	hypothetical protein	0.0047	0.127	0.1417
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1522	0.3966
Brugia malayi	PHD-finger family protein	0.0029	0.0645	0.0558
Schistosoma mansoni	survival motor neuron protein	0.0047	0.127	0.1417
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0037	0.0922	0.0872
Plasmodium vivax	vivapain-2	0.0054	0.1522	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0143	0.4672	0.513
Brugia malayi	RNA recognition motif domain containing protein	0.0264	0.8961	1
Loa Loa (eye worm)	hypothetical protein	0.0181	0.604	0.6683
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0855	0.0796
Onchocerca volvulus		0.0047	0.127	0.1158
Loa Loa (eye worm)	RNA binding protein	0.0264	0.8961	1
Leishmania major	cathepsin L-like protease	0.0054	0.1522	0.1097
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0855	0.0796
Schistosoma mansoni	ap endonuclease	0.0037	0.0922	0.1029
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0054	0.1522	0.3966
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0094	0.2933	0.424
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0036	0.0891	0.0837
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0154	0.0171
Schistosoma mansoni	tar DNA-binding protein	0.0264	0.8961	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0037	0.0922	0.5
Schistosoma mansoni	hypothetical protein	0.0015	0.0154	0.0171
Leishmania major	cathepsin L-like protease	0.0054	0.1522	0.1097
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0478	0.0241
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0855	0.1109
Schistosoma mansoni	hypothetical protein	0.0015	0.0154	0.0171
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1522	0.1554
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0037	0.0922	0.4251
Onchocerca volvulus		0.0054	0.1522	0.1626
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0028	0.0596	0.0362
Brugia malayi	hypothetical protein	0.0229	0.7745	0.8619
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0855	0.5
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0855	0.0954
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0855	0.1109
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0293	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1522	0.3966
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0891	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0478	0.0368
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0037	0.0922	0.5
Echinococcus multilocularis	survival motor neuron protein 1	0.0229	0.7745	0.8643
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1522	0.3966
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1522	0.1554
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0139	0.4528	0.4253
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0054	0.1522	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0028	0.0596	0.0362
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0855	0.0627
Brugia malayi	cathepsin L-like precursor	0.0036	0.0891	0.0837
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.1218	0.1209
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0243	0.0101
Onchocerca volvulus		0.0054	0.1522	0.1626
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0855	0.4783
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0478	0.0241
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1522	0.1097
Plasmodium vivax	vivapain-2	0.0054	0.1522	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1522	0.3966
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0037	0.0922	0.5308
Loa Loa (eye worm)	transcription factor SMAD2	0.0143	0.4672	0.513
Brugia malayi	Bromodomain containing protein	0.0029	0.0645	0.0558
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0037	0.0922	0.0466
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0154	0.0171
Onchocerca volvulus		0.0035	0.0855	0.0388
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0645	0.0558
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0096	0.2999	0.3346
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.1072	0.085
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0054	0.1522	0.3966
Schistosoma mansoni	kinase	0.0048	0.1299	0.145
Echinococcus granulosus	cathepsin l1	0.0054	0.1522	0.1699
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0855	0.1109
Brugia malayi	exodeoxyribonuclease III family protein	0.0037	0.0922	0.0872
Leishmania major	cysteine peptidase A (CPA)	0.0054	0.1522	0.1097
Brugia malayi	RNA binding protein	0.0264	0.8961	1
Echinococcus multilocularis	cysteine protease	0.0054	0.1522	0.1699
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0891	0.0837
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0028	0.0596	0.0665
Mycobacterium ulcerans	hypothetical protein	0.0154	0.5083	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.1218	0.1359
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0645	0.1602
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2933	1
Onchocerca volvulus	Cathepsin F homolog	0.0054	0.1522	0.1626
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0036	0.0891	0.0664
Trypanosoma brucei	polo-like protein kinase	0.0094	0.2933	0.2578
Loa Loa (eye worm)	jmjC domain-containing protein	0.0035	0.0863	0.0805
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1522	0.1097
Brugia malayi	TAR-binding protein	0.0264	0.8961	1
Schistosoma mansoni	ap endonuclease	0.0037	0.0922	0.1029
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1522	0.3966
Leishmania major	cathepsin L-like protease	0.0054	0.1522	0.1097
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0863	0.0963
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1522	0.1097
Echinococcus multilocularis	cathepsin L	0.0028	0.0596	0.0665
Echinococcus granulosus	cathepsin l1	0.0036	0.0891	0.0994
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1218	0.1359
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0224	0.7558	1
Schistosoma mansoni	tar DNA-binding protein	0.0264	0.8961	1
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0645	0.072
Schistosoma mansoni	jumonji domain containing protein	0.0076	0.2303	0.2569
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0094	0.2933	0.3272
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1522	0.3966
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.1255	0.2823
Plasmodium vivax	vivapain-3	0.0028	0.0596	0.2757
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0891	0.1262
Onchocerca volvulus		0.0054	0.1522	0.1626
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.0478	0.1838
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0096	0.2999	0.3346
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0855	0.0796
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2933	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0855	0.1109
Leishmania major	cathepsin L-like protease	0.0054	0.1522	0.1097
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0037	0.0922	0.1209
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0855	0.0796
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.005	0.1391	0.1177
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0054	0.1522	0.1554
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1522	0.3966
Echinococcus multilocularis	cathepsin L cysteine protease	0.0054	0.1522	0.1699
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1522	0.3966
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.1051	0.1172
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1522	0.1097
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.1218	0.1209
Echinococcus granulosus	cathepsin L	0.0028	0.0596	0.0665
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.1255	0.2823
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0783	0.0715
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0028	0.0596	0.0665
Trypanosoma cruzi	polo-like protein kinase, putative	0.0094	0.2933	0.2757
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.1522	0.1311
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0139	0.4528	0.4392
Echinococcus multilocularis	peregrin	0.0029	0.0645	0.072
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1522	0.1554
Schistosoma mansoni	hypothetical protein	0.0029	0.0645	0.072
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2933	1
Leishmania major	cathepsin L-like protease	0.0054	0.1522	0.1097
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.0645	0.072
Entamoeba histolytica	cysteine proteinase, putative	0.0054	0.1522	0.3966
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0855	0.0954
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0264	0.8961	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0855	0.0954
Entamoeba histolytica	cysteine proteinase, putative	0.0054	0.1522	0.3966
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0154	0.0171
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0028	0.0596	0.0123
Schistosoma mansoni	tar DNA-binding protein	0.0264	0.8961	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.1218	0.1359
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0028	0.0596	0.0123
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2933	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1326	0.1331
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0855	0.0396
Brugia malayi	cathepsin F-like cysteine proteinase	0.0018	0.0243	0.0101
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0054	0.1522	0.1699
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1522	0.3966
Loa Loa (eye worm)	jmjC domain-containing protein	0.006	0.1747	0.1809
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.0243	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0855	0.0796
Echinococcus granulosus	tar DNA binding protein	0.0264	0.8961	1
Echinococcus granulosus	survival motor neuron protein 1	0.0229	0.7745	0.8643
Echinococcus multilocularis	tar DNA binding protein	0.0264	0.8961	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.127	0.1268
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0094	0.2933	0.3155
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0037	0.0922	0.1397
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0891	0.0837
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.1522	0.1311
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0054	0.1522	0.1699
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0645	0.1602
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1522	0.3966
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.1218	0.1359
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0645	0.3146
Plasmodium falciparum	phd finger protein, putative	0.0029	0.0645	0.1602
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0783	0.0715
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0139	0.4528	0.4253
Trichomonas vaginalis	ap endonuclease, putative	0.0037	0.0922	0.1397
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0037	0.0922	0.0696
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0054	0.1522	0.1699
Brugia malayi	beta-lactamase family protein	0.0035	0.0855	0.0796
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0037	0.0922	0.1029
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0154	0.5083	0.6308
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0863	0.0963
Entamoeba histolytica	cysteine protease, putative	0.0054	0.1522	0.3966
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0855	0.0796
Trypanosoma cruzi	polo-like protein kinase, putative	0.0094	0.2933	0.2757
Loa Loa (eye worm)	hypothetical protein	0.005	0.1384	0.1397
Brugia malayi	hypothetical protein	0.0016	0.0171	0.002
Onchocerca volvulus		0.0054	0.1522	0.1626
Schistosoma mansoni	serine/threonine protein kinase	0.0094	0.2933	0.3272
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0855	0.1109
Onchocerca volvulus		0.0054	0.1522	0.1626
Leishmania major	hypothetical protein, conserved	0.0035	0.0855	0.0396
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2933	1
Onchocerca volvulus	Cathepsin L homolog	0.0054	0.1522	0.1626
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0154	0.0171
Echinococcus multilocularis	lysine specific demethylase 5A	0.0035	0.0863	0.0963
Toxoplasma gondii	hypothetical protein	0.0047	0.1287	0.7742
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2933	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0037	0.0922	0.0159
Echinococcus granulosus	peregrin	0.0029	0.0645	0.072
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0037	0.0922	0.0466
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1522	0.3966
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1522	0.3966
Echinococcus granulosus	lysine specific demethylase 5A	0.0035	0.0863	0.0963
Schistosoma mansoni	cathepsin F (C01 family)	0.0036	0.0891	0.0994
Leishmania major	cathepsin L-like protease	0.0054	0.1522	0.1097
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1522	0.1554
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0855	0.5
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1522	0.1554
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1522	0.1554
Toxoplasma gondii	ABC1 family protein	0.0035	0.0855	0.3608
Plasmodium vivax	vivapain-1	0.0028	0.0596	0.2757
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0154	0.0171
Echinococcus multilocularis	cathepsin L cysteine protease	0.0054	0.1522	0.1699
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1522	0.1097
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0243	0.0101
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0037	0.0922	0.01
Loa Loa (eye worm)	TAR-binding protein	0.0264	0.8961	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1522	0.3966
Brugia malayi	N-terminal motif family protein	0.0181	0.604	0.6683
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0054	0.1522	1
Brugia malayi	hypothetical protein	0.0024	0.0478	0.0368
Onchocerca volvulus	Cathepsin L homolog	0.0054	0.1522	0.1626
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0243	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0243	0.0101
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2933	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1522	0.3966
Brugia malayi	beta-lactamase	0.0035	0.0855	0.0796
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0181	0.604	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0891	0.0837
Schistosoma mansoni	hypothetical protein	0.0015	0.0154	0.0171
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.1326	0.1331
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0028	0.0596	0.0665
Schistosoma mansoni	hypothetical protein	0.0033	0.0783	0.0874
Onchocerca volvulus		0.0035	0.0855	0.0388
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0094	0.2933	0.3272
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1522	0.3966
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0037	0.0922	0.1029
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0891	0.1262
Brugia malayi	Papain family cysteine protease containing protein	0.0054	0.1522	0.1554
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0018	0.0243	0.0101
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1522	0.1097
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0855	0.0954
Loa Loa (eye worm)	hypothetical protein	0.0229	0.7745	0.8619
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0054	0.1522	0.1699
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0891	0.0837
Leishmania major	cathepsin L-like protease	0.0054	0.1522	0.1097
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0855	0.0796
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0293	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1522	0.3966
Trypanosoma cruzi	cysteine proteinase, putative	0.0028	0.0596	0.0362
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1522	0.3966
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0094	0.2933	0.2578
Loa Loa (eye worm)	fibroinase	0.0054	0.1522	0.1554
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0041	0.1072	0.085
Echinococcus multilocularis	cysteine protease	0.0054	0.1522	0.1699
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1522	0.1097
Onchocerca volvulus		0.0035	0.0855	0.0388
Onchocerca volvulus		0.0054	0.1522	0.1626
Onchocerca volvulus		0.0036	0.0891	0.0454
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0054	0.1522	0.1554
Brugia malayi	Papain family cysteine protease containing protein	0.0028	0.0596	0.0502
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1522	0.1097
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1522	0.3966
Brugia malayi	jmjC domain containing protein	0.0035	0.0863	0.0805
Entamoeba histolytica	cysteine proteinase, putative	0.0036	0.0891	0.1262
Schistosoma mansoni	hypothetical protein	0.0015	0.0154	0.0171
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1522	0.3966
Schistosoma mansoni	tar DNA-binding protein	0.0264	0.8961	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.1326	0.1331
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.1326	0.1331
Leishmania major	cathepsin L-like protease	0.0054	0.1522	0.1097
Trichomonas vaginalis	ap endonuclease, putative	0.0037	0.0922	0.1397
Trypanosoma cruzi	cysteine protease, putative	0.0028	0.0596	0.0362
Toxoplasma gondii	exonuclease III APE	0.0037	0.0922	0.4251
Echinococcus granulosus	GPCR family 2	0.0015	0.0154	0.0171
Brugia malayi	Papain family cysteine protease containing protein	0.0028	0.0596	0.0502
Brugia malayi	beta-lactamase family protein	0.0035	0.0855	0.0796
Trichomonas vaginalis	esterase, putative	0.0035	0.0855	0.1109
Schistosoma mansoni	cathepsin F (C01 family)	0.0054	0.1522	0.1699
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1522	0.1097
Giardia lamblia	Kinase, PLK	0.0094	0.2933	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0855	0.0796
Loa Loa (eye worm)	ctsf protein	0.0054	0.1522	0.1554
Schistosoma mansoni	tar DNA-binding protein	0.0264	0.8961	1
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0094	0.2933	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0645	0.0558
Echinococcus granulosus	cathepsin L cysteine protease	0.0028	0.0596	0.0665

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 4.5 nM	Inhibition of human recombinant cathepsin S expressed in baculovirus by fluorescence assay	ChEMBL.	19124252
Ki (binding)	= 640 nM	Inhibition of human recombinant cathepsin K expressed in baculovirus by fluorescence assay	ChEMBL.	19124252
Ki (binding)	= 24000 nM	Inhibition of human cathepsin L by fluorescence assay	ChEMBL.	19124252

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL519136

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1016940