Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.013 | 0.4233 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0191 | 0.0279 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0062 | 0.1644 | 0.3446 |
Schistosoma mansoni | hypothetical protein | 0.013 | 0.4233 | 0.4189 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0116 | 0.0116 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1098 | 0.2461 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.1098 | 0.0838 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.013 | 0.4233 | 0.9132 |
Schistosoma mansoni | thyroid hormone receptor | 0.0141 | 0.4628 | 0.4587 |
Schistosoma mansoni | glutaminase | 0.0283 | 1 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0283 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1098 | 0.1031 |
Schistosoma mansoni | thyroid hormone receptor | 0.0141 | 0.4628 | 0.4587 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0191 | 0.0117 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1098 | 0.1031 |
Loa Loa (eye worm) | glutaminase | 0.0283 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0141 | 0.4628 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1098 | 0.2247 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0116 | 0.0042 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0714 | 0.1405 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0902 | 0.0902 |
Mycobacterium ulcerans | glutaminase | 0.0283 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0977 | 0.0977 |
Schistosoma mansoni | bromodomain containing protein | 0.0065 | 0.1784 | 0.1722 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0714 | 0.1538 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1098 | 0.2461 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.0807 | 0.0539 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1098 | 0.2247 |
Trichomonas vaginalis | glutaminase, putative | 0.0283 | 1 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0062 | 0.1644 | 0.3774 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.1098 | 0.1098 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.081 | 0.081 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0191 | 0.0255 |
Brugia malayi | Bromodomain containing protein | 0.0078 | 0.2242 | 0.2016 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.2075 | 0.2075 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1098 | 0.1031 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 70.7 % | Inhibition of COX2 at 10 uM | ChEMBL. | 18412396 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.