Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3463 | 0.2823 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0892 | 0.0951 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0892 | 0.0892 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.3463 | 0.3692 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0892 | 0.0892 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.1227 | 0.1227 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0069 | 0.3617 | 0.3724 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.3617 | 0.3855 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0892 | 0.0892 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3842 | 0.4095 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.3463 | 0.3463 |
Loa Loa (eye worm) | potassium voltage-gated channel subfamily Q member 5 | 0.0073 | 0.3842 | 0.4095 |
Echinococcus multilocularis | geminin | 0.0168 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.3463 | 0.3562 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.1227 | 0.12 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.1227 | 0.1227 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.3463 | 0.3562 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1227 | 0.1308 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.1227 | 0.12 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0892 | 0.0951 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1227 | 0.0368 |
Onchocerca volvulus | 0.0027 | 0.0892 | 0.5 | |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.3463 | 0.3463 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.3463 | 0.3692 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.1227 | 0.1227 |
Brugia malayi | RNA binding protein | 0.0067 | 0.3463 | 0.3562 |
Echinococcus granulosus | potassium voltage gated channel subfamily KQT | 0.0073 | 0.3842 | 0.3842 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.3463 | 0.3692 |
Onchocerca volvulus | 0.0027 | 0.0892 | 0.5 | |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.0161 | 0.9557 | 0.9557 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.1227 | 0.1308 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0892 | 0.0892 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.3617 | 0.2992 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1227 | 0.0368 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.1227 | 0.1227 |
Schistosoma mansoni | voltage-gated potassium channel KCNQ | 0.0161 | 0.9557 | 0.9514 |
Brugia malayi | Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog | 0.0161 | 0.9557 | 1 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.0158 | 0.9382 | 1 |
Echinococcus granulosus | potassium channel KvQLT family member kqt 1 | 0.0161 | 0.9557 | 0.9557 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0101 | 0.5676 | 0.605 |
Echinococcus granulosus | lamin | 0.0027 | 0.0892 | 0.0892 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.1227 | 0.1227 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0892 | 0.0892 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.086 | 0.0917 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0892 | 0.0951 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3463 | 0.2823 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3842 | 0.4095 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0101 | 0.5676 | 0.59 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.0073 | 0.3842 | 0.3842 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3463 | 0.2823 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0101 | 0.5676 | 0.59 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3463 | 0.2823 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.5676 | 0.605 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.1227 | 0.1227 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1227 | 0.0368 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0892 | 0.0846 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0092 | 0.0098 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3463 | 0.2823 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1227 | 0.0368 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0892 | 0.0846 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 107 nM | Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of CI-IB-MECA-mediated inhibition of cAMP accumulation by competition protein binding assay | ChEMBL. | 18996701 |
Inhibition (binding) | = 3 % | Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells at 1 uM by scintillation counting | ChEMBL. | 18996701 |
Inhibition (binding) | = 9 % | Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in CHO cells at 1 uM by scintillation counting | ChEMBL. | 18996701 |
Inhibition (functional) | = 15 % | Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-induced cAMP accumulation at 1 uM | ChEMBL. | 18996701 |
Inhibition (binding) | = 23 % | Displacement of [125I]AB-MECA from rat adenosine A3 receptor expressed in HEK293 cells at 1 uM by scintillation counting | ChEMBL. | 18996701 |
Ki (binding) | = 15.5 nM | Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells by scintillation counting | ChEMBL. | 18996701 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.