Detailed information for compound 1017777

Basic information

Technical information
  • TDR Targets ID: 1017777
  • Name: 1,1,1-trifluoro-3-[2-[3-(1,1,2,2-tetrafluoroe thoxy)phenyl]-5-thiophen-2-yl-3,4-dihydro-2H- quinolin-1-yl]propan-2-ol
  • MW: 519.475 | Formula: C24H20F7NO2S
  • H donors: 1 H acceptors: 1 LogP: 7.39 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(C(F)(F)F)CN1C(CCc2c1cccc2c1cccs1)c1cccc(c1)OC(C(F)F)(F)F
  • InChi: 1S/C24H20F7NO2S/c25-22(26)24(30,31)34-15-5-1-4-14(12-15)18-10-9-16-17(20-8-3-11-35-20)6-2-7-19(16)32(18)13-21(33)23(27,28)29/h1-8,11-12,18,21-22,33H,9-10,13H2
  • InChiKey: FYFTYARJWCTIHC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,1,1-trifluoro-3-[2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-5-(2-thienyl)-3,4-dihydro-2H-quinolin-1-yl]propan-2-ol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.028 0.1082
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0042 0.0029
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0161 0.0148
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0158 0.0184
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0161 0.062
Mycobacterium tuberculosis Conserved protein 0.0072 0.1165 0.1248
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0244 0.0156
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.1874 1
Onchocerca volvulus 0.0029 0.0345 0.0339
Loa Loa (eye worm) beta-lactamase 0.0072 0.1165 0.1324
Toxoplasma gondii peptidylprolyl isomerase 0.0025 0.0278 0.1193
Brugia malayi MH1 domain containing protein 0.0016 0.0108 0.0125
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0158 0.0401
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.1165 0.6116
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0357 0.1979
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0961 0.0949
Schistosoma mansoni zinc finger protein 0.0015 0.0087 0.0074
Brugia malayi hypothetical protein 0.0037 0.0503 0.0586
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.1874 0.1863
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0244 0.0815
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0357 0.3143
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0158 0.0401
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0158 0.0054
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0642 0.3255
Loa Loa (eye worm) hypothetical protein 0.0053 0.0806 0.0905
Schistosoma mansoni hypothetical protein 0.0072 0.1167 0.1155
Echinococcus multilocularis expressed protein 0.0026 0.029 0.0277
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0244 0.05
Loa Loa (eye worm) hypothetical protein 0.0023 0.0244 0.0247
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0357 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0674 0.0662
Loa Loa (eye worm) hypothetical protein 0.0179 0.3225 0.3732
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0792 1
Mycobacterium tuberculosis Conserved protein 0.0072 0.1165 0.1248
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0244 0.0881
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0161 0.062
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0158 0.0332
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0357 0.2192
Loa Loa (eye worm) RNA binding protein 0.0189 0.3407 0.3946
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0357 0.1454
Onchocerca volvulus Huntingtin homolog 0.0123 0.2148 0.6388
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.1167 0.1155
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0188 0.0182
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0108 0.0095
Schistosoma mansoni ap endonuclease 0.0019 0.0158 0.0145
Loa Loa (eye worm) hypothetical protein 0.0072 0.1165 0.1324
Onchocerca volvulus 0.0053 0.0806 0.1887
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0161 0.0148
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0244 0.0284
Loa Loa (eye worm) hypothetical protein 0.0017 0.0131 0.0115
Mycobacterium leprae conserved hypothetical protein 0.0072 0.1165 0.6002
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0161 0.0057
Loa Loa (eye worm) hypothetical protein 0.0028 0.0336 0.0354
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.1874 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.045 0.0525
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0108 0.0095
Loa Loa (eye worm) hypothetical protein 0.0044 0.0642 0.0713
Schistosoma mansoni tar DNA-binding protein 0.0189 0.3407 0.3398
Mycobacterium ulcerans hypothetical protein 0.0023 0.0244 0.065
Entamoeba histolytica hypothetical protein 0.0072 0.1167 0.5877
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0357 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0158 0.0607
Schistosoma mansoni DNA polymerase eta 0.0044 0.0642 0.063
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0044 0.0637 0.0707
Schistosoma mansoni tar DNA-binding protein 0.0189 0.3407 0.3398
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0161 0.062
Echinococcus multilocularis musashi 0.0027 0.0306 0.0293
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0792 0.0888
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0011
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0306 0.0356
Echinococcus granulosus lamin dm0 0.0027 0.0306 0.0293
Echinococcus granulosus intermediate filament protein 0.0027 0.0306 0.0293
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.1874 0.1863
Schistosoma mansoni hypothetical protein 0.0016 0.0099 0.0086
Schistosoma mansoni integrin alpha 0.0054 0.0832 0.082
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.1165 0.1248
Loa Loa (eye worm) hypothetical protein 0.0152 0.2707 0.3127
Brugia malayi MAP kinase sur-1 0.0052 0.0792 0.0922
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0457 0.854 1
Echinococcus multilocularis dna polymerase eta 0.0044 0.0642 0.063
Echinococcus granulosus geminin 0.0507 0.9501 0.95
Echinococcus granulosus protein tyrosine kinase 0.0254 0.4648 0.4641
Loa Loa (eye worm) hypothetical protein 0.0037 0.0503 0.055
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0158 0.0145
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0255 0.0243
Schistosoma mansoni hypothetical protein 0.0034 0.045 0.0438
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0099 0.0086
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0158 0.0147
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0161 0.0148
Brugia malayi phosphofructokinase 0.0109 0.1874 0.2183
Schistosoma mansoni aryl hydrocarbon receptor 0.0016 0.0104 0.0092
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.1165 0.6002
Schistosoma mansoni cpg binding protein 0.0029 0.0345 0.0332
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0025 0.0278 0.1073
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0792 0.3902
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.1874 0.209
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.012 0.0107
Brugia malayi hypothetical protein 0.0152 0.2707 0.3153
Schistosoma mansoni hypothetical protein 0.0026 0.0293 0.028
Echinococcus multilocularis integrin alpha ps 0.0026 0.0293 0.028
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0792 0.3946
Brugia malayi Protein kinase domain containing protein 0.0257 0.4706 0.5481
Onchocerca volvulus 0.0027 0.0306 0.0207
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0017 0.0126 0.022
Loa Loa (eye worm) hypothetical protein 0.0026 0.0293 0.0304
Onchocerca volvulus Huntingtin homolog 0.0123 0.2148 0.6388
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0459 0.8585 0.8583
Brugia malayi Bromodomain containing protein 0.0076 0.1252 0.1458
Entamoeba histolytica hypothetical protein 0.0072 0.1167 0.5877
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0161 0.0345
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0161 0.062
Leishmania major DNA polymerase eta, putative 0.0031 0.0391 0.17
Brugia malayi hypothetical protein 0.0123 0.2148 0.2502
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.1874 0.1863
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0357 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0161 0.062
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0357 0.1454
Brugia malayi MH2 domain containing protein 0.0016 0.0108 0.0125
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0099 0.0086
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0244 0.05
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0674 0.0662
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.028 0.1443
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0642 0.3107
Schistosoma mansoni rotamase 0.0026 0.029 0.0277
Schistosoma mansoni integrin alpha-ps 0.0054 0.0832 0.082
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0161 0.0345
Echinococcus granulosus c-Jun N-terminal kinases 0.0459 0.8585 0.8583
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.1165 0.1248
Leishmania major protein kinase, putative 0.0021 0.02 0.0634
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0792 0.3902
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0792 0.3902
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0037 0.0503 0.0586
Schistosoma mansoni smad1 5 8 and 0.0016 0.0108 0.0095
Loa Loa (eye worm) hypothetical protein 0.0023 0.0244 0.0247
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.1165 0.1153
Schistosoma mansoni smad 0.0016 0.0108 0.0095
Loa Loa (eye worm) hypothetical protein 0.0028 0.0336 0.0354
Echinococcus multilocularis integrin alpha 3 0.0026 0.0293 0.028
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0099 0.0077
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0161 0.0414
Mycobacterium leprae Probable lipase LipE 0.0072 0.1165 0.6002
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.1165 0.6031
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.1165 0.6002
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0161 0.0014
Brugia malayi hypothetical protein 0.0037 0.0508 0.0592
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0961 0.0949
Trichomonas vaginalis esterase, putative 0.0072 0.1165 0.6002
Schistosoma mansoni cpg binding protein 0.0032 0.0413 0.04
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0244 0.065
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.1874 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0099 0.0078
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0753 0.0877
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.1874 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.1165 0.1248
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0108 0.0095
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0099 0.0072
Trichomonas vaginalis rotamase, putative 0.0025 0.0278 0.1008
Mycobacterium ulcerans lipase LipD 0.0072 0.1165 0.5931
Echinococcus multilocularis microtubule associated protein 2 0.0533 1 1
Brugia malayi 6-phosphofructokinase 0.0109 0.1874 0.2183
Schistosoma mansoni cpg binding protein 0.0032 0.0413 0.04
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0037 0.0508 0.0496
Toxoplasma gondii ABC1 family protein 0.0072 0.1165 1
Trypanosoma brucei ISWI complex protein 0.0015 0.0087 0.0214
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0161 0.062
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0161 0.0148
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.012 0.0107
Brugia malayi MH2 domain containing protein 0.0016 0.0108 0.0125
Brugia malayi Smad1 0.0016 0.0108 0.0125
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0357 0.1454
Trypanosoma brucei unspecified product 0.0019 0.0161 0.062
Echinococcus multilocularis protein tyrosine kinase 0.0254 0.4648 0.4641
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0244 0.05
Mycobacterium ulcerans beta-lactamase 0.0072 0.1165 0.5931
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0161 0.0057
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0158 0.5
Loa Loa (eye worm) phosphofructokinase 0.0109 0.1874 0.2153
Loa Loa (eye worm) hypothetical protein 0.0123 0.2148 0.2474
Loa Loa (eye worm) hypothetical protein 0.0017 0.0131 0.0115
Echinococcus multilocularis integrin alpha ps 0.0054 0.0832 0.082
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0037 0.0508 0.0556
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0674 0.0662
Echinococcus multilocularis zinc finger protein 0.0021 0.0199 0.0186
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0357 0.1454
Leishmania major protein kinase, putative 0.0017 0.0126 0.022
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0792 0.078
Trichomonas vaginalis rotamase, putative 0.0026 0.029 0.1073
Echinococcus multilocularis lamin dm0 0.0027 0.0306 0.0293
Loa Loa (eye worm) hypothetical protein 0.0017 0.0131 0.0115
Loa Loa (eye worm) hypothetical protein 0.0037 0.0503 0.055
Loa Loa (eye worm) hypothetical protein 0.0023 0.0244 0.0247
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0158 0.0401
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0161 0.0172
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0357 0.2192
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0161 0.0187
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0131 0.0022
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.4243 0.4923
Brugia malayi N-terminal motif family protein 0.0179 0.3225 0.3756
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0042 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0244 0.065
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.1874 1
Schistosoma mansoni hypothetical protein 0.0016 0.0099 0.0086
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0025 0.0278 0.1073
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0025 0.0278 0.07
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.1165 0.6002
Loa Loa (eye worm) hypothetical protein 0.0025 0.028 0.0289
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.437 0.5072
Echinococcus multilocularis GPCR, family 2 0.0016 0.0099 0.0086
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.1165 0.6002
Brugia malayi hypothetical protein 0.0016 0.0108 0.0126
Schistosoma mansoni bromodomain containing protein 0.0064 0.1029 0.1017
Loa Loa (eye worm) hypothetical protein 0.0038 0.0525 0.0575
Echinococcus granulosus tumor protein p63 0.0339 0.6283 0.6279
Loa Loa (eye worm) hypothetical protein 0.0072 0.1165 0.1324
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0753 0.0877
Schistosoma mansoni tar DNA-binding protein 0.0189 0.3407 0.3398
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0244 0.0156
Onchocerca volvulus 0.0027 0.0306 0.0207
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0391 0.17
Onchocerca volvulus 0.005 0.0746 0.1683
Loa Loa (eye worm) Smad1 0.0016 0.0108 0.0088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0674 0.0785
Schistosoma mansoni lamin 0.0027 0.0306 0.0293
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0161 0.0414
Schistosoma mansoni tar DNA-binding protein 0.0189 0.3407 0.3398
Loa Loa (eye worm) hypothetical protein 0.007 0.1139 0.1294
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0161 0.0414
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.1874 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.028 0.1082
Brugia malayi 6-phosphofructokinase 0.0109 0.1874 0.2183
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0132 0.0119
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.1165 0.1324
Schistosoma mansoni intermediate filament proteins 0.0027 0.0306 0.0293
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0099 0.0115
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0108 0.0088
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0016 0.0104 0.0092
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0255 0.0243
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0792 0.078
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0478 0.0466
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0357 0.1454
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0161 0.062
Echinococcus granulosus integrin alpha ps 0.0026 0.0293 0.028
Loa Loa (eye worm) hypothetical protein 0.0072 0.1165 0.1324
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.1165 0.1153
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0099 0.0072
Schistosoma mansoni tar DNA-binding protein 0.0189 0.3407 0.3398
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.1165 0.1248
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.028 0.1209
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0131 0.1213
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0099 0.0115
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0132 0.0119
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0642 0.0748
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.437 0.5072
Schistosoma mansoni integrin alpha-ps 0.0028 0.0336 0.0323
Loa Loa (eye worm) hypothetical protein 0.0072 0.1165 0.1324
Schistosoma mansoni microtubule-associated protein tau 0.0533 1 1
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0037 0.0508 0.0592
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0244 0.065
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0357 0.1454
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0161 0.0414
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.012 0.0107
Schistosoma mansoni tyrosine kinase 0.0254 0.4648 0.4641
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0357 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0244 0.065
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0674 0.0662
Entamoeba histolytica hypothetical protein 0.0072 0.1167 0.5877
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0244 0.0284
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.1165 0.6031
Echinococcus multilocularis smad 0.0016 0.0108 0.0095
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.028 0.6584
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0881 0.7183
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0345 0.0365
Echinococcus multilocularis Smad4 0.0016 0.0108 0.0095
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0025 0.0278 0.1073
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0244 0.0881
Echinococcus multilocularis tumor protein p63 0.0339 0.6283 0.6279
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0132 0.0119
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0244 0.0815
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0674 0.0662
Leishmania major DNA polymerase eta, putative 0.0044 0.0642 0.3107
Echinococcus granulosus integrin alpha ps 0.0054 0.0832 0.082
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0391 0.2308
Schistosoma mansoni hypothetical protein 0.0507 0.9501 0.95
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.1874 1
Brugia malayi Bromodomain containing protein 0.0038 0.0523 0.061
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.1874 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0108 0.0095
Brugia malayi follicle stimulating hormone receptor 0.0232 0.4243 0.4942
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0357 0.1979
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0792 0.3946
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0017 0.0126 0.022
Echinococcus granulosus dna polymerase eta 0.0044 0.0642 0.063
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0091 0.1544 0.1799
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0792 0.078
Echinococcus granulosus smad 0.0016 0.0108 0.0095
Brugia malayi Stress-activated protein kinase jnk-1 0.0459 0.8585 1
Brugia malayi RNA binding protein 0.0189 0.3407 0.3969
Echinococcus granulosus lamin 0.0027 0.0306 0.0293
Loa Loa (eye worm) hypothetical protein 0.0016 0.0099 0.0077
Echinococcus multilocularis aryl hydrocarbon receptor 0.0053 0.0811 0.0799
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0792 0.3946
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.1165 0.1248
Onchocerca volvulus 0.0072 0.1165 0.3088
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.1165 0.5931
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0244 0.065
Schistosoma mansoni smad1 5 8 and 0.0016 0.0108 0.0095
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0108 0.0095
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0016 0.0099 0.0072
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.028 0.6584
Mycobacterium tuberculosis Conserved protein 0.0072 0.1165 0.1248
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.029 0.1073
Onchocerca volvulus 0.0072 0.1165 0.3088
Mycobacterium ulcerans hypothetical protein 0.0072 0.1165 0.5931
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0308
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.1874 1
Brugia malayi RNA recognition motif domain containing protein 0.0189 0.3407 0.3969
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0255 0.0243
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0161 0.062
Brugia malayi beta-lactamase 0.0072 0.1165 0.1357
Brugia malayi hypothetical protein 0.0072 0.1167 0.1359
Brugia malayi beta-lactamase family protein 0.0072 0.1165 0.1357
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0189 0.3407 0.3946
Echinococcus multilocularis tar DNA binding protein 0.0189 0.3407 0.3398
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0357 0.1161
Echinococcus granulosus Smad4 0.0016 0.0108 0.0095
Echinococcus granulosus cpg binding protein 0.0032 0.0413 0.04
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.1165 0.1153
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.1167 0.1155
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0161 0.062
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0161 0.062
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0026 0.029 0.0338
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.012 0.0107
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0108 0.0095
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.1167 0.1155
Schistosoma mansoni hypothetical protein 0.0016 0.0099 0.0086
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0792 0.3946
Leishmania major DNA polymerase kappa, putative 0.0019 0.0161 0.0414
Loa Loa (eye worm) hypothetical protein 0.005 0.0746 0.0834
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.1874 0.2153
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.1165 0.1248
Echinococcus multilocularis geminin 0.0507 0.9501 0.95
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0792 0.3946
Schistosoma mansoni zinc finger protein 0.0021 0.0199 0.0186
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0674 0.075
Brugia malayi hypothetical protein 0.0025 0.028 0.0326
Trypanosoma brucei protein kinase, putative 0.0052 0.0792 0.4076
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0746 0.0733
Loa Loa (eye worm) hypothetical protein 0.0017 0.0131 0.0115
Loa Loa (eye worm) hypothetical protein 0.005 0.0753 0.0842
Schistosoma mansoni single-minded 0.0016 0.0099 0.0086
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0108 0.0088
Schistosoma mansoni hypothetical protein 0.0507 0.9501 0.95
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0478 0.0466
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0244 0.065
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0158 0.0145
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.1165 0.1248
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0357 0.1979
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.1165 0.1153
Schistosoma mansoni lamin 0.0027 0.0306 0.0293
Brugia malayi intermediate filament protein 0.0027 0.0306 0.0356
Brugia malayi beta-lactamase family protein 0.0072 0.1165 0.1357
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.1874 0.2153
Onchocerca volvulus 0.0152 0.2707 0.8262
Echinococcus granulosus dna polymerase kappa 0.0019 0.0161 0.0148
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0306 0.0319
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0099 0.0086
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0161 0.0414
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0244 0.0881
Loa Loa (eye worm) TAR-binding protein 0.0189 0.3407 0.3946
Leishmania major hypothetical protein, conserved 0.0072 0.1165 0.6031
Loa Loa (eye worm) hypothetical protein 0.0018 0.0132 0.0116
Loa Loa (eye worm) hypothetical protein 0.0017 0.0131 0.0115
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0025 0.0278 0.1264
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0244 0.0284
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.1874 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0069 0.0043
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0161 0.015
Echinococcus granulosus integrin alpha 3 0.0026 0.0293 0.028
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0792 0.6296
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0306 0.0319
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.1874 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0244 0.065
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0792 0.3946
Echinococcus granulosus GPCR family 2 0.0016 0.0099 0.0086
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0753 0.0842
Echinococcus multilocularis integrin alpha ps 0.0054 0.0832 0.082
Giardia lamblia DINP protein human, muc B family 0.0019 0.0161 0.0038
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.1165 0.5931
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0099 0.0086
Brugia malayi hypothetical protein 0.0053 0.0806 0.0939
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.1165 0.1357
Entamoeba histolytica hypothetical protein 0.0072 0.1167 0.5877
Echinococcus granulosus zinc finger protein 0.0021 0.0199 0.0186
Loa Loa (eye worm) hypothetical protein 0.0027 0.0306 0.0319
Brugia malayi MH1 domain containing protein 0.0016 0.0108 0.0125
Loa Loa (eye worm) hypothetical protein 0.004 0.057 0.0628
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.3225 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0345 0.0402
Brugia malayi Integrin alpha pat-2 precursor 0.0054 0.0832 0.0969
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0158 0.0332
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.028 0.1273
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.1165 0.6002
Echinococcus multilocularis cpg binding protein 0.0032 0.0413 0.04
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0016 0.0104 0.0092
Echinococcus granulosus tar DNA binding protein 0.0189 0.3407 0.3398
Schistosoma mansoni hypothetical protein 0.002 0.0188 0.0175
Onchocerca volvulus Protein cycle homolog 0.0037 0.0508 0.0886
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0053 0.0811 0.0911
Loa Loa (eye worm) integrin alpha pat-2 0.012 0.2084 0.2399
Leishmania major hypothetical protein, conserved 0.0025 0.028 0.1082
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0792 0.078
Echinococcus granulosus expressed protein 0.0026 0.029 0.0277
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.1874 1
Schistosoma mansoni hypothetical protein 0.0016 0.0099 0.0086
Schistosoma mansoni serine/threonine protein kinase 0.0459 0.8585 0.8583
Brugia malayi MH2 domain containing protein 0.0239 0.437 0.5091
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0158 0.0266
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0037 0.0508 0.0592
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0792 0.078
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0132 0.0119
Schistosoma mansoni Smad4 0.0016 0.0108 0.0095
Brugia malayi PHD-finger family protein 0.0026 0.03 0.035
Plasmodium vivax hypothetical protein, conserved 0.0072 0.1165 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.0126 0.022
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0161 0.0148
Echinococcus granulosus aryl hydrocarbon receptor 0.0053 0.0811 0.0799
Schistosoma mansoni ap endonuclease 0.0019 0.0158 0.0145
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0357 0.1161
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0674 0.0662
Loa Loa (eye worm) hypothetical protein 0.0072 0.1165 0.1324
Schistosoma mansoni hypothetical protein 0.0015 0.0087 0.0074
Loa Loa (eye worm) TK/FAK protein kinase 0.0257 0.4706 0.5464
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0961 0.0949
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.1874 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.045 0.0488
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0161 0.062
Loa Loa (eye worm) hypothetical protein 0.0072 0.1165 0.1324
Loa Loa (eye worm) hypothetical protein 0.0123 0.2148 0.2474
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0161 0.062
Echinococcus multilocularis lamin 0.0027 0.0306 0.0293
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0069 0.008
Loa Loa (eye worm) hypothetical protein 0.0037 0.0503 0.055
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0158 0.1214
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0792 0.4076
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0161 0.0172
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0026 0.029 0.0301
Brugia malayi TAR-binding protein 0.0189 0.3407 0.3969
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.1874 0.1863
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0132 0.0116
Loa Loa (eye worm) hypothetical protein 0.0037 0.0503 0.055
Brugia malayi PAS domain containing protein 0.0016 0.0099 0.0116
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0674 0.0662
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0459 0.8585 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.1544 0.1768
Onchocerca volvulus 0.0072 0.1165 0.3088
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0357 0.1454
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0161 0.062
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.0126 0.022
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0792 0.3902

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 317 uM Inhibition of human plasma derived CETP ChEMBL. 19339179
Inhibition (binding) = 63 % Inhibition of human plasma derived CETP relative to control ChEMBL. 19339179

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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