Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0038 | 1 | 0.5 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 1 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 1 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.5128 | 0.5128 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0034 | 0.8332 | 0.5 |
Loa Loa (eye worm) | inositol-1 | 0.0038 | 1 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0038 | 1 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0038 | 1 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.8818 | 0.7574 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.8818 | 0.7574 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.4926 | 0.4926 |
Onchocerca volvulus | 0.0026 | 0.5128 | 0.5 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.8818 | 0.7574 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.5128 | 0.5128 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.8818 | 0.7574 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.5128 | 0.5128 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.5128 | 0.5128 |
Onchocerca volvulus | 0.0026 | 0.5128 | 0.5 | |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0038 | 1 | 0.5 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0034 | 0.8332 | 0.5 |
Brugia malayi | hypothetical protein | 0.0035 | 0.8818 | 0.8818 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 1 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 1 | 0.5 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0038 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.5128 | 0.5128 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0038 | 1 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0038 | 1 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.